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Determinants of the effect of extracorporeal carbon dioxide removal in the SUPERNOVA trial: implications for trial design.

Goligher EC, Combes A, Brodie D, Ferguson ND, Pesenti AM, Ranieri VM, Slutsky AS; for the SUPERNOVA investigators (European Society of Intensive Care Medicine trials group)  and for the International ECMO Network (ECMONet).

Intensive Care Med. 2019 Sep;45(9):1219-1230. doi: 10.1007/s00134-019-05708-9. Epub 2019 Aug 20.


Body Mass Index and Mortality in Subjects With ARDS: Post-hoc Analysis of the OSCILLATE Trial.

Tlayjeh H, Arabi YM, Ferguson ND, Zhou Q, Lamontagne F, Arroliga A, Danesh V, Dominguez-Cherit G, Jimenez E, Mullaly A, Staub B, Meade MO; Canadian Critical Care Trials Group.

Respir Care. 2019 Sep;64(9):1042-1048. doi: 10.4187/respcare.06675. Epub 2019 May 28.


Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome.

National Heart, Lung, and Blood Institute PETAL Clinical Trials Network, Moss M, Huang DT, Brower RG, Ferguson ND, Ginde AA, Gong MN, Grissom CK, Gundel S, Hayden D, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Khan A, Liu KD, Talmor D, Thompson BT, Ulysse CA, Yealy DM, Angus DC.

N Engl J Med. 2019 May 23;380(21):1997-2008. doi: 10.1056/NEJMoa1901686. Epub 2019 May 19.


ECMO for ARDS: from salvage to standard of care?

Abrams D, Ferguson ND, Brochard L, Fan E, Mercat A, Combes A, Pellegrino V, Schmidt M, Slutsky AS, Brodie D.

Lancet Respir Med. 2019 Feb;7(2):108-110. doi: 10.1016/S2213-2600(18)30506-X. Epub 2019 Jan 11. No abstract available. Erratum in: Lancet Respir Med. 2019 Feb;7(2):e9.


Acute respiratory distress syndrome (ARDS) phenotyping.

Shankar-Hari M, Fan E, Ferguson ND.

Intensive Care Med. 2019 Apr;45(4):516-519. doi: 10.1007/s00134-018-5480-6. Epub 2018 Dec 5. No abstract available.


Diaphragmatic myotrauma: a mediator of prolonged ventilation and poor patient outcomes in acute respiratory failure.

Goligher EC, Brochard LJ, Reid WD, Fan E, Saarela O, Slutsky AS, Kavanagh BP, Rubenfeld GD, Ferguson ND.

Lancet Respir Med. 2019 Jan;7(1):90-98. doi: 10.1016/S2213-2600(18)30366-7. Epub 2018 Nov 16. Review.


Long-Term Effects of Phased Implementation of Antimicrobial Stewardship in Academic ICUs: 2007-2015.

Morris AM, Bai A, Burry L, Dresser LD, Ferguson ND, Lapinsky SE, Lazar NM, McIntyre M, Matelski J, Minnema B, Mok K, Nelson S, Poutanen SM, Singh JM, So M, Steinberg M, Bell CM.

Crit Care Med. 2019 Feb;47(2):159-166. doi: 10.1097/CCM.0000000000003514.


Weaning From Mechanical Ventilation: What Should Be Done When a Patient's Spontaneous Breathing Trial Fails?

Munshi L, Ferguson ND.

JAMA. 2018 Nov 13;320(18):1865-1867. doi: 10.1001/jama.2018.13762. No abstract available.


Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome.

Combes A, Hajage D, Capellier G, Demoule A, Lavoué S, Guervilly C, Da Silva D, Zafrani L, Tirot P, Veber B, Maury E, Levy B, Cohen Y, Richard C, Kalfon P, Bouadma L, Mehdaoui H, Beduneau G, Lebreton G, Brochard L, Ferguson ND, Fan E, Slutsky AS, Brodie D, Mercat A; EOLIA Trial Group, REVA, and ECMONet.

N Engl J Med. 2018 May 24;378(21):1965-1975. doi: 10.1056/NEJMoa1800385.


Continuous Negative Abdominal Pressure Reduces Ventilator-induced Lung Injury in a Porcine Model.

Yoshida T, Engelberts D, Otulakowski G, Katira B, Post M, Ferguson ND, Brochard L, Amato MBP, Kavanagh BP.

Anesthesiology. 2018 Jul;129(1):163-172. doi: 10.1097/ALN.0000000000002236.


Are systematic reviews and meta-analyses still useful research? No.

Chevret S, Ferguson ND, Bellomo R.

Intensive Care Med. 2018 Apr;44(4):515-517. doi: 10.1007/s00134-018-5066-3. Epub 2018 Apr 16. No abstract available.


Continuous negative abdominal pressure: mechanism of action and comparison with prone position.

Yoshida T, Engelberts D, Otulakowski G, Katira B, Ferguson ND, Brochard L, Amato MBP, Kavanagh BP.

J Appl Physiol (1985). 2018 Jul 1;125(1):107-116. doi: 10.1152/japplphysiol.01125.2017. Epub 2018 Mar 29.


Inspiratory Muscle Rehabilitation in Critically Ill Adults. A Systematic Review and Meta-Analysis.

Vorona S, Sabatini U, Al-Maqbali S, Bertoni M, Dres M, Bissett B, Van Haren F, Martin AD, Urrea C, Brace D, Parotto M, Herridge MS, Adhikari NKJ, Fan E, Melo LT, Reid WD, Brochard LJ, Ferguson ND, Goligher EC.

Ann Am Thorac Soc. 2018 Jun;15(6):735-744. doi: 10.1513/AnnalsATS.201712-961OC.


A Fine Balance for Oxygen in Acute Respiratory Distress Syndrome.

Urner M, Ferguson ND.

Crit Care Med. 2018 Apr;46(4):646-647. doi: 10.1097/CCM.0000000000002910. No abstract available.


Unproven and Expensive May Still Be Justifiable.

Abrams D, Fan E, Ferguson ND, Brodie D.

Am J Respir Crit Care Med. 2018 Jul 1;198(1):140. doi: 10.1164/rccm.201801-0112LE. No abstract available.


Position paper for the organization of ECMO programs for cardiac failure in adults.

Abrams D, Garan AR, Abdelbary A, Bacchetta M, Bartlett RH, Beck J, Belohlavek J, Chen YS, Fan E, Ferguson ND, Fowles JA, Fraser J, Gong M, Hassan IF, Hodgson C, Hou X, Hryniewicz K, Ichiba S, Jakobleff WA, Lorusso R, MacLaren G, McGuinness S, Mueller T, Park PK, Peek G, Pellegrino V, Price S, Rosenzweig EB, Sakamoto T, Salazar L, Schmidt M, Slutsky AS, Spaulding C, Takayama H, Takeda K, Vuylsteke A, Combes A, Brodie D; International ECMO Network (ECMONet) and The Extracorporeal Life Support Organization (ELSO).

Intensive Care Med. 2018 Jun;44(6):717-729. doi: 10.1007/s00134-018-5064-5. Epub 2018 Feb 15.


Opportunity Knocks? The Expansion of Volatile Agent Use in New Clinical Settings.

Jerath A, Parotto M, Wasowicz M, Ferguson ND.

J Cardiothorac Vasc Anesth. 2018 Aug;32(4):1946-1954. doi: 10.1053/j.jvca.2017.12.035. Epub 2017 Dec 21. Review. No abstract available.


Research in Extracorporeal Life Support: A Call to Action.

Brodie D, Vincent JL, Brochard LJ, Combes A, Ferguson ND, Hodgson CL, Laffey JG, Mercat A, Pesenti A, Quintel M, Slutsky AS, Ranieri VM; International ECMO Network (ECMONet).

Chest. 2018 Apr;153(4):788-791. doi: 10.1016/j.chest.2017.12.024. Epub 2018 Jan 31. No abstract available.


Adjunct and rescue therapies for refractory hypoxemia: prone position, inhaled nitric oxide, high frequency oscillation, extra corporeal life support.

Ferguson ND, Guérin C.

Intensive Care Med. 2018 Sep;44(9):1528-1531. doi: 10.1007/s00134-017-5040-5. Epub 2018 Jan 18. No abstract available.


Extracorporeal life support as a bridge to lung transplantation-experience of a high-volume transplant center.

Hoetzenecker K, Donahoe L, Yeung JC, Azad S, Fan E, Ferguson ND, Del Sorbo L, de Perrot M, Pierre A, Yasufuku K, Singer L, Waddell TK, Keshavjee S, Cypel M.

J Thorac Cardiovasc Surg. 2018 Mar;155(3):1316-1328.e1. doi: 10.1016/j.jtcvs.2017.09.161. Epub 2017 Nov 22.


Reply to Dreyfuss and Gaudry: Might High-Frequency Oscillatory Ventilation Improve the Prognosis of More Severe Acute Respiratory Distress Syndrome? Not So Sure.

Meade MO, Young D, Ferguson ND.

Am J Respir Crit Care Med. 2018 Mar 15;197(6):839. doi: 10.1164/rccm.201710-2021LE. No abstract available.


Long-Term Quality of Life After Extracorporeal Membrane Oxygenation in ARDS Survivors: Systematic Review and Meta-Analysis.

Wilcox ME, Jaramillo-Rocha V, Hodgson C, Taglione MS, Ferguson ND, Fan E.

J Intensive Care Med. 2017 Jan 1:885066617737035. doi: 10.1177/0885066617737035. [Epub ahead of print]


Lung Recruitment Maneuvers for Adult Patients with Acute Respiratory Distress Syndrome. A Systematic Review and Meta-Analysis.

Goligher EC, Hodgson CL, Adhikari NKJ, Meade MO, Wunsch H, Uleryk E, Gajic O, Amato MPB, Ferguson ND, Rubenfeld GD, Fan E.

Ann Am Thorac Soc. 2017 Oct;14(Supplement_4):S304-S311. doi: 10.1513/AnnalsATS.201704-340OT. Review.


High-Frequency Oscillation for Adult Patients with Acute Respiratory Distress Syndrome. A Systematic Review and Meta-Analysis.

Goligher EC, Munshi L, Adhikari NKJ, Meade MO, Hodgson CL, Wunsch H, Uleryk E, Gajic O, Amato MPB, Ferguson ND, Rubenfeld GD, Fan E.

Ann Am Thorac Soc. 2017 Oct;14(Supplement_4):S289-S296. doi: 10.1513/AnnalsATS.201704-341OT. Review.


High-flow oxygen via nasal cannulae in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis.

Leeies M, Flynn E, Turgeon AF, Paunovic B, Loewen H, Rabbani R, Abou-Setta AM, Ferguson ND, Zarychanski R.

Syst Rev. 2017 Oct 16;6(1):202. doi: 10.1186/s13643-017-0593-5. Review.


Use of a structured panel process to define antimicrobial prescribing appropriateness in critical care.

Dresser LD, Bell CM, Steinberg M, Ferguson ND, Lapinsky S, Lazar N, Murphy P, Singh JM, Morris AM.

J Antimicrob Chemother. 2018 Jan 1;73(1):246-249. doi: 10.1093/jac/dkx341.


Mechanical Ventilation-induced Diaphragm Atrophy Strongly Impacts Clinical Outcomes.

Goligher EC, Dres M, Fan E, Rubenfeld GD, Scales DC, Herridge MS, Vorona S, Sklar MC, Rittayamai N, Lanys A, Murray A, Brace D, Urrea C, Reid WD, Tomlinson G, Slutsky AS, Kavanagh BP, Brochard LJ, Ferguson ND.

Am J Respir Crit Care Med. 2018 Jan 15;197(2):204-213. doi: 10.1164/rccm.201703-0536OC.


Management of Acute Respiratory Distress Syndrome and Refractory Hypoxemia. A Multicenter Observational Study.

Duan EH, Adhikari NKJ, D'Aragon F, Cook DJ, Mehta S, Alhazzani W, Goligher E, Charbonney E, Arabi YM, Karachi T, Turgeon AF, Hand L, Zhou Q, Austin P, Friedrich J, Lamontagne F, Lauzier F, Patel R, Muscedere J, Hall R, Aslanian P, Piraino T, Albert M, Bagshaw SM, Jacka M, Wood G, Henderson W, Dorscheid D, Ferguson ND, Meade MO; Canadian Critical Care Trials Group.

Ann Am Thorac Soc. 2017 Dec;14(12):1818-1826. doi: 10.1513/AnnalsATS.201612-1042OC.


Oxygen Thresholds and Mortality During Extracorporeal Life Support in Adult Patients.

Munshi L, Kiss A, Cypel M, Keshavjee S, Ferguson ND, Fan E.

Crit Care Med. 2017 Dec;45(12):1997-2005. doi: 10.1097/CCM.0000000000002643.


Continuous Negative Abdominal Pressure Recruits Lungs at Lower Distending Pressures.

Yoshida T, Engelberts D, Otulakowski G, Katira B, Post M, Ferguson ND, Brochard L, Amato MBP, Kavanagh BP.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):534-537. doi: 10.1164/rccm.201705-0979LE. No abstract available.


Rethinking Inspiratory Pressure Augmentation in Spontaneous Breathing Trials.

Goligher EC, Detsky ME, Sklar MC, Campbell VT, Greco P, Amaral ACKB, Ferguson ND, Brochard LJ.

Chest. 2017 Jun;151(6):1399-1400. doi: 10.1016/j.chest.2017.02.033. No abstract available.


An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome.

Fan E, Del Sorbo L, Goligher EC, Hodgson CL, Munshi L, Walkey AJ, Adhikari NKJ, Amato MBP, Branson R, Brower RG, Ferguson ND, Gajic O, Gattinoni L, Hess D, Mancebo J, Meade MO, McAuley DF, Pesenti A, Ranieri VM, Rubenfeld GD, Rubin E, Seckel M, Slutsky AS, Talmor D, Thompson BT, Wunsch H, Uleryk E, Brozek J, Brochard LJ; American Thoracic Society, European Society of Intensive Care Medicine, and Society of Critical Care Medicine.

Am J Respir Crit Care Med. 2017 May 1;195(9):1253-1263. doi: 10.1164/rccm.201703-0548ST. Erratum in: Am J Respir Crit Care Med. 2017 Jun 1;195(11):1540.


Severity of Hypoxemia and Effect of High-Frequency Oscillatory Ventilation in Acute Respiratory Distress Syndrome.

Meade MO, Young D, Hanna S, Zhou Q, Bachman TE, Bollen C, Slutsky AS, Lamb SE, Adhikari NKJ, Mentzelopoulos SD, Cook DJ, Sud S, Brower RG, Thompson BT, Shah S, Stenzler A, Guyatt G, Ferguson ND.

Am J Respir Crit Care Med. 2017 Sep 15;196(6):727-733. doi: 10.1164/rccm.201609-1938OC.


High-frequency oscillatory ventilation: still a role?

Ng J, Ferguson ND.

Curr Opin Crit Care. 2017 Apr;23(2):175-179. doi: 10.1097/MCC.0000000000000387. Review.


Severe hypercapnia and outcome of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome.

Nin N, Muriel A, Peñuelas O, Brochard L, Lorente JA, Ferguson ND, Raymondos K, Ríos F, Violi DA, Thille AW, González M, Villagomez AJ, Hurtado J, Davies AR, Du B, Maggiore SM, Soto L, D'Empaire G, Matamis D, Abroug F, Moreno RP, Soares MA, Arabi Y, Sandi F, Jibaja M, Amin P, Koh Y, Kuiper MA, Bülow HH, Zeggwagh AA, Anzueto A, Sznajder JI, Esteban A; VENTILA Group.

Intensive Care Med. 2017 Feb;43(2):200-208. doi: 10.1007/s00134-016-4611-1. Epub 2017 Jan 20.


Bilateral pneumonectomy to treat uncontrolled sepsis in a patient awaiting lung transplantation.

Cypel M, Waddell T, Singer LG, Del Sorbo L, Fan E, Binnie M, Ferguson ND, Keshavjee S.

J Thorac Cardiovasc Surg. 2017 Apr;153(4):e67-e69. doi: 10.1016/j.jtcvs.2016.11.031. Epub 2016 Nov 23. No abstract available.


Association between ventilatory settings and development of acute respiratory distress syndrome in mechanically ventilated patients due to brain injury.

Tejerina E, Pelosi P, Muriel A, Peñuelas O, Sutherasan Y, Frutos-Vivar F, Nin N, Davies AR, Rios F, Violi DA, Raymondos K, Hurtado J, González M, Du B, Amin P, Maggiore SM, Thille AW, Soares MA, Jibaja M, Villagomez AJ, Kuiper MA, Koh Y, Moreno RP, Zeggwagh AA, Matamis D, Anzueto A, Ferguson ND, Esteban A; for VENTILA group.

J Crit Care. 2017 Apr;38:341-345. doi: 10.1016/j.jcrc.2016.11.010. Epub 2016 Nov 18.


Intensive Care Physiotherapy during Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome.

Munshi L, Kobayashi T, DeBacker J, Doobay R, Telesnicki T, Lo V, Cote N, Cypel M, Keshavjee S, Ferguson ND, Fan E.

Ann Am Thorac Soc. 2017 Feb;14(2):246-253. doi: 10.1513/AnnalsATS.201606-484OC.


Airway Management Strategies for Brain-injured Patients Meeting Standard Criteria to Consider Extubation. A Prospective Cohort Study.

McCredie VA, Ferguson ND, Pinto RL, Adhikari NK, Fowler RA, Chapman MG, Burrell A, Baker AJ, Cook DJ, Meade MO, Scales DC; Canadian Critical Care Trials Group.

Ann Am Thorac Soc. 2017 Jan;14(1):85-93. doi: 10.1513/AnnalsATS.201608-620OC.


Safety and Efficacy of Volatile Anesthetic Agents Compared With Standard Intravenous Midazolam/Propofol Sedation in Ventilated Critical Care Patients: A Meta-analysis and Systematic Review of Prospective Trials.

Jerath A, Panckhurst J, Parotto M, Lightfoot N, Wasowicz M, Ferguson ND, Steel A, Beattie WS.

Anesth Analg. 2017 Apr;124(4):1190-1199. doi: 10.1213/ANE.0000000000001634. Review.


Design and Rationale of the Reevaluation of Systemic Early Neuromuscular Blockade Trial for Acute Respiratory Distress Syndrome.

Huang DT, Angus DC, Moss M, Thompson BT, Ferguson ND, Ginde A, Gong MN, Gundel S, Hayden DL, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Liu KD, Talmor DS, Yealy DM; Reevaluation of Systemic Early Neuromuscular Blockade Protocol Committee and the National Institutes of Health National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Network Investigators.

Ann Am Thorac Soc. 2017 Jan;14(1):124-133. doi: 10.1513/AnnalsATS.201608-629OT.


Oxygen in the ICU: Too Much of a Good Thing?

Ferguson ND.

JAMA. 2016 Oct 18;316(15):1553-1554. doi: 10.1001/jama.2016.13800. No abstract available.


Adjuvants to Mechanical Ventilation for Acute Respiratory Failure. Adoption, De-adoption, and Factors Associated with Selection.

Munshi L, Gershengorn HB, Fan E, Wunsch H, Ferguson ND, Stukel TA, Rubenfeld GD.

Ann Am Thorac Soc. 2017 Jan;14(1):94-102. doi: 10.1513/AnnalsATS.201606-438OC.


The impact of hospital experience with out-of-hospital cardiac arrest patients on post cardiac arrest care.

Worthington H, Pickett W, Morrison LJ, Scales DC, Zhan C, Lin S, Dorian P, Dainty KN, Ferguson ND, Brooks SC; Rescu Investigators.

Resuscitation. 2017 Jan;110:169-175. doi: 10.1016/j.resuscitation.2016.08.032. Epub 2016 Sep 20.


Clinical challenges in mechanical ventilation.

Goligher EC, Ferguson ND, Brochard LJ.

Lancet. 2016 Apr 30;387(10030):1856-66. doi: 10.1016/S0140-6736(16)30176-3. Epub 2016 Apr 28. Review.


One-Year Outcomes in Caregivers of Critically Ill Patients.

Cameron JI, Chu LM, Matte A, Tomlinson G, Chan L, Thomas C, Friedrich JO, Mehta S, Lamontagne F, Levasseur M, Ferguson ND, Adhikari NK, Rudkowski JC, Meggison H, Skrobik Y, Flannery J, Bayley M, Batt J, dos Santos C, Abbey SE, Tan A, Lo V, Mathur S, Parotto M, Morris D, Flockhart L, Fan E, Lee CM, Wilcox ME, Ayas N, Choong K, Fowler R, Scales DC, Sinuff T, Cuthbertson BH, Rose L, Robles P, Burns S, Cypel M, Singer L, Chaparro C, Chow CW, Keshavjee S, Brochard L, Hébert P, Slutsky AS, Marshall JC, Cook D, Herridge MS; RECOVER Program Investigators (Phase 1: towards RECOVER); Canadian Critical Care Trials Group.

N Engl J Med. 2016 May 12;374(19):1831-41. doi: 10.1056/NEJMoa1511160.


Prediction and Outcome of Intensive Care Unit-Acquired Paresis.

Peñuelas O, Muriel A, Frutos-Vivar F, Fan E, Raymondos K, Rios F, Nin N, Thille AW, González M, Villagomez AJ, Davies AR, Du B, Maggiore SM, Matamis D, Abroug F, Moreno RP, Kuiper MA, Anzueto A, Ferguson ND, Esteban A.

J Intensive Care Med. 2018 Jan;33(1):16-28. doi: 10.1177/0885066616643529. Epub 2016 Apr 13.


Monitoring during extracorporeal membrane oxygenation.

Douflé G, Ferguson ND.

Curr Opin Crit Care. 2016 Jun;22(3):230-8. doi: 10.1097/MCC.0000000000000309. Review.


High-frequency oscillatory ventilation versus conventional ventilation for acute respiratory distress syndrome.

Sud S, Sud M, Friedrich JO, Wunsch H, Meade MO, Ferguson ND, Adhikari NK.

Cochrane Database Syst Rev. 2016 Apr 4;4:CD004085. doi: 10.1002/14651858.CD004085.pub4. Review.


The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness.

Delaney JW, Pinto R, Long J, Lamontagne F, Adhikari NK, Kumar A, Marshall JC, Cook DJ, Jouvet P, Ferguson ND, Griesdale D, Burry LD, Burns KE, Hutchison J, Mehta S, Menon K, Fowler RA; Canadian Critical Care Trials Group H1N1 Collaborative.

Crit Care. 2016 Mar 30;20:75. doi: 10.1186/s13054-016-1230-8.

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