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Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care: NHLBI Working Group Report.

Semler MW, Bernard GR, Aaron SD, Angus DC, Biros MH, Brower RG, Calfee CS, Colantuoni EA, Ferguson ND, Gong MN, Hopkins RO, Hough CL, Iwashyna TJ, Levy BD, Martin TR, Matthay MA, Mizgerd JP, Moss M, Needham DM, Self WH, Seymour CW, Stapleton RD, Thompson BT, Wunderink RG, Aggarwal NR, Reineck LA.

Am J Respir Crit Care Med. 2020 Mar 9. doi: 10.1164/rccm.201908-1595WS. [Epub ahead of print]


Airway Occlusion Pressure as an Estimate of Respiratory Drive and Inspiratory Effort During Assisted Ventilation.

Telias I, Junhasavasdikul D, Rittayamai N, Piquilloud L, Chen L, Ferguson ND, Goligher EC, Brochard L.

Am J Respir Crit Care Med. 2020 Feb 25. doi: 10.1164/rccm.201907-1425OC. [Epub ahead of print]


Association of Low Baseline Diaphragm Muscle Mass With Prolonged Mechanical Ventilation and Mortality Among Critically Ill Adults.

Sklar MC, Dres M, Fan E, Rubenfeld GD, Scales DC, Herridge MS, Rittayamai N, Harhay MO, Reid WD, Tomlinson G, Rozenberg D, McClelland W, Riegler S, Slutsky AS, Brochard L, Ferguson ND, Goligher EC.

JAMA Netw Open. 2020 Feb 5;3(2):e1921520. doi: 10.1001/jamanetworkopen.2019.21520.


Evolving Issues in Oxygen Therapy in Acute Care Medicine.

Munshi L, Ferguson ND.

JAMA. 2020 Jan 24. doi: 10.1001/jama.2019.22029. [Epub ahead of print] No abstract available.


Compliance With Evidence-Based Processes of Care After Transitions Between Staff Intensivists.

Angriman F, Pinto R, Friedrich JO, Ferguson ND, Rubenfeld G, Amaral ACK.

Crit Care Med. 2020 Mar;48(3):e227-e232. doi: 10.1097/CCM.0000000000004201.


Inter-country variability over time in the mortality of mechanically ventilated patients.

Peñuelas O, Muriel A, Abraira V, Frutos-Vivar F, Mancebo J, Raymondos K, Du B, Thille AW, Ríos F, González M, Del-Sorbo L, Ferguson ND, Del Carmen Marín M, Pinheiro BV, Soares MA, Nin N, Maggiore SM, Bersten A, Amin P, Cakar N, Suh GY, Abroug F, Jibaja M, Matamis D, Zeggwagh AA, Sutherasan Y, Anzueto A, Esteban A.

Intensive Care Med. 2020 Mar;46(3):444-453. doi: 10.1007/s00134-019-05867-9. Epub 2020 Jan 7.


Mechanical Ventilation for Acute Respiratory Distress Syndrome during Extracorporeal Life Support. Research and Practice.

Abrams D, Schmidt M, Pham T, Beitler JR, Fan E, Goligher EC, McNamee JJ, Patroniti N, Wilcox ME, Combes A, Ferguson ND, McAuley DF, Pesenti A, Quintel M, Fraser J, Hodgson CL, Hough CL, Mercat A, Mueller T, Pellegrino V, Ranieri VM, Rowan K, Shekar K, Brochard L, Brodie D.

Am J Respir Crit Care Med. 2020 Mar 1;201(5):514-525. doi: 10.1164/rccm.201907-1283CI.


A novel non-invasive method to detect excessively high respiratory effort and dynamic transpulmonary driving pressure during mechanical ventilation.

Bertoni M, Telias I, Urner M, Long M, Del Sorbo L, Fan E, Sinderby C, Beck J, Liu L, Qiu H, Wong J, Slutsky AS, Ferguson ND, Brochard LJ, Goligher EC.

Crit Care. 2019 Nov 6;23(1):346. doi: 10.1186/s13054-019-2617-0.


Correction to: Focus on ventilation and ARDS: recent insights.

De Jong A, Jaber S, Ferguson ND.

Intensive Care Med. 2020 Jan;46(1):152. doi: 10.1007/s00134-019-05843-3.


The harm of high-frequency oscillatory ventilation (HFOV) in ARDS is not related to a high baseline risk of acute cor pulmonale or short-term changes in hemodynamics.

Angriman F, Ferreyro BL, Donaldson L, Cuthbertson BH, Ferguson ND, Bollen CW, Bachman TE, Lamontagne F, Adhikari NKJ.

Intensive Care Med. 2020 Jan;46(1):132-134. doi: 10.1007/s00134-019-05806-8. Epub 2019 Oct 29. No abstract available.


Focus on ventilation and ARDS: recent insights.

De Jong A, Jaber S, Ferguson ND.

Intensive Care Med. 2019 Nov;45(11):1635-1638. doi: 10.1007/s00134-019-05804-w. Epub 2019 Oct 16. No abstract available. Erratum in: Intensive Care Med. 2019 Oct 30;:.


Frailty and invasive mechanical ventilation: association with outcomes, extubation failure, and tracheostomy.

Fernando SM, McIsaac DI, Rochwerg B, Bagshaw SM, Muscedere J, Munshi L, Ferguson ND, Seely AJE, Cook DJ, Dave C, Tanuseputro P, Kyeremanteng K.

Intensive Care Med. 2019 Dec;45(12):1742-1752. doi: 10.1007/s00134-019-05795-8. Epub 2019 Oct 8.


Potential for Lung Recruitment Estimated by the Recruitment-to-Inflation Ratio in Acute Respiratory Distress Syndrome. A Clinical Trial.

Chen L, Del Sorbo L, Grieco DL, Junhasavasdikul D, Rittayamai N, Soliman I, Sklar MC, Rauseo M, Ferguson ND, Fan E, Richard JM, Brochard L.

Am J Respir Crit Care Med. 2020 Jan 15;201(2):178-187. doi: 10.1164/rccm.201902-0334OC.


Added Benefit of Noninvasive Ventilation to High-Flow Nasal Oxygen to Prevent Reintubation in Higher-Risk Patients.

Telias I, Ferguson ND.

JAMA. 2019 Oct 2. doi: 10.1001/jama.2019.14609. [Epub ahead of print] No abstract available.


Determinants of the effect of extracorporeal carbon dioxide removal in the SUPERNOVA trial: implications for trial design.

Goligher EC, Combes A, Brodie D, Ferguson ND, Pesenti AM, Ranieri VM, Slutsky AS; SUPERNOVA investigators (European Society of Intensive Care Medicine trials group)  and for the International ECMO Network (ECMONet).

Intensive Care Med. 2019 Sep;45(9):1219-1230. doi: 10.1007/s00134-019-05708-9. Epub 2019 Aug 20.


Body Mass Index and Mortality in Subjects With ARDS: Post-hoc Analysis of the OSCILLATE Trial.

Tlayjeh H, Arabi YM, Ferguson ND, Zhou Q, Lamontagne F, Arroliga A, Danesh V, Dominguez-Cherit G, Jimenez E, Mullaly A, Staub B, Meade MO; Canadian Critical Care Trials Group.

Respir Care. 2019 Sep;64(9):1042-1048. doi: 10.4187/respcare.06675. Epub 2019 May 28.


Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome.

National Heart, Lung, and Blood Institute PETAL Clinical Trials Network, Moss M, Huang DT, Brower RG, Ferguson ND, Ginde AA, Gong MN, Grissom CK, Gundel S, Hayden D, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Khan A, Liu KD, Talmor D, Thompson BT, Ulysse CA, Yealy DM, Angus DC.

N Engl J Med. 2019 May 23;380(21):1997-2008. doi: 10.1056/NEJMoa1901686. Epub 2019 May 19.


ECMO for ARDS: from salvage to standard of care?

Abrams D, Ferguson ND, Brochard L, Fan E, Mercat A, Combes A, Pellegrino V, Schmidt M, Slutsky AS, Brodie D.

Lancet Respir Med. 2019 Feb;7(2):108-110. doi: 10.1016/S2213-2600(18)30506-X. Epub 2019 Jan 11. No abstract available. Erratum in: Lancet Respir Med. 2019 Feb;7(2):e9.


Acute respiratory distress syndrome (ARDS) phenotyping.

Shankar-Hari M, Fan E, Ferguson ND.

Intensive Care Med. 2019 Apr;45(4):516-519. doi: 10.1007/s00134-018-5480-6. Epub 2018 Dec 5. No abstract available.


Diaphragmatic myotrauma: a mediator of prolonged ventilation and poor patient outcomes in acute respiratory failure.

Goligher EC, Brochard LJ, Reid WD, Fan E, Saarela O, Slutsky AS, Kavanagh BP, Rubenfeld GD, Ferguson ND.

Lancet Respir Med. 2019 Jan;7(1):90-98. doi: 10.1016/S2213-2600(18)30366-7. Epub 2018 Nov 16. Review.


Long-Term Effects of Phased Implementation of Antimicrobial Stewardship in Academic ICUs: 2007-2015.

Morris AM, Bai A, Burry L, Dresser LD, Ferguson ND, Lapinsky SE, Lazar NM, McIntyre M, Matelski J, Minnema B, Mok K, Nelson S, Poutanen SM, Singh JM, So M, Steinberg M, Bell CM.

Crit Care Med. 2019 Feb;47(2):159-166. doi: 10.1097/CCM.0000000000003514.


Weaning From Mechanical Ventilation: What Should Be Done When a Patient's Spontaneous Breathing Trial Fails?

Munshi L, Ferguson ND.

JAMA. 2018 Nov 13;320(18):1865-1867. doi: 10.1001/jama.2018.13762. No abstract available.


Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome.

Combes A, Hajage D, Capellier G, Demoule A, Lavoué S, Guervilly C, Da Silva D, Zafrani L, Tirot P, Veber B, Maury E, Levy B, Cohen Y, Richard C, Kalfon P, Bouadma L, Mehdaoui H, Beduneau G, Lebreton G, Brochard L, Ferguson ND, Fan E, Slutsky AS, Brodie D, Mercat A; EOLIA Trial Group, REVA, and ECMONet.

N Engl J Med. 2018 May 24;378(21):1965-1975. doi: 10.1056/NEJMoa1800385.


Continuous Negative Abdominal Pressure Reduces Ventilator-induced Lung Injury in a Porcine Model.

Yoshida T, Engelberts D, Otulakowski G, Katira B, Post M, Ferguson ND, Brochard L, Amato MBP, Kavanagh BP.

Anesthesiology. 2018 Jul;129(1):163-172. doi: 10.1097/ALN.0000000000002236.


Are systematic reviews and meta-analyses still useful research? No.

Chevret S, Ferguson ND, Bellomo R.

Intensive Care Med. 2018 Apr;44(4):515-517. doi: 10.1007/s00134-018-5066-3. Epub 2018 Apr 16. No abstract available.


Continuous negative abdominal pressure: mechanism of action and comparison with prone position.

Yoshida T, Engelberts D, Otulakowski G, Katira B, Ferguson ND, Brochard L, Amato MBP, Kavanagh BP.

J Appl Physiol (1985). 2018 Jul 1;125(1):107-116. doi: 10.1152/japplphysiol.01125.2017. Epub 2018 Mar 29.


Inspiratory Muscle Rehabilitation in Critically Ill Adults. A Systematic Review and Meta-Analysis.

Vorona S, Sabatini U, Al-Maqbali S, Bertoni M, Dres M, Bissett B, Van Haren F, Martin AD, Urrea C, Brace D, Parotto M, Herridge MS, Adhikari NKJ, Fan E, Melo LT, Reid WD, Brochard LJ, Ferguson ND, Goligher EC.

Ann Am Thorac Soc. 2018 Jun;15(6):735-744. doi: 10.1513/AnnalsATS.201712-961OC.


A Fine Balance for Oxygen in Acute Respiratory Distress Syndrome.

Urner M, Ferguson ND.

Crit Care Med. 2018 Apr;46(4):646-647. doi: 10.1097/CCM.0000000000002910. No abstract available.


Unproven and Expensive May Still Be Justifiable.

Abrams D, Fan E, Ferguson ND, Brodie D.

Am J Respir Crit Care Med. 2018 Jul 1;198(1):140. doi: 10.1164/rccm.201801-0112LE. No abstract available.


Position paper for the organization of ECMO programs for cardiac failure in adults.

Abrams D, Garan AR, Abdelbary A, Bacchetta M, Bartlett RH, Beck J, Belohlavek J, Chen YS, Fan E, Ferguson ND, Fowles JA, Fraser J, Gong M, Hassan IF, Hodgson C, Hou X, Hryniewicz K, Ichiba S, Jakobleff WA, Lorusso R, MacLaren G, McGuinness S, Mueller T, Park PK, Peek G, Pellegrino V, Price S, Rosenzweig EB, Sakamoto T, Salazar L, Schmidt M, Slutsky AS, Spaulding C, Takayama H, Takeda K, Vuylsteke A, Combes A, Brodie D; International ECMO Network (ECMONet) and The Extracorporeal Life Support Organization (ELSO).

Intensive Care Med. 2018 Jun;44(6):717-729. doi: 10.1007/s00134-018-5064-5. Epub 2018 Feb 15.


Opportunity Knocks? The Expansion of Volatile Agent Use in New Clinical Settings.

Jerath A, Parotto M, Wasowicz M, Ferguson ND.

J Cardiothorac Vasc Anesth. 2018 Aug;32(4):1946-1954. doi: 10.1053/j.jvca.2017.12.035. Epub 2017 Dec 21. Review. No abstract available.


Research in Extracorporeal Life Support: A Call to Action.

Brodie D, Vincent JL, Brochard LJ, Combes A, Ferguson ND, Hodgson CL, Laffey JG, Mercat A, Pesenti A, Quintel M, Slutsky AS, Ranieri VM; International ECMO Network (ECMONet).

Chest. 2018 Apr;153(4):788-791. doi: 10.1016/j.chest.2017.12.024. Epub 2018 Jan 31. No abstract available.


Adjunct and rescue therapies for refractory hypoxemia: prone position, inhaled nitric oxide, high frequency oscillation, extra corporeal life support.

Ferguson ND, Guérin C.

Intensive Care Med. 2018 Sep;44(9):1528-1531. doi: 10.1007/s00134-017-5040-5. Epub 2018 Jan 18. No abstract available.


Extracorporeal life support as a bridge to lung transplantation-experience of a high-volume transplant center.

Hoetzenecker K, Donahoe L, Yeung JC, Azad S, Fan E, Ferguson ND, Del Sorbo L, de Perrot M, Pierre A, Yasufuku K, Singer L, Waddell TK, Keshavjee S, Cypel M.

J Thorac Cardiovasc Surg. 2018 Mar;155(3):1316-1328.e1. doi: 10.1016/j.jtcvs.2017.09.161. Epub 2017 Nov 22.


Reply to Dreyfuss and Gaudry: Might High-Frequency Oscillatory Ventilation Improve the Prognosis of More Severe Acute Respiratory Distress Syndrome? Not So Sure.

Meade MO, Young D, Ferguson ND.

Am J Respir Crit Care Med. 2018 Mar 15;197(6):839. doi: 10.1164/rccm.201710-2021LE. No abstract available.


Long-Term Quality of Life After Extracorporeal Membrane Oxygenation in ARDS Survivors: Systematic Review and Meta-Analysis.

Wilcox ME, Jaramillo-Rocha V, Hodgson C, Taglione MS, Ferguson ND, Fan E.

J Intensive Care Med. 2020 Mar;35(3):233-243. doi: 10.1177/0885066617737035. Epub 2017 Oct 19.


Lung Recruitment Maneuvers for Adult Patients with Acute Respiratory Distress Syndrome. A Systematic Review and Meta-Analysis.

Goligher EC, Hodgson CL, Adhikari NKJ, Meade MO, Wunsch H, Uleryk E, Gajic O, Amato MPB, Ferguson ND, Rubenfeld GD, Fan E.

Ann Am Thorac Soc. 2017 Oct;14(Supplement_4):S304-S311. doi: 10.1513/AnnalsATS.201704-340OT. Review.


High-Frequency Oscillation for Adult Patients with Acute Respiratory Distress Syndrome. A Systematic Review and Meta-Analysis.

Goligher EC, Munshi L, Adhikari NKJ, Meade MO, Hodgson CL, Wunsch H, Uleryk E, Gajic O, Amato MPB, Ferguson ND, Rubenfeld GD, Fan E.

Ann Am Thorac Soc. 2017 Oct;14(Supplement_4):S289-S296. doi: 10.1513/AnnalsATS.201704-341OT. Review.


High-flow oxygen via nasal cannulae in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis.

Leeies M, Flynn E, Turgeon AF, Paunovic B, Loewen H, Rabbani R, Abou-Setta AM, Ferguson ND, Zarychanski R.

Syst Rev. 2017 Oct 16;6(1):202. doi: 10.1186/s13643-017-0593-5. Review.


Use of a structured panel process to define antimicrobial prescribing appropriateness in critical care.

Dresser LD, Bell CM, Steinberg M, Ferguson ND, Lapinsky S, Lazar N, Murphy P, Singh JM, Morris AM.

J Antimicrob Chemother. 2018 Jan 1;73(1):246-249. doi: 10.1093/jac/dkx341.


Mechanical Ventilation-induced Diaphragm Atrophy Strongly Impacts Clinical Outcomes.

Goligher EC, Dres M, Fan E, Rubenfeld GD, Scales DC, Herridge MS, Vorona S, Sklar MC, Rittayamai N, Lanys A, Murray A, Brace D, Urrea C, Reid WD, Tomlinson G, Slutsky AS, Kavanagh BP, Brochard LJ, Ferguson ND.

Am J Respir Crit Care Med. 2018 Jan 15;197(2):204-213. doi: 10.1164/rccm.201703-0536OC.


Management of Acute Respiratory Distress Syndrome and Refractory Hypoxemia. A Multicenter Observational Study.

Duan EH, Adhikari NKJ, D'Aragon F, Cook DJ, Mehta S, Alhazzani W, Goligher E, Charbonney E, Arabi YM, Karachi T, Turgeon AF, Hand L, Zhou Q, Austin P, Friedrich J, Lamontagne F, Lauzier F, Patel R, Muscedere J, Hall R, Aslanian P, Piraino T, Albert M, Bagshaw SM, Jacka M, Wood G, Henderson W, Dorscheid D, Ferguson ND, Meade MO; Canadian Critical Care Trials Group.

Ann Am Thorac Soc. 2017 Dec;14(12):1818-1826. doi: 10.1513/AnnalsATS.201612-1042OC.


Oxygen Thresholds and Mortality During Extracorporeal Life Support in Adult Patients.

Munshi L, Kiss A, Cypel M, Keshavjee S, Ferguson ND, Fan E.

Crit Care Med. 2017 Dec;45(12):1997-2005. doi: 10.1097/CCM.0000000000002643.


Continuous Negative Abdominal Pressure Recruits Lungs at Lower Distending Pressures.

Yoshida T, Engelberts D, Otulakowski G, Katira B, Post M, Ferguson ND, Brochard L, Amato MBP, Kavanagh BP.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):534-537. doi: 10.1164/rccm.201705-0979LE. No abstract available.


Rethinking Inspiratory Pressure Augmentation in Spontaneous Breathing Trials.

Goligher EC, Detsky ME, Sklar MC, Campbell VT, Greco P, Amaral ACKB, Ferguson ND, Brochard LJ.

Chest. 2017 Jun;151(6):1399-1400. doi: 10.1016/j.chest.2017.02.033. No abstract available.


An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome.

Fan E, Del Sorbo L, Goligher EC, Hodgson CL, Munshi L, Walkey AJ, Adhikari NKJ, Amato MBP, Branson R, Brower RG, Ferguson ND, Gajic O, Gattinoni L, Hess D, Mancebo J, Meade MO, McAuley DF, Pesenti A, Ranieri VM, Rubenfeld GD, Rubin E, Seckel M, Slutsky AS, Talmor D, Thompson BT, Wunsch H, Uleryk E, Brozek J, Brochard LJ; American Thoracic Society, European Society of Intensive Care Medicine, and Society of Critical Care Medicine.

Am J Respir Crit Care Med. 2017 May 1;195(9):1253-1263. doi: 10.1164/rccm.201703-0548ST. Erratum in: Am J Respir Crit Care Med. 2017 Jun 1;195(11):1540.


Severity of Hypoxemia and Effect of High-Frequency Oscillatory Ventilation in Acute Respiratory Distress Syndrome.

Meade MO, Young D, Hanna S, Zhou Q, Bachman TE, Bollen C, Slutsky AS, Lamb SE, Adhikari NKJ, Mentzelopoulos SD, Cook DJ, Sud S, Brower RG, Thompson BT, Shah S, Stenzler A, Guyatt G, Ferguson ND.

Am J Respir Crit Care Med. 2017 Sep 15;196(6):727-733. doi: 10.1164/rccm.201609-1938OC.


High-frequency oscillatory ventilation: still a role?

Ng J, Ferguson ND.

Curr Opin Crit Care. 2017 Apr;23(2):175-179. doi: 10.1097/MCC.0000000000000387. Review.


Severe hypercapnia and outcome of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome.

Nin N, Muriel A, Peñuelas O, Brochard L, Lorente JA, Ferguson ND, Raymondos K, Ríos F, Violi DA, Thille AW, González M, Villagomez AJ, Hurtado J, Davies AR, Du B, Maggiore SM, Soto L, D'Empaire G, Matamis D, Abroug F, Moreno RP, Soares MA, Arabi Y, Sandi F, Jibaja M, Amin P, Koh Y, Kuiper MA, Bülow HH, Zeggwagh AA, Anzueto A, Sznajder JI, Esteban A; VENTILA Group.

Intensive Care Med. 2017 Feb;43(2):200-208. doi: 10.1007/s00134-016-4611-1. Epub 2017 Jan 20.


Bilateral pneumonectomy to treat uncontrolled sepsis in a patient awaiting lung transplantation.

Cypel M, Waddell T, Singer LG, Del Sorbo L, Fan E, Binnie M, Ferguson ND, Keshavjee S.

J Thorac Cardiovasc Surg. 2017 Apr;153(4):e67-e69. doi: 10.1016/j.jtcvs.2016.11.031. Epub 2016 Nov 23. No abstract available.

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