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Items: 45


Reversible mislocalization of a disease-associated MRE11 splice variant product.

Hartlerode AJ, Regal JA, Ferguson DO.

Sci Rep. 2018 Jul 4;8(1):10121. doi: 10.1038/s41598-018-28370-5.


MRE11 Promotes Tumorigenesis by Facilitating Resistance to Oncogene-Induced Replication Stress.

Spehalski E, Capper KM, Smith CJ, Morgan MJ, Dinkelmann M, Buis J, Sekiguchi JM, Ferguson DO.

Cancer Res. 2017 Oct 1;77(19):5327-5338. doi: 10.1158/0008-5472.CAN-17-1355. Epub 2017 Aug 17.


Scaphoid fracture non-union: a systematic review of surgical treatment using bone graft.

Ferguson DO, Shanbhag V, Hedley H, Reichert I, Lipscombe S, Davis TR.

J Hand Surg Eur Vol. 2016 Jun;41(5):492-500. doi: 10.1177/1753193415604778. Epub 2015 Sep 30. Review.


Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors.

Hartlerode AJ, Morgan MJ, Wu Y, Buis J, Ferguson DO.

Nat Struct Mol Biol. 2015 Sep;22(9):736-43. doi: 10.1038/nsmb.3072. Epub 2015 Aug 17.


Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation.

Jones M, Osawa G, Regal JA, Weinberg DN, Taggart J, Kocak H, Friedman A, Ferguson DO, Keegan CE, Maillard I.

J Clin Invest. 2014 Jan;124(1):353-66. doi: 10.1172/JCI67871. Epub 2013 Dec 9.


Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms.

Regal JA, Festerling TA, Buis JM, Ferguson DO.

Hum Mol Genet. 2013 Dec 20;22(25):5146-59. doi: 10.1093/hmg/ddt368. Epub 2013 Aug 2.


Oncogenic Myc translocations are independent of chromosomal location and orientation of the immunoglobulin heavy chain locus.

Spehalski E, Kovalchuk AL, Collins JT, Liang G, Dubois W, Morse HC 3rd, Ferguson DO, Casellas R, Dunnick WA.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13728-32. doi: 10.1073/pnas.1202882109. Epub 2012 Aug 6.


A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability.

Xiao H, Yu Z, Wu Y, Nan J, Merry DE, Sekiguchi JM, Ferguson DO, Lieberman AP, Dressler GR.

Hum Mol Genet. 2012 Oct 1;21(19):4225-36. doi: 10.1093/hmg/dds246. Epub 2012 Jun 26.


Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2.

Buis J, Stoneham T, Spehalski E, Ferguson DO.

Nat Struct Mol Biol. 2012 Jan 8;19(2):246-52. doi: 10.1038/nsmb.2212.


The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation.

Yu Z, Vogel G, Coulombe Y, Dubeau D, Spehalski E, H├ębert J, Ferguson DO, Masson JY, Richard S.

Cell Res. 2012 Feb;22(2):305-20. doi: 10.1038/cr.2011.128. Epub 2011 Aug 9.


Chfr and RNF8 synergistically regulate ATM activation.

Wu J, Chen Y, Lu LY, Wu Y, Paulsen MT, Ljungman M, Ferguson DO, Yu X.

Nat Struct Mol Biol. 2011 Jun 26;18(7):761-8. doi: 10.1038/nsmb.2078.


Multiple functions of MRN in end-joining pathways during isotype class switching.

Dinkelmann M, Spehalski E, Stoneham T, Buis J, Wu Y, Sekiguchi JM, Ferguson DO.

Nat Struct Mol Biol. 2009 Aug;16(8):808-13. doi: 10.1038/nsmb.1639. Epub 2009 Jul 26.


Multiple roles for MRE11 at uncapped telomeres.

Deng Y, Guo X, Ferguson DO, Chang S.

Nature. 2009 Aug 13;460(7257):914-8. doi: 10.1038/nature08196. Epub 2009 Jul 26.


Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis.

Else T, Trovato A, Kim AC, Wu Y, Ferguson DO, Kuick RD, Lucas PC, Hammer GD.

Cancer Cell. 2009 Jun 2;15(6):465-76. doi: 10.1016/j.ccr.2009.04.011.


Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation.

Giblin W, Chatterji M, Westfield G, Masud T, Theisen B, Cheng HL, DeVido J, Alt FW, Ferguson DO, Schatz DG, Sekiguchi J.

Blood. 2009 Mar 26;113(13):2965-75. doi: 10.1182/blood-2008-07-165167. Epub 2009 Jan 6.


Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation.

Buis J, Wu Y, Deng Y, Leddon J, Westfield G, Eckersdorff M, Sekiguchi JM, Chang S, Ferguson DO.

Cell. 2008 Oct 3;135(1):85-96. doi: 10.1016/j.cell.2008.08.015.


Tpp1/Acd maintains genomic stability through a complex role in telomere protection.

Else T, Theisen BK, Wu Y, Hutz JE, Keegan CE, Hammer GD, Ferguson DO.

Chromosome Res. 2007;15(8):1001-13. doi: 10.1007/s10577-007-1175-5. Epub 2008 Jan 9.


Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation.

Hinoi T, Akyol A, Theisen BK, Ferguson DO, Greenson JK, Williams BO, Cho KR, Fearon ER.

Cancer Res. 2007 Oct 15;67(20):9721-30.


A deletion at the mouse Xist gene exposes trans-effects that alter the heterochromatin of the inactive X chromosome and the replication time and DNA stability of both X chromosomes.

Diaz-Perez SV, Ferguson DO, Wang C, Csankovszki G, Wang C, Tsai SC, Dutta D, Perez V, Kim S, Eller CD, Salstrom J, Ouyang Y, Teitell MA, Kaltenboeck B, Chess A, Huang S, Marahrens Y.

Genetics. 2006 Nov;174(3):1115-33. Epub 2006 Sep 15.


Dysregulated TCL1 requires the germinal center and genome instability for mature B-cell transformation.

Shen RR, Ferguson DO, Renard M, Hoyer KK, Kim U, Hao X, Alt FW, Roeder RG, Morse HC 3rd, Teitell MA.

Blood. 2006 Sep 15;108(6):1991-8. Epub 2006 May 25.


Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells.

Yilmaz OH, Valdez R, Theisen BK, Guo W, Ferguson DO, Wu H, Morrison SJ.

Nature. 2006 May 25;441(7092):475-82. Epub 2006 Apr 5.


DNA double-strand break repair: a relentless hunt uncovers new prey.

Sekiguchi JM, Ferguson DO.

Cell. 2006 Jan 27;124(2):260-2. Review.


The Polycomb group protein EZH2 impairs DNA repair in breast epithelial cells.

Zeidler M, Varambally S, Cao Q, Chinnaiyan AM, Ferguson DO, Merajver SD, Kleer CG.

Neoplasia. 2005 Nov;7(11):1011-9.


Rad50 depletion impacts upon ATR-dependent DNA damage responses.

Zhong H, Bryson A, Eckersdorff M, Ferguson DO.

Hum Mol Genet. 2005 Sep 15;14(18):2685-93. Epub 2005 Aug 8.


Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability.

Mills KD, Ferguson DO, Essers J, Eckersdorff M, Kanaar R, Alt FW.

Genes Dev. 2004 Jun 1;18(11):1283-92.


Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells.

Rooney S, Sekiguchi J, Whitlow S, Eckersdorff M, Manis JP, Lee C, Ferguson DO, Alt FW.

Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2410-5.


Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice.

Theunissen JW, Kaplan MI, Hunt PA, Williams BR, Ferguson DO, Alt FW, Petrini JH.

Mol Cell. 2003 Dec;12(6):1511-23.


Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors.

Bassing CH, Suh H, Ferguson DO, Chua KF, Manis J, Eckersdorff M, Gleason M, Bronson R, Lee C, Alt FW.

Cell. 2003 Aug 8;114(3):359-70.


The role of DNA breaks in genomic instability and tumorigenesis.

Mills KD, Ferguson DO, Alt FW.

Immunol Rev. 2003 Aug;194:77-95. Review.


The interplay between nonhomologous end-joining and cell cycle checkpoint factors in development, genomic stability, and tumorigenesis.

Ferguson DO, Sekiguchi JM, Frank KM, Gao Y, Sharpless NE, Gu Y, Manis J, DePinho RA, Alt FW.

Cold Spring Harb Symp Quant Biol. 2000;65:395-403. Review. No abstract available.


Defective DNA repair and increased genomic instability in Artemis-deficient murine cells.

Rooney S, Alt FW, Lombard D, Whitlow S, Eckersdorff M, Fleming J, Fugmann S, Ferguson DO, Schatz DG, Sekiguchi J.

J Exp Med. 2003 Mar 3;197(5):553-65.


Proapoptotic BID is required for myeloid homeostasis and tumor suppression.

Zinkel SS, Ong CC, Ferguson DO, Iwasaki H, Akashi K, Bronson RT, Kutok JL, Alt FW, Korsmeyer SJ.

Genes Dev. 2003 Jan 15;17(2):229-39.


Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.

Zhu C, Mills KD, Ferguson DO, Lee C, Manis J, Fleming J, Gao Y, Morton CC, Alt FW.

Cell. 2002 Jun 28;109(7):811-21.


Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX.

Bassing CH, Chua KF, Sekiguchi J, Suh H, Whitlow SR, Fleming JC, Monroe BC, Ciccone DN, Yan C, Vlasakova K, Livingston DM, Ferguson DO, Scully R, Alt FW.

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8173-8. Epub 2002 May 28.


Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions.

Sharpless NE, Ferguson DO, O'Hagan RC, Castrillon DH, Lee C, Farazi PA, Alson S, Fleming J, Morton CC, Frank K, Chin L, Alt FW, DePinho RA.

Mol Cell. 2001 Dec;8(6):1187-96.


DNA double strand break repair and chromosomal translocation: lessons from animal models.

Ferguson DO, Alt FW.

Oncogene. 2001 Sep 10;20(40):5572-9. Review.


Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development.

Sekiguchi J, Ferguson DO, Chen HT, Yang EM, Earle J, Frank K, Whitlow S, Gu Y, Xu Y, Nussenzweig A, Alt FW.

Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3243-8. Epub 2001 Mar 6.


Limitations of chromosome classification by multicolor karyotyping.

Lee C, Gisselsson D, Jin C, Nordgren A, Ferguson DO, Blennow E, Fletcher JA, Morton CC.

Am J Hum Genet. 2001 Apr;68(4):1043-7. Epub 2001 Feb 19.


DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway.

Frank KM, Sharpless NE, Gao Y, Sekiguchi JM, Ferguson DO, Zhu C, Manis JP, Horner J, DePinho RA, Alt FW.

Mol Cell. 2000 Jun;5(6):993-1002.


The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations.

Ferguson DO, Sekiguchi JM, Chang S, Frank KM, Gao Y, DePinho RA, Alt FW.

Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6630-3.


Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development.

Gao Y, Ferguson DO, Xie W, Manis JP, Sekiguchi J, Frank KM, Chaudhuri J, Horner J, DePinho RA, Alt FW.

Nature. 2000 Apr 20;404(6780):897-900.


Interaction between Ustilago maydis REC2 and RAD51 genes in DNA repair and mitotic recombination.

Ferguson DO, Rice MC, Rendi MH, Kotani H, Kmiec EB, Holloman WK.

Genetics. 1997 Feb;145(2):243-51.


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