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Items: 1 to 50 of 122

1.

Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors.

Grimster NP, Anderson E, Alimzhanov M, Bebernitz G, Bell K, Chuaqui C, Deegan T, Ferguson AD, Gero T, Harsch A, Huszar D, Kawatkar A, Kettle JG, Lyne P, Read JA, Rivard Costa C, Ruston L, Schroeder P, Shi J, Su Q, Throner S, Toader D, Vasbinder M, Woessner R, Wang H, Wu A, Ye M, Zheng W, Zinda M.

J Med Chem. 2018 Jun 28;61(12):5235-5244. doi: 10.1021/acs.jmedchem.8b00076. Epub 2018 Jun 13.

PMID:
29856615
2.

Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases.

Gingipalli L, Block MH, Bao L, Cooke E, Dakin LA, Denz CR, Ferguson AD, Johannes JW, Larsen NA, Lyne PD, Pontz TW, Wang T, Wu X, Wu A, Zhang HJ, Zheng X, Dowling JE, Lamb ML.

Bioorg Med Chem Lett. 2018 May 1;28(8):1336-1341. doi: 10.1016/j.bmcl.2018.03.018. Epub 2018 Mar 7.

PMID:
29559278
3.

Structure-Based Design of Selective Noncovalent CDK12 Inhibitors.

Johannes JW, Denz CR, Su N, Wu A, Impastato AC, Mlynarski S, Varnes JG, Prince DB, Cidado J, Gao N, Haddrick M, Jones NH, Li S, Li X, Liu Y, Nguyen TB, O'Connell N, Rivers E, Robbins DW, Tomlinson R, Yao T, Zhu X, Ferguson AD, Lamb ML, Manchester JI, Guichard S.

ChemMedChem. 2018 Feb 6;13(3):231-235. doi: 10.1002/cmdc.201700695. Epub 2018 Jan 26.

PMID:
29266803
4.

Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma.

Scott JS, Degorce SL, Anjum R, Culshaw J, Davies RDM, Davies NL, Dillman KS, Dowling JE, Drew L, Ferguson AD, Groombridge SD, Halsall CT, Hudson JA, Lamont S, Lindsay NA, Marden SK, Mayo MF, Pease JE, Perkins DR, Pink JH, Robb GR, Rosen A, Shen M, McWhirter C, Wu D.

J Med Chem. 2017 Dec 28;60(24):10071-10091. doi: 10.1021/acs.jmedchem.7b01290. Epub 2017 Dec 11.

PMID:
29172502
5.

Correction to "Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors".

Johannes JW, Bates S, Beigie C, Belmonte MA, Breen J, Cao S, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Ferguson AD, Habeshian S, Hargreaves D, Joubran C, Kazmirski S, Keefe AD, Lamb ML, Lan H, Li Y, Ma H, Mlynarski S, Packer MJ, Rawlins PB, Robbins DW, Shen H, Sigel EA, Soutter HH, Su N, Troast DM, Wang H, Wickson KF, Wu C, Zhang Y, Zhao Q, Zheng X, Hird AW.

ACS Med Chem Lett. 2017 Oct 18;8(11):1204. doi: 10.1021/acsmedchemlett.7b00397. eCollection 2017 Nov 9.

6.

It's Complicated: Navigating Multiple Identities in Small Town America.

Ferguson AD, Miville ML.

J Clin Psychol. 2017 Aug;73(8):975-984. doi: 10.1002/jclp.22507.

PMID:
28715612
7.

Correction to Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.

McCoull W, Abrams RD, Anderson E, Blades K, Barton P, Box M, Burgess J, Byth K, Cao Q, Chuaqui C, Carbajo RJ, Cheung T, Code E, Ferguson AD, Fillery S, Fuller NO, Gangl E, Gao N, Grist M, Hargreaves D, Howard MR, Hu J, Kemmitt PD, Nelson JE, O'Connell N, Prince DB, Raubo P, Rawlins PB, Robb GR, Shi J, Waring MJ, Whittaker D, Wylot M, Zhu X.

J Med Chem. 2017 Jul 27;60(14):6459. doi: 10.1021/acs.jmedchem.7b00962. Epub 2017 Jul 17. No abstract available.

PMID:
28714680
8.

Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.

McCoull W, Abrams RD, Anderson E, Blades K, Barton P, Box M, Burgess J, Byth K, Cao Q, Chuaqui C, Carbajo RJ, Cheung T, Code E, Ferguson AD, Fillery S, Fuller NO, Gangl E, Gao N, Grist M, Hargreaves D, Howard MR, Hu J, Kemmitt PD, Nelson JE, O'Connell N, Prince DB, Raubo P, Rawlins PB, Robb GR, Shi J, Waring MJ, Whittaker D, Wylot M, Zhu X.

J Med Chem. 2017 May 25;60(10):4386-4402. doi: 10.1021/acs.jmedchem.7b00359. Epub 2017 May 9.

PMID:
28485934
9.

Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.

Johannes JW, Bates S, Beigie C, Belmonte MA, Breen J, Cao S, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Ferguson AD, Habeshian S, Hargreaves D, Joubran C, Kazmirski S, Keefe AD, Lamb ML, Lan H, Li Y, Ma H, Mlynarski S, Packer MJ, Rawlins PB, Robbins DW, Shen H, Sigel EA, Soutter HH, Su N, Troast DM, Wang H, Wickson KF, Wu C, Zhang Y, Zhao Q, Zheng X, Hird AW.

ACS Med Chem Lett. 2016 Dec 27;8(2):239-244. doi: 10.1021/acsmedchemlett.6b00464. eCollection 2017 Feb 9. Erratum in: ACS Med Chem Lett. 2017 Oct 18;8(11):1204.

10.

Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors.

Cowen SD, Russell D, Dakin LA, Chen H, Larsen NA, Godin R, Throner S, Zheng X, Molina A, Wu J, Cheung T, Howard T, Garcia-Arenas R, Keen N, Pendleton CS, Pietenpol JA, Ferguson AD.

J Med Chem. 2016 Dec 22;59(24):11079-11097. Epub 2016 Dec 1.

PMID:
28002961
11.

Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors.

McCoull W, Hennessy EJ, Blades K, Chuaqui C, Dowling JE, Ferguson AD, Goldberg FW, Howe N, Jones CR, Kemmitt PD, Lamont G, Varnes JG, Ward RA, Yang B.

ACS Med Chem Lett. 2016 Sep 14;7(12):1118-1123. eCollection 2016 Dec 8.

12.

Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology.

Soutter HH, Centrella P, Clark MA, Cuozzo JW, Dumelin CE, Guie MA, Habeshian S, Keefe AD, Kennedy KM, Sigel EA, Troast DM, Zhang Y, Ferguson AD, Davies G, Stead ER, Breed J, Madhavapeddi P, Read JA.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):E7880-E7889. Epub 2016 Nov 18.

13.

Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors.

Cocozaki AI, Altman RB, Huang J, Buurman ET, Kazmirski SL, Doig P, Prince DB, Blanchard SC, Cate JH, Ferguson AD.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8188-93. doi: 10.1073/pnas.1605127113. Epub 2016 Jul 5.

14.

Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo.

Dowling JE, Alimzhanov M, Bao L, Chuaqui C, Denz CR, Jenkins E, Larsen NA, Lyne PD, Pontz T, Ye Q, Holdgate GA, Snow L, O'Connell N, Ferguson AD.

ACS Med Chem Lett. 2016 Jan 20;7(3):300-5. doi: 10.1021/acsmedchemlett.5b00452. eCollection 2016 Mar 10.

15.

Identification of azabenzimidazoles as potent JAK1 selective inhibitors.

Vasbinder MM, Alimzhanov M, Augustin M, Bebernitz G, Bell K, Chuaqui C, Deegan T, Ferguson AD, Goodwin K, Huszar D, Kawatkar A, Kawatkar S, Read J, Shi J, Steinbacher S, Steuber H, Su Q, Toader D, Wang H, Woessner R, Wu A, Ye M, Zinda M.

Bioorg Med Chem Lett. 2016 Jan 1;26(1):60-7. doi: 10.1016/j.bmcl.2015.11.031. Epub 2015 Nov 12.

PMID:
26614408
16.

Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering.

Johannes JW, Almeida L, Daly K, Ferguson AD, Grosskurth SE, Guan H, Howard T, Ioannidis S, Kazmirski S, Lamb ML, Larsen NA, Lyne PD, Mikule K, Ogoe C, Peng B, Petteruti P, Read JA, Su N, Sylvester M, Throner S, Wang W, Wang X, Wu J, Ye Q, Yu Y, Zheng X, Scott DA.

Bioorg Med Chem Lett. 2015 Dec 15;25(24):5743-7. doi: 10.1016/j.bmcl.2015.10.079. Epub 2015 Oct 27.

PMID:
26546219
17.

4,5-Disubstituted 6-Aryloxy-1,3-dihydrobenzo[c][1,2]oxaboroles Are Broad-Spectrum Serine β-Lactamase Inhibitors.

McKinney DC, Zhou F, Eyermann CJ, Ferguson AD, Prince DB, Breen J, Giacobbe RA, Lahiri S, Verheijen JC.

ACS Infect Dis. 2015 Jul 10;1(7):310-6. doi: 10.1021/acsinfecdis.5b00031. Epub 2015 Jun 18.

PMID:
27622821
18.

SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of Pseudomonas aeruginosa PBP3.

Murphy-Benenato KE, Dangel B, Davis HE, Durand-Réville TF, Ferguson AD, Gao N, Jahić H, Mueller JP, Manyak EL, Quiroga O, Rooney M, Sha L, Sylvester M, Wu F, Zambrowski M, Zhao SX.

ACS Med Chem Lett. 2015 Mar 22;6(5):537-42. doi: 10.1021/acsmedchemlett.5b00026. eCollection 2015 May 14.

19.

X-ray crystal structures of Escherichia coli RNA polymerase with switch region binding inhibitors enable rational design of squaramides with an improved fraction unbound to human plasma protein.

Molodtsov V, Fleming PR, Eyermann CJ, Ferguson AD, Foulk MA, McKinney DC, Masse CE, Buurman ET, Murakami KS.

J Med Chem. 2015 Apr 9;58(7):3156-71. doi: 10.1021/acs.jmedchem.5b00050. Epub 2015 Mar 23.

20.

Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.

Olivier NB, Altman RB, Noeske J, Basarab GS, Code E, Ferguson AD, Gao N, Huang J, Juette MF, Livchak S, Miller MD, Prince DB, Cate JH, Buurman ET, Blanchard SC.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16274-9. doi: 10.1073/pnas.1414401111. Epub 2014 Nov 3.

21.

Rapid isolation of extracellular vesicles from cell culture and biological fluids using a synthetic peptide with specific affinity for heat shock proteins.

Ghosh A, Davey M, Chute IC, Griffiths SG, Lewis S, Chacko S, Barnett D, Crapoulet N, Fournier S, Joy A, Caissie MC, Ferguson AD, Daigle M, Meli MV, Lewis SM, Ouellette RJ.

PLoS One. 2014 Oct 17;9(10):e110443. doi: 10.1371/journal.pone.0110443. eCollection 2014.

22.

The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability.

Abibi A, Ferguson AD, Fleming PR, Gao N, Hajec LI, Hu J, Laganas VA, McKinney DC, McLeod SM, Prince DB, Shapiro AB, Buurman ET.

J Biol Chem. 2014 Aug 1;289(31):21651-62. doi: 10.1074/jbc.M114.574061. Epub 2014 Jun 16.

23.

Fluorescent probe for high-throughput screening of membrane protein expression.

Backmark AE, Olivier N, Snijder A, Gordon E, Dekker N, Ferguson AD.

Protein Sci. 2013 Aug;22(8):1124-32. doi: 10.1002/pro.2297. Epub 2013 Jul 3.

24.

Review of the 92nd Annual Meeting of the British Association of Dermatologists, 3-5 July 2012, Birmingham, U.K.

Lam ML, Patel AN, Ferguson AD.

Br J Dermatol. 2013 Jan;168(1):32-8. doi: 10.1111/bjd.12172.

PMID:
23278558
25.

Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases.

Dakin LA, Block MH, Chen H, Code E, Dowling JE, Feng X, Ferguson AD, Green I, Hird AW, Howard T, Keeton EK, Lamb ML, Lyne PD, Pollard H, Read J, Wu AJ, Zhang T, Zheng X.

Bioorg Med Chem Lett. 2012 Jul 15;22(14):4599-604. doi: 10.1016/j.bmcl.2012.05.098. Epub 2012 Jun 6.

PMID:
22727640
26.

Structural approaches to obtain kinase selectivity.

Norman RA, Toader D, Ferguson AD.

Trends Pharmacol Sci. 2012 May;33(5):273-8. doi: 10.1016/j.tips.2012.03.005. Epub 2012 Apr 11. Review.

PMID:
22503441
27.

Discovery of aminopiperidine-based Smac mimetics as IAP antagonists.

Hennessy EJ, Saeh JC, Sha L, MacIntyre T, Wang H, Larsen NA, Aquila BM, Ferguson AD, Laing NM, Omer CA.

Bioorg Med Chem Lett. 2012 Feb 15;22(4):1690-4. doi: 10.1016/j.bmcl.2011.12.109. Epub 2011 Dec 31.

PMID:
22264476
28.

Structure-based drug design on membrane protein targets: human integral membrane protein 5-lipoxygenase-activating protein.

Ferguson AD.

Methods Mol Biol. 2012;841:267-90. doi: 10.1007/978-1-61779-520-6_12.

PMID:
22222457
29.

Structural basis of substrate methylation and inhibition of SMYD2.

Ferguson AD, Larsen NA, Howard T, Pollard H, Green I, Grande C, Cheung T, Garcia-Arenas R, Cowen S, Wu J, Godin R, Chen H, Keen N.

Structure. 2011 Sep 7;19(9):1262-73. doi: 10.1016/j.str.2011.06.011. Epub 2011 Jul 21.

30.

Biochemical characterization of human SET and MYND domain-containing protein 2 methyltransferase.

Wu J, Cheung T, Grande C, Ferguson AD, Zhu X, Theriault K, Code E, Birr C, Keen N, Chen H.

Biochemistry. 2011 Jul 26;50(29):6488-97. doi: 10.1021/bi200725p. Epub 2011 Jun 29.

PMID:
21678921
31.

Ischemic heart disease in women: a review for primary care physicians.

Kusnoor AV, Ferguson AD, Falik R.

South Med J. 2011 Mar;104(3):200-4. doi: 10.1097/SMJ.0b013e31820bffd3. Review.

PMID:
21297529
32.

Structural basis of CX-4945 binding to human protein kinase CK2.

Ferguson AD, Sheth PR, Basso AD, Paliwal S, Gray K, Fischmann TO, Le HV.

FEBS Lett. 2011 Jan 3;585(1):104-10. doi: 10.1016/j.febslet.2010.11.019. Epub 2010 Nov 18.

33.

Modifications to the hemagglutinin cleavage site control the virulence of a neurotropic H1N1 influenza virus.

Sun X, Tse LV, Ferguson AD, Whittaker GR.

J Virol. 2010 Sep;84(17):8683-90. doi: 10.1128/JVI.00797-10. Epub 2010 Jun 16.

34.

Aspirin and clopidogrel response variability: review of the published literature.

Ferguson AD, Dokainish H, Lakkis N.

Tex Heart Inst J. 2008;35(3):313-20. Review.

35.

What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases.

Evans JF, Ferguson AD, Mosley RT, Hutchinson JH.

Trends Pharmacol Sci. 2008 Feb;29(2):72-8. doi: 10.1016/j.tips.2007.11.006. Epub 2008 Jan 9. Review.

PMID:
18187210
36.

Expression, purification and crystallization of human 5-lipoxygenase-activating protein with leukotriene-biosynthesis inhibitors.

Xu S, McKeever BM, Wisniewski D, Miller DK, Spencer RH, Chu L, Ujjainwalla F, Yamin TT, Evans JF, Becker JW, Ferguson AD.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Dec 1;63(Pt 12):1054-7. Epub 2007 Nov 30.

37.

Rhinocerebral mucormycosis acquired after a short course of prednisone therapy.

Ferguson AD.

J Am Osteopath Assoc. 2007 Nov;107(11):491-3.

PMID:
18057223
38.

Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids.

Katona BW, Cummins CL, Ferguson AD, Li T, Schmidt DR, Mangelsdorf DJ, Covey DF.

J Med Chem. 2007 Nov 29;50(24):6048-58. Epub 2007 Oct 27.

PMID:
17963371
39.

Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein.

Ferguson AD, McKeever BM, Xu S, Wisniewski D, Miller DK, Yamin TT, Spencer RH, Chu L, Ujjainwalla F, Cunningham BR, Evans JF, Becker JW.

Science. 2007 Jul 27;317(5837):510-2. Epub 2007 Jun 28.

40.

Signal transduction pathway of TonB-dependent transporters.

Ferguson AD, Amezcua CA, Halabi NM, Chelliah Y, Rosen MK, Ranganathan R, Deisenhofer J.

Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):513-8. Epub 2006 Dec 29.

41.

Avian infectious bronchitis virus enters cells via the endocytic pathway.

Chu VC, McElroy LJ, Ferguson AD, Bauman BE, Whittaker GR.

Adv Exp Med Biol. 2006;581:309-12. No abstract available.

PMID:
17037550
42.

NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family.

Ferguson AD, Labunskyy VM, Fomenko DE, Araç D, Chelliah Y, Amezcua CA, Rizo J, Gladyshev VN, Deisenhofer J.

J Biol Chem. 2006 Feb 10;281(6):3536-43. Epub 2005 Nov 30.

43.

A novel cysteine-rich domain of Sep15 mediates the interaction with UDP-glucose:glycoprotein glucosyltransferase.

Labunskyy VM, Ferguson AD, Fomenko DE, Chelliah Y, Hatfield DL, Gladyshev VN.

J Biol Chem. 2005 Nov 11;280(45):37839-45. Epub 2005 Aug 29.

44.

Microcephaly-lymphoedema-chorioretinal-dysplasia syndrome with atrial septal defect.

Strauss RM, Ferguson AD, Rittey CD, Cork MJ.

Pediatr Dermatol. 2005 Jul-Aug;22(4):373-4. No abstract available.

PMID:
16060885
45.

Angina bullosa haemorrhagica--a localized amyloidosis?

Ferguson AD, Johnston M, Leach IH, Allen BR.

J Eur Acad Dermatol Venereol. 2005 Jul;19(4):513-4. No abstract available.

PMID:
15987313
46.

Psychological factors after traumatic amputation in landmine survivors: the bridge between physical healing and full recovery.

Ferguson AD, Richie BS, Gomez MJ.

Disabil Rehabil. 2004 Jul 22-Aug 5;26(14-15):931-8. Review.

PMID:
15497924
47.

Effects of maternally administered dexamethasone and acute hypoxemia at 0.7 gestation on blood pressure and placental perfusion in sheep.

Kutzler MA, Coksaygan TC, Ferguson AD, Nathanielsz PW.

Hypertens Pregnancy. 2004;23(1):75-90.

PMID:
15117602
48.

Maternally administered dexamethasone at 0.7 of gestation suppresses maternal and fetal pituitary and adrenal responses to hypoxemia in sheep.

Kutzler MA, Coksaygan T, Ferguson AD, Vincent SE, Nathanielsz PW.

Pediatr Res. 2004 May;55(5):755-63. Epub 2004 Feb 5.

PMID:
14764910
49.

The ER protein folding sensor UDP-glucose glycoprotein-glucosyltransferase modifies substrates distant to local changes in glycoprotein conformation.

Taylor SC, Ferguson AD, Bergeron JJ, Thomas DY.

Nat Struct Mol Biol. 2004 Feb;11(2):128-34. Epub 2004 Jan 4.

PMID:
14730348
50.

Metal import through microbial membranes.

Ferguson AD, Deisenhofer J.

Cell. 2004 Jan 9;116(1):15-24. Review.

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