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STAT3 and STAT5 Activation in Solid Cancers.

Igelmann S, Neubauer HA, Ferbeyre G.

Cancers (Basel). 2019 Sep 25;11(10). pii: E1428. doi: 10.3390/cancers11101428. Review.


The Inability of the Choroid to Revascularize in Oxygen-Induced Retinopathy Results from Increased p53/miR-Let-7b Activity.

Zhou TE, Zhu T, Rivera JC, Omri S, Tahiri H, Lahaie I, Rouget R, Wirth M, Nattel S, Lodygensky G, Ferbeyre G, Nezhady M, Desjarlais M, Hamel P, Chemtob S.

Am J Pathol. 2019 Aug 17. pii: S0002-9440(19)30665-0. doi: 10.1016/j.ajpath.2019.07.009. [Epub ahead of print]


Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice.

Caland L, Labbé P, Mamarbachi M, Villeneuve L, Ferbeyre G, Noly PE, Carrier M, Thorin-Trescases N, Thorin É.

Aging (Albany NY). 2019 Jun 11;11(11):3832-3850. doi: 10.18632/aging.102020.


Phosphorylation of SOCS1 Inhibits the SOCS1-p53 Tumor Suppressor Axis.

Saint-Germain E, Mignacca L, Huot G, Acevedo M, Moineau-Vallée K, Calabrese V, Bourdeau V, Rowell MC, Ilangumaran S, Lessard F, Ferbeyre G.

Cancer Res. 2019 Jul 1;79(13):3306-3319. doi: 10.1158/0008-5472.CAN-18-1503. Epub 2019 May 17.


Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex.

Del Toro N, Fernandez-Ruiz A, Mignacca L, Kalegari P, Rowell MC, Igelmann S, Saint-Germain E, Benfdil M, Lopes-Paciencia S, Brakier-Gingras L, Bourdeau V, Ferbeyre G, Lessard F.

Cell Cycle. 2019 Mar - Apr;18(6-7):759-770. doi: 10.1080/15384101.2019.1593708. Epub 2019 Mar 28.


The senescence-associated secretory phenotype and its regulation.

Lopes-Paciencia S, Saint-Germain E, Rowell MC, Ruiz AF, Kalegari P, Ferbeyre G.

Cytokine. 2019 May;117:15-22. doi: 10.1016/j.cyto.2019.01.013. Epub 2019 Feb 16.


Ribosomal Proteins Control Tumor Suppressor Pathways in Response to Nucleolar Stress.

Lessard F, Brakier-Gingras L, Ferbeyre G.

Bioessays. 2019 Mar;41(3):e1800183. doi: 10.1002/bies.201800183. Epub 2019 Feb 1.


Circumventing senescence is associated with stem cell properties and metformin sensitivity.

Deschênes-Simard X, Parisotto M, Rowell MC, Le Calvé B, Igelmann S, Moineau-Vallée K, Saint-Germain E, Kalegari P, Bourdeau V, Kottakis F, Bardeesy N, Ferbeyre G.

Aging Cell. 2019 Apr;18(2):e12889. doi: 10.1111/acel.12889. Epub 2019 Jan 6.


Molecular tools that block maturation of the nuclear lamin A and decelerate cancer cell migration.

Matralis AN, Xanthopoulos D, Huot G, Lopes-Paciencia S, Cole C, de Vries H, Ferbeyre G, Tsantrizos YS.

Bioorg Med Chem. 2018 Nov 1;26(20):5547-5554. doi: 10.1016/j.bmc.2018.10.001. Epub 2018 Oct 4.


Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.

Hulea L, Gravel SP, Morita M, Cargnello M, Uchenunu O, Im YK, Lehuédé C, Ma EH, Leibovitch M, McLaughlan S, Blouin MJ, Parisotto M, Papavasiliou V, Lavoie C, Larsson O, Ohh M, Ferreira T, Greenwood C, Bridon G, Avizonis D, Ferbeyre G, Siegel P, Jones RG, Muller W, Ursini-Siegel J, St-Pierre J, Pollak M, Topisirovic I.

Cell Metab. 2018 Dec 4;28(6):817-832.e8. doi: 10.1016/j.cmet.2018.09.001. Epub 2018 Sep 20.


The sequence features that define efficient and specific hAGO2-dependent miRNA silencing guides.

Yan Y, Acevedo M, Mignacca L, Desjardins P, Scott N, Imane R, Quenneville J, Robitaille J, Feghaly A, Gagnon E, Ferbeyre G, Major F.

Nucleic Acids Res. 2018 Sep 19;46(16):8181-8196. doi: 10.1093/nar/gky546.


Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway.

Lessard F, Igelmann S, Trahan C, Huot G, Saint-Germain E, Mignacca L, Del Toro N, Lopes-Paciencia S, Le Calvé B, Montero M, Deschênes-Simard X, Bury M, Moiseeva O, Rowell MC, Zorca CE, Zenklusen D, Brakier-Gingras L, Bourdeau V, Oeffinger M, Ferbeyre G.

Nat Cell Biol. 2018 Jul;20(7):789-799. doi: 10.1038/s41556-018-0127-y. Epub 2018 Jun 25.


Quantitative SUMO proteomics reveals the modulation of several PML nuclear body associated proteins and an anti-senescence function of UBC9.

McManus FP, Bourdeau V, Acevedo M, Lopes-Paciencia S, Mignacca L, Lamoliatte F, Rojas Pino JW, Ferbeyre G, Thibault P.

Sci Rep. 2018 May 17;8(1):7754. doi: 10.1038/s41598-018-25150-z.


SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes.

Saint-Germain E, Mignacca L, Vernier M, Bobbala D, Ilangumaran S, Ferbeyre G.

Aging (Albany NY). 2017 Oct 28;9(10):2137-2162. doi: 10.18632/aging.101306.


Aberrant signaling and senescence associated protein degradation.

Ferbeyre G.

Exp Gerontol. 2018 Jul 1;107:50-54. doi: 10.1016/j.exger.2017.06.016. Epub 2017 Jun 27. Review.


Senescence gives insights into the morphogenetic evolution of anamniotes.

Villiard É, Denis JF, Hashemi FS, Igelmann S, Ferbeyre G, Roy S.

Biol Open. 2017 Jun 15;6(6):891-896. doi: 10.1242/bio.025809.


Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer.

Chevrier M, Bobbala D, Villalobos-Hernandez A, Khan MG, Ramanathan S, Saucier C, Ferbeyre G, Geha S, Ilangumaran S.

BMC Cancer. 2017 Feb 24;17(1):157. doi: 10.1186/s12885-017-3141-8.


Correction: Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues.

Lacraz G, Rakotoarivelo V, Labbé SM, Vernier M, Noll C, Mayhue M, Stankova J, Schwertani A, Grenier G, Carpentier A, Richard D, Ferbeyre G, Fradette J, Rola-Pleszczynski M, Menendez A, Langlois MF, Ilangumaran S, Ramanathan S.

PLoS One. 2016 Nov 8;11(11):e0166537. doi: 10.1371/journal.pone.0166537. eCollection 2016.


SOCS1 inhibits migration and invasion of prostate cancer cells, attenuates tumor growth and modulates the tumor stroma.

Villalobos-Hernandez A, Bobbala D, Kandhi R, Khan MG, Mayhue M, Dubois CM, Ferbeyre G, Saucier C, Ramanathan S, Ilangumaran S.

Prostate Cancer Prostatic Dis. 2017 Mar;20(1):36-47. doi: 10.1038/pcan.2016.50. Epub 2016 Oct 25.


Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues.

Lacraz G, Rakotoarivelo V, Labbé SM, Vernier M, Noll C, Mayhue M, Stankova J, Schwertani A, Grenier G, Carpentier A, Richard D, Ferbeyre G, Fradette J, Rola-Pleszczynski M, Menendez A, Langlois MF, Ilangumaran S, Ramanathan S.

PLoS One. 2016 Sep 29;11(9):e0162995. doi: 10.1371/journal.pone.0162995. eCollection 2016. Erratum in: PLoS One. 2016 Nov 8;11(11):e0166537.


A CDK4/6-Dependent Epigenetic Mechanism Protects Cancer Cells from PML-induced Senescence.

Acevedo M, Vernier M, Mignacca L, Lessard F, Huot G, Moiseeva O, Bourdeau V, Ferbeyre G.

Cancer Res. 2016 Jun 1;76(11):3252-64. doi: 10.1158/0008-5472.CAN-15-2347. Epub 2016 Mar 29.


Dataset of STAT5A status in breast cancer.

Mukhopadhyay UK, Cass J, Raptis L, Craig AW, Bourdeau V, Varma S, Gupta SS, Elliott BE, Ferbeyre G.

Data Brief. 2016 Mar 4;7:490-2. doi: 10.1016/j.dib.2016.02.073. eCollection 2016 Jun.


Editorial: Cytokines in inflammation, aging, cancer and obesity.

Ilangumaran S, Ferbeyre G.

Cytokine. 2016 Jun;82:1-3. doi: 10.1016/j.cyto.2016.03.011. Epub 2016 Mar 17. No abstract available.


Permanent farnesylation of lamin A mutants linked to progeria impairs its phosphorylation at serine 22 during interphase.

Moiseeva O, Lopes-Paciencia S, Huot G, Lessard F, Ferbeyre G.

Aging (Albany NY). 2016 Feb;8(2):366-81.


STAT5A is regulated by DNA damage via the tumor suppressor p53.

Mukhopadhyay UK, Cass J, Raptis L, Craig AW, Bourdeau V, Varma S, SenGupta S, Elliott BE, Ferbeyre G.

Cytokine. 2016 Jun;82:70-9. doi: 10.1016/j.cyto.2016.01.013. Epub 2016 Feb 11.


Sponges against miR-19 and miR-155 reactivate the p53-Socs1 axis in hematopoietic cancers.

Mignacca L, Saint-Germain E, Benoit A, Bourdeau V, Moro A, Ferbeyre G.

Cytokine. 2016 Jun;82:80-6. doi: 10.1016/j.cyto.2016.01.015. Epub 2016 Feb 1.


Suppressor of cytokine signaling 1-dependent regulation of the expression and oncogenic functions of p21(CIP1/WAF1) in the liver.

Yeganeh M, Gui Y, Kandhi R, Bobbala D, Tobelaim WS, Saucier C, Yoshimura A, Ferbeyre G, Ramanathan S, Ilangumaran S.

Oncogene. 2016 Aug 11;35(32):4200-11. doi: 10.1038/onc.2015.485. Epub 2016 Jan 4.


The Role of HMGB1 in Radioresistance of Bladder Cancer.

Shrivastava S, Mansure JJ, Almajed W, Cury F, Ferbeyre G, Popovic M, Seuntjens J, Kassouf W.

Mol Cancer Ther. 2016 Mar;15(3):471-9. doi: 10.1158/1535-7163.MCT-15-0581. Epub 2015 Dec 30.


Tumour-promoting role of SOCS1 in colorectal cancer cells.

Tobelaim WS, Beaurivage C, Champagne A, Pomerleau V, Simoneau A, Chababi W, Yeganeh M, Thibault P, Klinck R, Carrier JC, Ferbeyre G, Ilangumaran S, Saucier C.

Sci Rep. 2015 Sep 22;5:14301. doi: 10.1038/srep14301.


Mutant lamin A links prophase to a p53 independent senescence program.

Moiseeva O, Lessard F, Acevedo-Aquino M, Vernier M, Tsantrizos YS, Ferbeyre G.

Cell Cycle. 2015 Aug 3;14(15):2408-21. doi: 10.1080/15384101.2015.1053671. Epub 2015 Jun 1.


Structural and functional characterization of the phosphorylation-dependent interaction between PML and SUMO1.

Cappadocia L, Mascle XH, Bourdeau V, Tremblay-Belzile S, Chaker-Margot M, Lussier-Price M, Wada J, Sakaguchi K, Aubry M, Ferbeyre G, Omichinski JG.

Structure. 2015 Jan 6;23(1):126-138. doi: 10.1016/j.str.2014.10.015. Epub 2014 Dec 11.


Cellular senescence and protein degradation: breaking down cancer.

Deschênes-Simard X, Lessard F, Gaumont-Leclerc MF, Bardeesy N, Ferbeyre G.

Cell Cycle. 2014;13(12):1840-58. doi: 10.4161/cc.29335. Epub 2014 May 27.


Complete senescence: RB and PML share the task.

Vernier M, Ferbeyre G.

Cell Cycle. 2014;13(5):696. doi: 10.4161/cc.28090. Epub 2014 Feb 4. No abstract available.


Engaging a senescent response to cure leukemia.

Bourdeau V, Ferbeyre G.

Nat Med. 2014 Feb;20(2):123-4. doi: 10.1038/nm.3469. No abstract available.


ERKs in cancer: friends or foes?

Deschênes-Simard X, Kottakis F, Meloche S, Ferbeyre G.

Cancer Res. 2014 Jan 15;74(2):412-9. doi: 10.1158/0008-5472.CAN-13-2381. Epub 2014 Jan 9. Review.


CHES1/FOXN3 regulates cell proliferation by repressing PIM2 and protein biosynthesis.

Huot G, Vernier M, Bourdeau V, Doucet L, Saint-Germain E, Gaumont-Leclerc MF, Moro A, Ferbeyre G.

Mol Biol Cell. 2014 Mar;25(5):554-65. doi: 10.1091/mbc.E13-02-0110. Epub 2014 Jan 8.


eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies.

Rajesh K, Papadakis AI, Kazimierczak U, Peidis P, Wang S, Ferbeyre G, Kaufman RJ, Koromilas AE.

Aging (Albany NY). 2013 Dec;5(12):884-901.


Metformin, aging and cancer.

Moiseeva O, Deschênes-Simard X, Pollak M, Ferbeyre G.

Aging (Albany NY). 2013 May;5(5):330-1. No abstract available.


Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation.

Deschênes-Simard X, Gaumont-Leclerc MF, Bourdeau V, Lessard F, Moiseeva O, Forest V, Igelmann S, Mallette FA, Saba-El-Leil MK, Meloche S, Saad F, Mes-Masson AM, Ferbeyre G.

Genes Dev. 2013 Apr 15;27(8):900-15. doi: 10.1101/gad.203984.112. Epub 2013 Apr 18.


Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation.

Moiseeva O, Deschênes-Simard X, St-Germain E, Igelmann S, Huot G, Cadar AE, Bourdeau V, Pollak MN, Ferbeyre G.

Aging Cell. 2013 Jun;12(3):489-98. doi: 10.1111/acel.12075. Epub 2013 Apr 23.


Histone deacetylase inhibitors globally enhance h3/h4 tail acetylation without affecting h3 lysine 56 acetylation.

Drogaris P, Villeneuve V, Pomiès C, Lee EH, Bourdeau V, Bonneil E, Ferbeyre G, Verreault A, Thibault P.

Sci Rep. 2012;2:220. doi: 10.1038/srep00220. Epub 2012 Jan 12. No abstract available.


The 5' UTR of HIV-1 full-length mRNA and the Tat viral protein modulate the programmed -1 ribosomal frameshift that generates HIV-1 enzymes.

Charbonneau J, Gendron K, Ferbeyre G, Brakier-Gingras L.

RNA. 2012 Mar;18(3):519-29. doi: 10.1261/rna.030346.111. Epub 2012 Jan 27.


Metformin reduces endogenous reactive oxygen species and associated DNA damage.

Algire C, Moiseeva O, Deschênes-Simard X, Amrein L, Petruccelli L, Birman E, Viollet B, Ferbeyre G, Pollak MN.

Cancer Prev Res (Phila). 2012 Apr;5(4):536-43. doi: 10.1158/1940-6207.CAPR-11-0536. Epub 2012 Jan 18.


SOCS1 controls liver regeneration by regulating HGF signaling in hepatocytes.

Gui Y, Yeganeh M, Ramanathan S, Leblanc C, Pomerleau V, Ferbeyre G, Saucier C, Ilangumaran S.

J Hepatol. 2011 Dec;55(6):1300-8. doi: 10.1016/j.jhep.2011.03.027. Epub 2011 May 19.


Identification of hammerhead ribozymes in all domains of life reveals novel structural variations.

Perreault J, Weinberg Z, Roth A, Popescu O, Chartrand P, Ferbeyre G, Breaker RR.

PLoS Comput Biol. 2011 May;7(5):e1002031. doi: 10.1371/journal.pcbi.1002031. Epub 2011 May 5.


Retinoblastoma-independent regulation of cell proliferation and senescence by the p53-p21 axis in lamin A /C-depleted cells.

Moiseeva O, Bourdeau V, Vernier M, Dabauvalle MC, Ferbeyre G.

Aging Cell. 2011 Oct;10(5):789-97. doi: 10.1111/j.1474-9726.2011.00719.x. Epub 2011 May 29.


ARF1 controls proliferation of breast cancer cells by regulating the retinoblastoma protein.

Boulay PL, Schlienger S, Lewis-Saravalli S, Vitale N, Ferbeyre G, Claing A.

Oncogene. 2011 Sep 8;30(36):3846-61. doi: 10.1038/onc.2011.100. Epub 2011 Apr 11.


Regulation of E2Fs and senescence by PML nuclear bodies.

Vernier M, Bourdeau V, Gaumont-Leclerc MF, Moiseeva O, Bégin V, Saad F, Mes-Masson AM, Ferbeyre G.

Genes Dev. 2011 Jan 1;25(1):41-50. doi: 10.1101/gad.1975111.


The role of Stat5 transcription factors as tumor suppressors or oncogenes.

Ferbeyre G, Moriggl R.

Biochim Biophys Acta. 2011 Jan;1815(1):104-14. doi: 10.1016/j.bbcan.2010.10.004. Epub 2010 Oct 20. Review.


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