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Searching for Small Molecules with an Atomic Sort.

Duggan BM, Cullum R, Fenical W, Amador LA, Rodríguez AD, La Clair JJ.

Angew Chem Int Ed Engl. 2019 Nov 6. doi: 10.1002/anie.201911862. [Epub ahead of print]


Response to Comment on "A commensal strain of Staphylococcus epidermidis protects against skin neoplasia" by Nakatsuji et al.

Nakatsuji T, Fenical W, Gallo RL.

Sci Adv. 2019 Sep 11;5(9):eaay5611. doi: 10.1126/sciadv.aay5611. eCollection 2019 Sep.


Photopiperazines A-D, Photosensitive Interconverting Diketopiperazines with Significant and Selective Activity against U87 Glioblastoma Cells, from a Rare, Marine-Derived Actinomycete of the Family Streptomycetaceae.

Kim MC, Cullum R, Machado H, Smith AJ, Yang I, Rodvold JJ, Fenical W.

J Nat Prod. 2019 Aug 23;82(8):2262-2267. doi: 10.1021/acs.jnatprod.9b00429. Epub 2019 Aug 1.


Meroindenon and Merochlorins E and F, Antibacterial Meroterpenoids from a Marine-Derived Sediment Bacterium of the Genus Streptomyces.

Ryu MJ, Hwang S, Kim S, Yang I, Oh DC, Nam SJ, Fenical W.

Org Lett. 2019 Aug 2;21(15):5779-5783. doi: 10.1021/acs.orglett.9b01440. Epub 2019 Jul 12.


Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.

Zhou X, Liang Z, Li K, Fang W, Tian Y, Luo X, Chen Y, Zhan Z, Zhang T, Liao S, Liu S, Liu Y, Fenical W, Tang L.

J Med Chem. 2019 Aug 8;62(15):7058-7069. doi: 10.1021/acs.jmedchem.9b00598. Epub 2019 Jul 25.


Advance of Seriniquinone Analogues as Melanoma Agents.

Hammons JC, Trzoss L, Jimenez PC, Hirata AS, Costa-Lotufo LV, La Clair JJ, Fenical W.

ACS Med Chem Lett. 2019 Feb 6;10(2):186-190. doi: 10.1021/acsmedchemlett.8b00391. eCollection 2019 Feb 14.


Salinipeptins: Integrated Genomic and Chemical Approaches Reveal Unusual d-Amino Acid-Containing Ribosomally Synthesized and Post-Translationally Modified Peptides (RiPPs) from a Great Salt Lake Streptomyces sp.

Shang Z, Winter JM, Kauffman CA, Yang I, Fenical W.

ACS Chem Biol. 2019 Mar 15;14(3):415-425. doi: 10.1021/acschembio.8b01058. Epub 2019 Feb 26.


Saccharoquinoline, a Cytotoxic Alkaloidal Meroterpenoid from Marine-Derived Bacterium Saccharomonospora sp.

Le TC, Lee EJ, Lee J, Hong A, Yim CY, Yang I, Choi H, Chin J, Cho SJ, Ko J, Hwang H, Nam SJ, Fenical W.

Mar Drugs. 2019 Feb 2;17(2). pii: E98. doi: 10.3390/md17020098.


Integration of Genomic Data with NMR Analysis Enables Assignment of the Full Stereostructure of Neaumycin B, a Potent Inhibitor of Glioblastoma from a Marine-Derived Micromonospora.

Kim MC, Machado H, Jang KH, Trzoss L, Jensen PR, Fenical W.

J Am Chem Soc. 2018 Aug 29;140(34):10775-10784. doi: 10.1021/jacs.8b04848. Epub 2018 Aug 20.


Correction to Organohalogens Naturally Biosynthesized in Marine Environments and Produced As Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics.

Zheng J, McKinnie SMK, El Gamal A, Feng W, Dong Y, Agarwal V, Fenical W, Kumar A, Cao Z, Moore BS, Pessah IN.

Environ Sci Technol. 2018 Jul 3;52(13):7594. doi: 10.1021/acs.est.8b03174. Epub 2018 Jun 19. No abstract available.


Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics.

Zheng J, McKinnie SMK, El Gamal A, Feng W, Dong Y, Agarwal V, Fenical W, Kumar A, Cao Z, Moore BS, Pessah IN.

Environ Sci Technol. 2018 May 1;52(9):5469-5478. doi: 10.1021/acs.est.8b00512. Epub 2018 Apr 20. Erratum in: Environ Sci Technol. 2018 Jul 3;52(13):7594.


A commensal strain of Staphylococcus epidermidis protects against skin neoplasia.

Nakatsuji T, Chen TH, Butcher AM, Trzoss LL, Nam SJ, Shirakawa KT, Zhou W, Oh J, Otto M, Fenical W, Gallo RL.

Sci Adv. 2018 Feb 28;4(2):eaao4502. doi: 10.1126/sciadv.aao4502. eCollection 2018 Feb.


Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis.

Leutou AS, Yang I, Le TC, Hahn D, Lim KM, Nam SJ, Fenical W.

J Antibiot (Tokyo). 2018 Jun;71(6):609-612. doi: 10.1038/s41429-018-0033-3. Epub 2018 Feb 21.


Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality.

Amos GCA, Awakawa T, Tuttle RN, Letzel AC, Kim MC, Kudo Y, Fenical W, Moore BS, Jensen PR.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11121-E11130. doi: 10.1073/pnas.1714381115. Epub 2017 Dec 11.


Marinocyanins, cytotoxic bromo-phenazinone meroterpenoids from a marine bacterium from the streptomycete clade MAR4.

Asolkar RN, Singh A, Jensen PR, Aalbersberg W, Carté BK, Feussner KD, Subramani R, DiPasquale A, Rheingold AL, Fenical W.

Tetrahedron. 2017 Apr 20;73(16):2234-2241. doi: 10.1016/j.tet.2017.03.003. Epub 2017 Mar 6.


Saccharomonopyrones A-C, New α-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp. CNQ-490.

Yim CY, Le TC, Lee TG, Yang I, Choi H, Lee J, Kang KY, Lee JS, Lim KM, Yee ST, Kang H, Nam SJ, Fenical W.

Mar Drugs. 2017 Aug 3;15(8). pii: E239. doi: 10.3390/md15080239.


Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp.

Le TC, Yim CY, Park S, Katila N, Yang I, Song MC, Yoon YJ, Choi DY, Choi H, Nam SJ, Fenical W.

Bioorg Med Chem Lett. 2017 Jul 15;27(14):3123-3126. doi: 10.1016/j.bmcl.2017.05.035. Epub 2017 May 12.


Potent Inhibition of Monoamine Oxidase B by a Piloquinone from Marine-Derived Streptomyces sp. CNQ-027.

Lee HW, Choi H, Nam SJ, Fenical W, Kim H.

J Microbiol Biotechnol. 2017 Apr 28;27(4):785-790. doi: 10.4014/jmb.1612.12025.


Ozone-Activated Halogenation of Mono- and Dimethylbipyrrole in Seawater.

Kumar A, Borgen M, Aluwihare LI, Fenical W.

Environ Sci Technol. 2017 Jan 3;51(1):589-595. doi: 10.1021/acs.est.6b03601. Epub 2016 Dec 16.


Calcium Enhances Bile Salt-Dependent Virulence Activation in Vibrio cholerae.

Hay AJ, Yang M, Xia X, Liu Z, Hammons J, Fenical W, Zhu J.

Infect Immun. 2016 Dec 29;85(1). pii: e00707-16. doi: 10.1128/IAI.00707-16. Print 2017 Jan.


Single dish gradient screening of small molecule localization.

Beuzer P, Axelrod J, Trzoss L, Fenical W, Dasari R, Evidente A, Kornienko A, Cang H, La Clair JJ.

Org Biomol Chem. 2016 Sep 21;14(35):8241-5. doi: 10.1039/c6ob01418f. Epub 2016 Aug 17.


The unique chemistry and biology of the piericidins.

Zhou X, Fenical W.

J Antibiot (Tokyo). 2016 Aug;69(8):582-93. doi: 10.1038/ja.2016.71. Epub 2016 Jun 15. Review.


Actinoquinolines A and B, anti-inflammatory quinoline alkaloids from a marine-derived Streptomyces sp., strain CNP975.

Hassan HM, Boonlarppradab C, Fenical W.

J Antibiot (Tokyo). 2016 Jul;69(7):511-4. doi: 10.1038/ja.2016.56. Epub 2016 May 25.


Ansalactams B-D Illustrate Further Biosynthetic Plasticity within the Ansamycin Pathway.

Le TC, Yang I, Yoon YJ, Nam SJ, Fenical W.

Org Lett. 2016 May 6;18(9):2256-9. doi: 10.1021/acs.orglett.6b00892. Epub 2016 Apr 27.


Nocarimidazoles A and B from a Marine-Derived Actinomycete of the Genus Nocardiopsis.

Leutou AS, Yang I, Kang H, Seo EK, Nam SJ, Fenical W.

J Nat Prod. 2015 Nov 25;78(11):2846-9. doi: 10.1021/acs.jnatprod.5b00746. Epub 2015 Oct 16.


Two of a Kind--The Biosynthetic Pathways of Chlorotonil and Anthracimycin.

Jungmann K, Jansen R, Gerth K, Huch V, Krug D, Fenical W, Müller R.

ACS Chem Biol. 2015 Nov 20;10(11):2480-90. doi: 10.1021/acschembio.5b00523. Epub 2015 Sep 8.


Complete genome sequence of Streptomyces sp. CNQ-509, a prolific producer of meroterpenoid chemistry.

Rückert C, Leipoldt F, Zeyhle P, Fenical W, Jensen PR, Kalinowski J, Heide L, Kaysser L.

J Biotechnol. 2015 Dec 20;216:140-1. doi: 10.1016/j.jbiotec.2015.08.009. Epub 2015 Aug 28.


Previously Uncultured Marine Bacteria Linked to Novel Alkaloid Production.

Choi EJ, Nam SJ, Paul L, Beatty D, Kauffman CA, Jensen PR, Fenical W.

Chem Biol. 2015 Sep 17;22(9):1270-9. doi: 10.1016/j.chembiol.2015.07.014. Epub 2015 Aug 20.


The Hybrid Pyrroloisoindolone-Dehydropyrrolizine Alkaloid (-)-Chlorizidine A Targets Proteins within the Glycolytic Pathway.

Álvarez-Micó X, Rocha DD, Guimarães LA, Ambrose A, Chapman E, Costa-Lotufo LV, La Clair JJ, Fenical W.

Chembiochem. 2015 Sep 21;16(14):2002-6. doi: 10.1002/cbic.201500229. Epub 2015 Aug 12.


Actinobenzoquinoline and Actinophenanthrolines A-C, Unprecedented Alkaloids from a Marine Actinobacterium.

Nam SJ, Kauffman CA, Jensen PR, Moore CE, Rheingold AL, Fenical W.

Org Lett. 2015 Jul 2;17(13):3240-3. doi: 10.1021/acs.orglett.5b01387. Epub 2015 Jun 18.


Salinipyrone and Pacificanone Are Biosynthetic By-products of the Rosamicin Polyketide Synthase.

Awakawa T, Crüsemann M, Munguia J, Ziemert N, Nizet V, Fenical W, Moore BS.

Chembiochem. 2015 Jul 6;16(10):1443-7. doi: 10.1002/cbic.201500177. Epub 2015 May 15.


The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery.

Jensen PR, Moore BS, Fenical W.

Nat Prod Rep. 2015 May;32(5):738-51. doi: 10.1039/c4np00167b. Review.


Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin.

Trzoss L, Fukuda T, Costa-Lotufo LV, Jimenez P, La Clair JJ, Fenical W.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14687-92. doi: 10.1073/pnas.1410932111. Epub 2014 Sep 30.


Salinamide F, new depsipeptide antibiotic and inhibitor of bacterial RNA polymerase from a marine-derived Streptomyces sp.

Hassan HM, Degen D, Jang KH, Ebright RH, Fenical W.

J Antibiot (Tokyo). 2015 Mar;68(3):206-9. doi: 10.1038/ja.2014.122. Epub 2014 Sep 17. No abstract available.


Transcription inhibition by the depsipeptide antibiotic salinamide A.

Degen D, Feng Y, Zhang Y, Ebright KY, Ebright YW, Gigliotti M, Vahedian-Movahed H, Mandal S, Talaue M, Connell N, Arnold E, Fenical W, Ebright RH.

Elife. 2014 Apr 30;3:e02451. doi: 10.7554/eLife.02451.


Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureus.

Hensler ME, Jang KH, Thienphrapa W, Vuong L, Tran DN, Soubih E, Lin L, Haste NM, Cunningham ML, Kwan BP, Shaw KJ, Fenical W, Nizet V.

J Antibiot (Tokyo). 2014 Aug;67(8):549-53. doi: 10.1038/ja.2014.36. Epub 2014 Apr 16.


Cytotoxic and Antimicrobial Napyradiomycins from Two Marine-Derived, MAR 4 Streptomyces Strains.

Cheng YB, Jensen PR, Fenical W.

European J Org Chem. 2013 Jun 1;2013(18). doi: 10.1002/ejoc.201300349.


Napyradiomycin derivatives, produced by a marine-derived actinomycete, illustrate cytotoxicity by induction of apoptosis.

Farnaes L, Coufal NG, Kauffman CA, Rheingold AL, DiPasquale AG, Jensen PR, Fenical W.

J Nat Prod. 2014 Jan 24;77(1):15-21. doi: 10.1021/np400466j. Epub 2013 Dec 13.


Napyradiomycins CNQ525.510B and A80915C target the Hsp90 paralogue Grp94.

Farnaes L, La Clair JJ, Fenical W.

Org Biomol Chem. 2014 Jan 21;12(3):418-23. doi: 10.1039/c3ob41355a. Epub 2013 Nov 29.


Purported Mcl-1 inhibitor marinopyrrole A fails to show selective cytotoxicity for Mcl-1-dependent cell lines.

Eichhorn JM, Alford SE, Hughes CC, Fenical W, Chambers TC.

Cell Death Dis. 2013 Oct 24;4:e880. doi: 10.1038/cddis.2013.411. No abstract available.


Actinoranone, a cytotoxic meroterpenoid of unprecedented structure from a marine adapted Streptomyces sp.

Nam SJ, Kauffman CA, Paul LA, Jensen PR, Fenical W.

Org Lett. 2013 Nov 1;15(21):5400-3. doi: 10.1021/ol402080s. Epub 2013 Oct 23.


Challenges and triumphs to genomics-based natural product discovery.

Jensen PR, Chavarria KL, Fenical W, Moore BS, Ziemert N.

J Ind Microbiol Biotechnol. 2014 Feb;41(2):203-9. doi: 10.1007/s10295-013-1353-8. Epub 2013 Oct 9.


Farnesides A and B, sesquiterpenoid nucleoside ethers from a marine-derived Streptomyces sp., strain CNT-372 from Fiji.

Zafrir Ilan E, Torres MR, Prudhomme J, Le Roch K, Jensen PR, Fenical W.

J Nat Prod. 2013 Sep 27;76(9):1815-8. doi: 10.1021/np400351t. Epub 2013 Aug 29.


Anthracimycin, a potent anthrax antibiotic from a marine-derived actinomycete.

Jang KH, Nam SJ, Locke JB, Kauffman CA, Beatty DS, Paul LA, Fenical W.

Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7822-4. doi: 10.1002/anie.201302749. Epub 2013 Jun 17. Erratum in: Angew Chem Int Ed Engl. 2014 Jan 13;53(3):621.


Structures and comparative characterization of biosynthetic gene clusters for cyanosporasides, enediyne-derived natural products from marine actinomycetes.

Lane AL, Nam SJ, Fukuda T, Yamanaka K, Kauffman CA, Jensen PR, Fenical W, Moore BS.

J Am Chem Soc. 2013 Mar 20;135(11):4171-4. doi: 10.1021/ja311065v. Epub 2013 Mar 7.


Chlorizidine, a cytotoxic 5H-pyrrolo[2,1-a]isoindol-5-one-containing alkaloid from a marine Streptomyces sp.

Alvarez-Mico X, Jensen PR, Fenical W, Hughes CC.

Org Lett. 2013 Mar 1;15(5):988-91. doi: 10.1021/ol303374e. Epub 2013 Feb 13.


Bile salt-induced intermolecular disulfide bond formation activates Vibrio cholerae virulence.

Yang M, Liu Z, Hughes C, Stern AM, Wang H, Zhong Z, Kan B, Fenical W, Zhu J.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2348-53. doi: 10.1073/pnas.1218039110. Epub 2013 Jan 22.


Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus.

Haste NM, Thienphrapa W, Tran DN, Loesgen S, Sun P, Nam SJ, Jensen PR, Fenical W, Sakoulas G, Nizet V, Hensler ME.

J Antibiot (Tokyo). 2012 Dec;65(12):593-8. doi: 10.1038/ja.2012.77. Epub 2012 Oct 10.


Structure assignment of lucentamycin E and revision of the olefin geometries of the marine-derived lucentamycins.

Cha JW, Park JS, Sim T, Nam SJ, Kwon HC, Del Valle JR, Fenical W.

J Nat Prod. 2012 Sep 28;75(9):1648-51. Epub 2012 Sep 6.


Suppression of nitric oxide synthase by thienodolin in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells.

Park EJ, Pezzuto JM, Jang KH, Nam SJ, Bucarey SA, Fenical W.

Nat Prod Commun. 2012 Jun;7(6):789-94.

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