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Items: 21

1.

Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy.

Riggs JR, Elsner J, Cashion D, Robinson D, Tehrani L, Nagy M, Fultz KE, Krishna Narla R, Peng X, Tran T, Kulkarni A, Bahmanyar S, Condroski K, Pagarigan B, Fenalti G, LeBrun L, Leftheris K, Zhu D, Boylan JF.

J Med Chem. 2019 May 9;62(9):4401-4410. doi: 10.1021/acs.jmedchem.8b01869. Epub 2019 Apr 30.

PMID:
30998356
2.

Fluorescence Recovery After Photobleaching in Lipidic Cubic Phase (LCP-FRAP): A Precrystallization Assay for Membrane Proteins.

Fenalti G, Abola EE, Wang C, Wu B, Cherezov V.

Methods Enzymol. 2015;557:417-37. doi: 10.1016/bs.mie.2014.12.008. Epub 2015 Mar 17.

PMID:
25950976
3.

Structural basis for bifunctional peptide recognition at human δ-opioid receptor.

Fenalti G, Zatsepin NA, Betti C, Giguere P, Han GW, Ishchenko A, Liu W, Guillemyn K, Zhang H, James D, Wang D, Weierstall U, Spence JC, Boutet S, Messerschmidt M, Williams GJ, Gati C, Yefanov OM, White TA, Oberthuer D, Metz M, Yoon CH, Barty A, Chapman HN, Basu S, Coe J, Conrad CE, Fromme R, Fromme P, Tourwé D, Schiller PW, Roth BL, Ballet S, Katritch V, Stevens RC, Cherezov V.

Nat Struct Mol Biol. 2015 Mar;22(3):265-8. doi: 10.1038/nsmb.2965. Epub 2015 Feb 16.

4.

Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine.

Qin L, Kufareva I, Holden LG, Wang C, Zheng Y, Zhao C, Fenalti G, Wu H, Han GW, Cherezov V, Abagyan R, Stevens RC, Handel TM.

Science. 2015 Mar 6;347(6226):1117-22. doi: 10.1126/science.1261064. Epub 2015 Jan 22.

5.

Allosteric sodium in class A GPCR signaling.

Katritch V, Fenalti G, Abola EE, Roth BL, Cherezov V, Stevens RC.

Trends Biochem Sci. 2014 May;39(5):233-44. doi: 10.1016/j.tibs.2014.03.002. Epub 2014 Apr 21.

6.

Structure of the human P2Y12 receptor in complex with an antithrombotic drug.

Zhang K, Zhang J, Gao ZG, Zhang D, Zhu L, Han GW, Moss SM, Paoletta S, Kiselev E, Lu W, Fenalti G, Zhang W, Müller CE, Yang H, Jiang H, Cherezov V, Katritch V, Jacobson KA, Stevens RC, Wu B, Zhao Q.

Nature. 2014 May 1;509(7498):115-8. doi: 10.1038/nature13083. Epub 2014 Mar 23.

7.

Molecular control of δ-opioid receptor signalling.

Fenalti G, Giguere PM, Katritch V, Huang XP, Thompson AA, Cherezov V, Roth BL, Stevens RC.

Nature. 2014 Feb 13;506(7487):191-6. doi: 10.1038/nature12944. Epub 2014 Jan 12.

8.

Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex.

Tan Q, Zhu Y, Li J, Chen Z, Han GW, Kufareva I, Li T, Ma L, Fenalti G, Li J, Zhang W, Xie X, Yang H, Jiang H, Cherezov V, Liu H, Stevens RC, Zhao Q, Wu B.

Science. 2013 Sep 20;341(6152):1387-90. doi: 10.1126/science.1241475. Epub 2013 Sep 12.

9.

A novel approach to quantify G-protein-coupled receptor dimerization equilibrium using bioluminescence resonance energy transfer.

Kufareva I, Stephens B, Gilliland CT, Wu B, Fenalti G, Hamel D, Stevens RC, Abagyan R, Handel TM.

Methods Mol Biol. 2013;1013:93-127. doi: 10.1007/978-1-62703-426-5_7.

10.

Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates.

Langendorf CG, Tuck KL, Key TL, Fenalti G, Pike RN, Rosado CJ, Wong AS, Buckle AM, Law RH, Whisstock JC.

Biosci Rep. 2013 Jan 11;33(1):137-44. doi: 10.1042/BSR20120111.

11.

Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.

Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V, Stevens RC.

Science. 2010 Nov 19;330(6007):1066-71. doi: 10.1126/science.1194396. Epub 2010 Oct 7.

12.

Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography.

Wacker D, Fenalti G, Brown MA, Katritch V, Abagyan R, Cherezov V, Stevens RC.

J Am Chem Soc. 2010 Aug 25;132(33):11443-5. doi: 10.1021/ja105108q.

13.

The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions.

Langendorf CG, Key TL, Fenalti G, Kan WT, Buckle AM, Caradoc-Davies T, Tuck KL, Law RH, Whisstock JC.

PLoS One. 2010 Feb 18;5(2):e9280. doi: 10.1371/journal.pone.0009280.

14.

Structural determinants of GAD antigenicity.

Arafat Y, Fenalti G, Whisstock JC, Mackay IR, Garcia de la Banda M, Rowley MJ, Buckle AM.

Mol Immunol. 2009 Dec;47(2-3):493-505. doi: 10.1016/j.molimm.2009.08.022. Epub 2009 Sep 23.

PMID:
19783309
15.

Structural biology of the GAD autoantigen.

Fenalti G, Buckle AM.

Autoimmun Rev. 2010 Jan;9(3):148-52. doi: 10.1016/j.autrev.2009.05.003. Epub 2009 May 22. Review.

PMID:
19465164
16.

GAD65 as a prototypic autoantigen.

Fenalti G, Rowley MJ.

J Autoimmun. 2008 Nov;31(3):228-32. doi: 10.1016/j.jaut.2008.04.013. Epub 2008 Jun 2.

PMID:
18514483
17.

COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity.

Fenalti G, Hampe CS, Arafat Y, Law RH, Banga JP, Mackay IR, Whisstock JC, Buckle AM, Rowley MJ.

Diabetes. 2008 May;57(5):1293-301. doi: 10.2337/db07-1461. Epub 2008 Jan 9.

18.

GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop.

Fenalti G, Law RH, Buckle AM, Langendorf C, Tuck K, Rosado CJ, Faux NG, Mahmood K, Hampe CS, Banga JP, Wilce M, Schmidberger J, Rossjohn J, El-Kabbani O, Pike RN, Smith AI, Mackay IR, Rowley MJ, Whisstock JC.

Nat Struct Mol Biol. 2007 Apr;14(4):280-6. Epub 2007 Mar 25.

PMID:
17384644
19.

Molecular characterization of a disease associated conformational epitope on GAD65 recognised by a human monoclonal antibody b96.11.

Fenalti G, Hampe CS, O'connor K, Banga JP, Mackay IR, Rowley MJ, El-Kabbani O.

Mol Immunol. 2007 Feb;44(6):1178-89. Epub 2006 Aug 22.

PMID:
16930708
20.

Managing and mining protein crystallization data.

Amin AA, Faux NG, Fenalti G, Williams G, Bernadou A, Daglish B, Keefe K, Middleton S, Rae J, Tetis K, Law RH, Fulton KF, Rossjohn J, Whisstock JC, Buckle AM.

Proteins. 2006 Jan 1;62(1):4-7.

PMID:
16287081
21.

A diabetes-related epitope of GAD65: a major diabetes-related conformational epitope on GAD65.

Myers MA, Fenalti G, Gray R, Scealy M, Tong JC, El-Kabbani O, Rowley MJ.

Ann N Y Acad Sci. 2003 Nov;1005:250-2.

PMID:
14679070

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