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Items: 39


High Sensitivity to Cholic Acid-induced Colonic Tumorigenesis Makes Female PIRC Rats (F344/NTac-Apcam1137) a Suitable Model for Studying CRC-promoting Agents.

Luceri C, Femia AP, D'Ambrosio M, Caderni G.

Anticancer Res. 2019 Sep;39(9):4673-4679. doi: 10.21873/anticanres.13649.


A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137).

Navarra M, Femia AP, Romagnoli A, Tortora K, Luceri C, Cirmi S, Ferlazzo N, Caderni G.

Eur J Nutr. 2019 Mar 27. doi: 10.1007/s00394-019-01948-z. [Epub ahead of print]


Morin-dependent inhibition of low molecular weight protein tyrosine phosphatase (LMW-PTP) restores sensitivity to apoptosis during colon carcinogenesis: Studies in vitro and in vivo, in an Apc-driven model of colon cancer.

Lori G, Paoli P, Femia AP, Pranzini E, Caselli A, Tortora K, Romagnoli A, Raugei G, Caderni G.

Mol Carcinog. 2019 May;58(5):686-698. doi: 10.1002/mc.22962. Epub 2019 Jan 16.


Aging related changes in circulating reactive oxygen species (ROS) and protein carbonyls are indicative of liver oxidative injury.

Luceri C, Bigagli E, Femia AP, Caderni G, Giovannelli L, Lodovici M.

Toxicol Rep. 2017 Dec 21;5:141-145. doi: 10.1016/j.toxrep.2017.12.017. eCollection 2018.


Pomegranate By-Products in Colorectal Cancer Chemoprevention: Effects in Apc-Mutated Pirc Rats and Mechanistic Studies In Vitro and Ex Vivo.

Tortora K, Femia AP, Romagnoli A, Sineo I, Khatib M, Mulinacci N, Giovannelli L, Caderni G.

Mol Nutr Food Res. 2018 Jan;62(2). doi: 10.1002/mnfr.201700401. Epub 2017 Nov 22.


Astragali radix: could it be an adjuvant for oxaliplatin-induced neuropathy?

Di Cesare Mannelli L, Pacini A, Micheli L, Femia AP, Maresca M, Zanardelli M, Vannacci A, Gallo E, Bilia AR, Caderni G, Firenzuoli F, Mugelli A, Ghelardini C.

Sci Rep. 2017 Feb 10;7:42021. doi: 10.1038/srep42021.


Risk factors for colorectal cancer in man induce aberrant crypt foci in rats: Preliminary findings.

Yang K, Fard S, Furrer R, Archer MC, Bruce WR, Lip H, Mehta R, O'Brien PJ, Giacca A, Ward WE, Femia AP, Caderni G, Medline A, Banks K.

Nutr Cancer. 2016;68(1):94-104. doi: 10.1080/01635581.2016.1115098. Epub 2015 Dec 28.


Effect of butyrate enemas on gene expression profiles and endoscopic/histopathological scores of diverted colorectal mucosa: A randomized trial.

Luceri C, Femia AP, Fazi M, Di Martino C, Zolfanelli F, Dolara P, Tonelli F.

Dig Liver Dis. 2016 Jan;48(1):27-33. doi: 10.1016/j.dld.2015.09.005. Epub 2015 Sep 28.


Sulindac, 3,3'-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis.

Femia AP, Soares PV, Luceri C, Lodovici M, Giannini A, Caderni G.

BMC Cancer. 2015 Sep 3;15:611. doi: 10.1186/s12885-015-1627-9.


Apc-driven colon carcinogenesis in Pirc rat is strongly reduced by polyethylene glycol.

Femia AP, Becherucci C, Crucitta S, Caderni G.

Int J Cancer. 2015 Nov 1;137(9):2270-3. doi: 10.1002/ijc.29581. Epub 2015 May 5.


Multiple mucin depleted foci, high proliferation and low apoptotic response in the onset of colon carcinogenesis of the PIRC rat, mutated in Apc.

Femia AP, Luceri C, Soares PV, Lodovici M, Caderni G.

Int J Cancer. 2015 Mar 15;136(6):E488-95. doi: 10.1002/ijc.29232. Epub 2014 Oct 6.


Characterization of hERG1 channel role in mouse colorectal carcinogenesis.

Fiore A, Carraresi L, Morabito A, Polvani S, Fortunato A, Lastraioli E, Femia AP, De Lorenzo E, Caderni G, Arcangeli A.

Cancer Med. 2013 Oct;2(5):583-94. doi: 10.1002/cam4.72. Epub 2013 Jul 22.


Long-term treatment with Sitagliptin, a dipeptidyl peptidase-4 inhibitor, reduces colon carcinogenesis and reactive oxygen species in 1,2-dimethylhydrazine-induced rats.

Femia AP, Raimondi L, Maglieri G, Lodovici M, Mannucci E, Caderni G.

Int J Cancer. 2013 Nov 15;133(10):2498-503. doi: 10.1002/ijc.28260. Epub 2013 May 29.


Marie Ménard apples with high polyphenol content and a low-fat diet reduce 1,2-dimethylhydrazine-induced colon carcinogenesis in rats: effects on inflammation and apoptosis.

Femia AP, Luceri C, Bianchini F, Salvadori M, Salvianti F, Pinzani P, Dolara P, Calorini L, Caderni G.

Mol Nutr Food Res. 2012 Aug;56(8):1353-7. doi: 10.1002/mnfr.201200122. Epub 2012 Jun 20.


Mucin depleted foci, colonic preneoplastic lesions lacking Muc2, show up-regulation of Tlr2 but not bacterial infiltration.

Femia AP, Swidsinski A, Dolara P, Salvadori M, Amedei A, Caderni G.

PLoS One. 2012;7(1):e29918. doi: 10.1371/journal.pone.0029918. Epub 2012 Jan 5.


Sustained proliferation and resistance to apoptosis after a cytotoxic insult are early alterations in rat colon carcinogenesis.

Femia AP, Salvianti F, Luceri C, Dolara P, Salvadori M, Pinzani P, Caderni G.

Int J Cancer. 2012 Aug 1;131(3):529-36. doi: 10.1002/ijc.26406. Epub 2011 Oct 5.


Gene expression profile and genomic alterations in colonic tumours induced by 1,2-dimethylhydrazine (DMH) in rats.

Femia AP, Luceri C, Toti S, Giannini A, Dolara P, Caderni G.

BMC Cancer. 2010 May 11;10:194. doi: 10.1186/1471-2407-10-194.


Arabinoxylan-oligosaccharides (AXOS) reduce preneoplastic lesions in the colon of rats treated with 1,2-dimethylhydrazine (DMH).

Femia AP, Salvadori M, Broekaert WF, François IE, Delcour JA, Courtin CM, Caderni G.

Eur J Nutr. 2010 Mar;49(2):127-32. doi: 10.1007/s00394-009-0050-x. Epub 2009 Aug 27.


Reduction of colonic inflammation in HLA-B27 transgenic rats by feeding Marie Ménard apples, rich in polyphenols.

Castagnini C, Luceri C, Toti S, Bigagli E, Caderni G, Femia AP, Giovannelli L, Lodovici M, Pitozzi V, Salvadori M, Messerini L, Martin R, Zoetendal EG, Gaj S, Eijssen L, Evelo CT, Renard CM, Baron A, Dolara P.

Br J Nutr. 2009 Dec;102(11):1620-8. doi: 10.1017/S0007114509990936. Epub 2009 Jul 22.


Correspondence between flat aberrant crypt foci and mucin-depleted foci in rodent colon carcinogenesis.

Femia AP, Paulsen JE, Dolara P, Alexander J, Caderni G.

Anticancer Res. 2008 Nov-Dec;28(6A):3771-5.


Identification of mucin depleted foci in the human colon.

Femia AP, Giannini A, Fazi M, Tarquini E, Salvadori M, Roncucci L, Tonelli F, Dolara P, Caderni G.

Cancer Prev Res (Phila). 2008 Dec;1(7):562-7. doi: 10.1158/1940-6207.CAPR-08-0125.


No effects of olive oils with different phenolic content compared to corn oil on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats.

Femia AP, Dolara P, Servili M, Esposto S, Taticchi A, Urbani S, Giannini A, Salvadori M, Caderni G.

Eur J Nutr. 2008 Sep;47(6):329-34. doi: 10.1007/s00394-008-0731-x. Epub 2008 Aug 1.


Rodent models of colon carcinogenesis for the study of chemopreventive activity of natural products.

Femia AP, Caderni G.

Planta Med. 2008 Oct;74(13):1602-7. doi: 10.1055/s-2008-1074577. Epub 2008 Jul 4.


K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine.

Femia AP, Tarquini E, Salvadori M, Ferri S, Giannini A, Dolara P, Caderni G.

Int J Cancer. 2008 Jan 1;122(1):117-23.


Mucin-depleted foci are modulated by dietary treatments and show deregulation of proliferative activity in carcinogen-treated rodents.

Femia AP, Caderni G, Bottini C, Salvadori M, Dolara P, Tessitore L.

Int J Cancer. 2007 Jun 1;120(11):2301-5.


Frequent mutation of Apc gene in rat colon tumors and mucin-depleted foci, preneoplastic lesions in experimental colon carcinogenesis.

Femia AP, Dolara P, Giannini A, Salvadori M, Biggeri A, Caderni G.

Cancer Res. 2007 Jan 15;67(2):445-9.


Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats.

Dolara P, Luceri C, De Filippo C, Femia AP, Giovannelli L, Caderni G, Cecchini C, Silvi S, Orpianesi C, Cresci A.

Mutat Res. 2005 Dec 11;591(1-2):237-46. Epub 2005 Nov 15.


Mucin-depleted foci have beta-catenin gene mutations, altered expression of its protein, and are dose- and time-dependent in the colon of 1,2-dimethylhydrazine-treated rats.

Femia AP, Bendinelli B, Giannini A, Salvadori M, Pinzani P, Dolara P, Caderni G.

Int J Cancer. 2005 Aug 10;116(1):9-15.


Effect of polyphenolic extracts from red wine and 4-OH-coumaric acid on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats.

Femia AP, Caderni G, Vignali F, Salvadori M, Giannini A, Biggeri A, Gee J, Przybylska K, Cheynier V, Dolara P.

Eur J Nutr. 2005 Mar;44(2):79-84. Epub 2004 Apr 14.


Effect of diets fortified with tomatoes or onions with variable quercetin-glycoside content on azoxymethane-induced aberrant crypt foci in the colon of rats.

Femia AP, Caderni G, Ianni M, Salvadori M, Schijlen E, Collins G, Bovy A, Dolara P.

Eur J Nutr. 2003 Dec;42(6):346-52.


Mucin-depleted foci (MDF) in the colon of rats treated with azoxymethane (AOM) are useful biomarkers for colon carcinogenesis.

Femia AP, Dolara P, Caderni G.

Carcinogenesis. 2004 Feb;25(2):277-81. Epub 2003 Nov 6.


IS Rm31, a new insertion sequence of the IS 66 family in Sinorhizobium meliloti.

Biondi EG, Femia AP, Favilli F, Bazzicalupo M.

Arch Microbiol. 2003 Aug;180(2):118-26. Epub 2003 Jun 19.


Identification of mucin-depleted foci in the unsectioned colon of azoxymethane-treated rats: correlation with carcinogenesis.

Caderni G, Femia AP, Giannini A, Favuzza A, Luceri C, Salvadori M, Dolara P.

Cancer Res. 2003 May 15;63(10):2388-92.


Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats.

Femia AP, Luceri C, Dolara P, Giannini A, Biggeri A, Salvadori M, Clune Y, Collins KJ, Paglierani M, Caderni G.

Carcinogenesis. 2002 Nov;23(11):1953-60.


Effect of simple phenolic compounds on azoxymethane-induced aberrant crypt foci in rat colon.

Femia AP, Caderni G, Buzzigoli C, Cocca E, Salvadori M, Dolara P.

Nutr Cancer. 2001;41(1-2):107-10.


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