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Items: 28


Impact of a diagnostics-driven antifungal stewardship programme in a UK tertiary referral teaching hospital.

Rautemaa-Richardson R, Rautemaa V, Al-Wathiqi F, Moore CB, Craig L, Felton TW, Muldoon EG.

J Antimicrob Chemother. 2018 Dec 1;73(12):3488-3495. doi: 10.1093/jac/dky360.


Invasive pulmonary aspergillosis is associated with adverse clinical outcomes in critically ill patients receiving veno-venous extracorporeal membrane oxygenation.

Rodriguez-Goncer I, Thomas S, Foden P, Richardson MD, Ashworth A, Barker J, Geraghty CG, Muldoon EG, Felton TW.

Eur J Clin Microbiol Infect Dis. 2018 Jul;37(7):1251-1257. doi: 10.1007/s10096-018-3241-7. Epub 2018 Apr 6.


Comparison of piperacillin exposure in the lungs of critically ill patients and healthy volunteers.

Felton TW, Ogungbenro K, Boselli E, Hope WW, Rodvold KA.

J Antimicrob Chemother. 2018 May 1;73(5):1340-1347. doi: 10.1093/jac/dkx541.


The role of infection models and PK/PD modelling for optimising care of critically ill patients with severe infections.

Tängdén T, Ramos Martín V, Felton TW, Nielsen EI, Marchand S, Brüggemann RJ, Bulitta JB, Bassetti M, Theuretzbacher U, Tsuji BT, Wareham DW, Friberg LE, De Waele JJ, Tam VH, Roberts JA; Infection Section for the European Society of Intensive Care Medicine, the Pharmacokinetics and Pharmacodynamics Study Group of the European Society of Clinical Microbiology and Infectious Diseases, the International Society of Anti-Infective Pharmacology and the Critically Ill Patients Study Group of European Society of Clinical Microbiology and Infectious Diseases.

Intensive Care Med. 2017 Jul;43(7):1021-1032. doi: 10.1007/s00134-017-4780-6. Epub 2017 Apr 13. Review.


Capsaicin-evoked cough responses in asthmatic patients: Evidence for airway neuronal dysfunction.

Satia I, Tsamandouras N, Holt K, Badri H, Woodhead M, Ogungbenro K, Felton TW, O'Byrne PM, Fowler SJ, Smith JA.

J Allergy Clin Immunol. 2017 Mar;139(3):771-779.e10. doi: 10.1016/j.jaci.2016.04.045. Epub 2016 Jun 15.


Pharmacodynamics of vancomycin for CoNS infection: experimental basis for optimal use of vancomycin in neonates.

Ramos-Martín V, Johnson A, Livermore J, McEntee L, Goodwin J, Whalley S, Docobo-Pérez F, Felton TW, Zhao W, Jacqz-Aigrain E, Sharland M, Turner MA, Hope WW.

J Antimicrob Chemother. 2016 Apr;71(4):992-1002. doi: 10.1093/jac/dkv451. Epub 2016 Jan 10.


Pharmacodynamics of Isavuconazole in a Dynamic In Vitro Model of Invasive Pulmonary Aspergillosis.

Box H, Livermore J, Johnson A, McEntee L, Felton TW, Whalley S, Goodwin J, Hope WW.

Antimicrob Agents Chemother. 2015 Oct 26;60(1):278-87. doi: 10.1128/AAC.01364-15. Print 2016 Jan.


Population pharmacokinetics of teicoplanin in children.

Ramos-Martín V, Paulus S, Siner S, Scott E, Padmore K, Newland P, Drew RJ, Felton TW, Docobo-Pérez F, Pizer B, Pea F, Peak M, Turner MA, Beresford MW, Hope WW.

Antimicrob Agents Chemother. 2014 Nov;58(11):6920-7. doi: 10.1128/AAC.03685-14. Epub 2014 Sep 15.


How severe is antibiotic pharmacokinetic variability in critically ill patients and what can be done about it?

Felton TW, Hope WW, Roberts JA.

Diagn Microbiol Infect Dis. 2014 Aug;79(4):441-7. doi: 10.1016/j.diagmicrobio.2014.04.007. Epub 2014 Apr 30. Review.


Pulmonary penetration of piperacillin and tazobactam in critically ill patients.

Felton TW, McCalman K, Malagon I, Isalska B, Whalley S, Goodwin J, Bentley AM, Hope WW.

Clin Pharmacol Ther. 2014 Oct;96(4):438-48. doi: 10.1038/clpt.2014.131. Epub 2014 Jun 13.


Individualization of piperacillin dosing for critically ill patients: dosing software to optimize antimicrobial therapy.

Felton TW, Roberts JA, Lodise TP, Van Guilder M, Boselli E, Neely MN, Hope WW.

Antimicrob Agents Chemother. 2014 Jul;58(7):4094-102. doi: 10.1128/AAC.02664-14. Epub 2014 May 5.


Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions.

Roberts JA, Abdul-Aziz MH, Lipman J, Mouton JW, Vinks AA, Felton TW, Hope WW, Farkas A, Neely MN, Schentag JJ, Drusano G, Frey OR, Theuretzbacher U, Kuti JL; International Society of Anti-Infective Pharmacology and the Pharmacokinetics and Pharmacodynamics Study Group of the European Society of Clinical Microbiology and Infectious Diseases.

Lancet Infect Dis. 2014 Jun;14(6):498-509. doi: 10.1016/S1473-3099(14)70036-2. Epub 2014 Apr 24. Review.


Impact of Bolus dosing versus continuous infusion of Piperacillin and Tazobactam on the development of antimicrobial resistance in Pseudomonas aeruginosa.

Felton TW, Goodwin J, O'Connor L, Sharp A, Gregson L, Livermore J, Howard SJ, Neely MN, Hope WW.

Antimicrob Agents Chemother. 2013 Dec;57(12):5811-9. doi: 10.1128/AAC.00867-13. Epub 2013 Sep 3.


Pharmacodynamics of liposomal amphotericin B and flucytosine for cryptococcal meningoencephalitis: safe and effective regimens for immunocompromised patients.

O'Connor L, Livermore J, Sharp AD, Goodwin J, Gregson L, Howard SJ, Felton TW, Schwartz JA, Neely MN, Harrison TS, Perfect JR, Hope WW.

J Infect Dis. 2013 Jul 15;208(2):351-61. doi: 10.1093/infdis/jit164. Epub 2013 Apr 18.


Pharmacokinetics and pharmacodynamics of fluconazole for cryptococcal meningoencephalitis: implications for antifungal therapy and in vitro susceptibility breakpoints.

Sudan A, Livermore J, Howard SJ, Al-Nakeeb Z, Sharp A, Goodwin J, Gregson L, Warn PA, Felton TW, Perfect JR, Harrison TS, Hope WW.

Antimicrob Agents Chemother. 2013 Jun;57(6):2793-800. doi: 10.1128/AAC.00216-13. Epub 2013 Apr 9.


Pharmacokinetics and pharmacodynamics of anidulafungin for experimental Candida endophthalmitis: insights into the utility of echinocandins for treatment of a potentially sight-threatening infection.

Livermore JL, Felton TW, Abbott J, Sharp A, Goodwin J, Gregson L, Warn PA, Howard SJ, Hope WW.

Antimicrob Agents Chemother. 2013 Jan;57(1):281-8. doi: 10.1128/AAC.01387-12. Epub 2012 Oct 31.


Population pharmacokinetics of conventional and intermittent dosing of liposomal amphotericin B in adults: a first critical step for rational design of innovative regimens.

Hope WW, Goodwin J, Felton TW, Ellis M, Stevens DA.

Antimicrob Agents Chemother. 2012 Oct;56(10):5303-8. doi: 10.1128/AAC.00933-12. Epub 2012 Aug 6.


Isolation of Aspergillus species from the airway of lung transplant recipients is associated with excess mortality.

Felton TW, Roberts SA, Isalska B, Brennan S, Philips A, Whiteside S, Doran HM, Leonard C, Al-Aloul M, Yonan N, Hope WW.

J Infect. 2012 Oct;65(4):350-6. doi: 10.1016/j.jinf.2012.07.008. Epub 2012 Aug 3.


Pharmacodynamics of itraconazole against Aspergillus fumigatus in an in vitro model of the human alveolus: perspectives on the treatment of triazole-resistant infection and utility of airway administration.

Al-Nakeeb Z, Sudan A, Jeans AR, Gregson L, Goodwin J, Warn PA, Felton TW, Howard SJ, Hope WW.

Antimicrob Agents Chemother. 2012 Aug;56(8):4146-53. doi: 10.1128/AAC.00141-12. Epub 2012 May 21.


Population pharmacokinetics of extended-infusion piperacillin-tazobactam in hospitalized patients with nosocomial infections.

Felton TW, Hope WW, Lomaestro BM, Butterfield JM, Kwa AL, Drusano GL, Lodise TP.

Antimicrob Agents Chemother. 2012 Aug;56(8):4087-94. doi: 10.1128/AAC.00521-12. Epub 2012 May 14.


Posaconazole: the case for therapeutic drug monitoring.

Howard SJ, Felton TW, Gomez-Lopez A, Hope WW.

Ther Drug Monit. 2012 Feb;34(1):72-6. doi: 10.1097/FTD.0b013e31823cdeac. Review.


Anidulafungin for neonatal hematogenous Candida meningoencephalitis: identification of candidate regimens for humans using a translational pharmacological approach.

Warn PA, Livermore J, Howard S, Felton TW, Sharp A, Gregson L, Goodwin J, Petraitiene R, Petraitis V, Cohen-Wolkowiez M, Walsh TJ, Benjamin DK Jr, Hope WW.

Antimicrob Agents Chemother. 2012 Feb;56(2):708-14. doi: 10.1128/AAC.05826-11. Epub 2011 Nov 28.


Peripheral neuropathy in patients on long-term triazole antifungal therapy.

Baxter CG, Marshall A, Roberts M, Felton TW, Denning DW.

J Antimicrob Chemother. 2011 Sep;66(9):2136-9. doi: 10.1093/jac/dkr233. Epub 2011 Jun 17.


Efficacy and safety of posaconazole for chronic pulmonary aspergillosis.

Felton TW, Baxter C, Moore CB, Roberts SA, Hope WW, Denning DW.

Clin Infect Dis. 2010 Dec 15;51(12):1383-91. doi: 10.1086/657306. Epub 2010 Nov 5.


A 27-year-old woman with acute, severe asthma who developed respiratory failure.

Felton TW, Plested V, Walsham A, Dark P, O'Driscoll R, Denning DW.

Chest. 2010 Mar;137(3):724-7. doi: 10.1378/chest.09-1795. No abstract available.


Can a score derived from the Critical Care Minimum Data Set be used as a marker of organ dysfunction? - a pilot study.

Felton TW, Sander R, Al-Aloul M, Dark P, Bentley AM.

BMC Res Notes. 2009 May 6;2:77. doi: 10.1186/1756-0500-2-77.


A rare case of shock.

Felton TW, Drewe E, Jivan S, Hall RI, Powell RJ.

Ann Rheum Dis. 2003 Aug;62(8):705-6. No abstract available.

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