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DNA·RNA triple helix formation can function as a cis-acting regulatory mechanism at the human β-globin locus.

Zhou Z, Giles KE, Felsenfeld G.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6130-6139. doi: 10.1073/pnas.1900107116. Epub 2019 Mar 13.


Interactome mapping defines BRG1, a component of the SWI/SNF chromatin remodeling complex, as a new partner of the transcriptional regulator CTCF.

Marino MM, Rega C, Russo R, Valletta M, Gentile MT, Esposito S, Baglivo I, De Feis I, Angelini C, Xiao T, Felsenfeld G, Chambery A, Pedone PV.

J Biol Chem. 2019 Jan 18;294(3):861-873. doi: 10.1074/jbc.RA118.004882. Epub 2018 Nov 20.


Sodium valproate rescues expression of TRANK1 in iPSC-derived neural cells that carry a genetic variant associated with serious mental illness.

Jiang X, Detera-Wadleigh SD, Akula N, Mallon BS, Hou L, Xiao T, Felsenfeld G, Gu X, McMahon FJ.

Mol Psychiatry. 2019 Apr;24(4):613-624. doi: 10.1038/s41380-018-0207-1. Epub 2018 Aug 22.


Insulin promoter in human pancreatic β cells contacts diabetes susceptibility loci and regulates genes affecting insulin metabolism.

Jian X, Felsenfeld G.

Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4633-E4641. doi: 10.1073/pnas.1803146115. Epub 2018 Apr 30.


Human Argonaute 2 Is Tethered to Ribosomal RNA through MicroRNA Interactions.

Atwood BL, Woolnough JL, Lefevre GM, Saint Just Ribeiro M, Felsenfeld G, Giles KE.

J Biol Chem. 2016 Aug 19;291(34):17919-28. doi: 10.1074/jbc.M116.725051. Epub 2016 Jun 10.


CTCF: making the right connections.

Ghirlando R, Felsenfeld G.

Genes Dev. 2016 Apr 15;30(8):881-91. doi: 10.1101/gad.277863.116. Review.


Association of the Long Non-coding RNA Steroid Receptor RNA Activator (SRA) with TrxG and PRC2 Complexes.

Wongtrakoongate P, Riddick G, Fucharoen S, Felsenfeld G.

PLoS Genet. 2015 Oct 23;11(10):e1005615. doi: 10.1371/journal.pgen.1005615. eCollection 2015 Oct.


CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites.

Xiao T, Wongtrakoongate P, Trainor C, Felsenfeld G.

Cell Rep. 2015 Sep 8;12(10):1704-14. doi: 10.1016/j.celrep.2015.08.005. Epub 2015 Aug 28.


Mapping of long-range INS promoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion.

Xu Z, Lefevre GM, Gavrilova O, Foster St Claire MB, Riddick G, Felsenfeld G.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16760-5. doi: 10.1073/pnas.1419240111. Epub 2014 Nov 10.


The evolution of epigenetics.

Felsenfeld G.

Perspect Biol Med. 2014 Winter;57(1):132-48. doi: 10.1353/pbm.2014.0004.


Induced pluripotency enables differentiation of human nullipotent embryonal carcinoma cells N2102Ep.

Sutiwisesak R, Kitiyanant N, Kotchabhakdi N, Felsenfeld G, Andrews PW, Wongtrakoongate P.

Biochim Biophys Acta. 2014 Nov;1843(11):2611-9. doi: 10.1016/j.bbamcr.2014.07.013. Epub 2014 Jul 30.


A brief history of epigenetics.

Felsenfeld G.

Cold Spring Harb Perspect Biol. 2014 Jan 1;6(1). pii: a018200. doi: 10.1101/cshperspect.a018200.


Physical chemistry of nucleic acids and their complexes.

Ghirlando R, Felsenfeld G.

Biopolymers. 2013 Dec;99(12):910-5. doi: 10.1002/bip.22311.


Chromatin structure outside and inside the nucleus.

Ghirlando R, Felsenfeld G.

Biopolymers. 2013 Apr;99(4):225-32. doi: 10.1002/bip.22157.


Order from chaos in the nucleus.

Xu Z, Felsenfeld G.

Mol Cell. 2012 Nov 9;48(3):327-8. doi: 10.1016/j.molcel.2012.10.021.


Chromatin structure, epigenetic mechanisms and long-range interactions in the human insulin locus.

Xu Z, Lefevre GM, Felsenfeld G.

Diabetes Obes Metab. 2012 Oct;14 Suppl 3:1-11. doi: 10.1111/j.1463-1326.2012.01645.x. Review.


Genome architecture and expression.

Felsenfeld G, Dekker J.

Curr Opin Genet Dev. 2012 Apr;22(2):59-61. doi: 10.1016/j.gde.2012.03.003. Epub 2012 Apr 6. No abstract available.


Chromatin domains, insulators, and the regulation of gene expression.

Ghirlando R, Giles K, Gowher H, Xiao T, Xu Z, Yao H, Felsenfeld G.

Biochim Biophys Acta. 2012 Jul;1819(7):644-51. doi: 10.1016/j.bbagrm.2012.01.016. Epub 2012 Feb 2. Review.


Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II.

Gowher H, Brick K, Camerini-Otero RD, Felsenfeld G.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2370-5. doi: 10.1073/pnas.1121538109. Epub 2012 Jan 30.


High resolution analysis of the chromatin landscape of the IgE switch region in human B cells.

Dayal S, Nedbal J, Hobson P, Cooper AM, Gould HJ, Gellert M, Felsenfeld G, Fear DJ.

PLoS One. 2011;6(9):e24571. doi: 10.1371/journal.pone.0024571. Epub 2011 Sep 20.


Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes.

Li X, Wang S, Li Y, Deng C, Steiner LA, Xiao H, Wu C, Bungert J, Gallagher PG, Felsenfeld G, Qiu Y, Huang S.

Blood. 2011 Aug 4;118(5):1386-94. doi: 10.1182/blood-2010-11-319111. Epub 2011 Jun 8.


Specific sites in the C terminus of CTCF interact with the SA2 subunit of the cohesin complex and are required for cohesin-dependent insulation activity.

Xiao T, Wallace J, Felsenfeld G.

Mol Cell Biol. 2011 Jun;31(11):2174-83. doi: 10.1128/MCB.05093-11. Epub 2011 Mar 28.


Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription.

Xu Z, Wei G, Chepelev I, Zhao K, Felsenfeld G.

Nat Struct Mol Biol. 2011 Mar;18(3):372-8. doi: 10.1038/nsmb.1993. Epub 2011 Feb 20.


Chromatin boundaries, insulators, and long-range interactions in the nucleus.

Giles KE, Gowher H, Ghirlando R, Jin C, Felsenfeld G.

Cold Spring Harb Symp Quant Biol. 2010;75:79-85. doi: 10.1101/sqb.2010.75.006. Epub 2010 Nov 3.


Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA.

Yao H, Brick K, Evrard Y, Xiao T, Camerini-Otero RD, Felsenfeld G.

Genes Dev. 2010 Nov 15;24(22):2543-55. doi: 10.1101/gad.1967810. Epub 2010 Oct 21.


Epigenetic control of the variable expression of a Plasmodium falciparum receptor protein for erythrocyte invasion.

Jiang L, López-Barragán MJ, Jiang H, Mu J, Gaur D, Zhao K, Felsenfeld G, Miller LH.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2224-9. doi: 10.1073/pnas.0913396107. Epub 2010 Jan 13.


H4R3 methylation facilitates beta-globin transcription by regulating histone acetyltransferase binding and H3 acetylation.

Li X, Hu X, Patel B, Zhou Z, Liang S, Ybarra R, Qiu Y, Felsenfeld G, Bungert J, Huang S.

Blood. 2010 Mar 11;115(10):2028-37. doi: 10.1182/blood-2009-07-236059. Epub 2010 Jan 12.


VEZF1 elements mediate protection from DNA methylation.

Dickson J, Gowher H, Strogantsev R, Gaszner M, Hair A, Felsenfeld G, West AG.

PLoS Genet. 2010 Jan;6(1):e1000804. doi: 10.1371/journal.pgen.1000804. Epub 2010 Jan 8.


Maintenance of a constitutive heterochromatin domain in vertebrates by a Dicer-dependent mechanism.

Giles KE, Ghirlando R, Felsenfeld G.

Nat Cell Biol. 2010 Jan;12(1):94-9; sup pp 1-6. doi: 10.1038/ncb2010. Epub 2009 Dec 13.


The human insulin gene is part of a large open chromatin domain specific for human islets.

Mutskov V, Felsenfeld G.

Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17419-24. doi: 10.1073/pnas.0909288106. Epub 2009 Sep 28.


H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions.

Jin C, Zang C, Wei G, Cui K, Peng W, Zhao K, Felsenfeld G.

Nat Genet. 2009 Aug;41(8):941-5. doi: 10.1038/ng.409. Epub 2009 Jul 26.


Analysis of intergenic transcription and histone modification across the human immunoglobulin heavy-chain locus.

Chowdhury M, Forouhi O, Dayal S, McCloskey N, Gould HJ, Felsenfeld G, Fear DJ.

Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15872-7. doi: 10.1073/pnas.0808462105. Epub 2008 Oct 3.


Vezf1 regulates genomic DNA methylation through its effects on expression of DNA methyltransferase Dnmt3b.

Gowher H, Stuhlmann H, Felsenfeld G.

Genes Dev. 2008 Aug 1;22(15):2075-84. doi: 10.1101/gad.1658408.


Hydrodynamic studies on defined heterochromatin fragments support a 30-nm fiber having six nucleosomes per turn.

Ghirlando R, Felsenfeld G.

J Mol Biol. 2008 Mar 7;376(5):1417-25. doi: 10.1016/j.jmb.2007.12.051. Epub 2008 Jan 3.


We gather together: insulators and genome organization.

Wallace JA, Felsenfeld G.

Curr Opin Genet Dev. 2007 Oct;17(5):400-7. Epub 2007 Oct 24. Review.


USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier.

Huang S, Li X, Yusufzai TM, Qiu Y, Felsenfeld G.

Mol Cell Biol. 2007 Nov;27(22):7991-8002. Epub 2007 Sep 10.


Critical DNA binding interactions of the insulator protein CTCF: a small number of zinc fingers mediate strong binding, and a single finger-DNA interaction controls binding at imprinted loci.

Renda M, Baglivo I, Burgess-Beusse B, Esposito S, Fattorusso R, Felsenfeld G, Pedone PV.

J Biol Chem. 2007 Nov 16;282(46):33336-45. Epub 2007 Sep 7.


Nucleosome stability mediated by histone variants H3.3 and H2A.Z.

Jin C, Felsenfeld G.

Genes Dev. 2007 Jun 15;21(12):1519-29.


Extended core sequences from the cHS4 insulator are necessary for protecting retroviral vectors from silencing position effects.

Aker M, Tubb J, Groth AC, Bukovsky AA, Bell AC, Felsenfeld G, Kiem HP, Stamatoyannopoulos G, Emery DW.

Hum Gene Ther. 2007 Apr;18(4):333-43.


Insulators: exploiting transcriptional and epigenetic mechanisms.

Gaszner M, Felsenfeld G.

Nat Rev Genet. 2006 Sep;7(9):703-13. Epub 2006 Aug 15. Review.


Distribution of histone H3.3 in hematopoietic cell lineages.

Jin C, Felsenfeld G.

Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):574-9. Epub 2006 Jan 5.


Chromatin boundaries and chromatin domains.

Felsenfeld G, Burgess-Beusse B, Farrell C, Gaszner M, Ghirlando R, Huang S, Jin C, Litt M, Magdinier F, Mutskov V, Nakatani Y, Tagami H, West A, Yusufzai T.

Cold Spring Harb Symp Quant Biol. 2004;69:245-50. Review. No abstract available.


Recruitment of histone modifications by USF proteins at a vertebrate barrier element.

West AG, Huang S, Gaszner M, Litt MD, Felsenfeld G.

Mol Cell. 2004 Nov 5;16(3):453-63.


Transcription of Ig germline genes in single human B cells and the role of cytokines in isotype determination.

Fear DJ, McCloskey N, O'Connor B, Felsenfeld G, Gould HJ.

J Immunol. 2004 Oct 1;173(7):4529-38.


Antagonism between DNA hypermethylation and enhancer-blocking activity at the H19 DMD is uncovered by CpG mutations.

Engel N, West AG, Felsenfeld G, Bartolomei MS.

Nat Genet. 2004 Aug;36(8):883-8. Epub 2004 Jul 25.


Obituary. Robert Simpson.

Felsenfeld G.

Nucleic Acids Res. 2004 Jun 2;32(10):2975-6. Print 2004. No abstract available.


The 5'-HS4 chicken beta-globin insulator is a CTCF-dependent nuclear matrix-associated element.

Yusufzai TM, Felsenfeld G.

Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8620-4. Epub 2004 May 28.


Physical properties of a genomic condensed chromatin fragment.

Ghirlando R, Litt MD, Prioleau MN, Recillas-Targa F, Felsenfeld G.

J Mol Biol. 2004 Feb 20;336(3):597-605.


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