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Items: 17

1.

Long-acting CCK analogue NN9056 lowers food intake and body weight in obese Göttingen Minipigs.

Christoffersen BØ, Skyggebjerg RB, Bugge A, Kirk RK, Vestergaard B, Uldam HK, Fels JJ, Pyke C, Sensfuss U, Sanfridson A, Clausen TR.

Int J Obes (Lond). 2019 Jun 7. doi: 10.1038/s41366-019-0386-0. [Epub ahead of print]

PMID:
31175319
2.

The Effect of Diet-induced Obesity on Toxicological Parameters in the Polygenic Sprague-Dawley Rat Model.

Rojas JM, Bolze F, Thorup I, Nowak J, Dalsgaard CM, Skydsgaard M, Berthelsen LO, Keane KA, Søeborg H, Sjögren I, Jensen JT, Fels JJ, Offenberg HK, Andersen LW, Dalgaard M.

Toxicol Pathol. 2018 Oct;46(7):777-798. doi: 10.1177/0192623318803557. Epub 2018 Oct 22.

PMID:
30343647
3.

FGF21 decreases food intake and body weight in obese Göttingen minipigs.

Christoffersen B, Straarup EM, Lykkegaard K, Fels JJ, Sass-Ørum K, Zhang X, Raun K, Andersen B.

Diabetes Obes Metab. 2019 Mar;21(3):592-600. doi: 10.1111/dom.13560. Epub 2018 Nov 20.

PMID:
30328263
4.

Long-Acting Human Growth Hormone Analogue by Noncovalent Albumin Binding.

Ramírez-Andersen HS, Behrens C, Buchardt J, Fels JJ, Folkesson CG, Jianhe C, Nørskov-Lauritsen L, Nielsen PF, Reslow M, Rischel C, Su J, Thygesen P, Wiberg C, Zhao X, Wenjuan X, Johansen NL.

Bioconjug Chem. 2018 Sep 19;29(9):3129-3143. doi: 10.1021/acs.bioconjchem.8b00463. Epub 2018 Aug 31.

PMID:
30168709
5.

NKX6.1 induced pluripotent stem cell reporter lines for isolation and analysis of functionally relevant neuronal and pancreas populations.

Gupta SK, Wesolowska-Andersen A, Ringgaard AK, Jaiswal H, Song L, Hastoy B, Ingvorsen C, Taheri-Ghahfarokhi A, Magnusson B, Maresca M, Jensen RR, Beer NL, Fels JJ, Grunnet LG, Thomas MK, Gloyn AL, Hicks R, McCarthy MI, Hansson M, Honoré C.

Stem Cell Res. 2018 May;29:220-231. doi: 10.1016/j.scr.2018.04.010. Epub 2018 Apr 23.

6.

Long-term Western diet fed apolipoprotein E-deficient rats exhibit only modest early atherosclerotic characteristics.

Rune I, Rolin B, Lykkesfeldt J, Nielsen DS, Krych Ł, Kanter JE, Bornfeldt KE, Kihl P, Buschard K, Josefsen K, Fels JJ, Mortensen A, Christoffersen B, Kirk RK, Hansen AK.

Sci Rep. 2018 Apr 3;8(1):5416. doi: 10.1038/s41598-018-23835-z.

7.

The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates.

Tsonkova VG, Sand FW, Wolf XA, Grunnet LG, Kirstine Ringgaard A, Ingvorsen C, Winkel L, Kalisz M, Dalgaard K, Bruun C, Fels JJ, Helgstrand C, Hastrup S, Öberg FK, Vernet E, Sandrini MPB, Shaw AC, Jessen C, Grønborg M, Hald J, Willenbrock H, Madsen D, Wernersson R, Hansson L, Jensen JN, Plesner A, Alanentalo T, Petersen MBK, Grapin-Botton A, Honoré C, Ahnfelt-Rønne J, Hecksher-Sørensen J, Ravassard P, Madsen OD, Rescan C, Frogne T.

Mol Metab. 2018 Feb;8:144-157. doi: 10.1016/j.molmet.2017.12.007. Epub 2017 Dec 19.

8.

Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes.

An D, Chiu A, Flanders JA, Song W, Shou D, Lu YC, Grunnet LG, Winkel L, Ingvorsen C, Christophersen NS, Fels JJ, Sand FW, Ji Y, Qi L, Pardo Y, Luo D, Silberstein M, Fan J, Ma M.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E263-E272. doi: 10.1073/pnas.1708806115. Epub 2017 Dec 26.

9.

Nonclinical pharmacokinetic and pharmacodynamic characterisation of somapacitan: A reversible non-covalent albumin-binding growth hormone.

Thygesen P, Andersen HS, Behrens C, Fels JJ, Nørskov-Lauritsen L, Rischel C, Johansen NL.

Growth Horm IGF Res. 2017 Aug;35:8-16. doi: 10.1016/j.ghir.2017.05.006. Epub 2017 May 24.

PMID:
28595133
10.

The kidneys play a central role in the clearance of rhGH in rats.

Vestergaard B, Thygesen P, Kreilgaard M, Fels JJ, Lykkesfeldt J, Agersø H.

Eur J Pharm Sci. 2016 Apr 30;86:29-33. doi: 10.1016/j.ejps.2016.02.019. Epub 2016 Mar 2.

PMID:
26946443
11.

Modulating the Gut Microbiota Improves Glucose Tolerance, Lipoprotein Profile and Atherosclerotic Plaque Development in ApoE-Deficient Mice.

Rune I, Rolin B, Larsen C, Nielsen DS, Kanter JE, Bornfeldt KE, Lykkesfeldt J, Buschard K, Kirk RK, Christoffersen B, Fels JJ, Josefsen K, Kihl P, Hansen AK.

PLoS One. 2016 Jan 22;11(1):e0146439. doi: 10.1371/journal.pone.0146439. eCollection 2016.

12.

Effects of insulin therapy on weight gain and fat distribution in the HF/HS-STZ rat model of type 2 diabetes.

Skovsø S, Damgaard J, Fels JJ, Olsen GS, Wolf XA, Rolin B, Holst JJ.

Int J Obes (Lond). 2015 Oct;39(10):1531-8. doi: 10.1038/ijo.2015.92. Epub 2015 May 26.

PMID:
26121961
13.

High fat, low carbohydrate diet limit fear and aggression in Göttingen minipigs.

Haagensen AM, Sørensen DB, Sandøe P, Matthews LR, Birck MM, Fels JJ, Astrup A.

PLoS One. 2014 Apr 16;9(4):e93821. doi: 10.1371/journal.pone.0093821. eCollection 2014.

14.

Treatment with insulin analog X10 and IGF-1 increases growth of colon cancer allografts.

Hvid H, Blouin MJ, Birman E, Damgaard J, Poulsen F, Fels JJ, Fledelius C, Hansen BF, Pollak M.

PLoS One. 2013 Nov 18;8(11):e79710. doi: 10.1371/journal.pone.0079710. eCollection 2013.

15.

In situ phosphorylation of Akt and ERK1/2 in rat mammary gland, colon, and liver following treatment with human insulin and IGF-1.

Hvid H, Fels JJ, Kirk RK, Thorup I, Jensen HE, Hansen BF, Oleksiewicz MB.

Toxicol Pathol. 2011 Jun;39(4):623-40. doi: 10.1177/0192623311406936. Epub 2011 May 10.

PMID:
21558470
16.

Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus--an adaptive response to hyperglycaemia?

Hansen AM, Bödvarsdottir TB, Nordestgaard DN, Heller RS, Gotfredsen CF, Maedler K, Fels JJ, Holst JJ, Karlsen AE.

Diabetologia. 2011 Jun;54(6):1379-87. doi: 10.1007/s00125-011-2080-1. Epub 2011 Feb 25.

PMID:
21347622
17.

Quality of plasma sampled by different methods for multiple blood sampling in mice.

Christensen SD, Mikkelsen LF, Fels JJ, Bodvarsdóttir TB, Hansen AK.

Lab Anim. 2009 Jan;43(1):65-71. doi: 10.1258/la.2008.007075. Epub 2008 Nov 10.

PMID:
19001062

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