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Items: 20


Monocarboxylate Transporters (SLC16): Function, Regulation, and Role in Health and Disease.

Felmlee MA, Jones RS, Rodriguez-Cruz V, Follman KE, Morris ME.

Pharmacol Rev. 2020 Apr;72(2):466-485. doi: 10.1124/pr.119.018762. Review.


Developmental Expression of Monocarboxylate Transporter 1 and 4 in Rat Liver.

Ng M, Louie J, Cao J, Felmlee MA.

J Pharm Pharm Sci. 2019;22(1):376-387. doi: 10.18433/jpps30537.


The Drug of Abuse Gamma-Hydroxybutyric Acid Exhibits Tissue-Specific Nonlinear Distribution.

Felmlee MA, Morse BL, Follman KE, Morris ME.

AAPS J. 2017 Dec 26;20(1):21. doi: 10.1208/s12248-017-0180-7.


Sex Hormones Regulate Rat Hepatic Monocarboxylate Transporter Expression and Membrane Trafficking.

Cao J, Ng M, Felmlee MA.

J Pharm Pharm Sci. 2017;20(1):435-444. doi: 10.18433/J3CH29.


SLC and ABC Transporters: Expression, Localization, and Species Differences at the Blood-Brain and the Blood-Cerebrospinal Fluid Barriers.

Morris ME, Rodriguez-Cruz V, Felmlee MA.

AAPS J. 2017 Sep;19(5):1317-1331. doi: 10.1208/s12248-017-0110-8. Epub 2017 Jun 29. Review.


Effect of chronic γ-hydroxybutyrate (GHB) administration on GHB toxicokinetics and GHB-induced respiratory depression.

Morse BL, Chadha GS, Felmlee MA, Follman KE, Morris ME.

Am J Drug Alcohol Abuse. 2017 Nov;43(6):686-693. doi: 10.1080/00952990.2017.1339055. Epub 2017 Jun 29.


A novel mutant Na+ /HCO3- cotransporter NBCe1 in a case of compound-heterozygous inheritance of proximal renal tubular acidosis.

Myers EJ, Yuan L, Felmlee MA, Lin YY, Jiang Y, Pei Y, Wang O, Li M, Xing XP, Marshall A, Xia WB, Parker MD.

J Physiol. 2016 Nov 1;594(21):6267-6286. doi: 10.1113/JP272252. Epub 2016 Aug 2.


Brain extracellular γ-hydroxybutyrate concentrations are decreased by L-lactate in rats: role in the treatment of overdoses.

Roiko SA, Vijay N, Felmlee MA, Morris ME.

Pharm Res. 2013 May;30(5):1338-48. doi: 10.1007/s11095-013-0973-z. Epub 2013 Jan 15.


Mechanistic models describing active renal reabsorption and secretion: a simulation-based study.

Felmlee MA, Dave RA, Morris ME.

AAPS J. 2013 Jan;15(1):278-87. doi: 10.1208/s12248-012-9437-3. Epub 2012 Nov 30.


Mechanism-based pharmacodynamic modeling.

Felmlee MA, Morris ME, Mager DE.

Methods Mol Biol. 2012;929:583-600.


Brain uptake of the drug of abuse γ-hydroxybutyric acid in rats.

Roiko SA, Felmlee MA, Morris ME.

Drug Metab Dispos. 2012 Jan;40(1):212-8. doi: 10.1124/dmd.111.041749. Epub 2011 Oct 21.


γ-Hydroxybutyrate blood/plasma partitioning: effect of physiologic pH on transport by monocarboxylate transporters.

Morse BL, Felmlee MA, Morris ME.

Drug Metab Dispos. 2012 Jan;40(1):64-9. doi: 10.1124/dmd.111.041285. Epub 2011 Oct 5.


Use of a local sensitivity analysis to inform study design based on a mechanistic toxicokinetic model for γ-hydroxybutyric acid.

Felmlee MA, Krzyzanski W, Morse BL, Morris ME.

AAPS J. 2011 Jun;13(2):240-54. doi: 10.1208/s12248-011-9264-y. Epub 2011 Mar 9.


Mechanistic toxicokinetic model for gamma-hydroxybutyric acid: inhibition of active renal reabsorption as a potential therapeutic strategy.

Felmlee MA, Wang Q, Cui D, Roiko SA, Morris ME.

AAPS J. 2010 Sep;12(3):407-16. doi: 10.1208/s12248-010-9197-x. Epub 2010 May 12.


Concentration-effect relationships for the drug of abuse gamma-hydroxybutyric acid.

Felmlee MA, Roiko SA, Morse BL, Morris ME.

J Pharmacol Exp Ther. 2010 Jun;333(3):764-71. doi: 10.1124/jpet.109.165381. Epub 2010 Mar 9.


Monocarboxylate transporter-mediated transport of gamma-hydroxybutyric acid in human intestinal Caco-2 cells.

Lam WK, Felmlee MA, Morris ME.

Drug Metab Dispos. 2010 Mar;38(3):441-7. doi: 10.1124/dmd.109.030775. Epub 2009 Dec 1.


Effects of the flaxseed lignans secoisolariciresinol diglucoside and its aglycone on serum and hepatic lipids in hyperlipidaemic rats.

Felmlee MA, Woo G, Simko E, Krol ES, Muir AD, Alcorn J.

Br J Nutr. 2009 Aug;102(3):361-9. doi: 10.1017/S0007114508207488. Epub 2009 Feb 16.


Quantitation of human cytochrome P450 2D6 protein with immunoblot and mass spectrometry analysis.

Yu AM, Qu J, Felmlee MA, Cao J, Jiang XL.

Drug Metab Dispos. 2009 Jan;37(1):170-7. doi: 10.1124/dmd.108.024166. Epub 2008 Oct 2.


Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice.

Felmlee MA, Lon HK, Gonzalez FJ, Yu AM.

Drug Metab Dispos. 2008 Feb;36(2):435-41. Epub 2007 Nov 29. Erratum in: Drug Metab Dispos. 2009 Jul;37(7):1563.


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