Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 31

1.

Use of a highly purified alpha 1-antitrypsin standard to establish ranges for the common normal and deficient alpha 1-antitrypsin phenotypes.

Brantly ML, Wittes JT, Vogelmeier CF, Hubbard RC, Fells GA, Crystal RG.

Chest. 1991 Sep;100(3):703-8.

PMID:
1889260
2.

Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency. Spontaneous release of leukotriene B4 by alveolar macrophages.

Hubbard RC, Fells G, Gadek J, Pacholok S, Humes J, Crystal RG.

J Clin Invest. 1991 Sep;88(3):891-7.

3.
4.

Anti-neutrophil elastase defense of the normal human respiratory epithelial surface provided by the secretory leukoprotease inhibitor.

Vogelmeier C, Hubbard RC, Fells GA, Schnebli HP, Thompson RC, Fritz H, Crystal RG.

J Clin Invest. 1991 Feb;87(2):482-8.

5.

Aerosolization of recombinant SLPI to augment antineutrophil elastase protection of pulmonary epithelium.

Vogelmeier C, Buhl R, Hoyt RF, Wilson E, Fells GA, Hubbard RC, Schnebli HP, Thompson RC, Crystal RG.

J Appl Physiol (1985). 1990 Nov;69(5):1843-8.

PMID:
2272977
6.

Antioxidant macromolecules in the epithelial lining fluid of the normal human lower respiratory tract.

Cantin AM, Fells GA, Hubbard RC, Crystal RG.

J Clin Invest. 1990 Sep;86(3):962-71.

7.

Alpha 1-antitrypsin Wbethesda: molecular basis of an unusual alpha 1-antitrypsin deficiency variant.

Holmes MD, Brantly ML, Fells GA, Crystal RG.

Biochem Biophys Res Commun. 1990 Aug 16;170(3):1013-20.

PMID:
2390072
8.

Alveolar macrophages release an insulin-like growth factor I-type molecule.

Rom WN, Basset P, Fells GA, Nukiwa T, Trapnell BC, Crysal RG.

J Clin Invest. 1988 Nov;82(5):1685-93.

9.

Characterization of the gene and protein of the alpha 1-antitrypsin "deficiency" allele Mprocida.

Takahashi H, Nukiwa T, Satoh K, Ogushi F, Brantly M, Fells G, Stier L, Courtney M, Crystal RG.

J Biol Chem. 1988 Oct 25;263(30):15528-34.

10.

Characterization of the gene and protein of the common alpha 1-antitrypsin normal M2 allele.

Nukiwa T, Brantly ML, Ogushi F, Fells GA, Crystal RG.

Am J Hum Genet. 1988 Sep;43(3):322-30.

11.

High levels of transforming growth factor-beta are present in the epithelial lining fluid of the normal human lower respiratory tract.

Yamauchi K, Martinet Y, Basset P, Fells GA, Crystal RG.

Am Rev Respir Dis. 1988 Jun;137(6):1360-3.

PMID:
3202372
12.

Evaluation of the S-type of alpha-1-antitrypsin as an in vivo and in vitro inhibitor of neutrophil elastase.

Ogushi F, Hubbard RC, Fells GA, Casolaro MA, Curiel DT, Brantly ML, Crystal RG.

Am Rev Respir Dis. 1988 Feb;137(2):364-70.

PMID:
3257660
13.

Augmentation of lung antineutrophil elastase capacity with recombinant human alpha-1-antitrypsin.

Casolaro MA, Fells G, Wewers M, Pierce JE, Ogushi F, Hubbard R, Sellers S, Forstrom J, Lyons D, Kawasaki G, et al.

J Appl Physiol (1985). 1987 Nov;63(5):2015-23.

PMID:
3500941
14.

Z-type alpha 1-antitrypsin is less competent than M1-type alpha 1-antitrypsin as an inhibitor of neutrophil elastase.

Ogushi F, Fells GA, Hubbard RC, Straus SD, Crystal RG.

J Clin Invest. 1987 Nov;80(5):1366-74.

16.

Characterization of the M1(Ala213) type of alpha 1-antitrypsin, a newly recognized, common "normal" alpha 1-antitrypsin haplotype.

Nukiwa T, Brantly M, Ogushi F, Fells G, Satoh K, Stier L, Courtney M, Crystal RG.

Biochemistry. 1987 Aug 25;26(17):5259-67.

PMID:
2890373
17.

Oxidant-mediated epithelial cell injury in idiopathic pulmonary fibrosis.

Cantin AM, North SL, Fells GA, Hubbard RC, Crystal RG.

J Clin Invest. 1987 Jun;79(6):1665-73.

18.

Production of glycosylated physiologically "normal" human alpha 1-antitrypsin by mouse fibroblasts modified by insertion of a human alpha 1-antitrypsin cDNA using a retroviral vector.

Garver RI Jr, Chytil A, Karlsson S, Fells GA, Brantly ML, Courtney M, Kantoff PW, Nienhuis AW, Anderson WF, Crystal RG.

Proc Natl Acad Sci U S A. 1987 Feb;84(4):1050-4.

19.

Identification of a second mutation in the protein-coding sequence of the Z type alpha 1-antitrypsin gene.

Nukiwa T, Satoh K, Brantly ML, Ogushi F, Fells GA, Courtney M, Crystal RG.

J Biol Chem. 1986 Dec 5;261(34):15989-94. Erratum in: J Biol Chem 1987 Jul 25;262(21):10412.

20.

Evaluation of danazol therapy for patients with PiZZ alpha-1-antitrypsin deficiency.

Wewers MD, Gadek JE, Keogh BA, Fells GA, Crystal RG.

Am Rev Respir Dis. 1986 Sep;134(3):476-80.

PMID:
3530071
21.

Evaluation of recombinant DNA-directed E.coli produced alpha 1-antitrypsin as an anti-neutrophil elastase for potential use as replacement therapy of alpha 1-antitrypsin deficiency.

Straus SD, Fells GA, Wewers MD, Courtney M, Tessier LH, Tolstoshev P, Lecocq JP, Crystal RG.

Biochem Biophys Res Commun. 1985 Aug 15;130(3):1177-84.

PMID:
3896239
23.

Role of connective tissue proteases in the pathogenesis of chronic inflammatory lung disease.

Gadek JE, Fells GA, Zimmerman RL, Crystal RG.

Environ Health Perspect. 1984 Apr;55:297-306. Review.

24.

Role of proteolytic and oxidative products of the neutrophil in determining the specificity of the pulmonary lesion in fibrotic and destructive lung disease.

Gadek JE, Fells GA, Zimmerman RL, Keogh BA, Crystal RG.

Chest. 1983 May;83(5 Suppl):59S. No abstract available.

PMID:
6301769
25.

Antielastases of the human alveolar structures. Implications for the protease-antiprotease theory of emphysema.

Gadek JE, Fells GA, Zimmerman RL, Rennard SI, Crystal RG.

J Clin Invest. 1981 Oct;68(4):889-98.

26.

Pulmonary asbestosis and idiopathic pulmonary fibrosis: pathogenetic parallels.

Gadek J, Hunninghake G, Schoenberger C, Fells G, Crystal R.

Chest. 1981 Jul;80(1 Suppl):63-4. No abstract available.

PMID:
6265151
27.

Human neutrophil elastase functions as a type III collagen "collagenase".

Gadek JE, Fells GA, Wright DG, Crystal RG.

Biochem Biophys Res Commun. 1980 Aug 29;95(4):1815-22. No abstract available.

PMID:
6251855
28.

Evaluation of the protease-antiprotease theory of human destructive lung disease.

Gadek JE, Hunninghake GW, Fells GA, Zimmerman RL, Keogh BA, Crystal RG.

Bull Eur Physiopathol Respir. 1980;16 Suppl:27-40. No abstract available.

PMID:
7013877
29.

Cigarette smoking induces functional antiprotease deficiency in the lower respiratory tract of humans.

Gadek JE, Fells GA, Crystal RG.

Science. 1979 Dec 14;206(4424):1315-6.

PMID:
316188
30.

Collagenase in the lower respiratory tract of patients with idiopathic pulmonary fibrosis.

Gadek JE, Kelman JA, Fells G, Weinberger SE, Horwitz AL, Reynolds HY, Fulmer JD, Crystal RG.

N Engl J Med. 1979 Oct 4;301(14):737-42.

PMID:
225666
31.

Cells, collagen and idiopathic pulmonary fibrosis.

Crystal RG, Fulmer JD, Baum BJ, Bernardo J, Bradley KH, Bruel SD, Elson NA, Fells GA, Ferrans VJ, Gadek JE, Hunninghake GW, Kawanami O, Kelman JA, Line BR, McDonald JA, McLees BD, Roberts WC, Rosenberg DM, Tolstoshev P, Von Gal E, Weinberger SE.

Lung. 1978;155(3):199-224. No abstract available.

PMID:
703380

Supplemental Content

Support Center