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Development and interlaboratory evaluation of a NIST Reference Material RM 8366 for EGFR and MET gene copy number measurements.

He HJ, Das B, Cleveland MH, Chen L, Camalier CE, Liu LC, Norman KL, Fellowes AP, McEvoy CR, Lund SP, Almeida J, Steffen CR, Karlovich C, Williams PM, Cole KD.

Clin Chem Lab Med. 2019 Jul 26;57(8):1142-1152. doi: 10.1515/cclm-2018-1306.


First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study.

Khot A, Brajanovski N, Cameron DP, Hein N, Maclachlan KH, Sanij E, Lim J, Soong J, Link E, Blombery P, Thompson ER, Fellowes A, Sheppard KE, McArthur GA, Pearson RB, Hannan RD, Poortinga G, Harrison SJ.

Cancer Discov. 2019 Aug;9(8):1036-1049. doi: 10.1158/2159-8290.CD-18-1455. Epub 2019 May 15.


CNspector: a web-based tool for visualisation and clinical diagnosis of copy number variation from next generation sequencing.

Markham JF, Yerneni S, Ryland GL, Leong HS, Fellowes A, Thompson ER, De Silva W, Kumar A, Lupat R, Li J, Ellul J, Fox S, Dickinson M, Papenfuss AT, Blombery P.

Sci Rep. 2019 Apr 23;9(1):6426. doi: 10.1038/s41598-019-42858-8.


Profound MEK inhibitor response in a cutaneous melanoma harboring a GOLGA4-RAF1 fusion.

McEvoy CR, Xu H, Smith K, Etemadmoghadam D, San Leong H, Choong DY, Byrne DJ, Iravani A, Beck S, Mileshkin L, Tothill RW, Bowtell DD, Bates BM, Nastevski V, Browning J, Bell AH, Khoo C, Desai J, Fellowes AP, Fox SB, Prall OW.

J Clin Invest. 2019 May 1;129(5):1940-1945. doi: 10.1172/JCI123089. Epub 2019 Mar 5.


Breast cancer metastasis to gynaecological organs: a clinico-pathological and molecular profiling study.

Kutasovic JR, McCart Reed AE, Males R, Sim S, Saunus JM, Dalley A, McEvoy CR, Dedina L, Miller G, Peyton S, Reid L, Lal S, Niland C, Ferguson K, Fellowes AP, Al-Ejeh F, Lakhani SR, Cummings MC, Simpson PT.

J Pathol Clin Res. 2019 Jan;5(1):25-39. doi: 10.1002/cjp2.118. Epub 2018 Oct 22.


SDH-deficient renal cell carcinoma associated with biallelic mutation in succinate dehydrogenase A: comprehensive genetic profiling and its relation to therapy response.

McEvoy CR, Koe L, Choong DY, Leong HS, Xu H, Karikios D, Plew JD, Prall OW, Fellowes AP, Fox SB.

NPJ Precis Oncol. 2018 Mar 20;2:9. doi: 10.1038/s41698-018-0053-2. eCollection 2018.


Exploring the feasibility and utility of exome-scale tumour sequencing in a clinical setting.

Lee B, Tran B, Hsu AL, Taylor GR, Fox SB, Fellowes A, Marquis R, Mooi J, Desai J, Doig K, Ekert P, Gaff C, Herath D, Hamilton A, James P, Roberts A, Snyder R, Waring P, McArthur G.

Intern Med J. 2018 Jul;48(7):786-794. doi: 10.1111/imj.13806.


Canary: an atomic pipeline for clinical amplicon assays.

Doig KD, Ellul J, Fellowes A, Thompson ER, Ryland G, Blombery P, Papenfuss AT, Fox SB.

BMC Bioinformatics. 2017 Dec 15;18(1):555. doi: 10.1186/s12859-017-1950-z.


Precision oncology using a clinician-directed, tailored approach to molecular profiling.

Lam M, Tran B, Beck S, Tie J, Herath D, Whittle J, Kwan EM, Fox SB, Fellowes A, Ananda S, Lipton L, Gibbs P, Rosenthal MA, Desai J.

Asia Pac J Clin Oncol. 2018 Feb;14(1):84-90. doi: 10.1111/ajco.12787. Epub 2017 Oct 30.


Lessons learnt from implementation of a Lynch syndrome screening program for patients with gynaecological malignancy.

Najdawi F, Crook A, Maidens J, McEvoy C, Fellowes A, Pickett J, Ho M, Nevell D, McIlroy K, Sheen A, Sioson L, Ahadi M, Turchini J, Clarkson A, Hogg R, Valmadre S, Gard G, Dooley SJ, Scott RJ, Fox SB, Field M, Gill AJ.

Pathology. 2017 Aug;49(5):457-464. doi: 10.1016/j.pathol.2017.05.004. Epub 2017 Jun 30.


PathOS: a decision support system for reporting high throughput sequencing of cancers in clinical diagnostic laboratories.

Doig KD, Fellowes A, Bell AH, Seleznev A, Ma D, Ellul J, Li J, Doyle MA, Thompson ER, Kumar A, Lara L, Vedururu R, Reid G, Conway T, Papenfuss AT, Fox SB.

Genome Med. 2017 Apr 24;9(1):38. doi: 10.1186/s13073-017-0427-z.


Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer.

Pang JB, Savas P, Fellowes AP, Mir Arnau G, Kader T, Vedururu R, Hewitt C, Takano EA, Byrne DJ, Choong DY, Millar EK, Lee CS, O'Toole SA, Lakhani SR, Cummings MC, Mann GB, Campbell IG, Dobrovic A, Loi S, Gorringe KL, Fox SB.

Mod Pathol. 2017 Jul;30(7):952-963. doi: 10.1038/modpathol.2017.21. Epub 2017 Mar 24.


Multiplexed transcriptome analysis to detect ALK, ROS1 and RET rearrangements in lung cancer.

Rogers TM, Arnau GM, Ryland GL, Huang S, Lira ME, Emmanuel Y, Perez OD, Irwin D, Fellowes AP, Wong SQ, Fox SB.

Sci Rep. 2017 Feb 9;7:42259. doi: 10.1038/srep42259.


Clinicopathological differences exist between CALR- and JAK2-mutated myeloproliferative neoplasms despite a similar molecular landscape: data from targeted next-generation sequencing in the diagnostic laboratory.

Agarwal R, Blombery P, McBean M, Jones K, Fellowes A, Doig K, Forsyth C, Westerman DA.

Ann Hematol. 2017 May;96(5):725-732. doi: 10.1007/s00277-017-2937-6. Epub 2017 Feb 4.


Cost-effectiveness of precision medicine in the fourth-line treatment of metastatic lung adenocarcinoma: An early decision analytic model of multiplex targeted sequencing.

Doble B, John T, Thomas D, Fellowes A, Fox S, Lorgelly P.

Lung Cancer. 2017 May;107:22-35. doi: 10.1016/j.lungcan.2016.05.024. Epub 2016 Jun 2.


BRAF Inhibition in BRAFV600E-Positive Anaplastic Thyroid Carcinoma.

Lim AM, Taylor GR, Fellowes A, Cameron L, Lee B, Hicks RJ, McArthur GA, Angel C, Solomon B, Rischin D.

J Natl Compr Canc Netw. 2016 Mar;14(3):249-54. Epub 2016 Mar 8.


UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas.

Wong SQ, Waldeck K, Vergara IA, Schröder J, Madore J, Wilmott JS, Colebatch AJ, De Paoli-Iseppi R, Li J, Lupat R, Semple T, Arnau GM, Fellowes A, Leonard JH, Hruby G, Mann GJ, Thompson JF, Cullinane C, Johnston M, Shackleton M, Sandhu S, Bowtell DD, Johnstone RW, Fox SB, McArthur GA, Papenfuss AT, Scolyer RA, Gill AJ, Hicks RJ, Tothill RW.

Cancer Res. 2015 Dec 15;75(24):5228-34. doi: 10.1158/0008-5472.CAN-15-1877. Epub 2015 Dec 1.


"Cancer 2015": A Prospective, Population-Based Cancer Cohort-Phase 1: Feasibility of Genomics-Guided Precision Medicine in the Clinic.

Parisot JP, Thorne H, Fellowes A, Doig K, Lucas M, McNeil JJ, Doble B, Dobrovic A, John T, James PA, Lipton L, Ashley D, Hayes T, McMurrick P, Richardson G, Lorgelly P, Fox SB, Thomas DM.

J Pers Med. 2015 Oct 29;5(4):354-69. doi: 10.3390/jpm5040354.


Meaningful health outcomes for paediatric neurodisability: Stakeholder prioritisation and appropriateness of patient reported outcome measures.

Morris C, Janssens A, Shilling V, Allard A, Fellowes A, Tomlinson R, Williams J, Thompson Coon J, Rogers M, Beresford B, Green C, Jenkinson C, Tennant A, Logan S.

Health Qual Life Outcomes. 2015 Jun 25;13:87. doi: 10.1186/s12955-015-0284-7.


Molecular methods for somatic mutation testing in lung adenocarcinoma: EGFR and beyond.

Khoo C, Rogers TM, Fellowes A, Bell A, Fox S.

Transl Lung Cancer Res. 2015 Apr;4(2):126-41. doi: 10.3978/j.issn.2218-6751.2015.01.10. Review.


Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients.

Wong SQ, Fellowes A, Doig K, Ellul J, Bosma TJ, Irwin D, Vedururu R, Tan AY, Weiss J, Chan KS, Lucas M, Thomas DM, Dobrovic A, Parisot JP, Fox SB.

Br J Cancer. 2015 Apr 14;112(8):1411-20. doi: 10.1038/bjc.2015.80. Epub 2015 Mar 5.


Informing the NHS Outcomes Framework: evaluating meaningful health outcomes for children with neurodisability using multiple methods including systematic review, qualitative research, Delphi survey and consensus meeting.

Morris C, Janssens A, Allard A, Thompson Coon J, Shilling V, Tomlinson R, Williams J, Fellowes A, Rogers M, Allen K, Beresford B, Green C, Jenkinson C, Tennant A, Logan S.

Southampton (UK): NIHR Journals Library; 2014 May.


Mutational profiling of familial male breast cancers reveals similarities with luminal A female breast cancer with rare TP53 mutations.

Deb S, Wong SQ, Li J, Do H, Weiss J, Byrne D, Chakrabarti A, Bosma T; kConFab Investigators, Fellowes A, Dobrovic A, Fox SB.

Br J Cancer. 2014 Dec 9;111(12):2351-60. doi: 10.1038/bjc.2014.511.


Sequence artefacts in a prospective series of formalin-fixed tumours tested for mutations in hotspot regions by massively parallel sequencing.

Wong SQ, Li J, Tan AY, Vedururu R, Pang JM, Do H, Ellul J, Doig K, Bell A, MacArthur GA, Fox SB, Thomas DM, Fellowes A, Parisot JP, Dobrovic A; CANCER 2015 Cohort.

BMC Med Genomics. 2014 May 13;7:23. doi: 10.1186/1755-8794-7-23.


Studying cancer genomics through next-generation DNA sequencing and bioinformatics.

Doyle MA, Li J, Doig K, Fellowes A, Wong SQ.

Methods Mol Biol. 2014;1168:83-98. doi: 10.1007/978-1-4939-0847-9_6. Review.


A unique case of refractory primary mediastinal B-cell lymphoma with JAK3 mutation and the role for targeted therapy.

Hanna DM, Fellowes A, Vedururu R, Mechinaud F, Hansford JR.

Haematologica. 2014 Sep;99(9):e156-8. doi: 10.3324/haematol.2014.108142. Epub 2014 May 16. No abstract available.


Key health outcomes for children and young people with neurodisability: qualitative research with young people and parents.

Allard A, Fellowes A, Shilling V, Janssens A, Beresford B, Morris C.

BMJ Open. 2014 Apr 19;4(4):e004611. doi: 10.1136/bmjopen-2013-004611.


Characterization of a novel tumorigenic esophageal adenocarcinoma cell line: OANC1.

Clemons NJ, Do H, Fennell C, Deb S, Fellowes A, Dobrovic A, Phillips WA.

Dig Dis Sci. 2014 Jan;59(1):78-88.


Massively-parallel sequencing assists the diagnosis and guided treatment of cancers of unknown primary.

Tothill RW, Li J, Mileshkin L, Doig K, Siganakis T, Cowin P, Fellowes A, Semple T, Fox S, Byron K, Kowalczyk A, Thomas D, Schofield P, Bowtell DD.

J Pathol. 2013 Dec;231(4):413-23. doi: 10.1002/path.4251.


Preimplantation genetic diagnosis for hemophilia A using indirect linkage analysis and direct genotyping approaches.

Laurie AD, Hill AM, Harraway JR, Fellowes AP, Phillipson GT, Benny PS, Smith MP, George PM.

J Thromb Haemost. 2010 Apr;8(4):783-9. doi: 10.1111/j.1538-7836.2010.03768.x. Epub 2010 Jan 21.


Novel sequence insertion in a Mâori patient with transfusion-dependent beta-thalassaemia.

Blacklock HA, Case J, Chan T, Raizis T, Doocey R, Fellowes A, Royle G, Jackson S, Brennan S, George P.

Br J Haematol. 2005 Nov;131(3):400-2.


Familial hypofibrinogenaemia associated with heterozygous substitution of a conserved arginine residue; Bbeta255 Arg-->His (Fibrinogen Merivale).

Maghzal GJ, Brennan SO, Fellowes AP, Spearing R, George PM.

Biochim Biophys Acta. 2003 Feb 21;1645(2):146-51.


Gamma371 Thr-->Ile substitution in the fibrinogen gammaD domain causes hypofibrinogenaemia.

Brennan SO, Wyatt JM, Fellowes AP, Dlott JS, Triplett DA, George PM.

Biochim Biophys Acta. 2001 Dec 17;1550(2):183-8.


Molecular mechanisms of hypo- and afibrinogenemia.

Brennan SO, Fellowes AP, George PM.

Ann N Y Acad Sci. 2001;936:91-100. Review.


Identification and characterization of five new fibrinogen gene polymorphisms.

Fellowes AP, Brennan SO, George PM.

Ann N Y Acad Sci. 2001;936:536-41.


Homozygous truncation of the fibrinogen A alpha chain within the coiled coil causes congenital afibrinogenemia.

Fellowes AP, Brennan SO, Holme R, Stormorken H, Brosstad FR, George PM.

Blood. 2000 Jul 15;96(2):773-5.


Correction for Stott et al.: simple multiplex PCR for the simultaneous detection of the C282Y and H63D hemochromatosis (HFE) gene mutations.

Stott MK, Fellowes AP, Upton JD, Burt MJ, George PM.

Clin Chem. 2000 Feb;46(2):308-9. No abstract available.


Albumin banks peninsula: a new termination variant characterised by electrospray mass spectrometry.

Brennan SO, Fellowes AP, George PM.

Biochim Biophys Acta. 1999 Aug 17;1433(1-2):321-6.


Painful choices. A midwife's personal experience of antenatal testing.

Fellowes A.

Pract Midwife. 1999 Apr;2(4):18-9. No abstract available.


Simple multiplex PCR for the simultaneous detection of the C282Y and H63D hemochromatosis (HFE) gene mutations.

Stott MK, Fellowes AP, Upton JD, Burt MJ, George PM.

Clin Chem. 1999 Mar;45(3):426-8. No abstract available.


Rapid detection of the fibrinogen A alpha 16Arg --> His mutation.

Ridgway HJ, Brennan SO, Fellowes AP, George PM.

Clin Chem. 1997 Nov;43(11):2184-6. No abstract available.


Albumin Hawkes Bay; a low level variant caused by loss of a sulphydryl group at position 177.

Brennan SO, Fellowes AP.

Biochim Biophys Acta. 1993 Aug 4;1182(1):46-50.


Albumin Rugby Park: a truncated albumin variant caused by a G-->C splice-site mutation in intron 13.

Peach RJ, Fellowes AP, Brennan SO, George PM.

Biochim Biophys Acta. 1992 Oct 13;1180(1):107-10.


Apolipoprotein B-32: a new truncated mutant of human apolipoprotein B capable of forming particles in the low density lipoprotein range.

McCormick SP, Fellowes AP, Walmsley TA, George PM.

Biochim Biophys Acta. 1992 Apr 14;1138(4):290-6.


A novel variant of transthyretin (prealbumin), Thr119 to Met, associated with increased thyroxine binding.

Scrimshaw BJ, Fellowes AP, Palmer BN, Croxson MS, Stockigt JR, George PM.

Thyroid. 1992 Spring;2(1):21-6.


Molecular screening of cystic fibrosis patients.

Fellowes AP, Murphy JM, Wesley AW, Dawson KP, George PM.

N Z Med J. 1991 Oct 9;104(921):415-6.


Concurrence of hereditary spherocytosis and alpha thalassaemia.

Heaton DC, Fellowes AP, George PM.

Aust N Z J Med. 1991 Aug;21(4):485-6. No abstract available.


Apolipoprotein E variation in patients with hyperlipidaemia: DNA and protein phenotyping.

McCormick SP, Fellowes AP, Brennan SO, George PM.

N Z Med J. 1989 Oct 11;102(877):534-6.


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