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Items: 29


Identification and Quantification of Proteoforms by Mass Spectrometry.

Schaffer LV, Millikin RJ, Miller RM, Anderson LC, Fellers RT, Ge Y, Kelleher NL, LeDuc RD, Liu X, Payne SH, Sun L, Thomas PM, Tucholski T, Wang Z, Wu S, Wu Z, Yu D, Shortreed MR, Smith LM.

Proteomics. 2019 May;19(10):e1800361. doi: 10.1002/pmic.201800361. Review.


Accurate Estimation of Context-Dependent False Discovery Rates in Top-Down Proteomics.

LeDuc RD, Fellers RT, Early BP, Greer JB, Shams DP, Thomas PM, Kelleher NL.

Mol Cell Proteomics. 2019 Apr;18(4):796-805. doi: 10.1074/mcp.RA118.000993. Epub 2019 Jan 15.


The Value of Activated Ion Electron Transfer Dissociation for High-Throughput Top-Down Characterization of Intact Proteins.

Riley NM, Sikora JW, Seckler HS, Greer JB, Fellers RT, LeDuc RD, Westphall MS, Thomas PM, Kelleher NL, Coon JJ.

Anal Chem. 2018 Jul 17;90(14):8553-8560. doi: 10.1021/acs.analchem.8b01638. Epub 2018 Jul 5.


Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques.

Fornelli L, Srzentić K, Huguet R, Mullen C, Sharma S, Zabrouskov V, Fellers RT, Durbin KR, Compton PD, Kelleher NL.

Anal Chem. 2018 Jul 17;90(14):8421-8429. doi: 10.1021/acs.analchem.8b00984. Epub 2018 Jun 28.


Capillary HILIC-MS: A New Tool for Sensitive Top-Down Proteomics.

Gargano AFG, Roca LS, Fellers RT, Bocxe M, Domínguez-Vega E, Somsen GW.

Anal Chem. 2018 Jun 5;90(11):6601-6609. doi: 10.1021/acs.analchem.8b00382. Epub 2018 May 18.


Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk.

Ntai I, Fornelli L, DeHart CJ, Hutton JE, Doubleday PF, LeDuc RD, van Nispen AJ, Fellers RT, Whiteley G, Boja ES, Rodriguez H, Kelleher NL.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4140-4145. doi: 10.1073/pnas.1716122115. Epub 2018 Apr 2.


Top-Down Proteomics Enables Comparative Analysis of Brain Proteoforms Between Mouse Strains.

Davis RG, Park HM, Kim K, Greer JB, Fellers RT, LeDuc RD, Romanova EV, Rubakhin SS, Zombeck JA, Wu C, Yau PM, Gao P, van Nispen AJ, Patrie SM, Thomas PM, Sweedler JV, Rhodes JS, Kelleher NL.

Anal Chem. 2018 Mar 20;90(6):3802-3810. doi: 10.1021/acs.analchem.7b04108. Epub 2018 Feb 26.


Diversity of Amyloid-beta Proteoforms in the Alzheimer's Disease Brain.

Wildburger NC, Esparza TJ, LeDuc RD, Fellers RT, Thomas PM, Cairns NJ, Kelleher NL, Bateman RJ, Brody DL.

Sci Rep. 2017 Aug 25;7(1):9520. doi: 10.1038/s41598-017-10422-x.


Proteoforms in Peripheral Blood Mononuclear Cells as Novel Rejection Biomarkers in Liver Transplant Recipients.

Toby TK, Abecassis M, Kim K, Thomas PM, Fellers RT, LeDuc RD, Kelleher NL, Demetris J, Levitsky J.

Am J Transplant. 2017 Sep;17(9):2458-2467. doi: 10.1111/ajt.14359. Epub 2017 Jun 27.


High-Throughput Analysis of Intact Human Proteins Using UVPD and HCD on an Orbitrap Mass Spectrometer.

Cleland TP, DeHart CJ, Fellers RT, VanNispen AJ, Greer JB, LeDuc RD, Parker WR, Thomas PM, Kelleher NL, Brodbelt JS.

J Proteome Res. 2017 May 5;16(5):2072-2079. doi: 10.1021/acs.jproteome.7b00043. Epub 2017 Apr 19.


Defining Gas-Phase Fragmentation Propensities of Intact Proteins During Native Top-Down Mass Spectrometry.

Haverland NA, Skinner OS, Fellers RT, Tariq AA, Early BP, LeDuc RD, Fornelli L, Compton PD, Kelleher NL.

J Am Soc Mass Spectrom. 2017 Jun;28(6):1203-1215. doi: 10.1007/s13361-017-1635-x. Epub 2017 Apr 3.


Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer.

Fornelli L, Durbin KR, Fellers RT, Early BP, Greer JB, LeDuc RD, Compton PD, Kelleher NL.

J Proteome Res. 2017 Feb 3;16(2):609-618. doi: 10.1021/acs.jproteome.6b00698. Epub 2016 Dec 2.


Bioinformatics Analysis of Top-Down Mass Spectrometry Data with ProSight Lite.

DeHart CJ, Fellers RT, Fornelli L, Kelleher NL, Thomas PM.

Methods Mol Biol. 2017;1558:381-394. doi: 10.1007/978-1-4939-6783-4_18.


Identification and Characterization of Human Proteoforms by Top-Down LC-21 Tesla FT-ICR Mass Spectrometry.

Anderson LC, DeHart CJ, Kaiser NK, Fellers RT, Smith DF, Greer JB, LeDuc RD, Blakney GT, Thomas PM, Kelleher NL, Hendrickson CL.

J Proteome Res. 2017 Feb 3;16(2):1087-1096. doi: 10.1021/acs.jproteome.6b00696. Epub 2016 Dec 12.


Comparative top down proteomics of peripheral blood mononuclear cells from kidney transplant recipients with normal kidney biopsies or acute rejection.

Savaryn JP, Toby TK, Catherman AD, Fellers RT, LeDuc RD, Thomas PM, Friedewald JJ, Salomon DR, Abecassis MM, Kelleher NL.

Proteomics. 2016 Jul;16(14):2048-58. doi: 10.1002/pmic.201600008.


Quantitation and Identification of Thousands of Human Proteoforms below 30 kDa.

Durbin KR, Fornelli L, Fellers RT, Doubleday PF, Narita M, Kelleher NL.

J Proteome Res. 2016 Mar 4;15(3):976-82. doi: 10.1021/acs.jproteome.5b00997. Epub 2016 Feb 11.


An informatic framework for decoding protein complexes by top-down mass spectrometry.

Skinner OS, Havugimana PC, Haverland NA, Fornelli L, Early BP, Greer JB, Fellers RT, Durbin KR, Do Vale LH, Melani RD, Seckler HS, Nelp MT, Belov ME, Horning SR, Makarov AA, LeDuc RD, Bandarian V, Compton PD, Kelleher NL.

Nat Methods. 2016 Mar;13(3):237-40. doi: 10.1038/nmeth.3731. Epub 2016 Jan 18.


Integrated Bottom-Up and Top-Down Proteomics of Patient-Derived Breast Tumor Xenografts.

Ntai I, LeDuc RD, Fellers RT, Erdmann-Gilmore P, Davies SR, Rumsey J, Early BP, Thomas PM, Li S, Compton PD, Ellis MJ, Ruggles KV, Fenyö D, Boja ES, Rodriguez H, Townsend RR, Kelleher NL.

Mol Cell Proteomics. 2016 Jan;15(1):45-56. doi: 10.1074/mcp.M114.047480. Epub 2015 Oct 26.


Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression.

Zheng Y, Fornelli L, Compton PD, Sharma S, Canterbury J, Mullen C, Zabrouskov V, Fellers RT, Thomas PM, Licht JD, Senko MW, Kelleher NL.

Mol Cell Proteomics. 2016 Mar;15(3):776-90. doi: 10.1074/mcp.M115.053819. Epub 2015 Aug 13.


Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry.

Savaryn JP, Skinner OS, Fornelli L, Fellers RT, Compton PD, Terhune SS, Abecassis MM, Kelleher NL.

J Proteomics. 2016 Feb 16;134:76-84. doi: 10.1016/j.jprot.2015.04.025. Epub 2015 May 4.


ProSight Lite: graphical software to analyze top-down mass spectrometry data.

Fellers RT, Greer JB, Early BP, Yu X, LeDuc RD, Kelleher NL, Thomas PM.

Proteomics. 2015 Apr;15(7):1235-8. doi: 10.1002/pmic.201570050.


Analyzing internal fragmentation of electrosprayed ubiquitin ions during beam-type collisional dissociation.

Durbin KR, Skinner OS, Fellers RT, Kelleher NL.

J Am Soc Mass Spectrom. 2015 May;26(5):782-7. doi: 10.1007/s13361-015-1078-1. Epub 2015 Feb 26.


The C-score: a Bayesian framework to sharply improve proteoform scoring in high-throughput top down proteomics.

LeDuc RD, Fellers RT, Early BP, Greer JB, Thomas PM, Kelleher NL.

J Proteome Res. 2014 Jul 3;13(7):3231-40. doi: 10.1021/pr401277r. Epub 2014 Jun 12.


Applying label-free quantitation to top down proteomics.

Ntai I, Kim K, Fellers RT, Skinner OS, Smith AD 4th, Early BP, Savaryn JP, LeDuc RD, Thomas PM, Kelleher NL.

Anal Chem. 2014 May 20;86(10):4961-8. doi: 10.1021/ac500395k. Epub 2014 May 7.


The first pilot project of the consortium for top-down proteomics: a status report.

Dang X, Scotcher J, Wu S, Chu RK, Tolić N, Ntai I, Thomas PM, Fellers RT, Early BP, Zheng Y, Durbin KR, Leduc RD, Wolff JJ, Thompson CJ, Pan J, Han J, Shaw JB, Salisbury JP, Easterling M, Borchers CH, Brodbelt JS, Agar JN, Paša-Tolić L, Kelleher NL, Young NL.

Proteomics. 2014 May;14(10):1130-40. doi: 10.1002/pmic.201300438. Epub 2014 Apr 14.


Ultraviolet photodissociation for characterization of whole proteins on a chromatographic time scale.

Cannon JR, Cammarata MB, Robotham SA, Cotham VC, Shaw JB, Fellers RT, Early BP, Thomas PM, Kelleher NL, Brodbelt JS.

Anal Chem. 2014 Feb 18;86(4):2185-92. doi: 10.1021/ac403859a. Epub 2014 Jan 29.


Autopilot: an online data acquisition control system for the enhanced high-throughput characterization of intact proteins.

Durbin KR, Fellers RT, Ntai I, Kelleher NL, Compton PD.

Anal Chem. 2014 Feb 4;86(3):1485-92. doi: 10.1021/ac402904h. Epub 2014 Jan 23.


Large-scale top-down proteomics of the human proteome: membrane proteins, mitochondria, and senescence.

Catherman AD, Durbin KR, Ahlf DR, Early BP, Fellers RT, Tran JC, Thomas PM, Kelleher NL.

Mol Cell Proteomics. 2013 Dec;12(12):3465-73. doi: 10.1074/mcp.M113.030114. Epub 2013 Sep 10.


Complete protein characterization using top-down mass spectrometry and ultraviolet photodissociation.

Shaw JB, Li W, Holden DD, Zhang Y, Griep-Raming J, Fellers RT, Early BP, Thomas PM, Kelleher NL, Brodbelt JS.

J Am Chem Soc. 2013 Aug 28;135(34):12646-51. doi: 10.1021/ja4029654. Epub 2013 Jun 4.

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