Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 39

1.

Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding Proteins.

Chothani S, Schäfer S, Adami E, Viswanathan S, Widjaja AA, Langley SR, Tan J, Wang M, Quaife NM, Pua CJ, D'Agostino G, Shekeran SG, George BL, Lim S, Cao EY, van Heesch S, Witte F, Felkin LE, Christodoulou EG, Dong J, Blachut S, Patone G, Barton PJR, Hubner N, Cook SA, Rackham OJL.

Circulation. 2019 Jul 9. doi: 10.1161/CIRCULATIONAHA.119.039596. [Epub ahead of print]

PMID:
31284728
2.

The Translational Landscape of the Human Heart.

van Heesch S, Witte F, Schneider-Lunitz V, Schulz JF, Adami E, Faber AB, Kirchner M, Maatz H, Blachut S, Sandmann CL, Kanda M, Worth CL, Schafer S, Calviello L, Merriott R, Patone G, Hummel O, Wyler E, Obermayer B, Mücke MB, Lindberg EL, Trnka F, Memczak S, Schilling M, Felkin LE, Barton PJR, Quaife NM, Vanezis K, Diecke S, Mukai M, Mah N, Oh SJ, Kurtz A, Schramm C, Schwinge D, Sebode M, Harakalova M, Asselbergs FW, Vink A, de Weger RA, Viswanathan S, Widjaja AA, Gärtner-Rommel A, Milting H, Dos Remedios C, Knosalla C, Mertins P, Landthaler M, Vingron M, Linke WA, Seidman JG, Seidman CE, Rajewsky N, Ohler U, Cook SA, Hubner N.

Cell. 2019 Jun 27;178(1):242-260.e29. doi: 10.1016/j.cell.2019.05.010. Epub 2019 May 30.

PMID:
31155234
3.

A gene-centric strategy for identifying disease-causing rare variants in dilated cardiomyopathy.

Horvat C, Johnson R, Lam L, Munro J, Mazzarotto F, Roberts AM, Herman DS, Parfenov M, Haghighi A, McDonough B, DePalma SR, Keogh AM, Macdonald PS, Hayward CS, Roberts A, Barton PJR, Felkin LE, Giannoulatou E, Cook SA, Seidman JG, Seidman CE, Fatkin D.

Genet Med. 2019 Jan;21(1):133-143. doi: 10.1038/s41436-018-0036-2. Epub 2018 Jun 11.

PMID:
29892087
4.

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy.

Heinig M, Adriaens ME, Schafer S, van Deutekom HWM, Lodder EM, Ware JS, Schneider V, Felkin LE, Creemers EE, Meder B, Katus HA, Rühle F, Stoll M, Cambien F, Villard E, Charron P, Varro A, Bishopric NH, George AL Jr, Dos Remedios C, Moreno-Moral A, Pesce F, Bauerfeind A, Rüschendorf F, Rintisch C, Petretto E, Barton PJ, Cook SA, Pinto YM, Bezzina CR, Hubner N.

Genome Biol. 2017 Sep 14;18(1):170. doi: 10.1186/s13059-017-1286-z.

5.

Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes.

Walsh R, Buchan R, Wilk A, John S, Felkin LE, Thomson KL, Chiaw TH, Loong CCW, Pua CJ, Raphael C, Prasad S, Barton PJ, Funke B, Watkins H, Ware JS, Cook SA.

Eur Heart J. 2017 Dec 7;38(46):3461-3468. doi: 10.1093/eurheartj/ehw603.

6.

The Calcineurin Variant CnAβ1 Controls Mouse Embryonic Stem Cell Differentiation by Directing mTORC2 Membrane Localization and Activation.

Gómez-Salinero JM, López-Olañeta MM, Ortiz-Sánchez P, Larrasa-Alonso J, Gatto A, Felkin LE, Barton PJR, Navarro-Lérida I, Ángel Del Pozo M, García-Pavía P, Sundararaman B, Giovinazo G, Yeo GW, Lara-Pezzi E.

Cell Chem Biol. 2016 Nov 17;23(11):1372-1382. doi: 10.1016/j.chembiol.2016.09.010. Epub 2016 Oct 13.

7.

Recovery of Cardiac Function in Cardiomyopathy Caused by Titin Truncation.

Felkin LE, Walsh R, Ware JS, Yacoub MH, Birks EJ, Barton PJ, Cook SA.

JAMA Cardiol. 2016 May 1;1(2):234-5. doi: 10.1001/jamacardio.2016.0208. No abstract available.

8.

ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure.

Buyandelger B, Mansfield C, Kostin S, Choi O, Roberts AM, Ware JS, Mazzarotto F, Pesce F, Buchan R, Isaacson RL, Vouffo J, Gunkel S, Knöll G, McSweeney SJ, Wei H, Perrot A, Pfeiffer C, Toliat MR, Ilieva K, Krysztofinska E, López-Olañeta MM, Gómez-Salinero JM, Schmidt A, Ng KE, Teucher N, Chen J, Teichmann M, Eilers M, Haverkamp W, Regitz-Zagrosek V, Hasenfuss G, Braun T, Pennell DJ, Gould I, Barton PJ, Lara-Pezzi E, Schäfer S, Hübner N, Felkin LE, O'Regan DP, Brand T, Milting H, Nürnberg P, Schneider MD, Prasad S, Petretto E, Knöll R.

Circ Cardiovasc Genet. 2015 Oct;8(5):643-52. doi: 10.1161/CIRCGENETICS.113.000690. Epub 2015 Jul 14.

9.

Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease.

Roberts AM, Ware JS, Herman DS, Schafer S, Baksi J, Bick AG, Buchan RJ, Walsh R, John S, Wilkinson S, Mazzarotto F, Felkin LE, Gong S, MacArthur JA, Cunningham F, Flannick J, Gabriel SB, Altshuler DM, Macdonald PS, Heinig M, Keogh AM, Hayward CS, Banner NR, Pennell DJ, O'Regan DP, San TR, de Marvao A, Dawes TJ, Gulati A, Birks EJ, Yacoub MH, Radke M, Gotthardt M, Wilson JG, O'Donnell CJ, Prasad SK, Barton PJ, Fatkin D, Hubner N, Seidman JG, Seidman CE, Cook SA.

Sci Transl Med. 2015 Jan 14;7(270):270ra6. doi: 10.1126/scitranslmed.3010134.

10.

Regulated inositol-requiring protein 1-dependent decay as a mechanism of corin RNA and protein deficiency in advanced human systolic heart failure.

Lee R, Xu B, Rame JE, Felkin LE, Barton P, Dries DL.

J Am Heart Assoc. 2014 Dec;3(6):e001104. doi: 10.1161/JAHA.114..

11.

Heat shock protein-27 delays acute rejection after cardiac transplantation: an experimental model.

Seemampillai B, Germack R, Felkin LE, McCormack A, Rose ML.

Transplantation. 2014 Jul 15;98(1):29-38. doi: 10.1097/TP.0000000000000170.

12.

Follistatin-like 3 mediates paracrine fibroblast activation by cardiomyocytes.

Panse KD, Felkin LE, López-Olañeta MM, Gómez-Salinero J, Villalba M, Muñoz L, Nakamura K, Shimano M, Walsh K, Barton PJ, Rosenthal N, Lara-Pezzi E.

J Cardiovasc Transl Res. 2012 Dec;5(6):814-26. doi: 10.1007/s12265-012-9400-9. Epub 2012 Aug 23.

PMID:
22915069
13.

Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function.

McDermott-Roe C, Ye J, Ahmed R, Sun XM, Serafín A, Ware J, Bottolo L, Muckett P, Cañas X, Zhang J, Rowe GC, Buchan R, Lu H, Braithwaite A, Mancini M, Hauton D, Martí R, García-Arumí E, Hubner N, Jacob H, Serikawa T, Zidek V, Papousek F, Kolar F, Cardona M, Ruiz-Meana M, García-Dorado D, Comella JX, Felkin LE, Barton PJ, Arany Z, Pravenec M, Petretto E, Sanchis D, Cook SA.

Nature. 2011 Oct 5;478(7367):114-8. doi: 10.1038/nature10490.

14.

Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart.

Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didié M, Quentin T, Maier LS, Teucher N, Unsöld B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR.

Circ Res. 2011 Sep 16;109(7):758-69. doi: 10.1161/CIRCRESAHA.111.245787. Epub 2011 Jul 28.

15.

Calcineurin splicing variant calcineurin Aβ1 improves cardiac function after myocardial infarction without inducing hypertrophy.

Felkin LE, Narita T, Germack R, Shintani Y, Takahashi K, Sarathchandra P, López-Olañeta MM, Gómez-Salinero JM, Suzuki K, Barton PJ, Rosenthal N, Lara-Pezzi E.

Circulation. 2011 Jun 21;123(24):2838-47. doi: 10.1161/CIRCULATIONAHA.110.012211. Epub 2011 May 31.

PMID:
21632490
16.

Reverse remodelling and recovery from heart failure are associated with complex patterns of gene expression.

Felkin LE, Lara-Pezzi EA, Hall JL, Birks EJ, Barton PJ.

J Cardiovasc Transl Res. 2011 Jun;4(3):321-31. doi: 10.1007/s12265-011-9267-1. Epub 2011 Mar 22.

PMID:
21424859
17.

Clenbuterol induces cardiac myocyte hypertrophy via paracrine signalling and fibroblast-derived IGF-1.

Bhavsar PK, Brand NJ, Felkin LE, Luther PK, Cullen ME, Yacoub MH, Barton PJ.

J Cardiovasc Transl Res. 2010 Dec;3(6):688-95. doi: 10.1007/s12265-010-9199-1. Epub 2010 Jun 25.

PMID:
20577844
18.

A gene expression profile of the myocardial response to clenbuterol.

Lara-Pezzi E, Terracciano CM, Soppa GK, Smolenski RT, Felkin LE, Yacoub MH, Barton PJ.

J Cardiovasc Transl Res. 2009 Jun;2(2):191-7. doi: 10.1007/s12265-009-9097-6. Epub 2009 Mar 13.

PMID:
20559987
19.

Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice.

Breckenridge RA, Zuberi Z, Gomes J, Orford R, Dupays L, Felkin LE, Clark JE, Magee AI, Ehler E, Birks EJ, Barton PJ, Tinker A, Mohun TJ.

J Mol Cell Cardiol. 2009 Jul;47(1):133-41. doi: 10.1016/j.yjmcc.2009.04.007. Epub 2009 Apr 17.

PMID:
19376125
20.

Expression of extracellular matrix genes during myocardial recovery from heart failure after left ventricular assist device support.

Felkin LE, Lara-Pezzi E, George R, Yacoub MH, Birks EJ, Barton PJ.

J Heart Lung Transplant. 2009 Feb;28(2):117-22. doi: 10.1016/j.healun.2008.11.910.

PMID:
19201335
21.

Choice of cell-delivery route for skeletal myoblast transplantation for treating post-infarction chronic heart failure in rat.

Fukushima S, Coppen SR, Lee J, Yamahara K, Felkin LE, Terracciano CM, Barton PJ, Yacoub MH, Suzuki K.

PLoS One. 2008 Aug 27;3(8):e3071. doi: 10.1371/journal.pone.0003071.

22.

Expression of follistatin-related genes is altered in heart failure.

Lara-Pezzi E, Felkin LE, Birks EJ, Sarathchandra P, Panse KD, George R, Hall JL, Yacoub MH, Rosenthal N, Barton PJ.

Endocrinology. 2008 Nov;149(11):5822-7. doi: 10.1210/en.2008-0151. Epub 2008 Jul 10.

PMID:
18617621
23.

Heterogeneic nature of adult cardiac side population cells.

Yamahara K, Fukushima S, Coppen SR, Felkin LE, Varela-Carver A, Barton PJ, Yacoub MH, Suzuki K.

Biochem Biophys Res Commun. 2008 Jul 11;371(4):615-20. doi: 10.1016/j.bbrc.2008.04.021. Epub 2008 Apr 14.

PMID:
18413147
24.

Role and possible mechanisms of clenbuterol in enhancing reverse remodelling during mechanical unloading in murine heart failure.

Soppa GK, Lee J, Stagg MA, Felkin LE, Barton PJ, Siedlecka U, Youssef S, Yacoub MH, Terracciano CM.

Cardiovasc Res. 2008 Mar 1;77(4):695-706. doi: 10.1093/cvr/cvm106. Epub 2008 Jan 4. Erratum in: Cardiovasc Res. 2008 Oct 1;80(1):159.

25.

Direct intramyocardial but not intracoronary injection of bone marrow cells induces ventricular arrhythmias in a rat chronic ischemic heart failure model.

Fukushima S, Varela-Carver A, Coppen SR, Yamahara K, Felkin LE, Lee J, Barton PJ, Terracciano CM, Yacoub MH, Suzuki K.

Circulation. 2007 May 1;115(17):2254-61. Epub 2007 Apr 16.

PMID:
17438152
26.
27.

Molecular signature of recovery following combination left ventricular assist device (LVAD) support and pharmacologic therapy.

Hall JL, Birks EJ, Grindle S, Cullen ME, Barton PJ, Rider JE, Lee S, Harwalker S, Mariash A, Adhikari N, Charles NJ, Felkin LE, Polster S, George RS, Miller LW, Yacoub MH.

Eur Heart J. 2007 Mar;28(5):613-27. Epub 2006 Nov 28.

PMID:
17132651
28.

Correlation between vascular responsivensss and expression of novel transcripts of the ETA-receptor in human vascular tissue.

Chester AH, Azam R, Felkin LE, George R, Brand N.

Vascul Pharmacol. 2007 Mar;46(3):181-7. Epub 2006 Oct 18.

PMID:
17126612
29.

Myocardial expression of the arginine:glycine amidinotransferase gene is elevated in heart failure and normalized after recovery: potential implications for local creatine synthesis.

Cullen ME, Yuen AH, Felkin LE, Smolenski RT, Hall JL, Grindle S, Miller LW, Birks EJ, Yacoub MH, Barton PJ.

Circulation. 2006 Jul 4;114(1 Suppl):I16-20.

PMID:
16820567
30.

Real-time quantitative polymerase chain reaction in cardiac transplant research.

Felkin LE, Taegtmeyer AB, Barton PJ.

Methods Mol Biol. 2006;333:305-30. Review.

PMID:
16790858
31.

Myocardial insulin-like growth factor-I gene expression during recovery from heart failure after combined left ventricular assist device and clenbuterol therapy.

Barton PJ, Felkin LE, Birks EJ, Cullen ME, Banner NR, Grindle S, Hall JL, Miller LW, Yacoub MH.

Circulation. 2005 Aug 30;112(9 Suppl):I46-50.

PMID:
16159864
32.

Expression of human membrane skeleton protein genes for protein 4.1 and betaIISigma2-spectrin assayed by real-time RT-PCR.

Taylor-Harris PM, Felkin LE, Birks EJ, Franklin RC, Yacoub MH, Baines AJ, Barton PJ, Pinder JC.

Cell Mol Biol Lett. 2005;10(1):135-49.

33.

Phenylephrine requires the TATA box to activate transcription of GLUT1 in neonatal rat cardiac myocytes.

Santalucía T, Sánchez-Feutrie M, Felkin LE, Bhavsar PK, Barton PJ, Zorzano A, Yacoub MH, Brand NJ.

J Mol Cell Cardiol. 2005 Apr;38(4):677-84.

PMID:
15808844
34.

Sequential expression of three known protective genes in cardiac biopsies after transplantation.

Souza AI, Felkin LE, McCormack AM, Holder A, Barton PJ, Banner NR, Rose ML.

Transplantation. 2005 Mar 15;79(5):584-90.

PMID:
15753848
35.

The slow skeletal muscle troponin T gene is expressed in developing and diseased human heart.

Barton PJ, Felkin LE, Koban MU, Cullen ME, Brand NJ, Dhoot GK.

Mol Cell Biochem. 2004 Aug;263(1-2):91-7.

PMID:
15524170
36.

The slow skeletal muscle troponin T gene is expressed in developing and diseased human heart.

Barton PJ, Felkin LE, Koban MU, Cullen ME, Brand NJ, Dhoot GK.

Mol Cell Biochem. 2004 Aug;263(1):91-7. doi: 10.1023/B:MCBI.0000041851.53074.72.

PMID:
27520668
37.

Increased toll-like receptor 4 in the myocardium of patients requiring left ventricular assist devices.

Birks EJ, Felkin LE, Banner NR, Khaghani A, Barton PJ, Yacoub MH.

J Heart Lung Transplant. 2004 Feb;23(2):228-35.

PMID:
14761771
38.

Increased expression of extracellular matrix regulators TIMP1 and MMP1 in deteriorating heart failure.

Barton PJ, Birks EJ, Felkin LE, Cullen ME, Koban MU, Yacoub MH.

J Heart Lung Transplant. 2003 Jul;22(7):738-44.

PMID:
12873541
39.

Quantitative myocardial cytokine expression and activation of the apoptotic pathway in patients who require left ventricular assist devices.

Birks EJ, Latif N, Owen V, Bowles C, Felkin LE, Mullen AJ, Khaghani A, Barton PJ, Polak JM, Pepper JR, Banner NR, Yacoub MH.

Circulation. 2001 Sep 18;104(12 Suppl 1):I233-40.

PMID:
11568062

Supplemental Content

Loading ...
Support Center