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Blockade of nitric oxide signalling promotes resilience to the effects of social defeat stress on the conditioned rewarding properties of MDMA in mice.

García-Pardo MP, LLansola M, Felipo V, De la Rubia Ortí JE, Aguilar MA.

Nitric Oxide. 2020 May 1;98:29-32. doi: 10.1016/j.niox.2020.03.001. Epub 2020 Mar 3.


Extracellular Vesicles from Hyperammonemic Rats Induce Neuroinflammation and Motor Incoordination in Control Rats.

Izquierdo-Altarejos P, Cabrera-Pastor A, Gonzalez-King H, Montoliu C, Felipo V.

Cells. 2020 Feb 28;9(3). pii: E572. doi: 10.3390/cells9030572.


Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-κB pathway.

Balzano T, Arenas YM, Dadsetan S, Forteza J, Gil-Perotin S, Cubas-Nuñez L, Casanova B, Gracià F, Varela-Andrés N, Montoliu C, Llansola M, Felipo V.

J Neuroinflammation. 2020 Feb 22;17(1):70. doi: 10.1186/s12974-020-01746-z.


Hyperammonemia alters the mismatch negativity in the auditory evoked potential by altering functional connectivity and neurotransmission.

García-García R, Guerrero JF, Lavilla-Miyasato M, Magdalena JR, Ordoño JF, Llansola M, Montoliu C, Teruel-Martí V, Felipo V.

J Neurochem. 2019 Dec 15:e14941. doi: 10.1111/jnc.14941. [Epub ahead of print]


Tadalafil Treatment Improves Inflammation, Cognitive Function, And Mismatch Negativity Of Patients With Low Urinary Tract Symptoms And Erectile Dysfunction.

Urios A, Ordoño F, García-García R, Mangas-Losada A, Leone P, José Gallego J, Cabrera-Pastor A, Megías J, Fermin Ordoño J, Felipo V, Montoliu C.

Sci Rep. 2019 Nov 19;9(1):17119. doi: 10.1038/s41598-019-53136-y.


A Multiomics Study To Unravel the Effects of Developmental Exposure to Endosulfan in Rats: Molecular Explanation for Sex-Dependent Effects.

Tarazona S, Bernabeu E, Carmona H, Gómez-Giménez B, García-Planells J, Leonards PEG, Jung S, Conesa A, Felipo V, Llansola M.

ACS Chem Neurosci. 2019 Oct 16;10(10):4264-4279. doi: 10.1021/acschemneuro.9b00304. Epub 2019 Sep 10.


Selective improvement by rifaximin of changes in the immunophenotype in patients who improve minimal hepatic encephalopathy.

Mangas-Losada A, García-García R, Leone P, Ballester MP, Cabrera-Pastor A, Urios A, Gallego JJ, Martínez-Pretel JJ, Giménez-Garzó C, Revert F, Escudero-García D, Tosca J, Ríos MP, Montón C, Durbán L, Aparicio L, Montoliu C, Felipo V.

J Transl Med. 2019 Aug 28;17(1):293. doi: 10.1186/s12967-019-2046-5.


Differential role of interleukin-1β in neuroinflammation-induced impairment of spatial and nonspatial memory in hyperammonemic rats.

Taoro-González L, Cabrera-Pastor A, Sancho-Alonso M, Arenas YM, Meseguer-Estornell F, Balzano T, ElMlili N, Felipo V.

FASEB J. 2019 Sep;33(9):9913-9928. doi: 10.1096/fj.201900230RR. Epub 2019 Jun 4.


Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors.

Malaguarnera M, Llansola M, Balzano T, Gómez-Giménez B, Antúnez-Muñoz C, Martínez-Alarcón N, Mahdinia R, Felipo V.

Front Pharmacol. 2019 Feb 25;10:132. doi: 10.3389/fphar.2019.00132. eCollection 2019.


Peripheral inflammation induces neuroinflammation that alters neurotransmission and cognitive and motor function in hepatic encephalopathy: Underlying mechanisms and therapeutic implications.

Cabrera-Pastor A, Llansola M, Montoliu C, Malaguarnera M, Balzano T, Taoro-Gonzalez L, García-García R, Mangas-Losada A, Izquierdo-Altarejos P, Arenas YM, Leone P, Felipo V.

Acta Physiol (Oxf). 2019 Jun;226(2):e13270. doi: 10.1111/apha.13270. Epub 2019 Mar 22. Review.


The influence of HE history, HE status and neuropsychological test type on learning ability in patients with cirrhosis.

Zarantonello L, Turco M, Formentin C, Izquierdo-Altarejos P, Vuerich A, Barcenas Jimenez MJ, Montoliu C, Felipo V, Angeli P, Amodio P, Montagnese S.

Liver Int. 2019 May;39(5):861-870. doi: 10.1111/liv.14046. Epub 2019 Feb 17.


Chronic hyperammonemia induces peripheral inflammation that leads to cognitive impairment in rats: reversal by anti-tnfa treatment.

Balzano T, Dadsetan S, Forteza J, Cabrera-Pastor A, Taoro-Gonzalez L, Malaguarnera M, Gil-Perotin S, Cubas-Nuñez L, Casanova B, Castro-Quintas A, Ponce-Mora A, Arenas YM, Leone P, Llansola M, Felipo V.

J Hepatol. 2019 Jan 14. pii: S0168-8278(19)30019-4. doi: 10.1016/j.jhep.2019.01.008. [Epub ahead of print]


Chronic hyperammonemia alters extracellular glutamate, glutamine and GABA and membrane expression of their transporters in rat cerebellum. Modulation by extracellular cGMP.

Cabrera-Pastor A, Arenas YM, Taoro-Gonzalez L, Montoliu C, Felipo V.

Neuropharmacology. 2019 Dec 15;161:107496. doi: 10.1016/j.neuropharm.2019.01.011. Epub 2019 Jan 11. Review.


Extracellular cGMP Reverses Altered Membrane Expression of AMPA Receptors in Hippocampus of Hyperammonemic Rats: Underlying Mechanisms.

Taoro-Gonzalez L, Arenas YM, Cabrera-Pastor A, Felipo V.

Mol Neurobiol. 2019 Jun;56(6):4428-4439. doi: 10.1007/s12035-018-1387-z. Epub 2018 Oct 17.


Role of NMDA and AMPA glutamatergic receptors in the effects of social defeat on the rewarding properties of MDMA in mice.

García-Pardo MP, Miñarro J, Llansola M, Felipo V, Aguilar MA.

Eur J Neurosci. 2019 Aug;50(3):2623-2634. doi: 10.1111/ejn.14190. Epub 2018 Oct 24.


Histological Features of Cerebellar Neuropathology in Patients With Alcoholic and Nonalcoholic Steatohepatitis.

Balzano T, Forteza J, Borreda I, Molina P, Giner J, Leone P, Urios A, Montoliu C, Felipo V.

J Neuropathol Exp Neurol. 2018 Sep 1;77(9):837-845. doi: 10.1093/jnen/nly061.


Urea cycle dysregulation in non-alcoholic fatty liver disease.

De Chiara F, Heebøll S, Marrone G, Montoliu C, Hamilton-Dutoit S, Ferrandez A, Andreola F, Rombouts K, Grønbæk H, Felipo V, Gracia-Sancho J, Mookerjee RP, Vilstrup H, Jalan R, Thomsen KL.

J Hepatol. 2018 Oct;69(4):905-915. doi: 10.1016/j.jhep.2018.06.023. Epub 2018 Jul 5.


Learning and Memory Impairments in Patients with Minimal Hepatic Encephalopathy are Associated with Structural and Functional Connectivity Alterations in Hippocampus.

García-García R, Cruz-Gómez ÁJ, Urios A, Mangas-Losada A, Forn C, Escudero-García D, Kosenko E, Torregrosa I, Tosca J, Giner-Durán R, Serra MA, Avila C, Belloch V, Felipo V, Montoliu C.

Sci Rep. 2018 Jun 25;8(1):9664. doi: 10.1038/s41598-018-27978-x.


The Cerebellum of Patients with Steatohepatitis Shows Lymphocyte Infiltration, Microglial Activation and Loss of Purkinje and Granular Neurons.

Balzano T, Forteza J, Molina P, Giner J, Monzó A, Sancho-Jiménez J, Urios A, Montoliu C, Felipo V.

Sci Rep. 2018 Feb 14;8(1):3004. doi: 10.1038/s41598-018-21399-6.


Hyperammonemia alters membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus by enhancing activation of the IL-1 receptor: underlying mechanisms.

Taoro-Gonzalez L, Arenas YM, Cabrera-Pastor A, Felipo V.

J Neuroinflammation. 2018 Feb 8;15(1):36. doi: 10.1186/s12974-018-1082-z.


Increasing extracellular cGMP in cerebellum in vivo reduces neuroinflammation, GABAergic tone and motor in-coordination in hyperammonemic rats.

Cabrera-Pastor A, Balzano T, Hernández-Rabaza V, Malaguarnera M, Llansola M, Felipo V.

Brain Behav Immun. 2018 Mar;69:386-398. doi: 10.1016/j.bbi.2017.12.013. Epub 2017 Dec 27.


Cirrhotic patients with minimal hepatic encephalopathy have increased capacity to eliminate superoxide and peroxynitrite in lymphocytes, associated with cognitive impairment.

Giménez-Garzó C, Urios A, Agustí A, Mangas-Losada A, García-García R, Escudero-García D, Kosenko E, Ordoño JF, Tosca J, Giner-Durán R, Serra MA, Felipo V, Montoliu C.

Free Radic Res. 2018 Jan;52(1):118-133. doi: 10.1080/10715762.2017.1420183.


Extracellular Cyclic GMP Modulates Membrane Expression of The GluA1 and GluA2 Subunits of AMPA Receptor in Cerebellum: Molecular Mechanisms Involved.

Cabrera-Pastor A, Taoro-González L, Cuñat AN, Canet-López D, Balzano T, Felipo V.

Sci Rep. 2017 Dec 15;7(1):17656. doi: 10.1038/s41598-017-18024-3.


Chronic hyperammonemia alters in opposite ways membrane expression of GluA1 and GluA2 AMPA receptor subunits in cerebellum. Molecular mechanisms involved.

Cabrera-Pastor A, Taoro-González L, López-Merino E, Celma F, Llansola M, Felipo V.

Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):286-295. doi: 10.1016/j.bbadis.2017.10.031. Epub 2017 Oct 28.


Endosulfan and Cypermethrin Pesticide Mixture Induces Synergistic or Antagonistic Effects on Developmental Exposed Rats Depending on the Analyzed Behavioral or Neurochemical End Points.

Gómez-Giménez B, Llansola M, Cabrera-Pastor A, Hernández-Rabaza V, Agustí A, Felipo V.

ACS Chem Neurosci. 2018 Feb 21;9(2):369-380. doi: 10.1021/acschemneuro.7b00364. Epub 2017 Nov 13.


Reduced resting state connectivity and gray matter volume correlate with cognitive impairment in minimal hepatic encephalopathy.

García-García R, Cruz-Gómez ÁJ, Mangas-Losada A, Urios A, Forn C, Escudero-García D, Kosenko E, Ordoño JF, Tosca J, Giner-Durán R, Serra MA, Avila C, Belloch V, Felipo V, Montoliu C.

PLoS One. 2017 Oct 12;12(10):e0186463. doi: 10.1371/journal.pone.0186463. eCollection 2017.


Developmental Exposure to Pesticides Alters Motor Activity and Coordination in Rats: Sex Differences and Underlying Mechanisms.

Gómez-Giménez B, Felipo V, Cabrera-Pastor A, Agustí A, Hernández-Rabaza V, Llansola M.

Neurotox Res. 2018 Feb;33(2):247-258. doi: 10.1007/s12640-017-9823-9. Epub 2017 Oct 3.


Inhibition of γ-Secretase Leads to an Increase in Presenilin-1.

Sogorb-Esteve A, García-Ayllón MS, Llansola M, Felipo V, Blennow K, Sáez-Valero J.

Mol Neurobiol. 2018 Jun;55(6):5047-5058. doi: 10.1007/s12035-017-0705-1. Epub 2017 Aug 16.


Determination of selected neurotoxic insecticides in small amounts of animal tissue utilizing a newly constructed mini-extractor.

Seifertová M, Čechová E, Llansola M, Felipo V, Vykoukalová M, Kočan A.

Anal Bioanal Chem. 2017 Oct;409(25):6015-6026. doi: 10.1007/s00216-017-0533-1. Epub 2017 Aug 10.


Minimal hepatic encephalopathy is associated with expansion and activation of CD4+CD28-, Th22 and Tfh and B lymphocytes.

Mangas-Losada A, García-García R, Urios A, Escudero-García D, Tosca J, Giner-Durán R, Serra MA, Montoliu C, Felipo V.

Sci Rep. 2017 Jul 27;7(1):6683. doi: 10.1038/s41598-017-05938-1.


Sildenafil reduces neuroinflammation in cerebellum, restores GABAergic tone, and improves motor in-coordination in rats with hepatic encephalopathy.

Agusti A, Hernández-Rabaza V, Balzano T, Taoro-Gonzalez L, Ibañez-Grau A, Cabrera-Pastor A, Fustero S, Llansola M, Montoliu C, Felipo V.

CNS Neurosci Ther. 2017 May;23(5):386-394. doi: 10.1111/cns.12688. Epub 2017 Mar 11.


The PHES battery does not detect all cirrhotic patients with early neurological deficits, which are different in different patients.

Giménez-Garzó C, Garcés JJ, Urios A, Mangas-Losada A, García-García R, González-López O, Giner-Durán R, Escudero-García D, Serra MA, Soria E, Felipo V, Montoliu C.

PLoS One. 2017 Feb 1;12(2):e0171211. doi: 10.1371/journal.pone.0171211. eCollection 2017.


Altered postural control and stability in cirrhotic patients with minimal hepatic encephalopathy correlate with cognitive deficits.

Urios A, Mangas-Losada A, Gimenez-Garzó C, González-López O, Giner-Durán R, Serra MA, Noe E, Felipo V, Montoliu C.

Liver Int. 2017 Jul;37(7):1013-1022. doi: 10.1111/liv.13345. Epub 2017 Feb 3.


Sex-dependent effects of developmental exposure to different pesticides on spatial learning. The role of induced neuroinflammation in the hippocampus.

Gómez-Giménez B, Llansola M, Hernández-Rabaza V, Cabrera-Pastor A, Malaguarnera M, Agusti A, Felipo V.

Food Chem Toxicol. 2017 Jan;99:135-148. doi: 10.1016/j.fct.2016.11.028. Epub 2016 Nov 29.


Reducing Peripheral Inflammation with Infliximab Reduces Neuroinflammation and Improves Cognition in Rats with Hepatic Encephalopathy.

Dadsetan S, Balzano T, Forteza J, Cabrera-Pastor A, Taoro-Gonzalez L, Hernandez-Rabaza V, Gil-Perotín S, Cubas-Núñez L, García-Verdugo JM, Agusti A, Llansola M, Felipo V.

Front Mol Neurosci. 2016 Nov 2;9:106. eCollection 2016.


A rare and revealing glimpse of the cerebrospinal fluid of patients with hepatic encephalopathy.

Felipo V, Montagnese S.

J Hepatol. 2016 Dec;65(6):1077-1078. doi: 10.1016/j.jhep.2016.09.011. Epub 2016 Sep 24. No abstract available.


Extracellular cGMP Modulates Learning Biphasically by Modulating Glycine Receptors, CaMKII and Glutamate-Nitric Oxide-cGMP Pathway.

Cabrera-Pastor A, Malaguarnera M, Taoro-Gonzalez L, Llansola M, Felipo V.

Sci Rep. 2016 Sep 16;6:33124. doi: 10.1038/srep33124.


Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy.

Dadsetan S, Balzano T, Forteza J, Agusti A, Cabrera-Pastor A, Taoro-Gonzalez L, Hernandez-Rabaza V, Gomez-Gimenez B, ElMlili N, Llansola M, Felipo V.

J Neuroinflammation. 2016 Sep 13;13(1):245. doi: 10.1186/s12974-016-0710-8.


Sildenafil Treatment Eliminates Pruritogenesis and Thermal Hyperalgesia in Rats with Portacaval Shunts.

Belghiti M, Agusti A, Hernandez-Rabaza V, Cabrera-Pastor A, Llansola M, Felipo V.

Neurochem Res. 2017 Mar;42(3):788-794. doi: 10.1007/s11064-016-1980-3. Epub 2016 Jun 20.


In vivo administration of extracellular cGMP normalizes TNF-α and membrane expression of AMPA receptors in hippocampus and spatial reference memory but not IL-1β, NMDA receptors in membrane and working memory in hyperammonemic rats.

Cabrera-Pastor A, Hernandez-Rabaza V, Taoro-Gonzalez L, Balzano T, Llansola M, Felipo V.

Brain Behav Immun. 2016 Oct;57:360-370. doi: 10.1016/j.bbi.2016.05.011. Epub 2016 May 14.


Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia.

Hernandez-Rabaza V, Cabrera-Pastor A, Taoro-Gonzalez L, Gonzalez-Usano A, Agusti A, Balzano T, Llansola M, Felipo V.

J Neuroinflammation. 2016 Apr 18;13(1):83. doi: 10.1186/s12974-016-0549-z.


Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane.

Hernández-Rabaza V, Cabrera-Pastor A, Taoro-González L, Malaguarnera M, Agustí A, Llansola M, Felipo V.

J Neuroinflammation. 2016 Feb 16;13:41. doi: 10.1186/s12974-016-0505-y.


Hyperammonemia alters glycinergic neurotransmission and modulation of the glutamate-nitric oxide-cGMP pathway by extracellular glycine in cerebellum in vivo.

Cabrera-Pastor A, Taoro-Gonzalez L, Felipo V.

J Neurochem. 2016 May;137(4):539-48. doi: 10.1111/jnc.13579. Epub 2016 Mar 2.


Sildenafil reduces neuroinflammation and restores spatial learning in rats with hepatic encephalopathy: underlying mechanisms.

Hernandez-Rabaza V, Agusti A, Cabrera-Pastor A, Fustero S, Delgado O, Taoro-Gonzalez L, Montoliu C, Llansola M, Felipo V.

J Neuroinflammation. 2015 Oct 29;12:195. doi: 10.1186/s12974-015-0420-7.


Roles of the NMDA Receptor and EAAC1 Transporter in the Modulation of Extracellular Glutamate by Low and High Affinity AMPA Receptors in the Cerebellum in Vivo: Differential Alteration in Chronic Hyperammonemia.

Cabrera-Pastor A, Taoro L, Llansola M, Felipo V.

ACS Chem Neurosci. 2015 Dec 16;6(12):1913-21. doi: 10.1021/acschemneuro.5b00212. Epub 2015 Oct 13.


The expression levels of prolyl oligopeptidase responds not only to neuroinflammation but also to systemic inflammation upon liver failure in rat models and cirrhotic patients.

Tenorio-Laranga J, Montoliu C, Urios A, Hernandez-Rabaza V, Ahabrach H, García-Horsman JA, Felipo V.

J Neuroinflammation. 2015 Sep 30;12:183. doi: 10.1186/s12974-015-0404-7.


Modulation of GABAA receptors by neurosteroids. A new concept to improve cognitive and motor alterations in hepatic encephalopathy.

Agusti A, Llansola M, Hernández-Rabaza V, Cabrera-Pastor A, Montoliu C, Felipo V.

J Steroid Biochem Mol Biol. 2016 Jun;160:88-93. doi: 10.1016/j.jsbmb.2015.08.020. Epub 2015 Aug 22. Review.


Rats with minimal hepatic encephalopathy show reduced cGMP-dependent protein kinase activity in hypothalamus correlating with circadian rhythms alterations.

Felipo V, Piedrafita B, Barios JA, Agustí A, Ahabrach H, Romero-Vives M, Barrio LC, Rey B, Gaztelu JM, Llansola M.

Chronobiol Int. 2015;32(7):966-79. doi: 10.3109/07420528.2015.1057640.


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