Format

Send to

Choose Destination
J Am Board Fam Med. 2011 Mar-Apr;24(2):181-6. doi: 10.3122/jabfm.2011.02.100086.

Interference potential of personal lubricants and vaginal medications on ThinPrep pap tests.

Author information

1
Dane County Cytology Center, Inc., Madison, WI 53713, USA. tfeit@meriter.com

Abstract

BACKGROUND:

The effects of water-based speculum lubricants on both conventional Papanicolaou smears and liquid-based Papanicolaou tests have been well documented. However, studies are lacking concerning the effects on these tests of personal lubricants and/or vaginal medications. Lubricants containing "carbomers" or "carbopol polymers" are known to interfere with ThinPrep® Papanicolaou test processing. Many over-the-counter products that advertise effects lasting several days may contain these substances. This study tests 2 popular personal lubricants (KY Warming Liquid [Johnson & Johnson, New Brunswick, NJ] and Replens [KoRa Health Care, Swords, Ireland]) and one yeast medication (Monistat 7, McNeill-PPC, Inc., Skillman, NJ) for interference on ThinPrep® Papanicolaou tests.

METHODS:

The residual specimens from 270 ThinPrep® vials were combined to form 100 homogenous ThinPrep® Papanicolaou specimens. Nine groups of 10 vials were then contaminated with 20 μL, 100 μL, and 500 μL of each of the 3 products. One group of 10 vials served as control. Cell counts were performed after processing the specimens onto slides, and the results were recorded.

RESULTS:

KY Warming Liquid had no effect at any volume of contamination. Replens caused a drastic reduction in cellularity at even the lowest volume. Monistat 7 reduced cellularity incrementally as the volume increased.

CONCLUSION:

The potential exists for some over-the-counter lubricants and vaginal medications to interfere with the ThinPrep® Papanicolaou test.

Comment in

PMID:
21383218
DOI:
10.3122/jabfm.2011.02.100086
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center