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A Peptide Inhibitor of NADPH Oxidase (NOX2) Activation Markedly Decreases Mouse Lung Injury and Mortality Following Administration of Lipopolysaccharide (LPS).

Fisher AB, Dodia C, Chatterjee S, Feinstein SI.

Int J Mol Sci. 2019 May 15;20(10). pii: E2395. doi: 10.3390/ijms20102395. Erratum in: Int J Mol Sci. 2020 Jan 08;21(2):.


Mouse Models of Genetically Altered Peroxiredoxin 6.

Feinstein SI.

Antioxidants (Basel). 2019 Mar 27;8(4). pii: E77. doi: 10.3390/antiox8040077. Review.


Genetic inactivation of the phospholipase A2 activity of peroxiredoxin 6 in mice protects against LPS-induced acute lung injury.

Vázquez-Medina JP, Tao JQ, Patel P, Bannitz-Fernandes R, Dodia C, Sorokina EM, Feinstein SI, Chatterjee S, Fisher AB.

Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1;316(4):L656-L668. doi: 10.1152/ajplung.00344.2018. Epub 2019 Jan 31.


Oxidation of Peroxiredoxin 6 in the Presence of GSH Increases its Phospholipase A₂ Activity at Cytoplasmic pH.

Zhou S, Dodia C, Feinstein SI, Harper S, Forman HJ, Speicher DW, Fisher AB.

Antioxidants (Basel). 2018 Dec 24;8(1). pii: E4. doi: 10.3390/antiox8010004.


Identification of Small Peptides that Inhibit NADPH Oxidase (Nox2) Activation.

Fisher AB, Dodia C, Feinstein SI.

Antioxidants (Basel). 2018 Dec 5;7(12). pii: E181. doi: 10.3390/antiox7120181.


Deficiency of peroxiredoxin 6 or inhibition of its phospholipase A2 activity impair the in vitro sperm fertilizing competence in mice.

Moawad AR, Fernandez MC, Scarlata E, Dodia C, Feinstein SI, Fisher AB, O'Flaherty C.

Sci Rep. 2017 Oct 11;7(1):12994. doi: 10.1038/s41598-017-13411-2.


Peroxiredoxin 6 phospholipid hydroperoxidase activity in the repair of peroxidized cell membranes.

Fisher AB, Vasquez-Medina JP, Dodia C, Sorokina EM, Tao JQ, Feinstein SI.

Redox Biol. 2018 Apr;14:41-46. doi: 10.1016/j.redox.2017.08.008. Epub 2017 Aug 12.


The phospholipase A2 activity of peroxiredoxin 6 modulates NADPH oxidase 2 activation via lysophosphatidic acid receptor signaling in the pulmonary endothelium and alveolar macrophages.

Vázquez-Medina JP, Dodia C, Weng L, Mesaros C, Blair IA, Feinstein SI, Chatterjee S, Fisher AB.

FASEB J. 2016 Aug;30(8):2885-98. doi: 10.1096/fj.201500146R. Epub 2016 May 13.


Mutation of Serine 32 to Threonine in Peroxiredoxin 6 Preserves Its Structure and Enzymatic Function but Abolishes Its Trafficking to Lamellar Bodies.

Sorokina EM, Dodia C, Zhou S, Tao JQ, Gao L, Raabe T, Feinstein SI, Fisher AB.

J Biol Chem. 2016 Apr 22;291(17):9268-80. doi: 10.1074/jbc.M115.698894. Epub 2016 Feb 26.


Peroxiredoxin 6 homodimerization and heterodimerization with glutathione S-transferase pi are required for its peroxidase but not phospholipase A2 activity.

Zhou S, Sorokina EM, Harper S, Li H, Ralat L, Dodia C, Speicher DW, Feinstein SI, Fisher AB.

Free Radic Biol Med. 2016 May;94:145-56. doi: 10.1016/j.freeradbiomed.2016.02.012. Epub 2016 Feb 16.


A novel lysophosphatidylcholine acyl transferase activity is expressed by peroxiredoxin 6.

Fisher AB, Dodia C, Sorokina EM, Li H, Zhou S, Raabe T, Feinstein SI.

J Lipid Res. 2016 Apr;57(4):587-96. doi: 10.1194/jlr.M064758. Epub 2016 Feb 1.


Absence of Peroxiredoxin 6 Amplifies the Effect of Oxidant Stress on Mobility and SCSA/CMA3 Defined Chromatin Quality and Impairs Fertilizing Ability of Mouse Spermatozoa.

Ozkosem B, Feinstein SI, Fisher AB, O'Flaherty C.

Biol Reprod. 2016 Mar;94(3):68. doi: 10.1095/biolreprod.115.137646. Epub 2016 Jan 20.


Binding sites for interaction of peroxiredoxin 6 with surfactant protein A.

Krishnaiah SY, Dodia C, Sorokina EM, Li H, Feinstein SI, Fisher AB.

Biochim Biophys Acta. 2016 Apr;1864(4):419-25. doi: 10.1016/j.bbapap.2015.12.009. Epub 2015 Dec 23.


Critical role of peroxiredoxin 6 in the repair of peroxidized cell membranes following oxidative stress.

Li H, Benipal B, Zhou S, Dodia C, Chatterjee S, Tao JQ, Sorokina EM, Raabe T, Feinstein SI, Fisher AB.

Free Radic Biol Med. 2015 Oct;87:356-65. doi: 10.1016/j.freeradbiomed.2015.06.009. Epub 2015 Jun 25.


Advancing age increases sperm chromatin damage and impairs fertility in peroxiredoxin 6 null mice.

Ozkosem B, Feinstein SI, Fisher AB, O'Flaherty C.

Redox Biol. 2015 Aug;5:15-23. doi: 10.1016/j.redox.2015.02.004. Epub 2015 Feb 25.


Solution structure of the reduced form of human peroxiredoxin-6 elucidated using zero-length chemical cross-linking and homology modelling.

Rivera-Santiago RF, Harper SL, Zhou S, Sriswasdi S, Feinstein SI, Fisher AB, Speicher DW.

Biochem J. 2015 May 15;468(1):87-98. doi: 10.1042/BJ20141463.


Inhibition of the phospholipase A2 activity of peroxiredoxin 6 prevents lung damage with exposure to hyperoxia.

Benipal B, Feinstein SI, Chatterjee S, Dodia C, Fisher AB.

Redox Biol. 2015;4:321-7. doi: 10.1016/j.redox.2015.01.011. Epub 2015 Jan 16.


Protection against LPS-induced acute lung injury by a mechanism-based inhibitor of NADPH oxidase (type 2).

Lee I, Dodia C, Chatterjee S, Feinstein SI, Fisher AB.

Am J Physiol Lung Cell Mol Physiol. 2014 Apr 1;306(7):L635-44. doi: 10.1152/ajplung.00374.2013. Epub 2014 Jan 31.


NOX2 in lung inflammation: quantum dot based in situ imaging of NOX2-mediated expression of vascular cell adhesion molecule-1.

Orndorff RL, Hong N, Yu K, Feinstein SI, Zern BJ, Fisher AB, Muzykantov VR, Chatterjee S.

Am J Physiol Lung Cell Mol Physiol. 2014 Feb;306(3):L260-8. doi: 10.1152/ajplung.00278.2013. Epub 2013 Dec 6.


Pulmonary abnormalities in animal models due to Niemann-Pick type C1 (NPC1) or C2 (NPC2) disease.

Roszell BR, Tao JQ, Yu KJ, Gao L, Huang S, Ning Y, Feinstein SI, Vite CH, Bates SR.

PLoS One. 2013 Jul 2;8(7):e67084. doi: 10.1371/journal.pone.0067084. Print 2013.


Keratinocyte growth factor and glucocorticoid induction of human peroxiredoxin 6 gene expression occur by independent mechanisms that are synergistic.

Chowdhury I, Fisher AB, Christofidou-Solomidou M, Gao L, Tao JQ, Sorokina EM, Lien YC, Bates SR, Feinstein SI.

Antioxid Redox Signal. 2014 Jan 20;20(3):391-402. doi: 10.1089/ars.2012.4634. Epub 2013 Sep 5.


Mechanotransduction drives post ischemic revascularization through K(ATP) channel closure and production of reactive oxygen species.

Browning E, Wang H, Hong N, Yu K, Buerk DG, DeBolt K, Gonder D, Sorokina EM, Patel P, De Leon DD, Feinstein SI, Fisher AB, Chatterjee S.

Antioxid Redox Signal. 2014 Feb 20;20(6):872-86. doi: 10.1089/ars.2012.4971. Epub 2013 Jul 31.


A novel nontoxic inhibitor of the activation of NADPH oxidase reduces reactive oxygen species production in mouse lung.

Lee I, Dodia C, Chatterjee S, Zagorski J, Mesaros C, Blair IA, Feinstein SI, Jain M, Fisher AB.

J Pharmacol Exp Ther. 2013 May;345(2):284-96. doi: 10.1124/jpet.112.201079. Epub 2013 Mar 8.


p67(phox) terminates the phospholipase A(2)-derived signal for activation of NADPH oxidase (NOX2).

Krishnaiah SY, Dodia C, Feinstein SI, Fisher AB.

FASEB J. 2013 May;27(5):2066-73. doi: 10.1096/fj.12-222133. Epub 2013 Feb 11.


Functional interaction of glutathione S-transferase pi and peroxiredoxin 6 in intact cells.

Zhou S, Lien YC, Shuvaeva T, DeBolt K, Feinstein SI, Fisher AB.

Int J Biochem Cell Biol. 2013 Feb;45(2):401-7. doi: 10.1016/j.biocel.2012.11.005. Epub 2012 Nov 16.


Increased phospholipase A2 activity with phosphorylation of peroxiredoxin 6 requires a conformational change in the protein.

Rahaman H, Zhou S, Dodia C, Feinstein SI, Huang S, Speicher D, Fisher AB.

Biochemistry. 2012 Jul 10;51(27):5521-30. Epub 2012 Jun 29.


The roles of peroxidase and phospholipase A2 activities of peroxiredoxin 6 in protecting pulmonary microvascular endothelial cells against peroxidative stress.

Lien YC, Feinstein SI, Dodia C, Fisher AB.

Antioxid Redox Signal. 2012 Mar 1;16(5):440-51. doi: 10.1089/ars.2011.3950. Epub 2011 Dec 23.


Novel variants in the PRDX6 Gene and the risk of Acute Lung Injury following major trauma.

Rushefski M, Aplenc R, Meyer N, Li M, Feng R, Lanken PN, Gallop R, Bellamy S, Localio AR, Feinstein SI, Fisher AB, Albelda SM, Christie JD.

BMC Med Genet. 2011 May 31;12:77. doi: 10.1186/1471-2350-12-77.


Intracellular targeting of peroxiredoxin 6 to lysosomal organelles requires MAPK activity and binding to 14-3-3ε.

Sorokina EM, Feinstein SI, Zhou S, Fisher AB.

Am J Physiol Cell Physiol. 2011 Jun;300(6):C1430-41. doi: 10.1152/ajpcell.00285.2010. Epub 2011 Feb 23.


Peroxiredoxin 6 phosphorylation and subsequent phospholipase A2 activity are required for agonist-mediated activation of NADPH oxidase in mouse pulmonary microvascular endothelium and alveolar macrophages.

Chatterjee S, Feinstein SI, Dodia C, Sorokina E, Lien YC, Nguyen S, Debolt K, Speicher D, Fisher AB.

J Biol Chem. 2011 Apr 1;286(13):11696-706. doi: 10.1074/jbc.M110.206623. Epub 2011 Jan 24.


Role of the PI3-kinase signaling pathway in trafficking of the surfactant protein A receptor P63 (CKAP4) on type II pneumocytes.

Kazi AS, Tao JQ, Feinstein SI, Zhang L, Fisher AB, Bates SR.

Am J Physiol Lung Cell Mol Physiol. 2010 Dec;299(6):L794-807. doi: 10.1152/ajplung.00372.2009. Epub 2010 Sep 24.


Comparison of glutathione peroxidase 1 and peroxiredoxin 6 in protection against oxidative stress in the mouse lung.

Liu G, Feinstein SI, Wang Y, Dodia C, Fisher D, Yu K, Ho YS, Fisher AB.

Free Radic Biol Med. 2010 Oct 15;49(7):1172-81. doi: 10.1016/j.freeradbiomed.2010.07.002. Epub 2010 Jul 11.


Identification of the amino acid sequence that targets peroxiredoxin 6 to lysosome-like structures of lung epithelial cells.

Sorokina EM, Feinstein SI, Milovanova TN, Fisher AB.

Am J Physiol Lung Cell Mol Physiol. 2009 Nov;297(5):L871-80. doi: 10.1152/ajplung.00052.2009. Epub 2009 Aug 21.


Binding of peroxiredoxin 6 to substrate determines differential phospholipid hydroperoxide peroxidase and phospholipase A(2) activities.

Manevich Y, Shuvaeva T, Dodia C, Kazi A, Feinstein SI, Fisher AB.

Arch Biochem Biophys. 2009 May 15;485(2):139-49. doi: 10.1016/ Epub 2009 Feb 21.


Mitogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A(2) activity.

Wu Y, Feinstein SI, Manevich Y, Chowdhury I, Pak JH, Kazi A, Dodia C, Speicher DW, Fisher AB.

Biochem J. 2009 May 1;419(3):669-79. doi: 10.1042/BJ20082061.


Oxidant stress stimulates expression of the human peroxiredoxin 6 gene by a transcriptional mechanism involving an antioxidant response element.

Chowdhury I, Mo Y, Gao L, Kazi A, Fisher AB, Feinstein SI.

Free Radic Biol Med. 2009 Jan 15;46(2):146-53. doi: 10.1016/j.freeradbiomed.2008.09.027. Epub 2008 Oct 9.


Role of P63 (CKAP4) in binding of surfactant protein-A to type II pneumocytes.

Bates SR, Kazi AS, Tao JQ, Yu KJ, Gonder DS, Feinstein SI, Fisher AB.

Am J Physiol Lung Cell Mol Physiol. 2008 Oct;295(4):L658-69. doi: 10.1152/ajplung.90233.2008. Epub 2008 Aug 15.


Peroxiredoxin 6 as an antioxidant enzyme: protection of lung alveolar epithelial type II cells from H2O2-induced oxidative stress.

Wang Y, Feinstein SI, Fisher AB.

J Cell Biochem. 2008 Jul 1;104(4):1274-85. doi: 10.1002/jcb.21703.


Peroxiredoxins in the lung with emphasis on peroxiredoxin VI.

Schremmer B, Manevich Y, Feinstein SI, Fisher AB.

Subcell Biochem. 2007;44:317-44. Review.


Structure and phospholipase function of peroxiredoxin 6: identification of the catalytic triad and its role in phospholipid substrate binding.

Manevich Y, Reddy KS, Shuvaeva T, Feinstein SI, Fisher AB.

J Lipid Res. 2007 Oct;48(10):2306-18. Epub 2007 Jul 24.


Thyroid transcription factor in differentiating type II cells: regulation, isoforms, and target genes.

Kolla V, Gonzales LW, Gonzales J, Wang P, Angampalli S, Feinstein SI, Ballard PL.

Am J Respir Cell Mol Biol. 2007 Feb;36(2):213-25. Epub 2006 Sep 7.


Lung phospholipid metabolism in transgenic mice overexpressing peroxiredoxin 6.

Fisher AB, Dodia C, Yu K, Manevich Y, Feinstein SI.

Biochim Biophys Acta. 2006 Jul;1761(7):785-92. Epub 2006 May 23.


Peroxiredoxin 6 gene-targeted mice show increased lung injury with paraquat-induced oxidative stress.

Wang Y, Feinstein SI, Manevich Y, Ho YS, Fisher AB.

Antioxid Redox Signal. 2006 Jan-Feb;8(1-2):229-37.


Transgenic mice overexpressing peroxiredoxin 6 show increased resistance to lung injury in hyperoxia.

Wang Y, Phelan SA, Manevich Y, Feinstein SI, Fisher AB.

Am J Respir Cell Mol Biol. 2006 Apr;34(4):481-6. Epub 2006 Jan 6.


Interaction of surfactant protein A with peroxiredoxin 6 regulates phospholipase A2 activity.

Wu YZ, Manevich Y, Baldwin JL, Dodia C, Yu K, Feinstein SI, Fisher AB.

J Biol Chem. 2006 Mar 17;281(11):7515-25. Epub 2005 Dec 5.


Altered lung phospholipid metabolism in mice with targeted deletion of lysosomal-type phospholipase A2.

Fisher AB, Dodia C, Feinstein SI, Ho YS.

J Lipid Res. 2005 Jun;46(6):1248-56. Epub 2005 Mar 16.


Lung injury and mortality with hyperoxia are increased in peroxiredoxin 6 gene-targeted mice.

Wang Y, Feinstein SI, Manevich Y, Ho YS, Fisher AB.

Free Radic Biol Med. 2004 Dec 1;37(11):1736-43.


Adenovirus-mediated transfer of the 1-cys peroxiredoxin gene to mouse lung protects against hyperoxic injury.

Wang Y, Manevich Y, Feinstein SI, Fisher AB.

Am J Physiol Lung Cell Mol Physiol. 2004 Jun;286(6):L1188-93.


Activation of the antioxidant enzyme 1-CYS peroxiredoxin requires glutathionylation mediated by heterodimerization with pi GST.

Manevich Y, Feinstein SI, Fisher AB.

Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3780-5. Epub 2004 Mar 2.

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