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Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress.

Dickson DA, Paulus JK, Mensah V, Lem J, Saavedra-Rodriguez L, Gentry A, Pagidas K, Feig LA.

Transl Psychiatry. 2018 May 23;8(1):101. doi: 10.1038/s41398-018-0146-2.


Tyrosine phosphorylation of RalGDS by c-Met receptor blocks its interaction with Ras.

Wong R, Feig LA.

Biochem Biophys Res Commun. 2016 Nov 18;480(3):468-473. doi: 10.1016/j.bbrc.2016.10.074. Epub 2016 Oct 20.


RasGRF1 regulates the hypothalamic-pituitary-adrenal axis specifically in early-adolescent female mice.

Uzturk BG, Jin SX, Rubin B, Bartolome C, Feig LA.

J Endocrinol. 2015 Oct;227(1):1-12. doi: 10.1530/JOE-15-0304. Epub 2015 Aug 5.


R-Ras contributes to LTP and contextual discrimination.

Darcy MJ, Jin SX, Feig LA.

Neuroscience. 2014 Sep 26;277:334-42. doi: 10.1016/j.neuroscience.2014.07.010. Epub 2014 Jul 17.


Ras-GRF2 mediates long-term potentiation, survival, and response to an enriched environment of newborn neurons in the hippocampus.

Darcy MJ, Trouche S, Jin SX, Feig LA.

Hippocampus. 2014 Nov;24(11):1317-29. doi: 10.1002/hipo.22313. Epub 2014 Jun 17.


Domain contributions to signaling specificity differences between Ras-guanine nucleotide releasing factor (Ras-GRF) 1 and Ras-GRF2.

Jin SX, Bartolome C, Arai JA, Hoffman L, Uzturk BG, Kumar-Singh R, Waxham MN, Feig LA.

J Biol Chem. 2014 Jun 6;289(23):16551-64. doi: 10.1074/jbc.M114.557959. Epub 2014 Apr 22.


Age-dependent role for Ras-GRF1 in the late stages of adult neurogenesis in the dentate gyrus.

Darcy MJ, Trouche S, Jin SX, Feig LA.

Hippocampus. 2014 Mar;24(3):315-25.


Acquisition of contextual discrimination involves the appearance of a RAS-GRF1/p38 mitogen-activated protein (MAP) kinase-mediated signaling pathway that promotes long term potentiation (LTP).

Jin SX, Arai J, Tian X, Kumar-Singh R, Feig LA.

J Biol Chem. 2013 Jul 26;288(30):21703-13. doi: 10.1074/jbc.M113.471904. Epub 2013 Jun 13.


Chronic social instability induces anxiety and defective social interactions across generations.

Saavedra-Rodríguez L, Feig LA.

Biol Psychiatry. 2013 Jan 1;73(1):44-53. doi: 10.1016/j.biopsych.2012.06.035. Epub 2012 Aug 18.


Regulation of Neuronal Function by Ras-GRF Exchange Factors.

Feig LA.

Genes Cancer. 2011 Mar;2(3):306-19. doi: 10.1177/1947601911408077.


Suppression of E-cadherin function drives the early stages of Ras-induced squamous cell carcinoma through upregulation of FAK and Src.

Alt-Holland A, Sowalsky AG, Szwec-Levin Y, Shamis Y, Hatch H, Feig LA, Garlick JA.

J Invest Dermatol. 2011 Nov;131(11):2306-15. doi: 10.1038/jid.2011.188. Epub 2011 Jun 30.


RalA function in dermal fibroblasts is required for the progression of squamous cell carcinoma of the skin.

Sowalsky AG, Alt-Holland A, Shamis Y, Garlick JA, Feig LA.

Cancer Res. 2011 Feb 1;71(3):758-67. doi: 10.1158/0008-5472.CAN-10-2756. Epub 2010 Dec 15.


Long-lasting and transgenerational effects of an environmental enrichment on memory formation.

Arai JA, Feig LA.

Brain Res Bull. 2011 Apr 25;85(1-2):30-5. doi: 10.1016/j.brainresbull.2010.11.003. Epub 2010 Nov 13. Review.


Neural cell adhesion molecule-associated polysialic acid regulates synaptic plasticity and learning by restraining the signaling through GluN2B-containing NMDA receptors.

Kochlamazashvili G, Senkov O, Grebenyuk S, Robinson C, Xiao MF, Stummeyer K, Gerardy-Schahn R, Engel AK, Feig L, Semyanov A, Suppiramaniam V, Schachner M, Dityatev A.

J Neurosci. 2010 Mar 17;30(11):4171-83. doi: 10.1523/JNEUROSCI.5806-09.2010.


RalA suppresses early stages of Ras-induced squamous cell carcinoma progression.

Sowalsky AG, Alt-Holland A, Shamis Y, Garlick JA, Feig LA.

Oncogene. 2010 Jan 7;29(1):45-55. doi: 10.1038/onc.2009.307. Epub 2009 Oct 5.


Sos2 is dispensable for NMDA-induced Erk activation and LTP induction.

Arai JA, Li S, Feig LA.

Neurosci Lett. 2009 May 8;455(1):22-5. doi: 10.1016/j.neulet.2009.03.047. Epub 2009 Mar 18.


Transgenerational rescue of a genetic defect in long-term potentiation and memory formation by juvenile enrichment.

Arai JA, Li S, Hartley DM, Feig LA.

J Neurosci. 2009 Feb 4;29(5):1496-502. doi: 10.1523/JNEUROSCI.5057-08.2009.


RalGDS couples growth factor signaling to Akt activation.

Hao Y, Wong R, Feig LA.

Mol Cell Biol. 2008 May;28(9):2851-9. doi: 10.1128/MCB.01917-07. Epub 2008 Feb 19.


The environment versus genetics in controlling the contribution of MAP kinases to synaptic plasticity.

Li S, Tian X, Hartley DM, Feig LA.

Curr Biol. 2006 Dec 5;16(23):2303-13.


Molecular dissection of Rab11 binding from coiled-coil formation in the Rab11-FIP2 C-terminal domain.

Wei J, Fain S, Harrison C, Feig LA, Baleja JD.

Biochemistry. 2006 Jun 6;45(22):6826-34.


The odyssey of k-ras.

Feig LA.

Mol Cell. 2006 Feb 17;21(4):447-9.


Activation of RalA is critical for Ras-induced tumorigenesis of human cells.

Lim KH, Baines AT, Fiordalisi JJ, Shipitsin M, Feig LA, Cox AD, Der CJ, Counter CM.

Cancer Cell. 2005 Jun;7(6):533-45.


Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation.

Connolly BA, Rice J, Feig LA, Buchsbaum RJ.

Mol Cell Biol. 2005 Jun;25(11):4602-14. Erratum in: Mol Cell Biol. 2005 Sep;25(17):7928.


Tyrosine phosphatase SHP-2 is a mediator of activity-dependent neuronal excitotoxicity.

Rusanescu G, Yang W, Bai A, Neel BG, Feig LA.

EMBO J. 2005 Jan 26;24(2):305-14. Epub 2005 Jan 13.


Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB.

Tian X, Gotoh T, Tsuji K, Lo EH, Huang S, Feig LA.

EMBO J. 2004 Apr 7;23(7):1567-75. Epub 2004 Mar 18.


Ral-GTPases: approaching their 15 minutes of fame.

Feig LA.

Trends Cell Biol. 2003 Aug;13(8):419-25. Review.


The high-risk human papillomavirus type 16 E6 counters the GAP function of E6TP1 toward small Rap G proteins.

Singh L, Gao Q, Kumar A, Gotoh T, Wazer DE, Band H, Feig LA, Band V.

J Virol. 2003 Jan;77(2):1614-20.


Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors.

Cullis DN, Philip B, Baleja JD, Feig LA.

J Biol Chem. 2002 Dec 20;277(51):49158-66. Epub 2002 Oct 2.


Cell signaling: life or death decisions of ras proteins.

Feig LA, Buchsbaum RJ.

Curr Biol. 2002 Apr 2;12(7):R259-61. Review.


PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism.

Tian X, Rusanescu G, Hou W, Schaffhausen B, Feig LA.

EMBO J. 2002 Mar 15;21(6):1327-38.


Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles.

Polzin A, Shipitsin M, Goi T, Feig LA, Turner TJ.

Mol Cell Biol. 2002 Mar;22(6):1714-22.


Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1).

Giese KP, Friedman E, Telliez JB, Fedorov NB, Wines M, Feig LA, Silva AJ.

Neuropharmacology. 2001 Nov;41(6):791-800.


Basis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factors.

Tian X, Feig LA.

J Biol Chem. 2001 Dec 14;276(50):47248-56. Epub 2001 Sep 17.


Prenylation of target GTPases contributes to signaling specificity of Ras-guanine nucleotide exchange factors.

Gotoh T, Tian X, Feig LA.

J Biol Chem. 2001 Oct 12;276(41):38029-35. Epub 2001 Aug 10.


Solution structure of the Reps1 EH domain and characterization of its binding to NPF target sequences.

Kim S, Cullis DN, Feig LA, Baleja JD.

Biochemistry. 2001 Jun 12;40(23):6776-85.


RalA mediates v-Src, v-Ras, and v-Raf regulation of CD44 and fibronectin expression in NIH3T3 fibroblasts.

Ladeda V, Frankel P, Feig LA, Foster DA, Bal de Kier Joffe E, Aguirre-Ghiso JA.

Biochem Biophys Res Commun. 2001 May 18;283(4):854-61.


Regulation of Ras signaling specificity by protein kinase C.

Rusanescu G, Gotoh T, Tian X, Feig LA.

Mol Cell Biol. 2001 Apr;21(8):2650-8.


1H, 15N, and 13C NMR resonance assignments for the Eps15 homology domain of Reps1.

Kim S, Dubelman AM, Goonesekera S, Feig LA, Baleja JD.

J Biomol NMR. 2000 Dec;18(4):367-8. No abstract available.


p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor.

Gotoh T, Cai D, Tian X, Feig LA, Lerner A.

J Biol Chem. 2000 Sep 29;275(39):30118-23.


An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity.

Goi T, Shipitsin M, Lu Z, Foster DA, Klinz SG, Feig LA.

EMBO J. 2000 Feb 15;19(4):623-30.


Phospholipase D and RalA cooperate with the epidermal growth factor receptor to transform 3Y1 rat fibroblasts.

Lu Z, Hornia A, Joseph T, Sukezane T, Frankel P, Zhong M, Bychenok S, Xu L, Feig LA, Foster DA.

Mol Cell Biol. 2000 Jan;20(2):462-7.

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