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Items: 1 to 50 of 194

1.

Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma.

Hossain JA, Latif MA, Ystaas LAR, Ninzima S, Riecken K, Muller A, Azuaje F, Joseph JV, Talasila KM, Ghimire J, Fehse B, Bjerkvig R, Miletic H.

Neuro Oncol. 2019 Apr 8. pii: noz060. doi: 10.1093/neuonc/noz060. [Epub ahead of print]

PMID:
30958558
2.

Imaging flow cytometry facilitates multiparametric characterization of extracellular vesicles in malignant brain tumours.

Ricklefs FL, Maire CL, Reimer R, Dührsen L, Kolbe K, Holz M, Schneider E, Rissiek A, Babayan A, Hille C, Pantel K, Krasemann S, Glatzel M, Heiland DH, Flitsch J, Martens T, Schmidt NO, Peine S, Breakefield XO, Lawler S, Chiocca EA, Fehse B, Giebel B, Görgens A, Westphal M, Lamszus K.

J Extracell Vesicles. 2019 Mar 21;8(1):1588555. doi: 10.1080/20013078.2019.1588555. eCollection 2019.

3.

Nanobody Targeting of Epidermal Growth Factor Receptor (EGFR) Ectodomain Variants Overcomes Resistance to Therapeutic EGFR Antibodies.

Tintelnot J, Baum N, Schultheiß C, Braig F, Trentmann M, Finter J, Fumey W, Bannas P, Fehse B, Riecken K, Schuetze K, Bokemeyer C, Rösner T, Valerius T, Peipp M, Koch-Nolte F, Binder M.

Mol Cancer Ther. 2019 Apr;18(4):823-833. doi: 10.1158/1535-7163.MCT-18-0849. Epub 2019 Mar 1.

PMID:
30824613
4.

Cancer Suicide Gene Therapy with TK.007.

Hossain JA, Riecken K, Miletic H, Fehse B.

Methods Mol Biol. 2019;1895:11-26. doi: 10.1007/978-1-4939-8922-5_2.

PMID:
30539526
5.

Consensus Statement of European Societies of Gene and Cell Therapy on the Reported Birth of Genome-Edited Babies in China.

Büning H, Griesenbach U, Fehse B, Ylä-Herttuala S, Anagnou NP, van Beusechem V, Raya A, Verhoeyen E.

Hum Gene Ther. 2018 Dec;29(12):1337-1338. doi: 10.1089/hum.2018.29081.con. Epub 2018 Dec 4. No abstract available.

PMID:
30511888
6.

Cellular Barcoding Identifies Clonal Substitution as a Hallmark of Local Recurrence in a Surgical Model of Head and Neck Squamous Cell Carcinoma.

Roh V, Abramowski P, Hiou-Feige A, Cornils K, Rivals JP, Zougman A, Aranyossy T, Thielecke L, Truan Z, Mermod M, Monnier Y, Prassolov V, Glauche I, Nowrouzi A, Abdollahi A, Fehse B, Simon C, Tolstonog GV.

Cell Rep. 2018 Nov 20;25(8):2208-2222.e7. doi: 10.1016/j.celrep.2018.10.090.

7.

Transient Retrovirus-Based CRISPR/Cas9 All-in-One Particles for Efficient, Targeted Gene Knockout.

Knopp Y, Geis FK, Heckl D, Horn S, Neumann T, Kuehle J, Meyer J, Fehse B, Baum C, Morgan M, Meyer J, Schambach A, Galla M.

Mol Ther Nucleic Acids. 2018 Dec 7;13:256-274. doi: 10.1016/j.omtn.2018.09.006. Epub 2018 Sep 13.

8.

Clonal dynamics studied in cultured induced pluripotent stem cells reveal major growth imbalances within a few weeks.

Brenière-Letuffe D, Domke-Shibamiya A, Hansen A, Eschenhagen T, Fehse B, Riecken K, Stenzig J.

Stem Cell Res Ther. 2018 Jun 18;9(1):165. doi: 10.1186/s13287-018-0893-2.

9.

Locally Ablative Radiation Therapy of a Primary Human Small Cell Lung Cancer Tumor Decreases the Number of Spontaneous Metastases in Two Xenograft Models.

Frenzel T, Siekmann J, Grohmann C, Valentiner U, Schmitz R, Riecken K, Fehse B, Schumacher U, Lange T, Krüll A.

Int J Radiat Oncol Biol Phys. 2018 Mar 15;100(4):1044-1056. doi: 10.1016/j.ijrobp.2017.11.044. Epub 2017 Dec 6.

PMID:
29485046
10.

The phosphotyrosine phosphatase SHP2 promotes anergy in chronic lymphocytic leukemia.

Schliffke S, Buhs S, Bolz S, Gerull H, von Wenserski L, Riecken K, Fehse B, Nollau P, Binder M.

Blood. 2018 Apr 12;131(15):1755-1758. doi: 10.1182/blood-2017-06-788166. Epub 2018 Feb 23. No abstract available.

11.

The Time Is Ripe for Somatic Genome Editing: NIH Program to Strengthen Translation.

Fehse B, Abramowski-Mock U.

Mol Ther. 2018 Mar 7;26(3):671-674. doi: 10.1016/j.ymthe.2018.02.005. Epub 2018 Feb 21. No abstract available.

12.

Multi-color RGB marking enables clonality assessment of liver tumors in a murine xenograft model.

Thomaschewski M, Riecken K, Unrau L, Volz T, Cornils K, Ittrich H, Heim D, Wege H, Akgün E, Lütgehetmann M, Dieckhoff J, Köpke M, Dandri M, Benten D, Fehse B.

Oncotarget. 2017 Dec 14;8(70):115582-115595. doi: 10.18632/oncotarget.23312. eCollection 2017 Dec 29.

13.

Hepatitis delta virus persists during liver regeneration and is amplified through cell division both in vitro and in vivo.

Giersch K, Bhadra OD, Volz T, Allweiss L, Riecken K, Fehse B, Lohse AW, Petersen J, Sureau C, Urban S, Dandri M, Lütgehetmann M.

Gut. 2019 Jan;68(1):150-157. doi: 10.1136/gutjnl-2017-314713. Epub 2017 Dec 7.

PMID:
29217749
14.

SHIP1, but not an AML-derived SHIP1 mutant, suppresses myeloid leukemia growth in a xenotransplantation mouse model.

Täger M, Horn S, Latuske E, Ehm P, Schaks M, Nalaskowski M, Fehse B, Fiedler W, Stocking C, Wellbrock J, Jücker M.

Gene Ther. 2017 Nov;24(11):749-753. doi: 10.1038/gt.2017.88. Epub 2017 Nov 16.

PMID:
29143813
15.

Gene and Cell Therapy in Germany.

von Kalle C, Fehse B, Büning H.

Hum Gene Ther. 2017 Oct;28(10):781. doi: 10.1089/hum.2017.29057.cvk. No abstract available.

PMID:
28952805
16.

Efficient gene editing via non-viral delivery of CRISPR-Cas9 system using polymeric and hybrid microcarriers.

Timin AS, Muslimov AR, Lepik KV, Epifanovskaya OS, Shakirova AI, Mock U, Riecken K, Okilova MV, Sergeev VS, Afanasyev BV, Fehse B, Sukhorukov GB.

Nanomedicine. 2018 Jan;14(1):97-108. doi: 10.1016/j.nano.2017.09.001. Epub 2017 Sep 14.

PMID:
28917642
17.

High Bone Turnover in Mice Carrying a Pathogenic Notch2 Mutation Causing Hajdu-Cheney Syndrome.

Vollersen N, Hermans-Borgmeyer I, Cornils K, Fehse B, Rolvien T, Triviai I, Jeschke A, Oheim R, Amling M, Schinke T, Yorgan TA.

J Bone Miner Res. 2018 Jan;33(1):70-83. doi: 10.1002/jbmr.3283. Epub 2017 Sep 20.

18.

Genetic Barcodes Facilitate Competitive Clonal Analyses In Vivo.

Aranyossy T, Thielecke L, Glauche I, Fehse B, Cornils K.

Hum Gene Ther. 2017 Oct;28(10):926-937. doi: 10.1089/hum.2017.124.

PMID:
28847169
19.

Impact of molecular residual disease post allografting in myelofibrosis patients.

Wolschke C, Badbaran A, Zabelina T, Christopeit M, Ayuk F, Triviai I, Zander A, Alchalby H, Bacher U, Fehse B, Kröger N.

Bone Marrow Transplant. 2017 Nov;52(11):1526-1529. doi: 10.1038/bmt.2017.157. Epub 2017 Jul 17.

PMID:
28714945
20.

Clonal competition in BcrAbl-driven leukemia: how transplantations can accelerate clonal conversion.

Cornils K, Thielecke L, Winkelmann D, Aranyossy T, Lesche M, Dahl A, Roeder I, Fehse B, Glauche I.

Mol Cancer. 2017 Jul 14;16(1):120. doi: 10.1186/s12943-017-0668-x.

21.

Impact of Molecular Genetics on Outcome in Myelofibrosis Patients after Allogeneic Stem Cell Transplantation.

Kröger N, Panagiota V, Badbaran A, Zabelina T, Triviai I, Araujo Cruz MM, Shahswar R, Ayuk F, Gehlhaar M, Wolschke C, Bollin R, Walter C, Dugas M, Wiehlmann L, Lehmann U, Koenecke C, Chaturvedi A, Alchalby H, Stadler M, Eder M, Christopeit M, Göhring G, Koenigsmann M, Schlegelberger B, Kreipe HH, Ganser A, Stocking C, Fehse B, Thol F, Heuser M.

Biol Blood Marrow Transplant. 2017 Jul;23(7):1095-1101. doi: 10.1016/j.bbmt.2017.03.034. Epub 2017 Apr 4.

22.

Limitations and challenges of genetic barcode quantification.

Thielecke L, Aranyossy T, Dahl A, Tiwari R, Roeder I, Geiger H, Fehse B, Glauche I, Cornils K.

Sci Rep. 2017 Mar 3;7:43249. doi: 10.1038/srep43249.

23.

IL-33-Mediated Expansion of Type 2 Innate Lymphoid Cells Protects from Progressive Glomerulosclerosis.

Riedel JH, Becker M, Kopp K, Düster M, Brix SR, Meyer-Schwesinger C, Kluth LA, Gnirck AC, Attar M, Krohn S, Fehse B, Stahl RAK, Panzer U, Turner JE.

J Am Soc Nephrol. 2017 Jul;28(7):2068-2080. doi: 10.1681/ASN.2016080877. Epub 2017 Feb 2.

24.

Optical Barcoding for Single-Clone Tracking to Study Tumor Heterogeneity.

Mohme M, Maire CL, Riecken K, Zapf S, Aranyossy T, Westphal M, Lamszus K, Fehse B.

Mol Ther. 2017 Mar 1;25(3):621-633. doi: 10.1016/j.ymthe.2016.12.014. Epub 2017 Jan 18.

25.

Cetuximab Resistance in Head and Neck Cancer Is Mediated by EGFR-K521 Polymorphism.

Braig F, Kriegs M, Voigtlaender M, Habel B, Grob T, Biskup K, Blanchard V, Sack M, Thalhammer A, Ben Batalla I, Braren I, Laban S, Danielczyk A, Goletz S, Jakubowicz E, Märkl B, Trepel M, Knecht R, Riecken K, Fehse B, Loges S, Bokemeyer C, Binder M.

Cancer Res. 2017 Mar 1;77(5):1188-1199. doi: 10.1158/0008-5472.CAN-16-0754. Epub 2016 Dec 28.

26.

Digital PCR Panel for Sensitive Hematopoietic Chimerism Quantification after Allogeneic Stem Cell Transplantation.

Stahl T, Rothe C, Böhme MU, Kohl A, Kröger N, Fehse B.

Int J Mol Sci. 2016 Sep 9;17(9). pii: E1515. doi: 10.3390/ijms17091515.

27.

Potent in vitro and in vivo effects of polyclonal anti-human-myeloma globulins.

Schieferdecker A, Shoshani O, Westner B, Zipori D, Fehse B, Kröger N, Ayuk F.

Oncotarget. 2016 Oct 11;7(41):67061-67070. doi: 10.18632/oncotarget.11489.

28.

Lentiviral HSV-Tk.007-mediated suicide gene therapy is not toxic for normal brain cells.

Hossain JA, Ystaas LR, Mrdalj J, Välk K, Riecken K, Fehse B, Bjerkvig R, Grønli J, Miletic H.

J Gene Med. 2016 Sep;18(9):234-43. doi: 10.1002/jgm.2895.

PMID:
27490042
29.

Investigation of the Mesenchymal Stem Cell Compartment by Means of a Lentiviral Barcode Library.

Bigildeev AE, Cornils K, Aranyossy T, Sats NV, Petinati NA, Shipounova IN, Surin VL, Pshenichnikova OS, Riecken K, Fehse B, Drize NI.

Biochemistry (Mosc). 2016 Apr;81(4):373-81. doi: 10.1134/S0006297916040076.

30.

Mesenchymal Stromal/Stem Cells Do Not Ameliorate Experimental Autoimmune Encephalomyelitis and Are Not Detectable in the Central Nervous System of Transplanted Mice.

Abramowski P, Krasemann S, Ernst T, Lange C, Ittrich H, Schweizer M, Zander AR, Martin R, Fehse B.

Stem Cells Dev. 2016 Aug 1;25(15):1134-48. doi: 10.1089/scd.2016.0020. Epub 2016 Jul 13.

PMID:
27250994
31.

Similar outcome of calreticulin type I and calreticulin type II mutations following RIC allogeneic haematopoietic stem cell transplantation for myelofibrosis.

Christopeit M, Badbaran A, Zabelina T, Zeck G, Fehse B, Ayuk F, Wolschke C, Kröger N.

Bone Marrow Transplant. 2016 Oct;51(10):1391-1393. doi: 10.1038/bmt.2016.128. Epub 2016 May 23. No abstract available.

PMID:
27214077
32.

Long-term in vivo single-cell tracking reveals the switch of migration patterns in adult-born juxtaglomerular cells of the mouse olfactory bulb.

Liang Y, Li K, Riecken K, Maslyukov A, Gomez-Nicola D, Kovalchuk Y, Fehse B, Garaschuk O.

Cell Res. 2016 Jul;26(7):805-21. doi: 10.1038/cr.2016.55. Epub 2016 May 13.

33.

Alpharetroviral self-inactivating vectors produced by a superinfection-resistant stable packaging cell line allow genetic modification of primary human T lymphocytes.

Labenski V, Suerth JD, Barczak E, Heckl D, Levy C, Bernadin O, Charpentier E, Williams DA, Fehse B, Verhoeyen E, Schambach A.

Biomaterials. 2016 Aug;97:97-109. doi: 10.1016/j.biomaterials.2016.04.019. Epub 2016 Apr 26.

PMID:
27162078
34.

Primary Human Hepatocytes Repopulate Livers of Mice After In Vitro Culturing and Lentiviral-Mediated Gene Transfer.

Bierwolf J, Volz T, Lütgehetmann M, Allweiss L, Riecken K, Warlich M, Fehse B, Kalff JC, Dandri M, Pollok JM.

Tissue Eng Part A. 2016 May;22(9-10):742-53. doi: 10.1089/ten.TEA.2015.0427.

35.

Massive Clonal Selection and Transiently Contributing Clones During Expansion of Mesenchymal Stem Cell Cultures Revealed by Lentiviral RGB-Barcode Technology.

Selich A, Daudert J, Hass R, Philipp F, von Kaisenberg C, Paul G, Cornils K, Fehse B, Rittinghausen S, Schambach A, Rothe M.

Stem Cells Transl Med. 2016 May;5(5):591-601. doi: 10.5966/sctm.2015-0176. Epub 2016 Mar 31.

36.

Digital PCR to assess gene-editing frequencies (GEF-dPCR) mediated by designer nucleases.

Mock U, Hauber I, Fehse B.

Nat Protoc. 2016 Mar;11(3):598-615. doi: 10.1038/nprot.2016.027. Epub 2016 Feb 25.

PMID:
26914317
37.

Digital-PCR assay for screening and quantitative monitoring of calreticulin (CALR) type-2 positive patients with myelofibrosis following allogeneic stem cell transplantation.

Badbaran A, Fehse B, Christopeit M, Aranyossy T, Ayuk FA, Wolschke C, Kröger N.

Bone Marrow Transplant. 2016 Jun;51(6):872-3. doi: 10.1038/bmt.2016.14. Epub 2016 Feb 15. No abstract available.

PMID:
26878663
38.

Microglia regulate hippocampal neurogenesis during chronic neurodegeneration.

De Lucia C, Rinchon A, Olmos-Alonso A, Riecken K, Fehse B, Boche D, Perry VH, Gomez-Nicola D.

Brain Behav Immun. 2016 Jul;55:179-190. doi: 10.1016/j.bbi.2015.11.001. Epub 2015 Nov 2.

39.

Treatment of multifocal breast cancer by systemic delivery of dual-targeted adeno-associated viral vectors.

Trepel M, Körbelin J, Spies E, Heckmann MB, Hunger A, Fehse B, Katus HA, Kleinschmidt JA, Müller OJ, Michelfelder S.

Gene Ther. 2015 Oct;22(10):848. doi: 10.1038/gt.2015.76. No abstract available.

PMID:
26446851
40.

Impaired bone remodeling and its correction by combination therapy in a mouse model of mucopolysaccharidosis-I.

Kuehn SC, Koehne T, Cornils K, Markmann S, Riedel C, Pestka JM, Schweizer M, Baldauf C, Yorgan TA, Krause M, Keller J, Neven M, Breyer S, Stuecker R, Muschol N, Busse B, Braulke T, Fehse B, Amling M, Schinke T.

Hum Mol Genet. 2015 Dec 15;24(24):7075-86. doi: 10.1093/hmg/ddv407. Epub 2015 Oct 1.

PMID:
26427607
41.

Combined Application of RGB Marking and Mass Spectrometric Imaging Facilitates Detection of Tumor Heterogeneity.

Abramowski P, Kraus O, Rohn S, Riecken K, Fehse B, Schlüter H.

Cancer Genomics Proteomics. 2015 Jul-Aug;12(4):179-87.

PMID:
26136218
42.

Donor choice in haploidentical stem cell transplantation: fetal microchimerism is associated with better outcome in pediatric leukemia patients.

Kruchen A, Stahl T, Gieseke F, Binder TM, Özcan Z, Meisel R, Kreyenberg H, Bader P, Gruhn B, Greil J, Pfeiffer M, Döring M, Handgretinger R, Fehse B, Müller I.

Bone Marrow Transplant. 2015 Oct;50(10):1367-70. doi: 10.1038/bmt.2015.136. Epub 2015 Jun 22. No abstract available.

PMID:
26098953
43.

Epidermal growth factor receptor mutation mediates cross-resistance to panitumumab and cetuximab in gastrointestinal cancer.

Braig F, März M, Schieferdecker A, Schulte A, Voigt M, Stein A, Grob T, Alawi M, Indenbirken D, Kriegs M, Engel E, Vanhoefer U, Grundhoff A, Loges S, Riecken K, Fehse B, Bokemeyer C, Binder M.

Oncotarget. 2015 May 20;6(14):12035-47.

44.

Treatment of multifocal breast cancer by systemic delivery of dual-targeted adeno-associated viral vectors.

Trepel M, Körbelin J, Spies E, Heckmann MB, Hunger A, Fehse B, Katus HA, Kleinschmidt JA, Müller OJ, Michelfelder S.

Gene Ther. 2015 Oct;22(10):840-7. doi: 10.1038/gt.2015.52. Epub 2015 Jun 2. Erratum in: Gene Ther. 2015 Oct;22(10):848.

PMID:
26034897
45.

Erratum: RGB marking with lentiviral vectors for multicolor clonal cell tracking.

Weber K, Thomaschewski M, Benten D, Fehse B.

Nat Protoc. 2015 Jun;10(6):939. doi: 10.1038/nprot0615-939b. Epub 2015 May 28. No abstract available.

PMID:
26020616
46.

mRNA transfection of a novel TAL effector nuclease (TALEN) facilitates efficient knockout of HIV co-receptor CCR5.

Mock U, Machowicz R, Hauber I, Horn S, Abramowski P, Berdien B, Hauber J, Fehse B.

Nucleic Acids Res. 2015 Jun 23;43(11):5560-71. doi: 10.1093/nar/gkv469. Epub 2015 May 11.

47.

Multicolor RGB Marking Allows Morphometric and Functional Analysis of Hippocampal Granule Neurons at the Single-Cell Level.

Gomez-Nicola D, Riecken K, Perry VH, Fehse B.

Hum Gene Ther. 2015 Jun;26(6):332-3. doi: 10.1089/hum.2015.010. Epub 2015 Apr 20.

48.

[Universal modular system for in vitro screening of potential inhibitors of HIV-1 replication].

Prokof'eva MM, Orlova NN, Gornostaeva AS, Shul'gin AA, Nikitenko NA, Senchenko VN, Lebedev TD, Spirin PV, Riechen K, Fehse B, Stocking C, Prasolov VS.

Mol Biol (Mosk). 2014 Mar-Apr;48(2):344-8. Russian.

49.

Cyclooxygenase-2 blockade can improve efficacy of VEGF-targeting drugs.

Ben-Batalla I, Cubas-Cordova M, Udonta F, Wroblewski M, Waizenegger JS, Janning M, Sawall S, Gensch V, Zhao L, Martinez-Zubiaurre I, Riecken K, Fehse B, Pantel K, Bokemeyer C, Loges S.

Oncotarget. 2015 Mar 20;6(8):6341-58.

50.

Targeting species D adenoviruses replication to counteract the epidemic keratoconjunctivitis.

Nikitenko NA, Speiseder T, Groitl P, Spirin PV, Prokofjeva MM, Lebedev TD, Rubtsov PM, Lam E, Riecken K, Fehse B, Dobner T, Prassolov VS.

Biochimie. 2015 Jun;113:10-6. doi: 10.1016/j.biochi.2015.03.010. Epub 2015 Mar 19. Erratum in: Biochimie. 2015 Sep;116:166.

PMID:
25796214

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