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Items: 1 to 50 of 118

1.

Development of a novel fluorescent ligand of growth hormone secretagogue receptor based on the N-Terminal Leap2 region.

Barrile F, M'Kadmi C, De Francesco PN, Cabral A, García Romero G, Mustafá ER, Cantel S, Damian M, Mary S, Denoyelle S, Banères JL, Marie J, Raingo J, Fehrentz JA, Perelló M.

Mol Cell Endocrinol. 2019 Sep 6;498:110573. doi: 10.1016/j.mce.2019.110573. [Epub ahead of print]

PMID:
31499133
2.

Growth hormone secretagogue receptor signalling affects high-fat intake independently of plasma levels of ghrelin and LEAP2, in a 4-day binge eating model.

Cornejo MP, Castrogiovanni D, Schiöth HB, Reynaldo M, Marie J, Fehrentz JA, Perello M.

J Neuroendocrinol. 2019 Aug 30:e12785. doi: 10.1111/jne.12785. [Epub ahead of print]

PMID:
31469195
3.

Structure and dynamics of G protein-coupled receptor-bound ghrelin reveal the critical role of the octanoyl chain.

Ferré G, Louet M, Saurel O, Delort B, Czaplicki G, M'Kadmi C, Damian M, Renault P, Cantel S, Gavara L, Demange P, Marie J, Fehrentz JA, Floquet N, Milon A, Banères JL.

Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17525-17530. doi: 10.1073/pnas.1905105116. Epub 2019 Aug 15.

PMID:
31416915
4.

Differential Effects of a Full and Biased Ghrelin Receptor Agonist in a Mouse Kindling Model.

Buckinx A, Van Den Herrewegen Y, Pierre A, Cottone E, Ben Haj Salah K, Fehrentz JA, Kooijman R, De Bundel D, Smolders I.

Int J Mol Sci. 2019 May 20;20(10). pii: E2480. doi: 10.3390/ijms20102480.

5.

N-Terminal Liver-Expressed Antimicrobial Peptide 2 (LEAP2) Region Exhibits Inverse Agonist Activity toward the Ghrelin Receptor.

M'Kadmi C, Cabral A, Barrile F, Giribaldi J, Cantel S, Damian M, Mary S, Denoyelle S, Dutertre S, Péraldi-Roux S, Neasta J, Oiry C, Banères JL, Marie J, Perello M, Fehrentz JA.

J Med Chem. 2019 Jan 24;62(2):965-973. doi: 10.1021/acs.jmedchem.8b01644. Epub 2018 Dec 24.

PMID:
30543423
6.

STIM Proteins and Orai Ca2+ Channels Are Involved in the Intracellular Pathways Activated by TLQP-21 in RAW264.7 Macrophages.

Molteni L, Rizzi L, Bresciani E, Meanti R, Fehrentz JA, Verdié P, Omeljaniuk RJ, Biagini G, Locatelli V, Torsello A.

Front Pharmacol. 2018 Nov 27;9:1386. doi: 10.3389/fphar.2018.01386. eCollection 2018.

7.

Study of the Tissue Distribution of TLQP-21 in Mice Using [18F]JMV5763, a Radiolabeled Analog Prepared via [18F]Aluminum Fluoride Chelation Chemistry.

Turolla EA, Valtorta S, Bresciani E, Fehrentz JA, Giuliano L, Stucchi S, Belloli S, Rainone P, Sudati F, Rizzi L, Molteni L, Verdiè P, Martinez J, Torsello A, Moresco RM, Todde S.

Front Pharmacol. 2018 Nov 13;9:1274. doi: 10.3389/fphar.2018.01274. eCollection 2018.

8.

Synthesis of [1,2,4]Triazolo[4,3- a]piperazin-6-ones: An Approach to the Triazole-Fused Ketopiperazine Scaffold.

Ben Haj Salah K, Legrand B, Bibian M, Wenger E, Fehrentz JA, Denoyelle S.

Org Lett. 2018 Jun 1;20(11):3250-3254. doi: 10.1021/acs.orglett.8b01112. Epub 2018 May 15.

PMID:
29763330
9.

GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation.

Damian M, Pons V, Renault P, M'Kadmi C, Delort B, Hartmann L, Kaya AI, Louet M, Gagne D, Ben Haj Salah K, Denoyelle S, Ferry G, Boutin JA, Wagner R, Fehrentz JA, Martinez J, Marie J, Floquet N, Galès C, Mary S, Hamm HE, Banères JL.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4501-4506. doi: 10.1073/pnas.1712725115. Epub 2018 Apr 9.

10.

Evidence Supporting a Role for Constitutive Ghrelin Receptor Signaling in Fasting-Induced Hyperphagia in Male Mice.

Fernandez G, Cabral A, Andreoli MF, Labarthe A, M'Kadmi C, Ramos JG, Marie J, Fehrentz JA, Epelbaum J, Tolle V, Perello M.

Endocrinology. 2018 Feb 1;159(2):1021-1034. doi: 10.1210/en.2017-03101.

PMID:
29300858
11.

The GHR-R antagonist JMV 2959 neither induces malaise nor alters the malaise property of LiCl in the adult male rat.

Rodriguez JA, Fehrentz JA, Martinez J, Ben Haj Salah K, Wellman PJ.

Physiol Behav. 2018 Jan 1;183:46-48. doi: 10.1016/j.physbeh.2017.10.017. Epub 2017 Oct 19.

PMID:
29056353
12.

Growth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle from mitochondrial damages in a rat model of cisplatin-induced cachexia.

Sirago G, Conte E, Fracasso F, Cormio A, Fehrentz JA, Martinez J, Musicco C, Camerino GM, Fonzino A, Rizzi L, Torsello A, Lezza AMS, Liantonio A, Cantatore P, Pesce V.

Sci Rep. 2017 Oct 12;7(1):13017. doi: 10.1038/s41598-017-13504-y.

13.

Involvement of PPARγ in the Anticonvulsant Activity of EP-80317, a Ghrelin Receptor Antagonist.

Lucchi C, Costa AM, Giordano C, Curia G, Piat M, Leo G, Vinet J, Brunel L, Fehrentz JA, Martinez J, Torsello A, Biagini G.

Front Pharmacol. 2017 Sep 22;8:676. doi: 10.3389/fphar.2017.00676. eCollection 2017.

14.

Pharmacological and Biochemical Characterization of TLQP-21 Activation of a Binding Site on CHO Cells.

Molteni L, Rizzi L, Bresciani E, Possenti R, Petrocchi Passeri P, Ghè C, Muccioli G, Fehrentz JA, Verdié P, Martinez J, Omeljaniuk RJ, Biagini G, Binda A, Rivolta I, Locatelli V, Torsello A.

Front Pharmacol. 2017 Mar 30;8:167. doi: 10.3389/fphar.2017.00167. eCollection 2017.

15.

Palatability Can Drive Feeding Independent of AgRP Neurons.

Denis RGP, Joly-Amado A, Webber E, Langlet F, Schaeffer M, Padilla SL, Cansell C, Dehouck B, Castel J, Delbès AS, Martinez S, Lacombe A, Rouch C, Kassis N, Fehrentz JA, Martinez J, Verdié P, Hnasko TS, Palmiter RD, Krashes MJ, Güler AD, Magnan C, Luquet S.

Cell Metab. 2017 Apr 4;25(4):975. doi: 10.1016/j.cmet.2017.03.001. No abstract available.

16.

Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia.

Conte E, Camerino GM, Mele A, De Bellis M, Pierno S, Rana F, Fonzino A, Caloiero R, Rizzi L, Bresciani E, Ben Haj Salah K, Fehrentz JA, Martinez J, Giustino A, Mariggiò MA, Coluccia M, Tricarico D, Lograno MD, De Luca A, Torsello A, Conte D, Liantonio A.

J Cachexia Sarcopenia Muscle. 2017 Jun;8(3):386-404. doi: 10.1002/jcsm.12185. Epub 2017 Mar 10.

17.

JMV5656, A Novel Derivative of TLQP-21, Triggers the Activation of a Calcium-Dependent Potassium Outward Current in Microglial Cells.

Rivolta I, Binda A, Molteni L, Rizzi L, Bresciani E, Possenti R, Fehrentz JA, Verdié P, Martinez J, Omeljaniuk RJ, Locatelli V, Torsello A.

Front Cell Neurosci. 2017 Feb 23;11:41. doi: 10.3389/fncel.2017.00041. eCollection 2017.

18.

Progressive Seizure Aggravation in the Repeated 6-Hz Corneal Stimulation Model Is Accompanied by Marked Increase in Hippocampal p-ERK1/2 Immunoreactivity in Neurons.

Giordano C, Costa AM, Lucchi C, Leo G, Brunel L, Fehrentz JA, Martinez J, Torsello A, Biagini G.

Front Cell Neurosci. 2016 Dec 16;10:281. doi: 10.3389/fncel.2016.00281. eCollection 2016.

19.

JMV2894, a novel growth hormone secretagogue, accelerates body mass recovery in an experimental model of cachexia.

Bresciani E, Rizzi L, Molteni L, Ravelli M, Liantonio A, Ben Haj Salah K, Fehrentz JA, Martinez J, Omeljaniuk RJ, Biagini G, Locatelli V, Torsello A.

Endocrine. 2017 Oct;58(1):106-114. doi: 10.1007/s12020-016-1184-2. Epub 2016 Nov 28.

PMID:
27896546
20.

Anticonvulsant effect of a ghrelin receptor agonist in 6Hz corneally kindled mice.

Coppens J, Aourz N, Walrave L, Fehrentz JA, Martinez J, De Bundel D, Portelli J, Smolders I.

Epilepsia. 2016 Sep;57(9):e195-9. doi: 10.1111/epi.13463. Epub 2016 Jul 5.

21.

New ligands of the ghrelin receptor based on the 1,2,4-triazole scaffold by introduction of a second chiral center.

Maingot M, Blayo AL, Denoyelle S, M'Kadmi C, Damian M, Mary S, Gagne D, Sanchez P, Aicher B, Schmidt P, Müller G, Teifel M, Günther E, Marie J, Banères JL, Martinez J, Fehrentz JA.

Bioorg Med Chem Lett. 2016 May 15;26(10):2408-2412. doi: 10.1016/j.bmcl.2016.04.003. Epub 2016 Apr 4.

PMID:
27072910
22.

Antidiabetic potential of two medicinal plants used in Gabonese folk medicine.

Agnaniet H, Mbot EJ, Keita O, Fehrentz JA, Ankli A, Gallud A, Garcia M, Gary-Bobo M, Lebibi J, Cresteil T, Menut C.

BMC Complement Altern Med. 2016 Feb 22;16:71. doi: 10.1186/s12906-016-1052-x.

23.

Imaging heterogeneity of peptide delivery and binding in solid tumors using SPECT imaging and MRI.

Haeck JC, Bol K, de Ridder CM, Brunel L, Fehrentz JA, Martinez J, van Weerden WM, Bernsen MR, de Jong M, Veenland JF.

EJNMMI Res. 2016 Dec;6(1):3. doi: 10.1186/s13550-016-0160-4. Epub 2016 Jan 14.

24.

In Vivo Stabilization of a Gastrin-Releasing Peptide Receptor Antagonist Enhances PET Imaging and Radionuclide Therapy of Prostate Cancer in Preclinical Studies.

Chatalic KL, Konijnenberg M, Nonnekens J, de Blois E, Hoeben S, de Ridder C, Brunel L, Fehrentz JA, Martinez J, van Gent DC, Nock BA, Maina T, van Weerden WM, de Jong M.

Theranostics. 2016 Jan 1;6(1):104-17. doi: 10.7150/thno.13580. eCollection 2016.

25.

Detergent-free Isolation of Functional G Protein-Coupled Receptors into Nanometric Lipid Particles.

Logez C, Damian M, Legros C, Dupré C, Guéry M, Mary S, Wagner R, M'Kadmi C, Nosjean O, Fould B, Marie J, Fehrentz JA, Martinez J, Ferry G, Boutin JA, Banères JL.

Biochemistry. 2016 Jan 12;55(1):38-48. doi: 10.1021/acs.biochem.5b01040. Epub 2015 Dec 24.

PMID:
26701065
26.

Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling.

M'Kadmi C, Leyris JP, Onfroy L, Galés C, Saulière A, Gagne D, Damian M, Mary S, Maingot M, Denoyelle S, Verdié P, Fehrentz JA, Martinez J, Banères JL, Marie J.

J Biol Chem. 2015 Nov 6;290(45):27021-39. doi: 10.1074/jbc.M115.659250. Epub 2015 Sep 11.

27.

Palatability Can Drive Feeding Independent of AgRP Neurons.

Denis RG, Joly-Amado A, Webber E, Langlet F, Schaeffer M, Padilla SL, Cansell C, Dehouck B, Castel J, Delbès AS, Martinez S, Lacombe A, Rouch C, Kassis N, Fehrentz JA, Martinez J, Verdié P, Hnasko TS, Palmiter RD, Krashes MJ, Güler AD, Magnan C, Luquet S.

Cell Metab. 2015 Oct 6;22(4):646-57. doi: 10.1016/j.cmet.2015.07.011. Epub 2015 Aug 13. Erratum in: Cell Metab. 2017 Apr 4;25(4):975.

28.

Involvement of PKA and ERK pathways in ghrelin-induced long-lasting potentiation of excitatory synaptic transmission in the CA1 area of rat hippocampus.

Cavalier M, Crouzin N, Ben Sedrine A, de Jesus Ferreira MC, Guiramand J, Cohen-Solal C, Fehrentz JA, Martinez J, Barbanel G, Vignes M.

Eur J Neurosci. 2015 Oct;42(8):2568-76. doi: 10.1111/ejn.13013. Epub 2015 Jul 29.

PMID:
26153524
29.

In vitro and in vivo application of radiolabeled gastrin-releasing peptide receptor ligands in breast cancer.

Dalm SU, Martens JW, Sieuwerts AM, van Deurzen CH, Koelewijn SJ, de Blois E, Maina T, Nock BA, Brunel L, Fehrentz JA, Martinez J, de Jong M, Melis M.

J Nucl Med. 2015 May;56(5):752-7. doi: 10.2967/jnumed.114.153023. Epub 2015 Mar 19.

30.

Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex.

Damian M, Mary S, Maingot M, M'Kadmi C, Gagne D, Leyris JP, Denoyelle S, Gaibelet G, Gavara L, Garcia de Souza Costa M, Perahia D, Trinquet E, Mouillac B, Galandrin S, Galès C, Fehrentz JA, Floquet N, Martinez J, Marie J, Banères JL.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1601-6. doi: 10.1073/pnas.1414618112. Epub 2015 Jan 20.

31.

New trisubstituted 1,2,4-triazoles as ghrelin receptor antagonists.

Blayo AL, Maingot M, Aicher B, M'Kadmi C, Schmidt P, Müller G, Teifel M, Günther E, Gagne D, Denoyelle S, Martinez J, Fehrentz JA.

Bioorg Med Chem Lett. 2015 Jan 1;25(1):20-4. doi: 10.1016/j.bmcl.2014.11.031. Epub 2014 Nov 15.

PMID:
25435152
32.

Preclinical comparison of Al18F- and 68Ga-labeled gastrin-releasing peptide receptor antagonists for PET imaging of prostate cancer.

Chatalic KL, Franssen GM, van Weerden WM, McBride WJ, Laverman P, de Blois E, Hajjaj B, Brunel L, Goldenberg DM, Fehrentz JA, Martinez J, Boerman OC, de Jong M.

J Nucl Med. 2014 Dec;55(12):2050-6. doi: 10.2967/jnumed.114.141143. Epub 2014 Nov 20.

33.

Triazole GHS-R1a antagonists JMV4208 and JMV3002 attenuate food intake, body weight, and adipose tissue mass in mice.

Holubová M, Nagelová V, Lacinová Z, Haluzík M, Sýkora D, Moulin A, Blayo AL, Fehrentz JA, Martinez J, Stofkova A, Jurčovičová J, Zelezná B, Maletínská L.

Mol Cell Endocrinol. 2014 Aug 5;393(1-2):120-8. doi: 10.1016/j.mce.2014.06.003. Epub 2014 Jun 20.

PMID:
24953973
34.

Heterodimerization with Its splice variant blocks the ghrelin receptor 1a in a non-signaling conformation: a study with a purified heterodimer assembled into lipid discs.

Mary S, Fehrentz JA, Damian M, Gaibelet G, Orcel H, Verdié P, Mouillac B, Martinez J, Marie J, Banères JL.

J Biol Chem. 2013 Aug 23;288(34):24656-65. doi: 10.1074/jbc.M113.453423. Epub 2013 Jul 9.

35.

Ghrelin agonist JMV 1843 increases food intake, body weight and expression of orexigenic neuropeptides in mice.

Holubová M, Spolcová A, Demianová Z, Sýkora D, Fehrentz JA, Martinez J, Stofková A, Jurčovičová J, Drápalová J, Lacinová Z, Haluzík M, Zelezná B, Maletínská L.

Physiol Res. 2013;62(4):435-44. Epub 2013 Apr 16.

36.

Ghrelin knockout mice show decreased voluntary alcohol consumption and reduced ethanol-induced conditioned place preference.

Bahi A, Tolle V, Fehrentz JA, Brunel L, Martinez J, Tomasetto CL, Karam SM.

Peptides. 2013 May;43:48-55. doi: 10.1016/j.peptides.2013.02.008. Epub 2013 Feb 18.

PMID:
23428971
37.

Gastrin releasing peptide receptor-directed radioligands based on a bombesin antagonist: synthesis, (111)in-labeling, and preclinical profile.

Marsouvanidis PJ, Nock BA, Hajjaj B, Fehrentz JA, Brunel L, M'Kadmi C, van der Graaf L, Krenning EP, Maina T, Martinez J, de Jong M.

J Med Chem. 2013 Mar 28;56(6):2374-84. doi: 10.1021/jm301692p. Epub 2013 Mar 8.

PMID:
23427837
38.

How ligands and signalling proteins affect G-protein-coupled receptors' conformational landscape.

Mary S, Fehrentz JA, Damian M, Verdié P, Martinez J, Marie J, Banères JL.

Biochem Soc Trans. 2013 Feb 1;41(1):144-7. doi: 10.1042/BST20120267. Review.

PMID:
23356274
39.

Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons.

Schaeffer M, Langlet F, Lafont C, Molino F, Hodson DJ, Roux T, Lamarque L, Verdié P, Bourrier E, Dehouck B, Banères JL, Martinez J, Méry PF, Marie J, Trinquet E, Fehrentz JA, Prévot V, Mollard P.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1512-7. doi: 10.1073/pnas.1212137110. Epub 2013 Jan 7.

40.

Biophysical characterization of a binding site for TLQP-21, a naturally occurring peptide which induces resistance to obesity.

Cassina V, Torsello A, Tempestini A, Salerno D, Brogioli D, Tamiazzo L, Bresciani E, Martinez J, Fehrentz JA, Verdié P, Omeljaniuk RJ, Possenti R, Rizzi L, Locatelli V, Mantegazza F.

Biochim Biophys Acta. 2013 Feb;1828(2):455-60. doi: 10.1016/j.bbamem.2012.10.023. Epub 2012 Oct 30.

41.

The 1,2,4-triazole as a scaffold for the design of ghrelin receptor ligands: development of JMV 2959, a potent antagonist.

Moulin A, Brunel L, Boeglin D, Demange L, Ryan J, M'Kadmi C, Denoyelle S, Martinez J, Fehrentz JA.

Amino Acids. 2013 Feb;44(2):301-14. doi: 10.1007/s00726-012-1355-2. Epub 2012 Jul 14. Review.

PMID:
22798076
42.

Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor.

Mary S, Damian M, Louet M, Floquet N, Fehrentz JA, Marie J, Martinez J, Banères JL.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8304-9. doi: 10.1073/pnas.1119881109. Epub 2012 May 9.

43.

High constitutive activity is an intrinsic feature of ghrelin receptor protein: a study with a functional monomeric GHS-R1a receptor reconstituted in lipid discs.

Damian M, Marie J, Leyris JP, Fehrentz JA, Verdié P, Martinez J, Banères JL, Mary S.

J Biol Chem. 2012 Feb 3;287(6):3630-41. doi: 10.1074/jbc.M111.288324. Epub 2011 Nov 23.

44.

Pharmacologic antagonism of ghrelin receptors attenuates development of nicotine induced locomotor sensitization in rats.

Wellman PJ, Clifford PS, Rodriguez J, Hughes S, Eitan S, Brunel L, Fehrentz JA, Martinez J.

Regul Pept. 2011 Dec 10;172(1-3):77-80. doi: 10.1016/j.regpep.2011.08.014. Epub 2011 Sep 6.

45.

Ghrelin agonists impact on Fos protein expression in brain areas related to food intake regulation in male C57BL/6 mice.

Pirnik Z, Bundziková J, Holubová M, Pýchová M, Fehrentz JA, Martinez J, Zelezná B, Maletínská L, Kiss A.

Neurochem Int. 2011 Nov;59(6):889-95. doi: 10.1016/j.neuint.2011.08.001. Epub 2011 Aug 6.

PMID:
21843570
46.

Attenuation of cocaine-induced locomotor sensitization in rats sustaining genetic or pharmacologic antagonism of ghrelin receptors.

Clifford PS, Rodriguez J, Schul D, Hughes S, Kniffin T, Hart N, Eitan S, Brunel L, Fehrentz JA, Martinez J, Wellman PJ.

Addict Biol. 2012 Nov;17(6):956-63. doi: 10.1111/j.1369-1600.2011.00339.x. Epub 2011 Jul 25.

47.

Homogeneous time-resolved fluorescence-based assay to screen for ligands targeting the growth hormone secretagogue receptor type 1a.

Leyris JP, Roux T, Trinquet E, Verdié P, Fehrentz JA, Oueslati N, Douzon S, Bourrier E, Lamarque L, Gagne D, Galleyrand JC, M'kadmi C, Martinez J, Mary S, Banères JL, Marie J.

Anal Biochem. 2011 Jan 15;408(2):253-62. doi: 10.1016/j.ab.2010.09.030. Epub 2010 Sep 24.

PMID:
20937574
48.

Involvement of tryptophan W276 and of two surrounding amino acid residues in the high constitutive activity of the ghrelin receptor GHS-R1a.

Gozé C, Bergé G, M'Kadmi C, Floquet N, Gagne D, Galleyrand JC, Fehrentz JA, Martinez J.

Eur J Pharmacol. 2010 Sep 25;643(2-3):153-61. doi: 10.1016/j.ejphar.2010.06.018. Epub 2010 Jun 30.

PMID:
20599926
49.

Ghrelin stimulation of growth hormone-releasing hormone neurons is direct in the arcuate nucleus.

Osterstock G, Escobar P, Mitutsova V, Gouty-Colomer LA, Fontanaud P, Molino F, Fehrentz JA, Carmignac D, Martinez J, Guerineau NC, Robinson IC, Mollard P, Méry PF.

PLoS One. 2010 Feb 11;5(2):e9159. doi: 10.1371/journal.pone.0009159.

50.

Synthesis of 3,4,5-trisubstituted-1,2,4-triazoles.

Moulin A, Bibian M, Blayo AL, El Habnouni S, Martinez J, Fehrentz JA.

Chem Rev. 2010 Apr 14;110(4):1809-27. doi: 10.1021/cr900107r. Review. No abstract available.

PMID:
20151658

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