Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 25

1.

Murine coronavirus infection activates AhR in an IDO1-independent manner contributing to cytokine modulation and pro-viral TiPARP expression.

Grunewald ME, Shaban MG, Mackin SR, Fehr AR, Perlman S.

J Virol. 2019 Nov 6. pii: JVI.01743-19. doi: 10.1128/JVI.01743-19. [Epub ahead of print]

PMID:
31694960
2.

IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes.

Channappanavar R, Fehr AR, Zheng J, Wohlford-Lenane C, Abrahante JE, Mack M, Sompallae R, McCray PB Jr, Meyerholz DK, Perlman S.

J Clin Invest. 2019 Jul 29;130:3625-3639. doi: 10.1172/JCI126363. eCollection 2019 Jul 29.

3.

The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression.

Grunewald ME, Chen Y, Kuny C, Maejima T, Lease R, Ferraris D, Aikawa M, Sullivan CS, Perlman S, Fehr AR.

PLoS Pathog. 2019 May 16;15(5):e1007756. doi: 10.1371/journal.ppat.1007756. eCollection 2019 May.

4.

Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses.

Athmer J, Fehr AR, Grunewald ME, Qu W, Wheeler DL, Graepel KW, Channappanavar R, Sekine A, Aldabeeb DS, Gale M Jr, Denison MR, Perlman S.

MBio. 2018 May 1;9(3). pii: e00272-18. doi: 10.1128/mBio.00272-18.

5.

Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.

Galasiti Kankanamalage AC, Kim Y, Damalanka VC, Rathnayake AD, Fehr AR, Mehzabeen N, Battaile KP, Lovell S, Lushington GH, Perlman S, Chang KO, Groutas WC.

Eur J Med Chem. 2018 Apr 25;150:334-346. doi: 10.1016/j.ejmech.2018.03.004. Epub 2018 Mar 6.

6.

MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection.

Canton J, Fehr AR, Fernandez-Delgado R, Gutierrez-Alvarez FJ, Sanchez-Aparicio MT, García-Sastre A, Perlman S, Enjuanes L, Sola I.

PLoS Pathog. 2018 Jan 25;14(1):e1006838. doi: 10.1371/journal.ppat.1006838. eCollection 2018 Jan.

7.

Viral Macrodomains: Unique Mediators of Viral Replication and Pathogenesis.

Fehr AR, Jankevicius G, Ahel I, Perlman S.

Trends Microbiol. 2018 Jul;26(7):598-610. doi: 10.1016/j.tim.2017.11.011. Review.

8.

The coronavirus nucleocapsid protein is ADP-ribosylated.

Grunewald ME, Fehr AR, Athmer J, Perlman S.

Virology. 2018 Apr;517:62-68. doi: 10.1016/j.virol.2017.11.020. Epub 2017 Dec 1.

9.

Virus-induced inflammasome activation is suppressed by prostaglandin D2/DP1 signaling.

Vijay R, Fehr AR, Janowski AM, Athmer J, Wheeler DL, Grunewald M, Sompallae R, Kurup SP, Meyerholz DK, Sutterwala FS, Narumiya S, Perlman S.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5444-E5453. doi: 10.1073/pnas.1704099114. Epub 2017 Jun 19.

10.

In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins.

Athmer J, Fehr AR, Grunewald M, Smith EC, Denison MR, Perlman S.

MBio. 2017 Jan 31;8(1). pii: e02320-16. doi: 10.1128/mBio.02320-16.

11.

The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection.

Fehr AR, Channappanavar R, Jankevicius G, Fett C, Zhao J, Athmer J, Meyerholz DK, Ahel I, Perlman S.

MBio. 2016 Dec 13;7(6). pii: e01721-16. doi: 10.1128/mBio.01721-16.

12.

Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism.

Park JE, Li K, Barlan A, Fehr AR, Perlman S, McCray PB Jr, Gallagher T.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12262-12267. Epub 2016 Oct 10.

13.

Middle East Respiratory Syndrome: Emergence of a Pathogenic Human Coronavirus.

Fehr AR, Channappanavar R, Perlman S.

Annu Rev Med. 2017 Jan 14;68:387-399. doi: 10.1146/annurev-med-051215-031152. Epub 2016 Aug 26. Review.

14.

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice.

Channappanavar R, Fehr AR, Vijay R, Mack M, Zhao J, Meyerholz DK, Perlman S.

Cell Host Microbe. 2016 Feb 10;19(2):181-93. doi: 10.1016/j.chom.2016.01.007.

15.

Coronaviruses: an overview of their replication and pathogenesis.

Fehr AR, Perlman S.

Methods Mol Biol. 2015;1282:1-23. doi: 10.1007/978-1-4939-2438-7_1. Review.

16.

The nsp3 macrodomain promotes virulence in mice with coronavirus-induced encephalitis.

Fehr AR, Athmer J, Channappanavar R, Phillips JM, Meyerholz DK, Perlman S.

J Virol. 2015 Feb;89(3):1523-36. doi: 10.1128/JVI.02596-14. Epub 2014 Nov 26.

17.

Cyclin A degradation by primate cytomegalovirus protein pUL21a counters its innate restriction of virus replication.

Caffarelli N, Fehr AR, Yu D.

PLoS Pathog. 2013;9(12):e1003825. doi: 10.1371/journal.ppat.1003825. Epub 2013 Dec 26.

19.

Control the host cell cycle: viral regulation of the anaphase-promoting complex.

Fehr AR, Yu D.

J Virol. 2013 Aug;87(16):8818-25. doi: 10.1128/JVI.00088-13. Epub 2013 Jun 12. Review.

20.

Murine cytomegalovirus protein pM79 is a key regulator for viral late transcription.

Chapa TJ, Johnson LS, Affolter C, Valentine MC, Fehr AR, Yokoyama WM, Yu D.

J Virol. 2013 Aug;87(16):9135-47. doi: 10.1128/JVI.00688-13. Epub 2013 Jun 12.

21.

Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a.

Fehr AR, Gualberto NC, Savaryn JP, Terhune SS, Yu D.

PLoS Pathog. 2012;8(7):e1002789. doi: 10.1371/journal.ppat.1002789. Epub 2012 Jul 5.

22.

The human cytomegalovirus gene UL79 is required for the accumulation of late viral transcripts.

Perng YC, Qian Z, Fehr AR, Xuan B, Yu D.

J Virol. 2011 May;85(10):4841-52. doi: 10.1128/JVI.02344-10. Epub 2011 Mar 2.

23.
24.

In vitro and in vivo characterization of the Pseudomonas aeruginosa cyclic AMP (cAMP) phosphodiesterase CpdA, required for cAMP homeostasis and virulence factor regulation.

Fuchs EL, Brutinel ED, Klem ER, Fehr AR, Yahr TL, Wolfgang MC.

J Bacteriol. 2010 Jun;192(11):2779-90. doi: 10.1128/JB.00168-10. Epub 2010 Mar 26.

25.

Supplemental Content

Support Center