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RORγt-Expressing Tregs Drive the Growth of Colitis-Associated Colorectal Cancer by Controlling IL6 in Dendritic Cells.

Rizzo A, Di Giovangiulio M, Stolfi C, Franzè E, Fehling HJ, Carsetti R, Giorda E, Colantoni A, Ortenzi A, Rugge M, Mescoli C, Monteleone G, Fantini MC.

Cancer Immunol Res. 2018 Jul 10. pii: canimm.0698.2017. doi: 10.1158/2326-6066.CIR-17-0698. [Epub ahead of print]


The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice.

Schmidt K, Zhang Q, Tasdogan A, Petzold A, Dahl A, Arneth BM, Slany R, Fehling HJ, Kranz A, Stewart AF, Anastassiadis K.

Elife. 2018 Jun 19;7. pii: e27157. doi: 10.7554/eLife.27157.


Dynamic changes in intrathymic ILC populations during murine neonatal development.

Jones R, Cosway EJ, Willis C, White AJ, Jenkinson WE, Fehling HJ, Anderson G, Withers DR.

Eur J Immunol. 2018 May 31. doi: 10.1002/eji.201847511. [Epub ahead of print]


Epigenome analysis links gene regulatory elements in group 2 innate lymphocytes to asthma susceptibility.

Stadhouders R, Li BWS, de Bruijn MJW, Gomez A, Rao TN, Fehling HJ, van IJcken WFJ, Lim AI, Di Santo JP, Graf T, Hendriks RW.

J Allergy Clin Immunol. 2018 Mar 2. pii: S0091-6749(18)30295-1. doi: 10.1016/j.jaci.2017.12.1006. [Epub ahead of print]


Group 2 Innate Lymphoid Cells Exhibit a Dynamic Phenotype in Allergic Airway Inflammation.

Li BWS, Stadhouders R, de Bruijn MJW, Lukkes M, Beerens DMJM, Brem MD, KleinJan A, Bergen I, Vroman H, Kool M, van IJcken WFJ, Rao TN, Fehling HJ, Hendriks RW.

Front Immunol. 2017 Dec 1;8:1684. doi: 10.3389/fimmu.2017.01684. eCollection 2017.


Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.

Kammertoens T, Friese C, Arina A, Idel C, Briesemeister D, Rothe M, Ivanov A, Szymborska A, Patone G, Kunz S, Sommermeyer D, Engels B, Leisegang M, Textor A, Fehling HJ, Fruttiger M, Lohoff M, Herrmann A, Yu H, Weichselbaum R, Uckert W, Hübner N, Gerhardt H, Beule D, Schreiber H, Blankenstein T.

Nature. 2017 May 4;545(7652):98-102. doi: 10.1038/nature22311. Epub 2017 Apr 26.


The IFN-1 > BID > ROS pathway: Linking DNA damage with HSPC malfunction.

Gross A, Tasdogan A, Fehling HJ.

Cell Cycle. 2017 May 3;16(9):819-820. doi: 10.1080/15384101.2017.1304742. Epub 2017 Mar 30. No abstract available.


DNA Damage-Induced HSPC Malfunction Depends on ROS Accumulation Downstream of IFN-1 Signaling and Bid Mobilization.

Tasdogan A, Kumar S, Allies G, Bausinger J, Beckel F, Hofemeister H, Mulaw M, Madan V, Scharffetter-Kochanek K, Feuring-Buske M, Doehner K, Speit G, Stewart AF, Fehling HJ.

Cell Stem Cell. 2017 Mar 2;20(3):415. doi: 10.1016/j.stem.2017.02.002. No abstract available.


DNA Damage-Induced HSPC Malfunction Depends on ROS Accumulation Downstream of IFN-1 Signaling and Bid Mobilization.

Tasdogan A, Kumar S, Allies G, Bausinger J, Beckel F, Hofemeister H, Mulaw M, Madan V, Scharfetter-Kochanek K, Feuring-Buske M, Doehner K, Speit G, Stewart AF, Fehling HJ.

Cell Stem Cell. 2016 Dec 1;19(6):752-767. doi: 10.1016/j.stem.2016.08.007. Epub 2016 Sep 15.


Overexpression of Differentially Expressed Genes Identified in Non-pathogenic and Pathogenic Entamoeba histolytica Clones Allow Identification of New Pathogenicity Factors Involved in Amoebic Liver Abscess Formation.

Meyer M, Fehling H, Matthiesen J, Lorenzen S, Schuldt K, Bernin H, Zaruba M, Lender C, Ernst T, Ittrich H, Roeder T, Tannich E, Lotter H, Bruchhaus I.

PLoS Pathog. 2016 Aug 30;12(8):e1005853. doi: 10.1371/journal.ppat.1005853. eCollection 2016 Aug.


RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus.

Drujont L, Lemoine A, Moreau A, Bienvenu G, Lancien M, Cens T, Guillot F, Bériou G, Bouchet-Delbos L, Fehling HJ, Chiffoleau E, Nicot AB, Charnet P, Martin JC, Josien R, Cuturi MC, Louvet C.

Sci Rep. 2016 Mar 24;6:23682. doi: 10.1038/srep23682.


Autoantibody-boosted T-cell reactivation in the target organ triggers manifestation of autoimmune CNS disease.

Flach AC, Litke T, Strauss J, Haberl M, Gómez CC, Reindl M, Saiz A, Fehling HJ, Wienands J, Odoardi F, Lühder F, Flügel A.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3323-8. doi: 10.1073/pnas.1519608113. Epub 2016 Mar 8.


The cytokine profile of human NKT cells and PBMCs is dependent on donor sex and stimulus.

Bernin H, Fehling H, Marggraff C, Tannich E, Lotter H.

Med Microbiol Immunol. 2016 Aug;205(4):321-32. doi: 10.1007/s00430-016-0449-y. Epub 2016 Feb 20.


IL-23 prevents IL-13-dependent tissue repair associated with Ly6C(lo) monocytes in Entamoeba histolytica-induced liver damage.

Noll J, Helk E, Fehling H, Bernin H, Marggraff C, Jacobs T, Huber S, Pelczar P, Ernst T, Ittrich H, Otto B, Mittrücker HW, Hölscher C, Tacke F, Bruchhaus I, Tannich E, Lotter H.

J Hepatol. 2016 May;64(5):1147-1157. doi: 10.1016/j.jhep.2016.01.013. Epub 2016 Jan 22.


Identification of a novel lymphoid population in the murine epidermis.

Almeida FF, Tenno M, Brzostek J, Li JL, Allies G, Hoeffel G, See P, Ng LG, Fehling HJ, Gascoigne NR, Taniuchi I, Ginhoux F.

Sci Rep. 2015 Jul 30;5:12554. doi: 10.1038/srep12554.


Magnetic resonance imaging of pathogenic protozoan parasite Entamoeba histolytica labeled with superparamagnetic iron oxide nanoparticles.

Ernst TM, Fehling H, Bernin H, Zaruba MD, Bruchhaus I, Adam G, Ittrich H, Lotter H.

Invest Radiol. 2015 Oct;50(10):709-18. doi: 10.1097/RLI.0000000000000175.


Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cells.

Franckaert D, Dooley J, Roos E, Floess S, Huehn J, Luche H, Fehling HJ, Liston A, Linterman MA, Schlenner SM.

Immunol Cell Biol. 2015 Apr;93(4):417-23. doi: 10.1038/icb.2014.108. Epub 2014 Dec 23.


Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates.

Lee SY, Coffey F, Fahl SP, Peri S, Rhodes M, Cai KQ, Carleton M, Hedrick SM, Fehling HJ, Zúñiga-Pflücker JC, Kappes DJ, Wiest DL.

Immunity. 2014 Dec 18;41(6):934-46. doi: 10.1016/j.immuni.2014.10.021. Epub 2014 Nov 28.


Conditional ablation of NKp46+ cells using a novel Ncr1(greenCre) mouse strain: NK cells are essential for protection against pulmonary B16 metastases.

Merzoug LB, Marie S, Satoh-Takayama N, Lesjean S, Albanesi M, Luche H, Fehling HJ, Di Santo JP, Vosshenrich CA.

Eur J Immunol. 2014 Nov;44(11):3380-91. doi: 10.1002/eji.201444643. Epub 2014 Sep 19.


Cell competition is a tumour suppressor mechanism in the thymus.

Martins VC, Busch K, Juraeva D, Blum C, Ludwig C, Rasche V, Lasitschka F, Mastitsky SE, Brors B, Hielscher T, Fehling HJ, Rodewald HR.

Nature. 2014 May 22;509(7501):465-70. doi: 10.1038/nature13317. Epub 2014 May 14.


Prospective molecular profiling of canine cancers provides a clinically relevant comparative model for evaluating personalized medicine (PMed) trials.

Paoloni M, Webb C, Mazcko C, Cherba D, Hendricks W, Lana S, Ehrhart EJ, Charles B, Fehling H, Kumar L, Vail D, Henson M, Childress M, Kitchell B, Kingsley C, Kim S, Neff M, Davis B, Khanna C, Trent J.

PLoS One. 2014 Mar 17;9(3):e90028. doi: 10.1371/journal.pone.0090028. eCollection 2014.


Improved method to retain cytosolic reporter protein fluorescence while staining for nuclear proteins.

Heinen AP, Wanke F, Moos S, Attig S, Luche H, Pal PP, Budisa N, Fehling HJ, Waisman A, Kurschus FC.

Cytometry A. 2014 Jul;85(7):621-7. doi: 10.1002/cyto.a.22451. Epub 2014 Feb 19.


Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells.

Hoshii T, Kasada A, Hatakeyama T, Ohtani M, Tadokoro Y, Naka K, Ikenoue T, Ikawa T, Kawamoto H, Fehling HJ, Araki K, Yamamura K, Matsuda S, Hirao A.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3805-10. doi: 10.1073/pnas.1320265111. Epub 2014 Feb 24.


Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program.

Nishikawa Y, Nishijima H, Matsumoto M, Morimoto J, Hirota F, Takahashi S, Luche H, Fehling HJ, Mouri Y, Matsumoto M.

J Immunol. 2014 Mar 15;192(6):2585-92. doi: 10.4049/jimmunol.1302786. Epub 2014 Feb 10.


Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response.

Bailey-Bucktrout SL, Martinez-Llordella M, Zhou X, Anthony B, Rosenthal W, Luche H, Fehling HJ, Bluestone JA.

Immunity. 2013 Nov 14;39(5):949-62. doi: 10.1016/j.immuni.2013.10.016.


TRAF6 is essential for maintenance of regulatory T cells that suppress Th2 type autoimmunity.

Muto G, Kotani H, Kondo T, Morita R, Tsuruta S, Kobayashi T, Luche H, Fehling HJ, Walsh M, Choi Y, Yoshimura A.

PLoS One. 2013 Sep 13;8(9):e74639. doi: 10.1371/journal.pone.0074639. eCollection 2013.


C-reactive protein (CRP) is essential for efficient systemic transduction of recombinant adeno-associated virus vector 1 (rAAV-1) and rAAV-6 in mice.

Denard J, Marolleau B, Jenny C, Rao TN, Fehling HJ, Voit T, Svinartchouk F.

J Virol. 2013 Oct;87(19):10784-91. doi: 10.1128/JVI.01813-13. Epub 2013 Jul 31.


A rare population of CD24(+)ITGB4(+)Notch(hi) cells drives tumor propagation in NSCLC and requires Notch3 for self-renewal.

Zheng Y, de la Cruz CC, Sayles LC, Alleyne-Chin C, Vaka D, Knaak TD, Bigos M, Xu Y, Hoang CD, Shrager JB, Fehling HJ, French D, Forrest W, Jiang Z, Carano RA, Barck KH, Jackson EL, Sweet-Cordero EA.

Cancer Cell. 2013 Jul 8;24(1):59-74. doi: 10.1016/j.ccr.2013.05.021.


In vivo fate mapping identifies pre-TCRα expression as an intra- and extrathymic, but not prethymic, marker of T lymphopoiesis.

Luche H, Nageswara Rao T, Kumar S, Tasdogan A, Beckel F, Blum C, Martins VC, Rodewald HR, Fehling HJ.

J Exp Med. 2013 Apr 8;210(4):699-714. doi: 10.1084/jem.20122609. Epub 2013 Mar 18.


T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development.

Ohkura N, Hamaguchi M, Morikawa H, Sugimura K, Tanaka A, Ito Y, Osaki M, Tanaka Y, Yamashita R, Nakano N, Huehn J, Fehling HJ, Sparwasser T, Nakai K, Sakaguchi S.

Immunity. 2012 Nov 16;37(5):785-99. doi: 10.1016/j.immuni.2012.09.010. Epub 2012 Nov 1.


Differential requirement for ROCK in dendritic cell migration within lymphatic capillaries in steady-state and inflammation.

Nitschké M, Aebischer D, Abadier M, Haener S, Lucic M, Vigl B, Luche H, Fehling HJ, Biehlmaier O, Lyck R, Halin C.

Blood. 2012 Sep 13;120(11):2249-58. doi: 10.1182/blood-2012-03-417923. Epub 2012 Jul 31.


Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

Miyao T, Floess S, Setoguchi R, Luche H, Fehling HJ, Waldmann H, Huehn J, Hori S.

Immunity. 2012 Feb 24;36(2):262-75. doi: 10.1016/j.immuni.2011.12.012. Epub 2012 Feb 9.


Transcriptional code and disease map for adult retinal cell types.

Siegert S, Cabuy E, Scherf BG, Kohler H, Panda S, Le YZ, Fehling HJ, Gaidatzis D, Stadler MB, Roska B.

Nat Neurosci. 2012 Jan 22;15(3):487-95, S1-2. doi: 10.1038/nn.3032.


Salmonella gut invasion involves TTSS-2-dependent epithelial traversal, basolateral exit, and uptake by epithelium-sampling lamina propria phagocytes.

Müller AJ, Kaiser P, Dittmar KE, Weber TC, Haueter S, Endt K, Songhet P, Zellweger C, Kremer M, Fehling HJ, Hardt WD.

Cell Host Microbe. 2012 Jan 19;11(1):19-32. doi: 10.1016/j.chom.2011.11.013.


Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity.

Feyerabend TB, Weiser A, Tietz A, Stassen M, Harris N, Kopf M, Radermacher P, Möller P, Benoist C, Mathis D, Fehling HJ, Rodewald HR.

Immunity. 2011 Nov 23;35(5):832-44. doi: 10.1016/j.immuni.2011.09.015.


Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice.

Asada N, Takase M, Nakamura J, Oguchi A, Asada M, Suzuki N, Yamamura K, Nagoshi N, Shibata S, Rao TN, Fehling HJ, Fukatsu A, Minegishi N, Kita T, Kimura T, Okano H, Yamamoto M, Yanagita M.

J Clin Invest. 2011 Oct;121(10):3981-90. doi: 10.1172/JCI57301. Epub 2011 Sep 12.


No reduction of atherosclerosis in C-reactive protein (CRP)-deficient mice.

Teupser D, Weber O, Rao TN, Sass K, Thiery J, Fehling HJ.

J Biol Chem. 2011 Feb 25;286(8):6272-9. doi: 10.1074/jbc.M110.161414. Epub 2010 Dec 11.


Lineage relationship analysis of RORgammat+ innate lymphoid cells.

Sawa S, Cherrier M, Lochner M, Satoh-Takayama N, Fehling HJ, Langa F, Di Santo JP, Eberl G.

Science. 2010 Oct 29;330(6004):665-9. doi: 10.1126/science.1194597. Epub 2010 Sep 23.


In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis.

Siffrin V, Radbruch H, Glumm R, Niesner R, Paterka M, Herz J, Leuenberger T, Lehmann SM, Luenstedt S, Rinnenthal JL, Laube G, Luche H, Lehnardt S, Fehling HJ, Griesbeck O, Zipp F.

Immunity. 2010 Sep 24;33(3):424-36. doi: 10.1016/j.immuni.2010.08.018.


Temporal specification of blood progenitors from mouse embryonic stem cells and induced pluripotent stem cells.

Irion S, Clarke RL, Luche H, Kim I, Morrison SJ, Fehling HJ, Keller GM.

Development. 2010 Sep 1;137(17):2829-39. doi: 10.1242/dev.042119. Epub 2010 Jul 21.


Preferential localization of IgG memory B cells adjacent to contracted germinal centers.

Aiba Y, Kometani K, Hamadate M, Moriyama S, Sakaue-Sawano A, Tomura M, Luche H, Fehling HJ, Casellas R, Kanagawa O, Miyawaki A, Kurosaki T.

Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12192-7. doi: 10.1073/pnas.1005443107. Epub 2010 Jun 14.


Dicer-dependent microRNAs control maturation, function, and maintenance of Langerhans cells in vivo.

Kuipers H, Schnorfeil FM, Fehling HJ, Bartels H, Brocker T.

J Immunol. 2010 Jul 1;185(1):400-9. doi: 10.4049/jimmunol.0903912. Epub 2010 Jun 7.


Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs.

Krol J, Busskamp V, Markiewicz I, Stadler MB, Ribi S, Richter J, Duebel J, Bicker S, Fehling HJ, Schübeler D, Oertner TG, Schratt G, Bibel M, Roska B, Filipowicz W.

Cell. 2010 May 14;141(4):618-31. doi: 10.1016/j.cell.2010.03.039.


Fate mapping reveals separate origins of T cells and myeloid lineages in the thymus.

Schlenner SM, Madan V, Busch K, Tietz A, Läufle C, Costa C, Blum C, Fehling HJ, Rodewald HR.

Immunity. 2010 Mar 26;32(3):426-36. doi: 10.1016/j.immuni.2010.03.005. Epub 2010 Mar 18.


Asynchronous RAG-1 expression during B lymphopoiesis.

Welner RS, Esplin BL, Garrett KP, Pelayo R, Luche H, Fehling HJ, Kincade PW.

J Immunol. 2009 Dec 15;183(12):7768-77. doi: 10.4049/jimmunol.0902333.


Intestinal lamina propria dendritic cell subsets have different origin and functions.

Varol C, Vallon-Eberhard A, Elinav E, Aychek T, Shapira Y, Luche H, Fehling HJ, Hardt WD, Shakhar G, Jung S.

Immunity. 2009 Sep 18;31(3):502-12. doi: 10.1016/j.immuni.2009.06.025. Epub 2009 Sep 3.


The patch-like pattern of OR37 receptors is formed by turning off gene expression in non-appropriate areas.

Strotmann J, Bader A, Luche H, Fehling HJ, Breer H.

Mol Cell Neurosci. 2009 Aug;41(4):474-85. doi: 10.1016/j.mcn.2009.05.005. Epub 2009 May 20.


Analysis and expression of a cloned pre-T cell receptor gene. Science. 1994. 266: 1208-1212.

Saint-Ruf C, Ungewiss K, Groettrup M, Bruno L, Fehling HJ, von Boehmer H.

J Immunol. 2009 May 1;182(9):5165-9. No abstract available.


The pluripotency-associated gene Dppa4 is dispensable for embryonic stem cell identity and germ cell development but essential for embryogenesis.

Madan B, Madan V, Weber O, Tropel P, Blum C, Kieffer E, Viville S, Fehling HJ.

Mol Cell Biol. 2009 Jun;29(11):3186-203. doi: 10.1128/MCB.01970-08. Epub 2009 Mar 30.


Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms.

Feyerabend TB, Terszowski G, Tietz A, Blum C, Luche H, Gossler A, Gale NW, Radtke F, Fehling HJ, Rodewald HR.

Immunity. 2009 Jan 16;30(1):67-79. doi: 10.1016/j.immuni.2008.10.016. Epub 2008 Dec 24.

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