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One-Time Intravitreal Injection of KVD001, a Plasma Kallikrein Inhibitor, in Patients with Central-Involved Diabetic Macular Edema and Reduced Vision: An Open-Label Phase 1B Study.

Sun JK, Maturi RK, Boyer DS, Wells JA, Gonzalez VH, Tansley R, Hernandez H, Maetzel A, Feener EP, Aiello LP.

Ophthalmol Retina. 2019 Dec;3(12):1107-1109. doi: 10.1016/j.oret.2019.07.006. Epub 2019 Jul 26. No abstract available.


Nomenclature of factor XI and the contact system.

Schmaier AH, Emsley J, Feener EP, Gailani D, Govers-Riemslag JWP, Kaplan AP, Maas C, Morrissey JH, Renné T, Sidelmann JJ, Meijers JCM.

J Thromb Haemost. 2019 Dec;17(12):2216-2219. doi: 10.1111/jth.14595. Epub 2019 Aug 13. No abstract available.


Retinal proteome associated with bradykinin-induced edema.

Murugesan N, Fickweiler W, Clermont AC, Zhou Q, Feener EP.

Exp Eye Res. 2019 Sep;186:107744. doi: 10.1016/j.exer.2019.107744. Epub 2019 Jul 24.


Retinol binding protein 3 is increased in the retina of patients with diabetes resistant to diabetic retinopathy.

Yokomizo H, Maeda Y, Park K, Clermont AC, Hernandez SL, Fickweiler W, Li Q, Wang CH, Paniagua SM, Simao F, Ishikado A, Sun B, Wu IH, Katagiri S, Pober DM, Tinsley LJ, Avery RL, Feener EP, Kern TS, Keenan HA, Aiello LP, Sun JK, King GL.

Sci Transl Med. 2019 Jul 3;11(499). pii: eaau6627. doi: 10.1126/scitranslmed.aau6627.


Plasma kallikrein activates the epithelial sodium channel in vitro but is not essential for volume retention in nephrotic mice.

Haerteis S, Schork A, Dörffel T, Bohnert BN, Nacken R, Wörn M, Xiao M, Essigke D, Janessa A, Schmaier AH, Feener EP, Häring HU, Bertog M, Korbmacher C, Artunc F.

Acta Physiol (Oxf). 2018 Sep;224(1):e13060. doi: 10.1111/apha.13060. Epub 2018 Mar 25.


The Effects of the Contact Activation System on Hemorrhage.

Simão F, Feener EP.

Front Med (Lausanne). 2017 Jul 31;4:121. doi: 10.3389/fmed.2017.00121. eCollection 2017. Review.


Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction.

Qi W, Keenan HA, Li Q, Ishikado A, Kannt A, Sadowski T, Yorek MA, Wu IH, Lockhart S, Coppey LJ, Pfenninger A, Liew CW, Qiang G, Burkart AM, Hastings S, Pober D, Cahill C, Niewczas MA, Israelsen WJ, Tinsley L, Stillman IE, Amenta PS, Feener EP, Vander Heiden MG, Stanton RC, King GL.

Nat Med. 2017 Jun;23(6):753-762. doi: 10.1038/nm.4328. Epub 2017 Apr 24.


Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke.

Simão F, Ustunkaya T, Clermont AC, Feener EP.

Blood. 2017 Apr 20;129(16):2280-2290. doi: 10.1182/blood-2016-09-740670. Epub 2017 Jan 27.


Evaluating anesthetic protocols for functional blood flow imaging in the rat eye.

Moult EM, Choi W, Boas DA, Baumann B, Clermont AC, Feener EP, Fujimoto JG.

J Biomed Opt. 2017 Jan 1;22(1):16005. doi: 10.1117/1.JBO.22.1.016005.


Plasma Kallikrein Mediates Vascular Endothelial Growth Factor-Induced Retinal Dysfunction and Thickening.

Clermont A, Murugesan N, Zhou Q, Kita T, Robson PA, Rushbrooke LJ, Evans DM, Aiello LP, Feener EP.

Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2390-9. doi: 10.1167/iovs.15-18272.


A comparison of the effects of factor XII deficiency and prekallikrein deficiency on thrombus formation.

Kokoye Y, Ivanov I, Cheng Q, Matafonov A, Dickeson SK, Mason S, Sexton DJ, Renné T, McCrae K, Feener EP, Gailani D.

Thromb Res. 2016 Apr;140:118-124. doi: 10.1016/j.thromres.2016.02.020. Epub 2016 Feb 18.


Proteomic Analysis of Embryonic and Young Human Vitreous.

Yee KM, Feener EP, Madigan M, Jackson NJ, Gao BB, Ross-Cisneros FN, Provis J, Aiello LP, Sadun AA, Sebag J.

Invest Ophthalmol Vis Sci. 2015 Nov;56(12):7036-42. doi: 10.1167/iovs.15-16809.


Negatively charged silver nanoparticles cause retinal vascular permeability by activating plasma contact system and disrupting adherens junction.

Long YM, Zhao XC, Clermont AC, Zhou QF, Liu Q, Feener EP, Yan B, Jiang GB.

Nanotoxicology. 2016;10(4):501-11. doi: 10.3109/17435390.2015.1088589. Epub 2015 Sep 23.


Thrombosis and Hemorrhage in Diabetic Retinopathy: A Perspective from an Inflammatory Standpoint.

Murugesan N, Üstunkaya T, Feener EP.

Semin Thromb Hemost. 2015 Sep;41(6):659-64. doi: 10.1055/s-0035-1556731. Epub 2015 Aug 25. Review.


Plasma Kallikrein-Kinin System as a VEGF-Independent Mediator of Diabetic Macular Edema.

Kita T, Clermont AC, Murugesan N, Zhou Q, Fujisawa K, Ishibashi T, Aiello LP, Feener EP.

Diabetes. 2015 Oct;64(10):3588-99. doi: 10.2337/db15-0317. Epub 2015 May 15.


Thioredoxin-interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress.

Lee S, Min Kim S, Dotimas J, Li L, Feener EP, Baldus S, Myers RB, Chutkow WA, Patwari P, Yoshioka J, Lee RT.

EMBO Mol Med. 2014 Jun;6(6):732-43. doi: 10.15252/emmm.201302561. Epub 2014 Apr 6.


Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells.

Park K, Li Q, Rask-Madsen C, Mima A, Mizutani K, Winnay J, Maeda Y, D'Aquino K, White MF, Feener EP, King GL.

Mol Cell Biol. 2013 Aug;33(16):3227-41. doi: 10.1128/MCB.00506-13. Epub 2013 Jun 17.


Role of plasma kallikrein in diabetes and metabolism.

Feener EP, Zhou Q, Fickweiler W.

Thromb Haemost. 2013 Sep;110(3):434-41. doi: 10.1160/TH13-02-0179. Epub 2013 May 16. Review.


Plasma kallikrein-kinin system and diabetic retinopathy.

Liu J, Feener EP.

Biol Chem. 2013 Mar;394(3):319-28. doi: 10.1515/hsz-2012-0316. Review.


Intraocular hemorrhage causes retinal vascular dysfunction via plasma kallikrein.

Liu J, Clermont AC, Gao BB, Feener EP.

Invest Ophthalmol Vis Sci. 2013 Feb 7;54(2):1086-94. doi: 10.1167/iovs.12-10537.


Measurement of pulsatile total blood flow in the human and rat retina with ultrahigh speed spectral/Fourier domain OCT.

Choi W, Baumann B, Liu JJ, Clermont AC, Feener EP, Duker JS, Fujimoto JG.

Biomed Opt Express. 2012 May 1;3(5):1047-61. doi: 10.1364/BOE.3.001047. Epub 2012 Apr 19.


The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke.

Wu LJ, Wu G, Akhavan Sharif MR, Baker A, Jia Y, Fahey FH, Luo HR, Feener EP, Clapham DE.

Nat Neurosci. 2012 Mar 4;15(4):565-73. doi: 10.1038/nn.3059.


Deletion of thioredoxin-interacting protein in mice impairs mitochondrial function but protects the myocardium from ischemia-reperfusion injury.

Yoshioka J, Chutkow WA, Lee S, Kim JB, Yan J, Tian R, Lindsey ML, Feener EP, Seidman CE, Seidman JG, Lee RT.

J Clin Invest. 2012 Jan;122(1):267-79. doi: 10.1172/JCI44927. Epub 2011 Dec 27.


Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K).

Maeno Y, Li Q, Park K, Rask-Madsen C, Gao B, Matsumoto M, Liu Y, Wu IH, White MF, Feener EP, King GL.

J Biol Chem. 2012 Feb 10;287(7):4518-30. doi: 10.1074/jbc.M111.286591. Epub 2011 Dec 12.


mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression.

Ekim B, Magnuson B, Acosta-Jaquez HA, Keller JA, Feener EP, Fingar DC.

Mol Cell Biol. 2011 Jul;31(14):2787-801. doi: 10.1128/MCB.05437-11. Epub 2011 May 16.


Plasma kallikrein mediates retinal vascular dysfunction and induces retinal thickening in diabetic rats.

Clermont A, Chilcote TJ, Kita T, Liu J, Riva P, Sinha S, Feener EP.

Diabetes. 2011 May;60(5):1590-8. doi: 10.2337/db10-1260. Epub 2011 Mar 28.


Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein.

Liu J, Gao BB, Clermont AC, Blair P, Chilcote TJ, Sinha S, Flaumenhaft R, Feener EP.

Nat Med. 2011 Feb;17(2):206-10. doi: 10.1038/nm.2295. Epub 2011 Jan 23.


Proteomic identification of novel plasma kallikrein substrates in the astrocyte secretome.

Liu J, Gao BB, Feener EP.

Transl Stroke Res. 2010 Dec;1(4):276-86. doi: 10.1007/s12975-010-0039-z. Epub 2010 Aug 28.


Vitreous proteomics and diabetic retinopathy.

Walia S, Clermont AC, Gao BB, Aiello LP, Feener EP.

Semin Ophthalmol. 2010 Sep-Nov;25(5-6):289-94. doi: 10.3109/08820538.2010.518912. Review.


Plasma kallikrein and diabetic macular edema.

Feener EP.

Curr Diab Rep. 2010 Aug;10(4):270-5. doi: 10.1007/s11892-010-0127-1.


Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle.

Treebak JT, Taylor EB, Witczak CA, An D, Toyoda T, Koh HJ, Xie J, Feener EP, Wojtaszewski JF, Hirshman MF, Goodyear LJ.

Am J Physiol Cell Physiol. 2010 Feb;298(2):C377-85. doi: 10.1152/ajpcell.00297.2009. Epub 2009 Nov 18.


Angiotensin AT1 receptor antagonism ameliorates murine retinal proteome changes induced by diabetes.

Gao BB, Phipps JA, Bursell D, Clermont AC, Feener EP.

J Proteome Res. 2009 Dec;8(12):5541-9. doi: 10.1021/pr9006415.


Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth.

Acosta-Jaquez HA, Keller JA, Foster KG, Ekim B, Soliman GA, Feener EP, Ballif BA, Fingar DC.

Mol Cell Biol. 2009 Aug;29(15):4308-24. doi: 10.1128/MCB.01665-08. Epub 2009 Jun 1.


Regulation of Jak2 function by phosphorylation of Tyr317 and Tyr637 during cytokine signaling.

Robertson SA, Koleva RI, Argetsinger LS, Carter-Su C, Marto JA, Feener EP, Myers MG Jr.

Mol Cell Biol. 2009 Jun;29(12):3367-78. doi: 10.1128/MCB.00278-09. Epub 2009 Apr 13.


Plasma kallikrein mediates angiotensin II type 1 receptor-stimulated retinal vascular permeability.

Phipps JA, Clermont AC, Sinha S, Chilcote TJ, Bursell SE, Feener EP.

Hypertension. 2009 Feb;53(2):175-81. doi: 10.1161/HYPERTENSIONAHA.108.117663. Epub 2009 Jan 5.


Label-free quantitative analysis of one-dimensional PAGE LC/MS/MS proteome: application on angiotensin II-stimulated smooth muscle cells secretome.

Gao BB, Stuart L, Feener EP.

Mol Cell Proteomics. 2008 Dec;7(12):2399-409. doi: 10.1074/mcp.M800104-MCP200. Epub 2008 Aug 2.


Characterization of the vitreous proteome in diabetes without diabetic retinopathy and diabetes with proliferative diabetic retinopathy.

Gao BB, Chen X, Timothy N, Aiello LP, Feener EP.

J Proteome Res. 2008 Jun;7(6):2516-25. doi: 10.1021/pr800112g. Epub 2008 Apr 24.


Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle.

Taylor EB, An D, Kramer HF, Yu H, Fujii NL, Roeckl KS, Bowles N, Hirshman MF, Xie J, Feener EP, Goodyear LJ.

J Biol Chem. 2008 Apr 11;283(15):9787-96. doi: 10.1074/jbc.M708839200. Epub 2008 Feb 13.


The kallikrein-kinin system in diabetic retinopathy: lessons for the kidney.

Phipps JA, Feener EP.

Kidney Int. 2008 May;73(10):1114-9. doi: 10.1038/ki.2008.9. Epub 2008 Feb 13. Review.


Glypican 4, a membrane binding protein for bactericidal/permeability-increasing protein signaling pathways in retinal pigment epithelial cells.

Geraldes P, Yamagata M, Rook SL, Sassa Y, Ma RC, Clermont A, Gao B, Aiello LP, Feener EP, King GL.

Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5750-5.


JAK2 tyrosine kinase phosphorylates PAK1 and regulates PAK1 activity and functions.

Rider L, Shatrova A, Feener EP, Webb L, Diakonova M.

J Biol Chem. 2007 Oct 19;282(42):30985-96. Epub 2007 Aug 28.


Phosphorylation of Irs1 at SER-522 inhibits insulin signaling.

Giraud J, Haas M, Feener EP, Copps KD, Dong X, Dunn SL, White MF.

Mol Endocrinol. 2007 Sep;21(9):2294-302. Epub 2007 Jun 19.


Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation.

Gao BB, Clermont A, Rook S, Fonda SJ, Srinivasan VJ, Wojtkowski M, Fujimoto JG, Avery RL, Arrigg PG, Bursell SE, Aiello LP, Feener EP.

Nat Med. 2007 Feb;13(2):181-8. Epub 2007 Jan 28.


Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects.

Yamagata M, Rook SL, Sassa Y, Ma RC, Geraldes P, Goddard L, Clermont A, Gao B, Salti H, Gundel R, White M, Feener EP, Aiello LP, King GL.

FASEB J. 2006 Oct;20(12):2058-67.


Phosphorylation of Jak2 on Ser(523) inhibits Jak2-dependent leptin receptor signaling.

Ishida-Takahashi R, Rosario F, Gong Y, Kopp K, Stancheva Z, Chen X, Feener EP, Myers MG Jr.

Mol Cell Biol. 2006 Jun;26(11):4063-73. Erratum in: Mol Cell Biol. 2006 Aug;26(16):6309.


Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium.

He Z, Way KJ, Arikawa E, Chou E, Opland DM, Clermont A, Isshiki K, Ma RC, Scott JA, Schoen FJ, Feener EP, King GL.

J Biol Chem. 2005 Apr 22;280(16):15719-26. Epub 2005 Feb 7.


Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling.

Feener EP, Rosario F, Dunn SL, Stancheva Z, Myers MG Jr.

Mol Cell Biol. 2004 Jun;24(11):4968-78.

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