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Items: 1 to 50 of 216

1.

Perioperative Oxidative Stress: The Unseen Enemy.

Stevens JL, Feelisch M, Martin DS.

Anesth Analg. 2019 Dec;129(6):1749-1760. doi: 10.1213/ANE.0000000000004455.

PMID:
31743197
2.

Characterising nitric oxide-mediated metabolic benefits of low-dose ultraviolet radiation in the mouse: a focus on brown adipose tissue.

Dhamrait GK, Panchal K, Fleury NJ, Abel TN, Ancliffe MK, Crew RC, Croft K, Fernandez BO, Minnion M, Hart PH, Lucas RM, Mark PJ, Feelisch M, Weller RB, Matthews V, Gorman S.

Diabetologia. 2019 Nov 11. doi: 10.1007/s00125-019-05022-5. [Epub ahead of print]

PMID:
31713010
3.

Cephalosporin nitric oxide-donor prodrug DEA-C3D disperses biofilms formed by clinical cystic fibrosis isolates of Pseudomonas aeruginosa.

Soren O, Rineh A, Silva DG, Cai Y, Howlin RP, Allan RN, Feelisch M, Davies JC, Connett GJ, Faust SN, Kelso MJ, Webb JS.

J Antimicrob Chemother. 2019 Sep 17. pii: dkz378. doi: 10.1093/jac/dkz378. [Epub ahead of print]

PMID:
31682251
4.

Perioperative Oxidative Stress: The Unseen Enemy.

Stevens JL, Feelisch M, Martin DS.

Anesth Analg. 2019 Oct 9. doi: 10.1213/ANE.0000000000004455. [Epub ahead of print]

PMID:
31609255
5.

Effects of dietary nitrate supplementation on microvascular physiology at 4559 m altitude - A randomised controlled trial (Xtreme Alps).

Cumpstey AF, Hennis PJ, Gilbert-Kawai ET, Fernandez BO, Grant D, Jenner W, Poudevigne M, Moyses H, Levett DZ, Cobb A, Meale P, Mitchell K, Pöhnl H, Mythen MG, Grocott MP, Martin DS, Feelisch M.

Nitric Oxide. 2019 Oct 8;94:27-35. doi: 10.1016/j.niox.2019.10.004. [Epub ahead of print]

6.

Inorganic nitrate and nitrite supplementation fails to improve skeletal muscle mitochondrial efficiency in mice and humans.

Ntessalen M, Procter NE, Schwarz K, Loudon BL, Minnion M, Fernandez BO, Vassiliou VS, Vauzour D, Madhani M, Constantin-Teodosiu D, Horowitz JD, Feelisch M, Dawson D, Crichton PG, Frenneaux MP.

Am J Clin Nutr. 2019 Oct 10. pii: nqz245. doi: 10.1093/ajcn/nqz245. [Epub ahead of print]

PMID:
31599928
7.

The Redox architecture of physiological function.

Santolini J, Wootton SA, Jackson AA, Feelisch M.

Curr Opin Physiol. 2019 Jun;9:34-47. doi: 10.1016/j.cophys.2019.04.009. Review.

8.

Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides and oxidation of protein kinase G 1α redox signaling.

Feelisch M, Akaike T, Griffiths K, Ida T, Prysyahna O, Goodwin JJ, Gollop ND, Fernandez BO, Minnion M, Cortese-Krott MM, Borgognone A, Hayes RM, Eaton P, Frenneaux MP, Madhani M.

Cardiovasc Res. 2019 Jul 31. pii: cvz202. doi: 10.1093/cvr/cvz202. [Epub ahead of print]

PMID:
31372656
9.

Red Blood Cell-Derived Nitric Oxide Bioactivity and Hypoxic Vasodilation.

Schmidt HHHW, Feelisch M.

Circulation. 2019 Jun 4;139(23):2664-2667. doi: 10.1161/CIRCULATIONAHA.119.040423. Epub 2019 Jun 3. No abstract available.

PMID:
31157996
10.

Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome-results from a 6-month, double-blind, randomized controlled trial.

Curtis PJ, van der Velpen V, Berends L, Jennings A, Feelisch M, Umpleby AM, Evans M, Fernandez BO, Meiss MS, Minnion M, Potter J, Minihane AM, Kay CD, Rimm EB, Cassidy A.

Am J Clin Nutr. 2019 Jun 1;109(6):1535-1545. doi: 10.1093/ajcn/nqy380. Erratum in: Am J Clin Nutr. 2019 Nov 1;110(5):1262.

11.

Chemistry, pharmacology, and cellular uptake mechanisms of thiometallate sulfide donors.

Durham T, Zander D, Stomeo N, Minnion M, Hogarth G, Feelisch M, Singer M, Dyson A.

Br J Pharmacol. 2019 Mar 29. doi: 10.1111/bph.14670. [Epub ahead of print]

PMID:
30924528
12.

Rapid free thiol rebound is a physiological response following cold-induced vasoconstriction in healthy humans, primary Raynaud and systemic sclerosis.

Abdulle AE, van Roon AM, Smit AJ, Pasch A, van Meurs M, Bootsma H, Bakker SJL, Said MY, Fernandez BO, Feelisch M, van Goor H, Mulder DJ.

Physiol Rep. 2019 Mar;7(6):e14017. doi: 10.14814/phy2.14017.

13.

Serum free thiols in type 2 diabetes mellitus: A prospective study.

Schillern EEM, Pasch A, Feelisch M, Waanders F, Hendriks SH, Mencke R, Harms G, Groenier KH, Bilo HJG, Hillebrands JL, van Goor H, van Dijk PR.

J Clin Transl Endocrinol. 2019 Feb 28;16:100182. doi: 10.1016/j.jcte.2019.100182. eCollection 2019 Jun.

14.

Reactive Species Interactome Alterations in Oocyte Donation Pregnancies in the Absence and Presence of Pre-Eclampsia.

Bos M, Schoots MH, Fernandez BO, Mikus-Lelinska M, Lau LC, Eikmans M, van Goor H, Gordijn SJ, Pasch A, Feelisch M, van der Hoorn MP.

Int J Mol Sci. 2019 Mar 6;20(5). pii: E1150. doi: 10.3390/ijms20051150.

15.

Lower limb ischemic preconditioning combined with dietary nitrate supplementation does not influence time-trial performance in well-trained cyclists.

McIlvenna LC, Muggeridge DJ, Forrest Nee Whyte LJ, Monaghan C, Liddle L, Burleigh MC, Sculthorpe N, Fernandez BO, Feelisch M, Easton C.

J Sci Med Sport. 2019 Jul;22(7):852-857. doi: 10.1016/j.jsams.2019.01.011. Epub 2019 Jan 26.

PMID:
30745097
16.

Pushing arterial-venous plasma biomarkers to new heights: A model for personalised redox metabolomics?

Cumpstey AF, Minnion M, Fernandez BO, Mikus-Lelinska M, Mitchell K, Martin DS, Grocott MPW, Feelisch M; Xtreme Alps research group.

Redox Biol. 2019 Feb;21:101113. doi: 10.1016/j.redox.2019.101113. Epub 2019 Jan 22.

17.

Endogenous H2S production deficiencies lead to impaired renal erythropoietin production.

Leigh J, Juriasingani S, Akbari M, Shao P, Saha MN, Lobb I, Bachtler M, Fernandez B, Qian Z, van Goor H, Pasch A, Feelisch M, Wang R, Sener A.

Can Urol Assoc J. 2018 Nov 20:E210-E219. doi: 10.5489/cuaj.5658. [Epub ahead of print]

18.

A time for everything and everything in its time - exploring the mechanisms underlying seasonality of COPD exacerbations.

Hicks A, Healy E, Sandeman N, Feelisch M, Wilkinson T.

Int J Chron Obstruct Pulmon Dis. 2018 Sep 5;13:2739-2749. doi: 10.2147/COPD.S146015. eCollection 2018. Review.

19.

The Role of Oxidative Stress in the Development of Systemic Sclerosis Related Vasculopathy.

Abdulle AE, Diercks GFH, Feelisch M, Mulder DJ, van Goor H.

Front Physiol. 2018 Aug 24;9:1177. doi: 10.3389/fphys.2018.01177. eCollection 2018. Review.

20.

Nitrite mediated vasorelaxation in human chorionic plate vessels is enhanced by hypoxia and dependent on the NO-sGC-cGMP pathway.

Tropea T, Wareing M, Greenwood SL, Feelisch M, Sibley CP, Cottrell EC.

Nitric Oxide. 2018 Nov 1;80:82-88. doi: 10.1016/j.niox.2018.08.009. Epub 2018 Sep 1.

21.

Pharmacological preconditioning with inhaled nitric oxide (NO): Organ-specific differences in the lifetime of blood and tissue NO metabolites.

Nagasaka Y, Fernandez BO, Steinbicker AU, Spagnolli E, Malhotra R, Bloch DB, Bloch KD, Zapol WM, Feelisch M.

Nitric Oxide. 2018 Nov 1;80:52-60. doi: 10.1016/j.niox.2018.08.006. Epub 2018 Aug 13.

22.

Speciation of reactive sulfur species and their reactions with alkylating agents: do we have any clue about what is present inside the cell?

Bogdándi V, Ida T, Sutton TR, Bianco C, Ditrói T, Koster G, Henthorn HA, Minnion M, Toscano JP, van der Vliet A, Pluth MD, Feelisch M, Fukuto JM, Akaike T, Nagy P.

Br J Pharmacol. 2019 Feb;176(4):646-670. doi: 10.1111/bph.14394. Epub 2018 Aug 23.

PMID:
29909607
23.

Urinary Excretion of Sulfur Metabolites and Risk of Cardiovascular Events and All-Cause Mortality in the General Population.

van den Born JC, Frenay AS, Koning AM, Bachtler M, Riphagen IJ, Minovíc I, Feelisch M, Dekker MM, Bulthuis MLC, Gansevoort RT, Hillebrands JL, Pasch A, Bakker SJL, van Goor H.

Antioxid Redox Signal. 2019 Jun 10;30(17):1999-2010. doi: 10.1089/ars.2017.7040. Epub 2018 Jul 25.

PMID:
29905081
24.

On the Effects of Reactive Oxygen Species and Nitric Oxide on Red Blood Cell Deformability.

Diederich L, Suvorava T, Sansone R, Keller TCS 4th, Barbarino F, Sutton TR, Kramer CM, Lückstädt W, Isakson BE, Gohlke H, Feelisch M, Kelm M, Cortese-Krott MM.

Front Physiol. 2018 May 11;9:332. doi: 10.3389/fphys.2018.00332. eCollection 2018.

25.

Nrf2 Deficiency Unmasks the Significance of Nitric Oxide Synthase Activity for Cardioprotection.

Erkens R, Suvorava T, Sutton TR, Fernandez BO, Mikus-Lelinska M, Barbarino F, Flögel U, Kelm M, Feelisch M, Cortese-Krott MM.

Oxid Med Cell Longev. 2018 Apr 30;2018:8309698. doi: 10.1155/2018/8309698. eCollection 2018.

26.

Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology.

Fukuto JM, Ignarro LJ, Nagy P, Wink DA, Kevil CG, Feelisch M, Cortese-Krott MM, Bianco CL, Kumagai Y, Hobbs AJ, Lin J, Ida T, Akaike T.

FEBS Lett. 2018 Jun;592(12):2140-2152. doi: 10.1002/1873-3468.13090. Epub 2018 May 24. Review.

27.

Metabolic adjustment to high-altitude hypoxia: from genetic signals to physiological implications.

Murray AJ, Montgomery HE, Feelisch M, Grocott MPW, Martin DS.

Biochem Soc Trans. 2018 Jun 19;46(3):599-607. doi: 10.1042/BST20170502. Epub 2018 Apr 20. Review.

PMID:
29678953
28.

Nitrite circumvents platelet resistance to nitric oxide in patients with heart failure preserved ejection fraction and chronic atrial fibrillation.

Borgognone A, Shantsila E, Worrall SM, Prompunt E, Loka T, Loudon BL, Chimen M, Ed Rainger G, Lord JM, Turner A, Nightingale P, Feelisch M, Kirchhof P, Lip GYH, Watson SP, Frenneaux MP, Madhani M.

Cardiovasc Res. 2018 Aug 1;114(10):1313-1323. doi: 10.1093/cvr/cvy087.

29.

A robust and versatile mass spectrometry platform for comprehensive assessment of the thiol redox metabolome.

Sutton TR, Minnion M, Barbarino F, Koster G, Fernandez BO, Cumpstey AF, Wischmann P, Madhani M, Frenneaux MP, Postle AD, Cortese-Krott MM, Feelisch M.

Redox Biol. 2018 Jun;16:359-380. doi: 10.1016/j.redox.2018.02.012. Epub 2018 Feb 19.

30.

The effects of two different doses of ultraviolet-A light exposure on nitric oxide metabolites and cardiorespiratory outcomes.

Monaghan C, McIlvenna LC, Liddle L, Burleigh M, Weller RB, Fernandez BO, Feelisch M, Muggeridge DJ, Easton C.

Eur J Appl Physiol. 2018 May;118(5):1043-1052. doi: 10.1007/s00421-018-3835-x. Epub 2018 Mar 7.

31.

Investigations on the role of hemoglobin in sulfide metabolism by intact human red blood cells.

Bianco CL, Savitsky A, Feelisch M, Cortese-Krott MM.

Biochem Pharmacol. 2018 Mar;149:163-173. doi: 10.1016/j.bcp.2018.01.045. Epub 2018 Jan 31.

32.

Metabolism of hydrogen sulfide (H2S) and Production of Reactive Sulfur Species (RSS) by superoxide dismutase.

Olson KR, Gao Y, Arif F, Arora K, Patel S, DeLeon ER, Sutton TR, Feelisch M, Cortese-Krott MM, Straub KD.

Redox Biol. 2018 May;15:74-85. doi: 10.1016/j.redox.2017.11.009. Epub 2017 Nov 20.

33.

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.

Akaike T, Ida T, Wei FY, Nishida M, Kumagai Y, Alam MM, Ihara H, Sawa T, Matsunaga T, Kasamatsu S, Nishimura A, Morita M, Tomizawa K, Nishimura A, Watanabe S, Inaba K, Shima H, Tanuma N, Jung M, Fujii S, Watanabe Y, Ohmuraya M, Nagy P, Feelisch M, Fukuto JM, Motohashi H.

Nat Commun. 2017 Oct 27;8(1):1177. doi: 10.1038/s41467-017-01311-y.

34.

Effects of dietary nitrate on respiratory physiology at high altitude - Results from the Xtreme Alps study.

Cumpstey AF, Hennis PJ, Gilbert-Kawai ET, Fernandez BO, Poudevigne M, Cobb A, Meale P, Mitchell K, Moyses H, Pöhnl H, Mythen MG, Grocott MPW, Feelisch M, Martin DS; Xtreme Alps research group.

Nitric Oxide. 2017 Dec 1;71:57-68. doi: 10.1016/j.niox.2017.10.005. Epub 2017 Oct 16.

35.

Identification of a soluble guanylate cyclase in RBCs: preserved activity in patients with coronary artery disease.

Cortese-Krott MM, Mergia E, Kramer CM, Lückstädt W, Yang J, Wolff G, Panknin C, Bracht T, Sitek B, Pernow J, Stasch JP, Feelisch M, Koesling D, Kelm M.

Redox Biol. 2018 Apr;14:328-337. doi: 10.1016/j.redox.2017.08.020. Epub 2017 Sep 8.

36.

Inorganic Nitrate in Angina Study: A Randomized Double-Blind Placebo-Controlled Trial.

Schwarz K, Singh S, Parasuraman SK, Rudd A, Shepstone L, Feelisch M, Minnion M, Ahmad S, Madhani M, Horowitz J, Dawson DK, Frenneaux MP.

J Am Heart Assoc. 2017 Sep 8;6(9). pii: e006478. doi: 10.1161/JAHA.117.006478.

37.

Hydrogen sulfide attenuates calcification of vascular smooth muscle cells via KEAP1/NRF2/NQO1 activation.

Aghagolzadeh P, Radpour R, Bachtler M, van Goor H, Smith ER, Lister A, Odermatt A, Feelisch M, Pasch A.

Atherosclerosis. 2017 Oct;265:78-86. doi: 10.1016/j.atherosclerosis.2017.08.012. Epub 2017 Aug 19.

PMID:
28865326
38.

Low-Dose Nitric Oxide as Targeted Anti-biofilm Adjunctive Therapy to Treat Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis.

Howlin RP, Cathie K, Hall-Stoodley L, Cornelius V, Duignan C, Allan RN, Fernandez BO, Barraud N, Bruce KD, Jefferies J, Kelso M, Kjelleberg S, Rice SA, Rogers GB, Pink S, Smith C, Sukhtankar PS, Salib R, Legg J, Carroll M, Daniels T, Feelisch M, Stoodley P, Clarke SC, Connett G, Faust SN, Webb JS.

Mol Ther. 2017 Sep 6;25(9):2104-2116. doi: 10.1016/j.ymthe.2017.06.021. Epub 2017 Jul 24.

39.

Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models.

Dyson A, Dal-Pizzol F, Sabbatini G, Lach AB, Galfo F, Dos Santos Cardoso J, Pescador Mendonça B, Hargreaves I, Bollen Pinto B, Bromage DI, Martin JF, Moore KP, Feelisch M, Singer M.

PLoS Med. 2017 Jul 5;14(7):e1002310. doi: 10.1371/journal.pmed.1002310. eCollection 2017 Jul.

40.

Sulfate, nitrate and blood pressure - An EPIC interaction between sulfur and nitrogen.

Kuhnle GG, Luben R, Khaw KT, Feelisch M.

Pharmacol Res. 2017 Aug;122:127-129. doi: 10.1016/j.phrs.2017.06.006. Epub 2017 Jun 10. Review.

41.

Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition.

Wandrag L, Siervo M, Riley HL, Khosravi M, Fernandez BO, Leckstrom CA, Martin DS, Mitchell K, Levett DZH, Montgomery HE, Mythen MG, Stroud MA, Grocott MPW, Feelisch M; Caudwell Xtreme Everest Research Group.

Redox Biol. 2017 Oct;13:60-68. doi: 10.1016/j.redox.2017.05.004. Epub 2017 May 8.

42.

Metabolic basis to Sherpa altitude adaptation.

Horscroft JA, Kotwica AO, Laner V, West JA, Hennis PJ, Levett DZH, Howard DJ, Fernandez BO, Burgess SL, Ament Z, Gilbert-Kawai ET, Vercueil A, Landis BD, Mitchell K, Mythen MG, Branco C, Johnson RS, Feelisch M, Montgomery HE, Griffin JL, Grocott MPW, Gnaiger E, Martin DS, Murray AJ.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6382-6387. doi: 10.1073/pnas.1700527114. Epub 2017 May 22.

43.

Low plasma homoarginine concentration is associated with high rates of all-cause mortality in renal transplant recipients.

Kayacelebi AA, Minović I, Hanff E, Frenay AS, de Borst MH, Feelisch M, van Goor H, Bakker SJL, Tsikas D.

Amino Acids. 2017 Jul;49(7):1193-1202. doi: 10.1007/s00726-017-2420-7. Epub 2017 Apr 20.

PMID:
28429125
44.

The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine.

Cortese-Krott MM, Koning A, Kuhnle GGC, Nagy P, Bianco CL, Pasch A, Wink DA, Fukuto JM, Jackson AA, van Goor H, Olson KR, Feelisch M.

Antioxid Redox Signal. 2017 Oct 1;27(10):684-712. doi: 10.1089/ars.2017.7083. Epub 2017 Jun 6. Review.

45.

Changes in acute pulmonary vascular responsiveness to hypoxia during a progressive ascent to high altitude (5300 m).

Luks AM, Levett D, Martin DS, Goss CH, Mitchell K, Fernandez BO, Feelisch M, Grocott MP, Swenson ER; Caudwell Xtreme Everest Investigators.

Exp Physiol. 2017 Jun 1;102(6):711-724. doi: 10.1113/EP086083. Epub 2017 May 21.

46.

Human Second Window Pre-Conditioning and Post-Conditioning by Nitrite Is Influenced by a Common Polymorphism in Mitochondrial Aldehyde Dehydrogenase.

Ormerod JO, Evans JD, Contractor H, Beretta M, Arif S, Fernandez BO, Feelisch M, Mayer B, Kharbanda RK, Frenneaux MP, Ashrafian H.

JACC Basic Transl Sci. 2017 Feb 15;2(1):13-21. doi: 10.1016/j.jacbts.2016.11.006. eCollection 2017 Feb.

47.

Cephalosporin-NO-donor prodrug PYRRO-C3D shows β-lactam-mediated activity against Streptococcus pneumoniae biofilms.

Allan RN, Kelso MJ, Rineh A, Yepuri NR, Feelisch M, Soren O, Brito-Mutunayagam S, Salib RJ, Stoodley P, Clarke SC, Webb JS, Hall-Stoodley L, Faust SN.

Nitric Oxide. 2017 May 1;65:43-49. doi: 10.1016/j.niox.2017.02.006. Epub 2017 Feb 21.

PMID:
28235635
48.

Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGF-β1.

Lee ES, Boldo LS, Fernandez BO, Feelisch M, Harmsen MC.

Sci Rep. 2017 Feb 17;7:42487. doi: 10.1038/srep42487.

49.

Sub-erythemal ultraviolet radiation reduces metabolic dysfunction in already overweight mice.

Fleury N, Feelisch M, Hart PH, Weller RB, Smoothy J, Matthews VB, Gorman S.

J Endocrinol. 2017 Apr;233(1):81-92. doi: 10.1530/JOE-16-0616. Epub 2017 Feb 2.

PMID:
28154004
50.

Sublingual microcirculatory blood flow and vessel density in Sherpas at high altitude.

Gilbert-Kawai E, Coppel J, Court J, van der Kaaij J, Vercueil A, Feelisch M, Levett D, Mythen M, Grocott MP, Martin D; Xtreme Everest 2 Research Group.

J Appl Physiol (1985). 2017 Apr 1;122(4):1011-1018. doi: 10.1152/japplphysiol.00970.2016. Epub 2017 Jan 26.

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