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Items: 1 to 50 of 158

1.

The IKs ion channel activator, mefenamic acid, requires KCNE1 and modulates channel gating in a subunit-dependent manner.

Wang Y, Eldstrom J, Fedida D.

Mol Pharmacol. 2019 Nov 13. pii: mol.119.117952. doi: 10.1124/mol.119.117952. [Epub ahead of print]

2.

I Ks ion-channel pore conductance can result from individual voltage sensor movements.

Westhoff M, Eldstrom J, Murray CI, Thompson E, Fedida D.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7879-7888. doi: 10.1073/pnas.1811623116. Epub 2019 Mar 27.

3.

The IKs Channel Response to cAMP Is Modulated by the KCNE1:KCNQ1 Stoichiometry.

Thompson E, Eldstrom J, Westhoff M, McAfee D, Fedida D.

Biophys J. 2018 Nov 6;115(9):1731-1740. doi: 10.1016/j.bpj.2018.09.018. Epub 2018 Sep 27.

4.

Single channel kinetic analysis of the cAMP effect on IKs mutants, S209F and S27D/S92D.

Thompson E, Eldstrom J, Fedida D.

Channels (Austin). 2018;12(1):276-283. doi: 10.1080/19336950.2018.1499369.

PMID:
30027808
5.

Modeling the Hidden Pathways of IKs Channel Activation.

Fedida D.

Biophys J. 2018 Jul 3;115(1):1-2. doi: 10.1016/j.bpj.2018.05.020. No abstract available.

6.

Probing the molecular basis of hERG drug block with unnatural amino acids.

Macdonald LC, Kim RY, Kurata HT, Fedida D.

Sci Rep. 2018 Jan 10;8(1):289. doi: 10.1038/s41598-017-18448-x.

7.

Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening.

Hou P, Eldstrom J, Shi J, Zhong L, McFarland K, Gao Y, Fedida D, Cui J.

Nat Commun. 2017 Nov 23;8(1):1730. doi: 10.1038/s41467-017-01911-8.

8.

The Fast Component of hERG Gating Charge: An Interaction between D411 in the S1 and S4 Residues.

Dou Y, Macdonald LC, Wu Y, Fedida D.

Biophys J. 2017 Nov 7;113(9):1979-1991. doi: 10.1016/j.bpj.2017.09.004.

9.

Photo-Cross-Linking of IKs Demonstrates State-Dependent Interactions between KCNE1 and KCNQ1.

Westhoff M, Murray CI, Eldstrom J, Fedida D.

Biophys J. 2017 Jul 25;113(2):415-425. doi: 10.1016/j.bpj.2017.06.005.

10.

cAMP-dependent regulation of IKs single-channel kinetics.

Thompson E, Eldstrom J, Westhoff M, McAfee D, Balse E, Fedida D.

J Gen Physiol. 2017 Aug 7;149(8):781-798. doi: 10.1085/jgp.201611734. Epub 2017 Jul 7.

11.

Binding and Proton Blockage by Amantadine Variants of the Influenza M2WT and M2S31N Explained.

Tzitzoglaki C, Wright A, Freudenberger K, Hoffmann A, Tietjen I, Stylianakis I, Kolarov F, Fedida D, Schmidtke M, Gauglitz G, Cross TA, Kolocouris A.

J Med Chem. 2017 Mar 9;60(5):1716-1733. doi: 10.1021/acs.jmedchem.6b01115. Epub 2017 Feb 15.

PMID:
28107633
12.

Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase.

Bround MJ, Wambolt R, Cen H, Asghari P, Albu RF, Han J, McAfee D, Pourrier M, Scott NE, Bohunek L, Kulpa JE, Chen SR, Fedida D, Brownsey RW, Borchers CH, Foster LJ, Mayor T, Moore ED, Allard MF, Johnson JD.

J Biol Chem. 2016 Nov 4;291(45):23490-23505. Epub 2016 Sep 12.

13.

Novel Acylguanidine-Based Inhibitor of HIV-1.

Mwimanzi P, Tietjen I, Miller SC, Shahid A, Cobarrubias K, Kinloch NN, Baraki B, Richard J, Finzi A, Fedida D, Brumme ZL, Brockman MA.

J Virol. 2016 Sep 29;90(20):9495-508. doi: 10.1128/JVI.01107-16. Print 2016 Oct 15.

14.

hERG long QT syndrome type 2 mutants need more than a chaperone to dance.

Fedida D, Macdonald L.

J Physiol. 2016 Aug 1;594(15):4095-6. doi: 10.1113/JP272417. No abstract available.

15.

Croton megalobotrys Müll Arg. and Vitex doniana (Sweet): Traditional medicinal plants in a three-step treatment regimen that inhibit in vitro replication of HIV-1.

Tietjen I, Gatonye T, Ngwenya BN, Namushe A, Simonambanga S, Muzila M, Mwimanzi P, Xiao J, Fedida D, Brumme ZL, Brockman MA, Andrae-Marobela K.

J Ethnopharmacol. 2016 Sep 15;191:331-340. doi: 10.1016/j.jep.2016.06.040. Epub 2016 Jun 24.

PMID:
27350006
16.

Mechanisms of Action of Novel Influenza A/M2 Viroporin Inhibitors Derived from Hexamethylene Amiloride.

Jalily PH, Eldstrom J, Miller SC, Kwan DC, Tai SS, Chou D, Niikura M, Tietjen I, Fedida D.

Mol Pharmacol. 2016 Aug;90(2):80-95. doi: 10.1124/mol.115.102731. Epub 2016 May 18.

PMID:
27193582
17.

AMP-activated protein kinase inhibits Kv 1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation.

Moral-Sanz J, Mahmoud AD, Ross FA, Eldstrom J, Fedida D, Hardie DG, Evans AM.

J Physiol. 2016 Sep 1;594(17):4901-15. doi: 10.1113/JP272032. Epub 2016 Jun 30.

18.

Office hysteroscopy: A report of 2402 cases.

Capmas P, Pourcelot AG, Giral E, Fedida D, Fernandez H.

J Gynecol Obstet Biol Reprod (Paris). 2016 May;45(5):445-50. doi: 10.1016/j.jgyn.2016.02.007. Epub 2016 Apr 4.

19.

Unnatural amino acid photo-crosslinking of the IKs channel complex demonstrates a KCNE1:KCNQ1 stoichiometry of up to 4:4.

Murray CI, Westhoff M, Eldstrom J, Thompson E, Emes R, Fedida D.

Elife. 2016 Jan 23;5. pii: e11815. doi: 10.7554/eLife.11815.

20.

De Novo Mutation in the SCN5A Gene Associated with Brugada Syndrome.

Wang L, Meng X, Yuchi Z, Zhao Z, Xu D, Fedida D, Wang Z, Huang C.

Cell Physiol Biochem. 2015;36(6):2250-62. doi: 10.1159/000430189. Epub 2015 Jul 24.

21.

Screening of the Pan-African natural product library identifies ixoratannin A-2 and boldine as novel HIV-1 inhibitors.

Tietjen I, Ntie-Kang F, Mwimanzi P, Onguéné PA, Scull MA, Idowu TO, Ogundaini AO, Meva'a LM, Abegaz BM, Rice CM, Andrae-Marobela K, Brockman MA, Brumme ZL, Fedida D.

PLoS One. 2015 Apr 1;10(4):e0121099. doi: 10.1371/journal.pone.0121099. eCollection 2015.

22.

Sequence of gating charge movement and pore gating in HERG activation and deactivation pathways.

Goodchild SJ, Macdonald LC, Fedida D.

Biophys J. 2015 Mar 24;108(6):1435-1447. doi: 10.1016/j.bpj.2015.02.014.

23.

Microscopic mechanisms for long QT syndrome type 1 revealed by single-channel analysis of I(Ks) with S3 domain mutations in KCNQ1.

Eldstrom J, Wang Z, Werry D, Wong N, Fedida D.

Heart Rhythm. 2015 Feb;12(2):386-94. doi: 10.1016/j.hrthm.2014.10.029. Epub 2014 Oct 29.

PMID:
25444851
24.

Aminoadamantanes with persistent in vitro efficacy against H1N1 (2009) influenza A.

Kolocouris A, Tzitzoglaki C, Johnson FB, Zell R, Wright AK, Cross TA, Tietjen I, Fedida D, Busath DD.

J Med Chem. 2014 Jun 12;57(11):4629-39. doi: 10.1021/jm500598u. Epub 2014 May 15.

25.

Rebuttal from Marc Pourrier, Sarah Williams, Donald McAfee, Luiz Belardinelli and David Fedida.

Pourrier M, Williams S, McAfee D, Belardinelli L, Fedida D.

J Physiol. 2014 Feb 1;592(3):419. doi: 10.1113/jphysiol.2013.268896. No abstract available.

26.

CrossTalk proposal: The late sodium current is an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction).

Pourrier M, Williams S, McAfee D, Belardinelli L, Fedida D.

J Physiol. 2014 Feb 1;592(3):411-4. doi: 10.1113/jphysiol.2013.262261. No abstract available.

27.

Ranolazine improves diastolic function in spontaneously hypertensive rats.

Williams S, Pourrier M, McAfee D, Lin S, Fedida D.

Am J Physiol Heart Circ Physiol. 2014 Mar;306(6):H867-81. doi: 10.1152/ajpheart.00704.2013. Epub 2014 Jan 24.

28.

Allosteric coupling of the inner activation gate to the outer pore of a potassium channel.

Peters CJ, Fedida D, Accili EA.

Sci Rep. 2013 Oct 23;3:3025. doi: 10.1038/srep03025.

29.

Gating charge movement precedes ionic current activation in hERG channels.

Goodchild SJ, Fedida D.

Channels (Austin). 2014;8(1):84-9. doi: 10.4161/chan.26775. Epub 2013 Oct 14.

30.

The neutral, hydrophobic isoleucine at position I521 in the extracellular S4 domain of hERG contributes to channel gating equilibrium.

Dou Y, Goodchild SJ, Velde RV, Wu Y, Fedida D.

Am J Physiol Cell Physiol. 2013 Aug 15;305(4):C468-78. doi: 10.1152/ajpcell.00147.2013. Epub 2013 Jun 12.

31.

ShakerIR and Kv1.5 mutant channels with enhanced slow inactivation also exhibit K⁺ o-dependent resting inactivation.

Cheng YM, Fedida D, Kehl SJ.

Pflugers Arch. 2013 Nov;465(11):1545-55. doi: 10.1007/s00424-013-1297-x. Epub 2013 May 26.

PMID:
23708835
32.

Cytoskeletal roles in cardiac ion channel expression.

Steele DF, Fedida D.

Biochim Biophys Acta. 2014 Feb;1838(2):665-73. doi: 10.1016/j.bbamem.2013.05.001. Epub 2013 May 13. Review.

33.

Components of gating charge movement and S4 voltage-sensor exposure during activation of hERG channels.

Wang Z, Dou Y, Goodchild SJ, Es-Salah-Lamoureux Z, Fedida D.

J Gen Physiol. 2013 Apr;141(4):431-43. doi: 10.1085/jgp.201210942. Epub 2013 Mar 11.

34.

Single-channel basis for the slow activation of the repolarizing cardiac potassium current, I(Ks).

Werry D, Eldstrom J, Wang Z, Fedida D.

Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):E996-1005. doi: 10.1073/pnas.1214875110. Epub 2013 Feb 19.

35.

The new antiarrhythmic drug vernakalant: ex vivo study of human atrial tissue from sinus rhythm and chronic atrial fibrillation.

Wettwer E, Christ T, Endig S, Rozmaritsa N, Matschke K, Lynch JJ, Pourrier M, Gibson JK, Fedida D, Knaut M, Ravens U.

Cardiovasc Res. 2013 Apr 1;98(1):145-54. doi: 10.1093/cvr/cvt006. Epub 2013 Jan 22.

PMID:
23341576
36.

External Ba(2+) block of Kv4.2 channels is enhanced in the closed-inactivated state.

Kehl SJ, Fedida D, Wang Z.

Am J Physiol Cell Physiol. 2013 Feb 15;304(4):C370-81. doi: 10.1152/ajpcell.00267.2012. Epub 2012 Dec 12.

37.

Biolistic transfection of freshly isolated adult ventricular myocytes.

Steele DF, Dou Y, Fedida D.

Methods Mol Biol. 2013;940:145-55. doi: 10.1007/978-1-62703-110-3_12.

PMID:
23104340
38.

Basis for allosteric open-state stabilization of voltage-gated potassium channels by intracellular cations.

Goodchild SJ, Xu H, Es-Salah-Lamoureux Z, Ahern CA, Fedida D.

J Gen Physiol. 2012 Nov;140(5):495-511. doi: 10.1085/jgp.201210823. Epub 2012 Oct 15.

39.

Dual effect of phosphatidylinositol (4,5)-bisphosphate PIP(2) on Shaker K(+) [corrected] channels.

Abderemane-Ali F, Es-Salah-Lamoureux Z, Delemotte L, Kasimova MA, Labro AJ, Snyders DJ, Fedida D, Tarek M, Baró I, Loussouarn G.

J Biol Chem. 2012 Oct 19;287(43):36158-67. doi: 10.1074/jbc.M112.382085. Epub 2012 Aug 29. Erratum in: J Biol Chem. 2013 Apr 12;288(15):10951.

40.

Trafficking of an endogenous potassium channel in adult ventricular myocytes.

Wang T, Cheng Y, Dou Y, Goonesekara C, David JP, Steele DF, Huang C, Fedida D.

Am J Physiol Cell Physiol. 2012 Nov 1;303(9):C963-76. doi: 10.1152/ajpcell.00217.2012. Epub 2012 Aug 22.

41.

Dynamic of ion channel expression at the plasma membrane of cardiomyocytes.

Balse E, Steele DF, Abriel H, Coulombe A, Fedida D, Hatem SN.

Physiol Rev. 2012 Jul;92(3):1317-58. doi: 10.1152/physrev.00041.2011. Review.

42.

Contributions of intracellular ions to kv channel voltage sensor dynamics.

Goodchild SJ, Fedida D.

Front Pharmacol. 2012 Jun 18;3:114. doi: 10.3389/fphar.2012.00114. eCollection 2012.

43.

Golgi export signal ties proper folding to AP1 binding.

Steele DF, Fedida D.

Circ Res. 2012 Mar 16;110(6):802-4. doi: 10.1161/RES.0b013e318250158b. No abstract available.

PMID:
22427322
44.

The voltage-gated channel accessory protein KCNE2: multiple ion channel partners, multiple ways to long QT syndrome.

Eldstrom J, Fedida D.

Expert Rev Mol Med. 2011 Dec 14;13:e38. doi: 10.1017/S1462399411002092. Review.

PMID:
22166675
45.

Mechanism of accelerated current decay caused by an episodic ataxia type-1-associated mutant in a potassium channel pore.

Peters CJ, Werry D, Gill HS, Accili EA, Fedida D.

J Neurosci. 2011 Nov 30;31(48):17449-59. doi: 10.1523/JNEUROSCI.2940-11.2011.

46.

The Ca(v)1.4 calcium channel is a critical regulator of T cell receptor signaling and naive T cell homeostasis.

Omilusik K, Priatel JJ, Chen X, Wang YT, Xu H, Choi KB, Gopaul R, McIntyre-Smith A, Teh HS, Tan R, Bech-Hansen NT, Waterfield D, Fedida D, Hunt SV, Jefferies WA.

Immunity. 2011 Sep 23;35(3):349-60. doi: 10.1016/j.immuni.2011.07.011. Epub 2011 Aug 11.

47.

Blockade of permeation by potassium but normal gating of the G628S nonconducting hERG channel mutant.

Es-Salah-Lamoureux Z, Xiong PY, Goodchild SJ, Ahern CA, Fedida D.

Biophys J. 2011 Aug 3;101(3):662-70. doi: 10.1016/j.bpj.2011.06.028.

48.

Functional characterization of the LQT2-causing mutation R582C and the associated voltage-dependent fluorescence signal.

Fougere RR, Es-Salah-Lamoureux Z, Rezazadeh S, Eldstrom J, Fedida D.

Heart Rhythm. 2011 Aug;8(8):1273-80. doi: 10.1016/j.hrthm.2011.02.035. Epub 2011 Mar 3.

PMID:
21376840
49.

A novel mechanism for LQT3 with 2:1 block: a pore-lining mutation in Nav1.5 significantly affects voltage-dependence of activation.

Horne AJ, Eldstrom J, Sanatani S, Fedida D.

Heart Rhythm. 2011 May;8(5):770-7. doi: 10.1016/j.hrthm.2010.12.041. Epub 2010 Dec 27.

PMID:
21193062
50.

Research into the therapeutic roles of two-pore-domain potassium channels.

Es-Salah-Lamoureux Z, Steele DF, Fedida D.

Trends Pharmacol Sci. 2010 Dec;31(12):587-95. doi: 10.1016/j.tips.2010.09.001. Epub 2010 Oct 15. Review.

PMID:
20951446

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