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Items: 1 to 50 of 121

1.

The novel phosphodiesterase 9A inhibitor BI 409306 increases cyclic guanosine monophosphate levels in the brain, promotes synaptic plasticity and enhances memory function in rodents.

Rosenbrock H, Giovannini R, Koros E, Runge F, Fuchs H, Marti A, Reymann KG, Schroeder UH, Fedele E, Dorner-Ciossek C.

J Pharmacol Exp Ther. 2019 Oct 2. pii: jpet.119.260059. doi: 10.1124/jpet.119.260059. [Epub ahead of print]

2.

Assessment of seasonal variation of diet composition in rodents using DNA barcoding and Real-Time PCR.

Dell'Agnello F, Natali C, Bertolino S, Fattorini L, Fedele E, Foggi B, Martini M, Pisani C, Riga F, Sgarlata A, Ciofi C, Zaccaroni M.

Sci Rep. 2019 Oct 1;9(1):14124. doi: 10.1038/s41598-019-50676-1.

3.

The strange case of congenital mitral stenosis in an adult man with cor triatriatum.

Burzo ML, De Matteis G, Nicolazzi MA, Fedele E, Della Polla DA, Pennestrì F, Favuzzi AMR.

Echocardiography. 2019 Oct 1. doi: 10.1111/echo.14497. [Epub ahead of print]

PMID:
31573705
4.

Enhanced Function and Overexpression of Metabotropic Glutamate Receptors 1 and 5 in the Spinal Cord of the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis during Disease Progression.

Bonifacino T, Rebosio C, Provenzano F, Torazza C, Balbi M, Milanese M, Raiteri L, Usai C, Fedele E, Bonanno G.

Int J Mol Sci. 2019 Sep 13;20(18). pii: E4552. doi: 10.3390/ijms20184552.

5.

Antagonizing α7 nicotinic receptors with methyllycaconitine (MLA) potentiates receptor activity and memory acquisition.

van Goethem NP, Paes D, Puzzo D, Fedele E, Rebosio C, Gulisano W, Palmeri A, Wennogle LP, Peng Y, Bertrand D, Prickaerts J.

Cell Signal. 2019 Oct;62:109338. doi: 10.1016/j.cellsig.2019.06.003. Epub 2019 Jun 5.

6.

Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites.

Marte A, Russo I, Rebosio C, Valente P, Belluzzi E, Pischedda F, Montani C, Lavarello C, Petretto A, Fedele E, Baldelli P, Benfenati F, Piccoli G, Greggio E, Onofri F.

J Neurochem. 2019 Aug;150(3):264-281. doi: 10.1111/jnc.14778. Epub 2019 Jul 10.

PMID:
31148170
7.

cAMP, cGMP and Amyloid β: Three Ideal Partners for Memory Formation.

Ricciarelli R, Fedele E.

Trends Neurosci. 2018 May;41(5):255-266. doi: 10.1016/j.tins.2018.02.001. Epub 2018 Feb 28. Review.

PMID:
29501262
8.

Presynaptic GLP-1 receptors enhance the depolarization-evoked release of glutamate and GABA in the mouse cortex and hippocampus.

Rebosio C, Balbi M, Passalacqua M, Ricciarelli R, Fedele E.

Biofactors. 2018 Mar;44(2):148-157. doi: 10.1002/biof.1406. Epub 2017 Dec 19.

PMID:
29265673
9.

Investigating the amyloid-beta enhancing effect of cGMP in neuro2a cells.

Calcagno E, Caudano F, Passalacqua M, Pronzato MA, Fedele E, Ricciarelli R.

Mech Ageing Dev. 2017 Sep;166:1-5. doi: 10.1016/j.mad.2017.08.001. Epub 2017 Aug 5.

PMID:
28789837
10.

Amyloid-β Peptide Is Needed for cGMP-Induced Long-Term Potentiation and Memory.

Palmeri A, Ricciarelli R, Gulisano W, Rivera D, Rebosio C, Calcagno E, Tropea MR, Conti S, Das U, Roy S, Pronzato MA, Arancio O, Fedele E, Puzzo D.

J Neurosci. 2017 Jul 19;37(29):6926-6937. doi: 10.1523/JNEUROSCI.3607-16.2017. Epub 2017 Jun 16.

11.

Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer's disease.

Ricciarelli R, Brullo C, Prickaerts J, Arancio O, Villa C, Rebosio C, Calcagno E, Balbi M, van Hagen BT, Argyrousi EK, Zhang H, Pronzato MA, Bruno O, Fedele E.

Sci Rep. 2017 Apr 12;7:46320. doi: 10.1038/srep46320.

12.

Subthalamic nucleus deep brain stimulation on motor-symptoms of Parkinson's disease: Focus on neurochemistry.

Stefani A, Trendafilov V, Liguori C, Fedele E, Galati S.

Prog Neurobiol. 2017 Apr;151:157-174. doi: 10.1016/j.pneurobio.2017.01.003. Epub 2017 Jan 31. Review.

PMID:
28159574
13.

Homovanillic acid in CSF of mild stage Parkinson's disease patients correlates with motor impairment.

Stefani A, Pierantozzi M, Olivola E, Galati S, Cerroni R, D'Angelo V, Hainsworth AH, Saviozzi V, Fedele E, Liguori C.

Neurochem Int. 2017 May;105:58-63. doi: 10.1016/j.neuint.2017.01.007. Epub 2017 Jan 18.

PMID:
28108196
14.

The Amyloid Cascade Hypothesis in Alzheimer's Disease: It's Time to Change Our Mind.

Ricciarelli R, Fedele E.

Curr Neuropharmacol. 2017;15(6):926-935. doi: 10.2174/1570159X15666170116143743. Review.

15.

Altered fronto-striatal functions in the Gdi1-null mouse model of X-linked Intellectual Disability.

Morè L, Künnecke B, Yekhlef L, Bruns A, Marte A, Fedele E, Bianchi V, Taverna S, Gatti S, D'Adamo P.

Neuroscience. 2017 Mar 6;344:346-359. doi: 10.1016/j.neuroscience.2016.12.043. Epub 2017 Jan 3.

16.

New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment.

Brullo C, Ricciarelli R, Prickaerts J, Arancio O, Massa M, Rotolo C, Romussi A, Rebosio C, Marengo B, Pronzato MA, van Hagen BTJ, van Goethem NP, D'Ursi P, Orro A, Milanesi L, Guariento S, Cichero E, Fossa P, Fedele E, Bruno O.

Eur J Med Chem. 2016 Nov 29;124:82-102. doi: 10.1016/j.ejmech.2016.08.018. Epub 2016 Aug 13.

PMID:
27560284
17.

Amyloid β: Walking on the dark side of the moon.

Fedele E, Rivera D, Marengo B, Pronzato MA, Ricciarelli R.

Mech Ageing Dev. 2015 Dec;152:1-4. doi: 10.1016/j.mad.2015.09.001. Epub 2015 Sep 8. Review.

PMID:
26362724
18.

Phosphodiesterase 4D: an enzyme to remember.

Ricciarelli R, Fedele E.

Br J Pharmacol. 2015 Oct;172(20):4785-9. doi: 10.1111/bph.13257. Epub 2015 Sep 22. Review.

19.

Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors.

Brullo C, Massa M, Villa C, Ricciarelli R, Rivera D, Pronzato MA, Fedele E, Barocelli E, Bertoni S, Flammini L, Bruno O.

Bioorg Med Chem. 2015 Jul 1;23(13):3426-35. doi: 10.1016/j.bmc.2015.04.027. Epub 2015 Apr 16.

PMID:
25936260
20.

Evaluating the role of hnRNP-C and FMRP in the cAMP-induced APP metabolism.

Rivera D, Fedele E, Marinari UM, Pronzato MA, Ricciarelli R.

Biofactors. 2015 Mar-Apr;41(2):121-6. doi: 10.1002/biof.1207. Epub 2015 Mar 23.

PMID:
25809670
21.

Isolation of hydroxyoctaprenyl-1',4'-hydroquinone, a new octaprenylhydroquinone from the marine sponge Sarcotragus spinosulus and evaluation of its pharmacological activity on acetylcholine and glutamate release in the rat central nervous system.

Bisio A, Fedele E, Pittaluga A, Olivero G, Grilli M, Chen J, Mele G, Malafronte N, De Tommasi N, Leddae F, Manconi R, Pronzato R, Marchi M.

Nat Prod Commun. 2014 Nov;9(11):1581-4.

PMID:
25532286
22.

Exocytosis regulates trafficking of GABA and glycine heterotransporters in spinal cord glutamatergic synapses: a mechanism for the excessive heterotransporter-induced release of glutamate in experimental amyotrophic lateral sclerosis.

Milanese M, Bonifacino T, Fedele E, Rebosio C, Cattaneo L, Benfenati F, Usai C, Bonanno G.

Neurobiol Dis. 2015 Feb;74:314-24. doi: 10.1016/j.nbd.2014.12.004. Epub 2014 Dec 10.

PMID:
25497732
23.

Synthesis, biological evaluation, and molecular modeling of new 3-(cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) related phosphodiesterase 4D (PDE4D) inhibitors.

Brullo C, Massa M, Rocca M, Rotolo C, Guariento S, Rivera D, Ricciarelli R, Fedele E, Fossa P, Bruno O.

J Med Chem. 2014 Aug 28;57(16):7061-72. doi: 10.1021/jm500855w. Epub 2014 Aug 15.

PMID:
25126889
24.

PDE4D inhibitors: a potential strategy for the treatment of memory impairment?

Bruno O, Ricciarelli R, Prickaerts J, Parker L, Fedele E.

Neuropharmacology. 2014 Oct;85:290-2. doi: 10.1016/j.neuropharm.2014.05.038. Epub 2014 Jun 2. No abstract available.

PMID:
24942130
25.

LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex.

Cirnaru MD, Marte A, Belluzzi E, Russo I, Gabrielli M, Longo F, Arcuri L, Murru L, Bubacco L, Matteoli M, Fedele E, Sala C, Passafaro M, Morari M, Greggio E, Onofri F, Piccoli G.

Front Mol Neurosci. 2014 May 27;7:49. doi: 10.3389/fnmol.2014.00049. eCollection 2014.

26.

A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: Role of amyloid beta.

Ricciarelli R, Puzzo D, Bruno O, Canepa E, Gardella E, Rivera D, Privitera L, Domenicotti C, Marengo B, Marinari UM, Palmeri A, Pronzato MA, Arancio O, Fedele E.

Ann Neurol. 2014 Apr;75(4):602-7. doi: 10.1002/ana.24130. Epub 2014 Apr 14.

PMID:
24591104
27.

Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D.

Sierksma AS, van den Hove DL, Pfau F, Philippens M, Bruno O, Fedele E, Ricciarelli R, Steinbusch HW, Vanmierlo T, Prickaerts J.

Neuropharmacology. 2014 Feb;77:120-30. doi: 10.1016/j.neuropharm.2013.09.015. Epub 2013 Sep 22.

PMID:
24067928
28.

Angiographic assessment of myocardial perfusion in Tako-Tsubo syndrome.

De Caterina AR, Leone AM, Galiuto L, Basile E, Fedele E, Paraggio L, De Maria GL, Porto I, Niccoli G, Burzotta F, Trani C, Rebuzzi AG, Crea F.

Int J Cardiol. 2013 Oct 12;168(5):4717-22. doi: 10.1016/j.ijcard.2013.07.172. Epub 2013 Jul 25.

PMID:
23948116
29.

Intramural atrial hematoma: a rare complication of a common procedure.

Galiuto L, Fedele E, Locorotondo G, Pisanello C, Favoccia C, Danza ML, De Vito E, Rebuzzi AG, Massetti M, Crea F.

Echocardiography. 2013 Sep;30(8):E255-7. doi: 10.1111/echo.12268. Epub 2013 Jun 10. No abstract available.

PMID:
23750750
30.

Cardiac thrombi mistaken for metastasis in recurrent melanoma.

Galiuto L, Locorotondo G, Fedele E, Danza ML, De Vito E, Masi A, Favoccia C, Rebuzzi AG, Crea F.

J Cardiovasc Med (Hagerstown). 2015 Jan;16 Suppl 1:S29-30. doi: 10.2459/JCM.0b013e3283613967.

PMID:
23588033
31.

Neuropeptide S inhibits release of 5-HT and glycine in mouse amygdala and frontal/prefrontal cortex through activation of the neuropeptide S receptor.

Gardella E, Romei C, Cavallero A, Trapella C, Fedele E, Raiteri L.

Neurochem Int. 2013 Mar;62(4):360-6. doi: 10.1016/j.neuint.2013.02.003. Epub 2013 Feb 11.

PMID:
23411412
32.

Re: Stereotactic microdialysis of the basal ganglia in Parkinson's disease.

Fedele E, Stanzione P, Stefani A.

J Neurosci Methods. 2013 Jan 30;212(2):362. doi: 10.1016/j.jneumeth.2013.01.004. No abstract available.

PMID:
23375022
33.

Cyclic adenosine monophosphate as an endogenous modulator of the amyloid-β precursor protein metabolism.

Canepa E, Domenicotti C, Marengo B, Passalacqua M, Marinari UM, Pronzato MA, Fedele E, Ricciarelli R.

IUBMB Life. 2013 Feb;65(2):127-33. doi: 10.1002/iub.1109. Epub 2013 Jan 8.

34.

Effects of late REopening of Coronary total Occlusion on micRovascular perfusion and myocarDial function: the RECORD study.

Galiuto L, Barchetta S, Fedele E, De Caterina AR, Locorotondo G, Leone AM, Burzotta F, Niccoli G, Rebuzzi AG, Crea F; RECORD investigators.

Eur Heart J Cardiovasc Imaging. 2013 May;14(5):487-94. doi: 10.1093/ehjci/jes188. Epub 2012 Oct 2.

PMID:
23034991
35.

Multiple vertebral fractures precipitate a platypnea-orthodeoxia syndrome in a patient with atrial septal defect and aortic root dilatation: When the upright position becomes intolerable.

Galiuto L, Fedele E, Locorotondo G, Paraggio L, Danza ML, DeVito E, Masi A, Rebuzzi AG, Crea F.

J Cardiol Cases. 2012 Jun 27;6(2):e45-e48. doi: 10.1016/j.jccase.2012.04.008. eCollection 2012 Aug.

36.

Comparison of diagnostic accuracy between three different rules of interpreting high sensitivity troponin T results.

Buccelletti F, Galiuto L, Marsiliani D, Iacomini P, Mattogno P, Carroccia A, Cordischi C, Antonini S, Fedele E, Sabbatini M, Silveri NG, Franceschi F.

Intern Emerg Med. 2012 Aug;7(4):365-70. doi: 10.1007/s11739-012-0787-8. Epub 2012 May 23.

PMID:
22618889
37.

Positron emission tomography in acute coronary syndromes.

Galiuto L, Paraggio L, De Caterina AR, Fedele E, Locorotondo G, Leccisotti L, Giordano A, Rebuzzi AG, Crea F.

J Cardiovasc Transl Res. 2012 Feb;5(1):11-21. doi: 10.1007/s12265-011-9332-9. Epub 2011 Dec 15. Review.

PMID:
22170257
38.

Characterization of microvascular and myocardial damage within perfusion defect area at myocardial contrast echocardiography in the subacute phase of myocardial infarction.

Galiuto L, Locorotondo G, Paraggio L, De Caterina AR, Leone AM, Fedele E, Barchetta S, Porto I, Natale L, Rebuzzi AG, Bonomo L, Crea F.

Eur Heart J Cardiovasc Imaging. 2012 Feb;13(2):174-80. doi: 10.1093/ejechocard/jer190. Epub 2011 Oct 16.

PMID:
22001191
39.

Microvascular dysfunction in the spectrum of coronary instability.

De Caterina AR, Galiuto L, Fedele E, Crea F.

Am J Cardiol. 2011 Nov 15;108(10):1513-6. doi: 10.1016/j.amjcard.2011.06.074. Epub 2011 Aug 24.

PMID:
21871593
40.

GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses.

Bruno O, Fedele E, Prickaerts J, Parker LA, Canepa E, Brullo C, Cavallero A, Gardella E, Balbi A, Domenicotti C, Bollen E, Gijselaers HJ, Vanmierlo T, Erb K, Limebeer CL, Argellati F, Marinari UM, Pronzato MA, Ricciarelli R.

Br J Pharmacol. 2011 Dec;164(8):2054-63. doi: 10.1111/j.1476-5381.2011.01524.x.

41.

The clinical efficacy of L-DOPA and STN-DBS share a common marker: reduced GABA content in the motor thalamus.

Stefani A, Fedele E, Vitek J, Pierantozzi M, Galati S, Marzetti F, Peppe A, Bassi MS, Bernardi G, Stanzione P.

Cell Death Dis. 2011 May 5;2:e154. doi: 10.1038/cddis.2011.35.

42.

Reduced GABA Content in the Motor Thalamus during Effective Deep Brain Stimulation of the Subthalamic Nucleus.

Stefani A, Fedele E, Pierantozzi M, Galati S, Marzetti F, Peppe A, Pastore FS, Bernardi G, Stanzione P.

Front Syst Neurosci. 2011 Apr 5;5:17. doi: 10.3389/fnsys.2011.00017. eCollection 2011.

43.

Presynaptic nicotinic α7 and non-α7 receptors stimulate endogenous GABA release from rat hippocampal synaptosomes through two mechanisms of action.

Zappettini S, Grilli M, Lagomarsino F, Cavallero A, Fedele E, Marchi M.

PLoS One. 2011 Feb 8;6(2):e16911. doi: 10.1371/journal.pone.0016911.

44.

Alterations of glutamate release in the spinal cord of mice with experimental autoimmune encephalomyelitis.

Marte A, Cavallero A, Morando S, Uccelli A, Raiteri M, Fedele E.

J Neurochem. 2010 Oct;115(2):343-52. doi: 10.1111/j.1471-4159.2010.06923.x. Epub 2010 Aug 25.

45.

Pre-synaptic nicotinic receptors evoke endogenous glutamate and aspartate release from hippocampal synaptosomes by way of distinct coupling mechanisms.

Zappettini S, Grilli M, Salamone A, Fedele E, Marchi M.

Br J Pharmacol. 2010 Nov;161(5):1161-71. doi: 10.1111/j.1476-5381.2010.00958.x.

46.

The pharmacological blockade of medial forebrain bundle induces an acute pathological synchronization of the cortico-subthalamic nucleus-globus pallidus pathway.

Galati S, Stanzione P, D'Angelo V, Fedele E, Marzetti F, Sancesario G, Procopio T, Stefani A.

J Physiol. 2009 Sep 15;587(Pt 18):4405-23. doi: 10.1113/jphysiol.2009.172759. Epub 2009 Jul 21.

47.

L-aspartate as an amino acid neurotransmitter: mechanisms of the depolarization-induced release from cerebrocortical synaptosomes.

Cavallero A, Marte A, Fedele E.

J Neurochem. 2009 Aug;110(3):924-34. doi: 10.1111/j.1471-4159.2009.06187.x. Epub 2009 Jun 22.

48.

Correlation between changes in CSF dopamine turnover and development of dyskinesia in Parkinson's disease.

Lunardi G, Galati S, Tropepi D, Moschella V, Brusa L, Pierantozzi M, Stefani A, Rossi S, Fornai F, Fedele E, Stanzione P, Hainsworth AH, Pisani A.

Parkinsonism Relat Disord. 2009 Jun;15(5):383-9. doi: 10.1016/j.parkreldis.2008.10.001. Epub 2008 Nov 17.

PMID:
19010710
49.

Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.

Costa C, Belcastro V, Tozzi A, Di Filippo M, Tantucci M, Siliquini S, Autuori A, Picconi B, Spillantini MG, Fedele E, Pittaluga A, Raiteri M, Calabresi P.

J Neurosci. 2008 Aug 6;28(32):8040-52. doi: 10.1523/JNEUROSCI.1947-08.2008.

50.

In vivo effects of phosphodiesterase inhibition on basal cyclic guanosine monophosphate levels in the prefrontal cortex, hippocampus and cerebellum of freely moving rats.

Marte A, Pepicelli O, Cavallero A, Raiteri M, Fedele E.

J Neurosci Res. 2008 Nov 15;86(15):3338-47. doi: 10.1002/jnr.21788.

PMID:
18655195

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