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Prostate cancer sheds the αvβ3 integrin in vivo through exosomes.

Krishn SR, Singh A, Bowler N, Duffy AN, Friedman A, Fedele C, Kurtoglu S, Tripathi SK, Wang K, Hawkins A, Sayeed A, Goswami CP, Thakur ML, Iozzo RV, Peiper SC, Kelly WK, Languino LR.

Matrix Biol. 2018 Aug 8. pii: S0945-053X(18)30146-X. doi: 10.1016/j.matbio.2018.08.004. [Epub ahead of print]


SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models.

Fedele C, Ran H, Diskin B, Wei W, Jen J, Geer MJ, Araki K, Ozerdem U, Simeone DM, Miller G, Neel BG, Tang KH.

Cancer Discov. 2018 Oct;8(10):1237-1249. doi: 10.1158/2159-8290.CD-18-0444. Epub 2018 Jul 25.


Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer.

Lu H, Bowler N, Harshyne LA, Craig Hooper D, Krishn SR, Kurtoglu S, Fedele C, Liu Q, Tang HY, Kossenkov AV, Kelly WK, Wang K, Kean RB, Weinreb PH, Yu L, Dutta A, Fortina P, Ertel A, Stanczak M, Forsberg F, Gabrilovich DI, Speicher DW, Altieri DC, Languino LR.

Matrix Biol. 2018 Sep;70:20-35. doi: 10.1016/j.matbio.2018.03.009. Epub 2018 Mar 9.


Azobenzene-based polymers: emerging applications as cell culture platforms.

Fedele C, Netti PA, Cavalli S.

Biomater Sci. 2018 May 1;6(5):990-995. doi: 10.1039/c8bm00019k. Review.


Single-Institution Propensity-Matched Study to Evaluate the Psychological Effect of Minimally Invasive Interval Debulking Surgery Versus Standard Laparotomic Treatment: From Body to Mind and Back.

Gueli Alletti S, Vizzielli G, Lafuenti L, Costantini B, Fagotti A, Fedele C, Cianci S, Perrone E, Gallotta V, Rossitto C, Scambia G.

J Minim Invasive Gynecol. 2018 Jul - Aug;25(5):816-822. doi: 10.1016/j.jmig.2017.12.007. Epub 2017 Dec 18.


Three-Dimensional Microstructured Azobenzene-Containing Gelatin as a Photoactuable Cell Confining System.

Pennacchio FA, Fedele C, De Martino S, Cavalli S, Vecchione R, Netti PA.

ACS Appl Mater Interfaces. 2018 Jan 10;10(1):91-97. doi: 10.1021/acsami.7b13176. Epub 2017 Dec 28.


Azopolymer photopatterning for directional control of angiogenesis.

Fedele C, De Gregorio M, Netti PA, Cavalli S, Attanasio C.

Acta Biomater. 2017 Nov;63:317-325. doi: 10.1016/j.actbio.2017.09.022. Epub 2017 Sep 18.


Comparison of Ultrasound-Accelerated versus Pigtail Catheter-Directed Thrombolysis for the Treatment of Acute Massive and Submassive Pulmonary Embolism.

Graif A, Grilli CJ, Kimbiris G, Agriantonis DJ, Chohan OZ, Fedele CR, Gakhal MS, Vance AZ, Leung DA.

J Vasc Interv Radiol. 2017 Oct;28(10):1339-1347. doi: 10.1016/j.jvir.2017.07.004. Epub 2017 Aug 18.


Hybrid Snorkel Endovascular Repair of a Ruptured Abdominal Aortic Aneurysm Related to a Type IA Endoleak Utilizing an Axillary Conduit.

Vance AZ, Fedele CR, Graif A, Rao DB, Leung DA.

J Vasc Interv Radiol. 2017 Apr;28(4):562-563. doi: 10.1016/j.jvir.2016.12.1210. No abstract available.


Calcium-Dependent Enhancement by Extracellular Acidity of the Cytotoxicity of Mitochondrial Inhibitors against Melanoma.

Noguchi F, Inui S, Fedele C, Shackleton M, Itami S.

Mol Cancer Ther. 2017 May;16(5):936-947. doi: 10.1158/1535-7163.MCT-15-0235. Epub 2017 Feb 21.


Archetype and Rearranged Non-coding Control Regions in Urothelial Bladder Carcinoma of Immunocompetent Individuals.

Anzivino E, Zingaropoli MA, Iannetta M, Pietropaolo VA, Oliva A, Iori F, Ciardi A, Rodio DM, Antonini F, Fedele CG, D'Abramo A, Mastroianni CM, Vullo V, Ciardi MR.

Cancer Genomics Proteomics. 2016 11-12;13(6):499-509.


Gastrostomy Placement in Children: Percutaneous Endoscopic Gastrostomy or Laparoscopic Gastrostomy?

Merli L, De Marco EA, Fedele C, Mason EJ, Taddei A, Paradiso FV, Catania VD, Nanni L.

Surg Laparosc Endosc Percutan Tech. 2016 Oct;26(5):381-384.


NS3 Resistance-Associated Variants (RAVs) in Patients Infected with HCV Genotype 1a in Spain.

Jimenez-Sousa MÁ, Gutiérrez-Rivas M, Álvaro-Meca A, García-Álvarez M, Harrigan PR, Fedele CG, Briz V, Vázquez-Morón S, Resino S.

PLoS One. 2016 Sep 29;11(9):e0163197. doi: 10.1371/journal.pone.0163197. eCollection 2016.


Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP.

Paul PJ, Raghu D, Chan AL, Gulati T, Lambeth L, Takano E, Herold MJ, Hagekyriakou J, Vessella RL, Fedele C, Shackleton M, Williams ED, Fox S, Williams S, Haupt S, Gamell C, Haupt Y.

Oncogene. 2016 Dec 1;35(48):6235-6245. doi: 10.1038/onc.2016.159. Epub 2016 Sep 19.


A community-based model of rapid autopsy in end-stage cancer patients.

Alsop K, Thorne H, Sandhu S, Hamilton A, Mintoff C, Christie E, Spruyt O, Williams S, McNally O, Mileshkin L, Ananda S, Hallo J, Loi S, Scott C, Savas P, Devereux L, O'Brien P, Gunawardena S, Hampson C, Strachan K, Jaravaza RD, Francis V, Young G, Ranson D, Samaranayake R, Stevens D, Boyle S, Fedele C, Topp M, Ho G, Teo ZL, Taylor RA, Papargiris MM, Lawrence MG, Wang H, Risbridger GP, Haynes NM, Medon M, Johnstone RW, Vidacs E, Arnau GM, Vergara IA, Papenfuss AT, McArthur G, Waring P, Carvosso S, Angel C, Gyorki D, Solomon B, Mitchell G, Shanley S, Francis PA, Dawson SJ, Haffenden A, Tidball E, Volchek M, Pyman J, Madadin M, Leditschke J, Cordner S; Melbourne Melanoma Project; Australian Ovarian Cancer Study Group (AOCS); Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab), Shackleton M, Bowtell DD.

Nat Biotechnol. 2016 Oct;34(10):1010-1014. doi: 10.1038/nbt.3674. Epub 2016 Sep 12. No abstract available.


Shedding light on azopolymer brush dynamics by fluorescence correlation spectroscopy.

Kollarigowda RH, De Santo I, Rianna C, Fedele C, Manikas AC, Cavalli S, Netti PA.

Soft Matter. 2016 Sep 14;12(34):7102-11. doi: 10.1039/c6sm01482h. Epub 2016 Aug 5.


αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor.

Lu H, Wang T, Li J, Fedele C, Liu Q, Zhang J, Jiang Z, Jain D, Iozzo RV, Violette SM, Weinreb PH, Davis RJ, Gioeli D, FitzGerald TJ, Altieri DC, Languino LR.

Cancer Res. 2016 Sep 1;76(17):5163-74. doi: 10.1158/0008-5472.CAN-16-0543. Epub 2016 Jul 22.


Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype.

Singh A, Fedele C, Lu H, Nevalainen MT, Keen JH, Languino LR.

Mol Cancer Res. 2016 Nov;14(11):1136-1146. Epub 2016 Jul 20.


Desmoglein 2 promotes vasculogenic mimicry in melanoma and is associated with poor clinical outcome.

Tan LY, Mintoff C, Johan MZ, Ebert BW, Fedele C, Zhang YF, Szeto P, Sheppard KE, McArthur GA, Foster-Smith E, Ruszkiewicz A, Brown MP, Bonder CS, Shackleton M, Ebert LM.

Oncotarget. 2016 Jul 19;7(29):46492-46508. doi: 10.18632/oncotarget.10216.


CD271 Expression on Patient Melanoma Cells Is Unstable and Unlinked to Tumorigenicity.

Boyle SE, Fedele CG, Corbin V, Wybacz E, Szeto P, Lewin J, Young RJ, Wong A, Fuller R, Spillane J, Speakman D, Donahoe S, Pohl M, Gyorki D, Henderson MA, Johnstone RW, Papenfuss AT, Shackleton M.

Cancer Res. 2016 Jul 1;76(13):3965-77. doi: 10.1158/0008-5472.CAN-15-2377. Epub 2016 Jun 20.


Erratum: Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts.

Trerotola M, Ganguly KK, Fazli L, Fedele C, Lu H, Dutta A, Liu Q, De Angelis T, Riddell LW, Riobo NA, Gleave ME, Zoubeidi A, Pestell RG, Altieri DC, Languino LR.

Oncotarget. 2015 Oct 20;6(32):34038. doi: 10.18632/oncotarget.6187. No abstract available.


The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis.

Ooms LM, Binge LC, Davies EM, Rahman P, Conway JR, Gurung R, Ferguson DT, Papa A, Fedele CG, Vieusseux JL, Chai RC, Koentgen F, Price JT, Tiganis T, Timpson P, McLean CA, Mitchell CA.

Cancer Cell. 2015 Aug 10;28(2):155-69. doi: 10.1016/j.ccell.2015.07.003.


Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts.

Trerotola M, Ganguly KK, Fazli L, Fedele C, Lu H, Dutta A, Liu Q, De Angelis T, Riddell LW, Riobo NA, Gleave ME, Zoubeidi A, Pestell RG, Altieri DC, Languino LR.

Oncotarget. 2015 Jun 10;6(16):14318-28. Erratum in: Oncotarget. 2015 Oct 20;6(32):34038.


Cholecystocolonic fistula.

Tahir OM, Fedele CR, Sneider MB, Collins DS, Maloney DB.

Del Med J. 2014 Dec;86(12):373-5.


The αvβ6 integrin is transferred intercellularly via exosomes.

Fedele C, Singh A, Zerlanko BJ, Iozzo RV, Languino LR.

J Biol Chem. 2015 Feb 20;290(8):4545-51. doi: 10.1074/jbc.C114.617662. Epub 2015 Jan 7.


αvβ6 integrin is required for TGFβ1-mediated matrix metalloproteinase2 expression.

Dutta A, Li J, Fedele C, Sayeed A, Singh A, Violette SM, Manes TD, Languino LR.

Biochem J. 2015 Mar 15;466(3):525-36. doi: 10.1042/BJ20140698.


INPP4B is highly expressed in prostate intermediate cells and its loss of expression in prostate carcinoma predicts for recurrence and poor long term survival.

Rynkiewicz NK, Fedele CG, Chiam K, Gupta R, Kench JG, Ooms LM, McLean CA, Giles GG, Horvath LG, Mitchell CA.

Prostate. 2015 Jan;75(1):92-102. doi: 10.1002/pros.22895. Epub 2014 Oct 4.


Recanalization of chronic total occlusions of the superior mesenteric artery in patients with chronic mesenteric ischemia: technical and clinical outcomes.

Grilli CJ, Fedele CR, Tahir OM, Wrigley CW, Garcia MJ, Kimbiris G, Agriantonis DJ, Leung DA.

J Vasc Interv Radiol. 2014 Oct;25(10):1515-22. doi: 10.1016/j.jvir.2014.07.003. Epub 2014 Aug 16.


Navigating the challenge of tumor heterogeneity in cancer therapy.

Fedele C, Tothill RW, McArthur GA.

Cancer Discov. 2014 Feb;4(2):146-8. doi: 10.1158/2159-8290.CD-13-1042.


IGF-IR promotes prostate cancer growth by stabilizing α5β1 integrin protein levels.

Sayeed A, Fedele C, Trerotola M, Ganguly KK, Languino LR.

PLoS One. 2013 Oct 9;8(10):e76513. doi: 10.1371/journal.pone.0076513. eCollection 2013.


Regulation of the transcriptional coactivator FHL2 licenses activation of the androgen receptor in castrate-resistant prostate cancer.

McGrath MJ, Binge LC, Sriratana A, Wang H, Robinson PA, Pook D, Fedele CG, Brown S, Dyson JM, Cottle DL, Cowling BS, Niranjan B, Risbridger GP, Mitchell CA.

Cancer Res. 2013 Aug 15;73(16):5066-79. doi: 10.1158/0008-5472.CAN-12-4520. Epub 2013 Jun 25.


Effects of a human compact anti-ErbB2 antibody on gastric cancer.

Fedele C, Carvalho S, Riccio G, Paciello R, Laccetti P, Schmitt F, De Lorenzo C.

Gastric Cancer. 2014 Jan;17(1):107-15. doi: 10.1007/s10120-013-0244-z. Epub 2013 Mar 5.


MDM4 is a key therapeutic target in cutaneous melanoma.

Gembarska A, Luciani F, Fedele C, Russell EA, Dewaele M, Villar S, Zwolinska A, Haupt S, de Lange J, Yip D, Goydos J, Haigh JJ, Haupt Y, Larue L, Jochemsen A, Shi H, Moriceau G, Lo RS, Ghanem G, Shackleton M, Bernal F, Marine JC.

Nat Med. 2012 Aug;18(8):1239-47. doi: 10.1038/nm.2863. Epub 2012 Jul 22.


Mechanisms of cardiotoxicity associated with ErbB2 inhibitors.

Fedele C, Riccio G, Malara AE, D'Alessio G, De Lorenzo C.

Breast Cancer Res Treat. 2012 Jul;134(2):595-602. doi: 10.1007/s10549-012-2103-8. Epub 2012 Jun 7.


Effects of a human compact anti-ErbB2 antibody on prostate cancer.

Malara AE, Fedele C, Aloj L, Arra C, Laccetti P, D'Alessio G, De Lorenzo C.

Oncol Rep. 2012 Jul;28(1):297-302. doi: 10.3892/or.2012.1760. Epub 2012 Apr 10.


The PTEN and Myotubularin phosphoinositide 3-phosphatases: linking lipid signalling to human disease.

Davies EM, Sheffield DA, Tibarewal P, Fedele CG, Mitchell CA, Leslie NR.

Subcell Biochem. 2012;58:281-336. doi: 10.1007/978-94-007-3012-0_8.


Phosphoinositide phosphatases: just as important as the kinases.

Dyson JM, Fedele CG, Davies EM, Becanovic J, Mitchell CA.

Subcell Biochem. 2012;58:215-79. doi: 10.1007/978-94-007-3012-0_7. Review.


Comparison of preclinical cardiotoxic effects of different ErbB2 inhibitors.

Fedele C, Riccio G, Coppola C, Barbieri A, Monti MG, Arra C, Tocchetti CG, D'Alessio G, Maurea N, De Lorenzo C.

Breast Cancer Res Treat. 2012 Jun;133(2):511-21. doi: 10.1007/s10549-011-1783-9. Epub 2011 Sep 27.


A novel ErbB2 epitope targeted by human antitumor immunoagents.

Troise F, Monti M, Merlino A, Cozzolino F, Fedele C, Russo Krauss I, Sica F, Pucci P, D'Alessio G, De Lorenzo C.

FEBS J. 2011 Apr;278(7):1156-66. doi: 10.1111/j.1742-4658.2011.08041.x. Epub 2011 Mar 1.


Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers.

Fedele CG, Ooms LM, Ho M, Vieusseux J, O'Toole SA, Millar EK, Lopez-Knowles E, Sriratana A, Gurung R, Baglietto L, Giles GG, Bailey CG, Rasko JE, Shields BJ, Price JT, Majerus PW, Sutherland RL, Tiganis T, McLean CA, Mitchell CA.

Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22231-6. doi: 10.1073/pnas.1015245107. Epub 2010 Dec 2.


Independent lineage of lymphocytic choriomeningitis virus in wood mice (Apodemus sylvaticus), Spain.

Ledesma J, Fedele CG, Carro F, Lledó L, Sánchez-Seco MP, Tenorio A, Soriguer RC, Saz JV, Domínguez G, Rosas MF, Barandika JF, Gegúndez MI.

Emerg Infect Dis. 2009 Oct;15(10):1677-80. doi: 10.3201/eid1510.090563.


[Microbiological diagnosis of chikungunya virus in Spain (2006-2007): case detection in travelers].

Sánchez-Seco MP, Negredo AI, Puente S, Pinazo MA, Shuffenecker I, Tenorio A, Fedele CG, Domingo C, Rubio JM, de Ory F.

Enferm Infecc Microbiol Clin. 2009 Oct;27(8):457-61. doi: 10.1016/j.eimc.2008.07.011. Epub 2009 Jun 12. Spanish.


[Toscana virus, West Nile virus and lymphochoriomeningitis virus as causing agents of aseptic meningitis in Spain].

De Ory F, Gegúndez MI, Fedele CG, Sánchez-Seco MP.

Med Clin (Barc). 2009 Apr 25;132(15):587-90. doi: 10.1016/j.medcli.2008.10.057. Epub 2009 Apr 16. Spanish.


Use of internally controlled real-time genome amplification for detection of variola virus and other orthopoxviruses infecting humans.

Fedele CG, Negredo A, Molero F, Sánchez-Seco MP, Tenorio A.

J Clin Microbiol. 2006 Dec;44(12):4464-70. Epub 2006 Oct 25.


Regulation of phosphoinositide signaling by the inositol polyphosphate 5-phosphatases.

Astle MV, Seaton G, Davies EM, Fedele CG, Rahman P, Arsala L, Mitchell CA.

IUBMB Life. 2006 Aug;58(8):451-6. Review.


The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation.

Ooms LM, Fedele CG, Astle MV, Ivetac I, Cheung V, Pearson RB, Layton MJ, Forrai A, Nandurkar HH, Mitchell CA.

Mol Biol Cell. 2006 Feb;17(2):607-22. Epub 2005 Nov 9.


The presence of myofibroblasts, smooth muscle cells and elastic fibers in the lymphatic collectors of horses.

Harland MM, Fedele C, Berens v Rautenfeld D.

Lymphology. 2004 Dec;37(4):190-8.


Lack of association of polyomavirus and herpesvirus types 6 and 7 in human lymphomas.

Hernández-Losa J, Fedele CG, Pozo F, Tenorio A, Fernández V, Castellví J, Parada C, Ramón y Cajal S.

Cancer. 2005 Jan 15;103(2):293-8.


Prevalence and patterns of polyomavirus urinary excretion in immunocompetent adults and children.

Polo C, Pérez JL, Mielnichuck A, Fedele CG, Niubò J, Tenorio A.

Clin Microbiol Infect. 2004 Jul;10(7):640-4.

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