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Can microbes increase exercise performance in athletes?

Turpin-Nolan SM, Joyner MJ, Febbraio MA.

Nat Rev Endocrinol. 2019 Aug 7. doi: 10.1038/s41574-019-0250-2. [Epub ahead of print] No abstract available.


Adipocyte specific deletion of IL-6 does not attenuate obesity-induced weight gain or glucose intolerance in mice.

Whitham M, Pal M, Petzold T, Hjorth M, Egan CL, Brunner JS, Estevez E, Iliades P, Zivanovic B, Reibe S, Hughes WE, Findeisen M, Hidalgo J, Febbraio MA.

Am J Physiol Endocrinol Metab. 2019 Aug 6. doi: 10.1152/ajpendo.00206.2019. [Epub ahead of print]


Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer.

Currey N, Jahan Z, Caldon CE, Tran PN, Benthani F, De Lacavalerie P, Roden DL, Gloss BS, Campos C, Bean EG, Bullman A, Reibe-Pal S, Dinger ME, Febbraio MA, Clarke SJ, Dahlstrom JE, Kohonen-Corish MRJ.

Cell Mol Gastroenterol Hepatol. 2019;7(4):819-839. doi: 10.1016/j.jcmgh.2019.01.009. Epub 2019 Mar 2.


Metabolic control and sex: A focus on inflammatory-linked mediators.

Henstridge DC, Abildgaard J, Lindegaard B, Febbraio MA.

Br J Pharmacol. 2019 Feb 28. doi: 10.1111/bph.14642. [Epub ahead of print] Review.


Author Correction: Relieving ER stress to target NASH-driven hepatocellular carcinoma.

Reibe S, Febbraio MA.

Nat Rev Endocrinol. 2019 Feb;15(2):126. doi: 10.1038/s41574-019-0154-1.


Relieving ER stress to target NASH-driven hepatocellular carcinoma.

Reibe S, Febbraio MA.

Nat Rev Endocrinol. 2019 Feb;15(2):73-74. doi: 10.1038/s41574-018-0145-7. Review. No abstract available. Erratum in: Nat Rev Endocrinol. 2019 Jan 8;:.


Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

Febbraio MA, Reibe S, Shalapour S, Ooi GJ, Watt MJ, Karin M.

Cell Metab. 2019 Jan 8;29(1):18-26. doi: 10.1016/j.cmet.2018.10.012. Epub 2018 Nov 15. Review.


Redefining Tissue Crosstalk via Shotgun Proteomic Analyses of Plasma Extracellular Vesicles.

Whitham M, Febbraio MA.

Proteomics. 2019 Jan;19(1-2):e1800154. doi: 10.1002/pmic.201800154. Epub 2018 Nov 29.


Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance.

Brandon AE, Liao BM, Diakanastasis B, Parker BL, Raddatz K, McManus SA, O'Reilly L, Kimber E, van der Kraan AG, Hancock D, Henstridge DC, Meikle PJ, Cooney GJ, James DE, Reibe S, Febbraio MA, Biden TJ, Schmitz-Peiffer C.

Cell Metab. 2019 Jan 8;29(1):183-191.e7. doi: 10.1016/j.cmet.2018.09.013. Epub 2018 Oct 11.


Exercise as medicine for survivors of paediatric cancer.

Hjorth M, Febbraio MA.

Nat Rev Endocrinol. 2018 Sep;14(9):506-508. doi: 10.1038/s41574-018-0065-6. No abstract available.


Defective cholesterol metabolism in haematopoietic stem cells promotes monocyte-driven atherosclerosis in rheumatoid arthritis.

Dragoljevic D, Kraakman MJ, Nagareddy PR, Ngo D, Shihata W, Kammoun HL, Whillas A, Lee MKS, Al-Sharea A, Pernes G, Flynn MC, Lancaster GI, Febbraio MA, Chin-Dusting J, Hanaoka BY, Wicks IP, Murphy AJ.

Eur Heart J. 2018 Jun 14;39(23):2158-2167. doi: 10.1093/eurheartj/ehy119.


Female sex hormones are necessary for the metabolic effects mediated by loss of Interleukin 18 signaling.

Lindegaard B, Abildgaard J, Heywood SE, Pedersen BK, Febbraio MA.

Mol Metab. 2018 Jun;12:89-97. doi: 10.1016/j.molmet.2018.04.005. Epub 2018 Apr 12.


Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism.

Lancaster GI, Langley KG, Berglund NA, Kammoun HL, Reibe S, Estevez E, Weir J, Mellett NA, Pernes G, Conway JRW, Lee MKS, Timpson P, Murphy AJ, Masters SL, Gerondakis S, Bartonicek N, Kaczorowski DC, Dinger ME, Meikle PJ, Bond PJ, Febbraio MA.

Cell Metab. 2018 May 1;27(5):1096-1110.e5. doi: 10.1016/j.cmet.2018.03.014. Epub 2018 Apr 19.


APP deficiency results in resistance to obesity but impairs glucose tolerance upon high fat feeding.

Czeczor JK, Genders AJ, Aston-Mourney K, Connor T, Hall LG, Hasebe K, Ellis M, De Jong KA, Henstridge DC, Meikle PJ, Febbraio MA, Walder K, McGee SL.

J Endocrinol. 2018 Jun;237(3):311-322. doi: 10.1530/JOE-18-0051. Epub 2018 Apr 19.


Skeletal muscle-specific overexpression of heat shock protein 72 improves skeletal muscle insulin-stimulated glucose uptake but does not alter whole body metabolism.

Marshall JPS, Estevez E, Kammoun HL, King EJ, Bruce CR, Drew BG, Qian H, Iliades P, Gregorevic P, Febbraio MA, Henstridge DC.

Diabetes Obes Metab. 2018 Aug;20(8):1928-1936. doi: 10.1111/dom.13319. Epub 2018 May 3.


GeneXX: an online tool for the exploration of transcript changes in skeletal muscle associated with exercise.

Reibe S, Hjorth M, Febbraio MA, Whitham M.

Physiol Genomics. 2018 May 1;50(5):376-384. doi: 10.1152/physiolgenomics.00127.2017. Epub 2018 Mar 16.


Evidence against a role for NLRP3-driven islet inflammation in db/db mice.

Kammoun HL, Allen TL, Henstridge DC, Barre S, Coll RC, Lancaster GI, Cron L, Reibe S, Chan JY, Bensellam M, Laybutt DR, Butler MS, Robertson AAB, O'Neill LA, Cooper MA, Febbraio MA.

Mol Metab. 2018 Apr;10:66-73. doi: 10.1016/j.molmet.2018.02.001. Epub 2018 Feb 7.


Activation of mitochondrial fusion provides a new treatment for mitochondria-related diseases.

Szabo A, Sumegi K, Fekete K, Hocsak E, Debreceni B, Setalo G Jr, Kovacs K, Deres L, Kengyel A, Kovacs D, Mandl J, Nyitrai M, Febbraio MA, Gallyas F Jr, Sumegi B.

Biochem Pharmacol. 2018 Apr;150:86-96. doi: 10.1016/j.bcp.2018.01.038. Epub 2018 Feb 3.


Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise.

Whitham M, Parker BL, Friedrichsen M, Hingst JR, Hjorth M, Hughes WE, Egan CL, Cron L, Watt KI, Kuchel RP, Jayasooriah N, Estevez E, Petzold T, Suter CM, Gregorevic P, Kiens B, Richter EA, James DE, Wojtaszewski JFP, Febbraio MA.

Cell Metab. 2018 Jan 9;27(1):237-251.e4. doi: 10.1016/j.cmet.2017.12.001.


Transcription Factor IRF4 Promotes CD8+ T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection.

Man K, Gabriel SS, Liao Y, Gloury R, Preston S, Henstridge DC, Pellegrini M, Zehn D, Berberich-Siebelt F, Febbraio MA, Shi W, Kallies A.

Immunity. 2017 Dec 19;47(6):1129-1141.e5. doi: 10.1016/j.immuni.2017.11.021. Epub 2017 Dec 12.


High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice.

Heywood SE, Richart AL, Henstridge DC, Alt K, Kiriazis H, Zammit C, Carey AL, Kammoun HL, Delbridge LM, Reddy M, Chen YC, Du XJ, Hagemeyer CE, Febbraio MA, Siebel AL, Kingwell BA.

Sci Transl Med. 2017 Oct 11;9(411). pii: eaam6084. doi: 10.1126/scitranslmed.aam6084.


Increased liver AGEs induce hepatic injury mediated through an OST48 pathway.

Zhuang A, Yap FY, Bruce C, Leung C, Plan MR, Sullivan MA, Herath C, McCarthy D, Sourris KC, Kantharidis P, Coughlan MT, Febbraio MA, Hodson MP, Watt MJ, Angus P, Schulz BL, Forbes JM.

Sci Rep. 2017 Sep 25;7(1):12292. doi: 10.1038/s41598-017-12548-4.


Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice.

Kammoun HL, Allen TL, Henstridge DC, Kraakman MJ, Peijs L, Rose-John S, Febbraio MA.

PLoS One. 2017 Jun 20;12(6):e0179099. doi: 10.1371/journal.pone.0179099. eCollection 2017.


Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes.

Kraakman MJ, Lee MK, Al-Sharea A, Dragoljevic D, Barrett TJ, Montenont E, Basu D, Heywood S, Kammoun HL, Flynn M, Whillas A, Hanssen NM, Febbraio MA, Westein E, Fisher EA, Chin-Dusting J, Cooper ME, Berger JS, Goldberg IJ, Nagareddy PR, Murphy AJ.

J Clin Invest. 2017 Jun 1;127(6):2133-2147. doi: 10.1172/JCI92450. Epub 2017 May 15.


Adiponectin serenades ceramidase to improve metabolism.

Reibe-Pal S, Febbraio MA.

Mol Metab. 2017 Feb 1;6(3):233-235. doi: 10.1016/j.molmet.2017.01.011. eCollection 2017 Mar. No abstract available.


IL-1β delivers a sweet deal.

Hjorth M, Febbraio MA.

Nat Immunol. 2017 Feb 15;18(3):247-248. doi: 10.1038/ni.3681. No abstract available.


Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice.

Gaur V, Connor T, Venardos K, Henstridge DC, Martin SD, Swinton C, Morrison S, Aston-Mourney K, Gehrig SM, van Ewijk R, Lynch GS, Febbraio MA, Steinberg GR, Hargreaves M, Walder KR, McGee SL.

Diabetes Obes Metab. 2017 Jul;19(7):936-943. doi: 10.1111/dom.12896. Epub 2017 Mar 3.


Muscle-specific overexpression of AdipoR1 or AdipoR2 gives rise to common and discrete local effects whilst AdipoR2 promotes additional systemic effects.

Keshvari S, Henstridge DC, Ng C, Febbraio MA, Whitehead JP.

Sci Rep. 2017 Feb 1;7:41792. doi: 10.1038/srep41792.


Exercise metabolism in 2016: Health benefits of exercise - more than meets the eye!

Febbraio MA.

Nat Rev Endocrinol. 2017 Feb;13(2):72-74. doi: 10.1038/nrendo.2016.218. Epub 2017 Jan 4. Review. No abstract available.


Inflammation, but not recruitment, of adipose tissue macrophages requires signalling through Mac-1 (CD11b/CD18) in diet-induced obesity (DIO).

Wolf D, Bukosza N, Engel D, Poggi M, Jehle F, Anto Michel N, Chen YC, Colberg C, Hoppe N, Dufner B, Boon L, Blankenbach H, Hilgendorf I, von Zur Muhlen C, Reinöhl J, Sommer B, Marchini T, Febbraio MA, Weber C, Bode C, Peter K, Lutgens E, Zirlik A.

Thromb Haemost. 2017 Jan 26;117(2):325-338. doi: 10.1160/TH16-07-0553. Epub 2016 Nov 17.


Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle.

Lee-Young RS, Hoffman NJ, Murphy KT, Henstridge DC, Samocha-Bonet D, Siebel AL, Iliades P, Zivanovic B, Hong YH, Colgan TD, Kraakman MJ, Bruce CR, Gregorevic P, McConell GK, Lynch GS, Drummond GR, Kingwell BA, Greenfield JR, Febbraio MA.

Mol Metab. 2016 Sep 9;5(11):1083-1091. doi: 10.1016/j.molmet.2016.09.002. eCollection 2016 Nov.


BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle.

Kennedy TL, Swiderski K, Murphy KT, Gehrig SM, Curl CL, Chandramouli C, Febbraio MA, Delbridge LM, Koopman R, Lynch GS.

Am J Pathol. 2016 Dec;186(12):3246-3260. doi: 10.1016/j.ajpath.2016.08.008. Epub 2016 Oct 14. Erratum in: Am J Pathol. 2017 Apr;187(4):937-938. Am J Pathol. 2017 Sep;187(9):2128.


Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity.

Cropley JE, Eaton SA, Aiken A, Young PE, Giannoulatou E, Ho JWK, Buckland ME, Keam SP, Hutvagner G, Humphreys DT, Langley KG, Henstridge DC, Martin DIK, Febbraio MA, Suter CM.

Mol Metab. 2016 Jun 23;5(8):699-708. doi: 10.1016/j.molmet.2016.06.008. eCollection 2016 Aug.


Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation.

Gaur V, Connor T, Sanigorski A, Martin SD, Bruce CR, Henstridge DC, Bond ST, McEwen KA, Kerr-Bayles L, Ashton TD, Fleming C, Wu M, Pike Winer LS, Chen D, Hudson GM, Schwabe JWR, Baar K, Febbraio MA, Gregorevic P, Pfeffer FM, Walder KR, Hargreaves M, McGee SL.

Cell Rep. 2016 Sep 13;16(11):2802-2810. doi: 10.1016/j.celrep.2016.08.005.


The ever-expanding myokinome: discovery challenges and therapeutic implications.

Whitham M, Febbraio MA.

Nat Rev Drug Discov. 2016 Oct;15(10):719-29. doi: 10.1038/nrd.2016.153. Epub 2016 Sep 12. Review.


High Fat Diet Inhibits Dendritic Cell and T Cell Response to Allergens but Does Not Impair Inhalational Respiratory Tolerance.

Pizzolla A, Oh DY, Luong S, Prickett SR, Henstridge DC, Febbraio MA, O'Hehir RE, Rolland JM, Hardy CL.

PLoS One. 2016 Aug 2;11(8):e0160407. doi: 10.1371/journal.pone.0160407. eCollection 2016.


NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells.

de Valle E, Grigoriadis G, O'Reilly LA, Willis SN, Maxwell MJ, Corcoran LM, Tsantikos E, Cornish JK, Fairfax KA, Vasanthakumar A, Febbraio MA, Hibbs ML, Pellegrini M, Banerjee A, Hodgkin PD, Kallies A, Mackay F, Strasser A, Gerondakis S, Gugasyan R.

J Exp Med. 2016 Apr 4;213(4):621-41. doi: 10.1084/jem.20151182. Epub 2016 Mar 28.


PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications.

Lancaster GI, Kammoun HL, Kraakman MJ, Kowalski GM, Bruce CR, Febbraio MA.

Nat Commun. 2016 Feb 3;7:10626. doi: 10.1038/ncomms10626.


The role of gp130 receptor cytokines in the regulation of metabolic homeostasis.

Cron L, Allen T, Febbraio MA.

J Exp Biol. 2016 Jan;219(Pt 2):259-65. doi: 10.1242/jeb.129213. Review.


Heat shock proteins and exercise adaptations. Our knowledge thus far and the road still ahead.

Henstridge DC, Febbraio MA, Hargreaves M.

J Appl Physiol (1985). 2016 Mar 15;120(6):683-91. doi: 10.1152/japplphysiol.00811.2015. Epub 2015 Dec 17. Review.


Exercise and the immune system: implications for elite athletes and the general population.

Lancaster GI, Febbraio MA.

Immunol Cell Biol. 2016 Feb;94(2):115-6. doi: 10.1038/icb.2015.103. Epub 2015 Dec 15. No abstract available.


Long-Term Overexpression of Hsp70 Does Not Protect against Cardiac Dysfunction and Adverse Remodeling in a MURC Transgenic Mouse Model with Chronic Heart Failure and Atrial Fibrillation.

Bernardo BC, Sapra G, Patterson NL, Cemerlang N, Kiriazis H, Ueyama T, Febbraio MA, McMullen JR.

PLoS One. 2015 Dec 14;10(12):e0145173. doi: 10.1371/journal.pone.0145173. eCollection 2015.


The roles of c-Jun NH2-terminal kinases (JNKs) in obesity and insulin resistance.

Pal M, Febbraio MA, Lancaster GI.

J Physiol. 2016 Jan 15;594(2):267-79. doi: 10.1113/JP271457. Epub 2015 Dec 14. Review.


IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.

Murphy AJ, Kraakman MJ, Kammoun HL, Dragoljevic D, Lee MK, Lawlor KE, Wentworth JM, Vasanthakumar A, Gerlic M, Whitehead LW, DiRago L, Cengia L, Lane RM, Metcalf D, Vince JE, Harrison LC, Kallies A, Kile BT, Croker BA, Febbraio MA, Masters SL.

Cell Metab. 2016 Jan 12;23(1):155-64. doi: 10.1016/j.cmet.2015.09.024. Epub 2015 Oct 22.


Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism.

Meex RC, Hoy AJ, Morris A, Brown RD, Lo JC, Burke M, Goode RJ, Kingwell BA, Kraakman MJ, Febbraio MA, Greve JW, Rensen SS, Molloy MP, Lancaster GI, Bruce CR, Watt MJ.

Cell Metab. 2015 Dec 1;22(6):1078-89. doi: 10.1016/j.cmet.2015.09.023. Epub 2015 Oct 22.


Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation.

Ramiscal RR, Parish IA, Lee-Young RS, Babon JJ, Blagih J, Pratama A, Martin J, Hawley N, Cappello JY, Nieto PF, Ellyard JI, Kershaw NJ, Sweet RA, Goodnow CC, Jones RG, Febbraio MA, Vinuesa CG, Athanasopoulos V.

Elife. 2015 Oct 23;4. pii: e08698. doi: 10.7554/eLife.08698.


Nanoporous Metal-Phenolic Particles as Ultrasound Imaging Probes for Hydrogen Peroxide.

Guo J, Wang X, Henstridge DC, Richardson JJ, Cui J, Sharma A, Febbraio MA, Peter K, de Haan JB, Hagemeyer CE, Caruso F.

Adv Healthc Mater. 2015 Oct;4(14):2170-2175. doi: 10.1002/adhm.201500528. Epub 2015 Sep 1.


Exercise improves adipose function and inflammation and ameliorates fatty liver disease in obese diabetic mice.

Haczeyni F, Barn V, Mridha AR, Yeh MM, Estevez E, Febbraio MA, Nolan CJ, Bell-Anderson KS, Teoh NC, Farrell GC.

Obesity (Silver Spring). 2015 Sep;23(9):1845-55. doi: 10.1002/oby.21170. Epub 2015 Aug 6.


The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity.

Selathurai A, Kowalski GM, Burch ML, Sepulveda P, Risis S, Lee-Young RS, Lamon S, Meikle PJ, Genders AJ, McGee SL, Watt MJ, Russell AP, Frank M, Jackowski S, Febbraio MA, Bruce CR.

Cell Metab. 2015 May 5;21(5):718-30. doi: 10.1016/j.cmet.2015.04.001.


Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance.

Kraakman MJ, Kammoun HL, Allen TL, Deswaerte V, Henstridge DC, Estevez E, Matthews VB, Neill B, White DA, Murphy AJ, Peijs L, Yang C, Risis S, Bruce CR, Du XJ, Bobik A, Lee-Young RS, Kingwell BA, Vasanthakumar A, Shi W, Kallies A, Lancaster GI, Rose-John S, Febbraio MA.

Cell Metab. 2015 Mar 3;21(3):403-16. doi: 10.1016/j.cmet.2015.02.006. Erratum in: Cell Metab. 2016 Mar 8;23(3):563.

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