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Items: 1 to 50 of 125

1.

Serum microRNA signature as a diagnostic and therapeutic marker in patients with psoriatic arthritis.

Wade SM, McGarry T, Wade SC, Fearon U, Veale DJ.

J Rheumatol. 2020 Mar 1. pii: jrheum.190602. doi: 10.3899/jrheum.190602. [Epub ahead of print]

PMID:
32115427
2.

Targeting bioenergetics prevents CD4 T cell-mediated activation of synovial fibroblasts in rheumatoid arthritis.

Petrasca A, Phelan JJ, Ansboro S, Veale DJ, Fearon U, Fletcher JM.

Rheumatology (Oxford). 2020 Feb 11. pii: kez682. doi: 10.1093/rheumatology/kez682. [Epub ahead of print]

PMID:
32047926
3.

Enrichment of polyfunctional T cells in PsA synovial tissue. Response to: 'Polyfunctional TEM cells in psoriatic arthritis synovium skewed towards Th17 cells' by Raychaudhuri et al.

Canavan M, Wade SM, Veale DJ, Fearon U.

Ann Rheum Dis. 2020 Jan 8. pii: annrheumdis-2019-216814. doi: 10.1136/annrheumdis-2019-216814. [Epub ahead of print] No abstract available.

PMID:
31915122
4.

Next-generation analysis of synovial tissue architecture.

Veale DJ, Fearon U.

Nat Rev Rheumatol. 2020 Feb;16(2):67-68. doi: 10.1038/s41584-019-0357-9. Review. No abstract available.

PMID:
31875055
5.

Enhanced angiogenic function in response to fibroblasts from psoriatic arthritis synovium compared to rheumatoid arthritis.

Fromm S, Cunningham CC, Dunne MR, Veale DJ, Fearon U, Wade SM.

Arthritis Res Ther. 2019 Dec 21;21(1):297. doi: 10.1186/s13075-019-2088-3.

6.

Insulin Resistant Pathways are associated with Disease Activity in Rheumatoid Arthritis and are Subject to Disease Modification through Metabolic Reprogramming; A Potential Novel Therapeutic Approach.

Gallagher L, Cregan S, Biniecka M, Cunningham C, Veale DJ, Kane DJ, Fearon U, Mullan RH.

Arthritis Rheumatol. 2019 Dec 16. doi: 10.1002/art.41190. [Epub ahead of print]

PMID:
31840936
7.

Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies.

Ui Mhaonaigh A, Coughlan AM, Dwivedi A, Hartnett J, Cabral J, Moran B, Brennan K, Doyle SL, Hughes K, Lucey R, Floudas A, Fearon U, McGrath S, Cormican S, De Bhailis A, Molloy EJ, Brady G, Little MA.

Front Immunol. 2019 Nov 7;10:2603. doi: 10.3389/fimmu.2019.02603. eCollection 2019.

8.

Increased T Cell Plasticity With Dysregulation of Follicular Helper T, Peripheral Helper T, and Treg Cell Responses in Children With Juvenile Idiopathic Arthritis and Down Syndrome-Associated Arthritis.

Foley C, Floudas A, Canavan M, Biniecka M, MacDermott EJ, Veale DJ, Mullan RH, Killeen OG, Fearon U.

Arthritis Rheumatol. 2020 Apr;72(4):677-686. doi: 10.1002/art.41150. Epub 2020 Mar 12.

PMID:
31657128
9.

Association of the Rheumatoid Arthritis Severity Variant rs26232 with the Invasive Activity of Synovial Fibroblasts.

Dorris ER, Linehan E, Trenkmann M, Veale DJ, Fearon U, Wilson AG.

Cells. 2019 Oct 22;8(10). pii: E1300. doi: 10.3390/cells8101300.

10.

STAT3 Mediates the Differential Effects of Oncostatin M and TNFα on RA Synovial Fibroblast and Endothelial Cell Function.

Hanlon MM, Rakovich T, Cunningham CC, Ansboro S, Veale DJ, Fearon U, McGarry T.

Front Immunol. 2019 Aug 28;10:2056. doi: 10.3389/fimmu.2019.02056. eCollection 2019.

11.

Dysregulated miR-125a promotes angiogenesis through enhanced glycolysis.

Wade SM, Ohnesorge N, McLoughlin H, Biniecka M, Carter SP, Trenkman M, Cunningham CC, McGarry T, Canavan M, Kennedy BN, Veale DJ, Fearon U.

EBioMedicine. 2019 Sep;47:402-413. doi: 10.1016/j.ebiom.2019.08.043. Epub 2019 Aug 26.

12.

Interleukin-6 does not upregulate pro-inflammatory cytokine expression in an ex vivo model of giant cell arteritis.

O'Neill L, McCormick J, Gao W, Veale DJ, McCarthy GM, Murphy CC, Fearon U, Molloy ES.

Rheumatol Adv Pract. 2019 May 6;3(1):rkz011. doi: 10.1093/rap/rkz011. eCollection 2019.

13.

Angiogenesis in Inflammatory Arthritis.

Balogh E, Biniecka M, Fearon U, Veale DJ, Szekanecz Z.

Isr Med Assoc J. 2019 May;5(21):345-352. Review.

14.

Association of synovial tissue polyfunctional T-cells with DAPSA in psoriatic arthritis.

Wade SM, Canavan M, McGarry T, Low C, Wade SC, Mullan RH, Veale DJ, Fearon U.

Ann Rheum Dis. 2019 Mar;78(3):350-354. doi: 10.1136/annrheumdis-2018-214138. Epub 2019 Jan 9.

15.

Performance characteristics and predictors of temporal artery ultrasound for the diagnosis of giant cell arteritis in routine clinical practice in a prospective cohort.

Conway R, O'Neill L, McCarthy GM, Murphy CC, Veale DJ, Fearon U, Killeen RP, Heffernan EJ, Molloy ES.

Clin Exp Rheumatol. 2019 Mar-Apr;37 Suppl 117(2):72-78. Epub 2019 Jan 4.

16.

Correction to: Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups.

Najm A, Le Goff B, Orr C, Thurlings R, Cañete JD, Humby F, Alivernini S, Manzo A, Just SA, Romão VC, Krenn V, Müller-Ladner U, Addimanda O, Tas SW, Stoenoiu M, de Bellefon LM, Durez P, Strand V, Wechalekar MD, Fonseca JE, Lauwerys B, Fearon U, Veale DJ; EULAR Synovitis Study Group and OMERACT Synovial Tissue Special Interest Group.

Arthritis Res Ther. 2018 Dec 19;20(1):282. doi: 10.1186/s13075-018-1795-5.

17.

Cell metabolism as a potentially targetable pathway in RA.

McGarry T, Fearon U.

Nat Rev Rheumatol. 2019 Feb;15(2):70-72. doi: 10.1038/s41584-018-0148-8. Review. No abstract available.

PMID:
30560909
18.

Autoimmune and angiogenic biomarkers in autoimmune atherosclerosis.

Balogh E, Pusztai A, Hamar A, Végh E, Szamosi S, Kerekes G, McCormick J, Biniecka M, Szántó S, Szűcs G, Nagy Z, Fearon U, Veale DJ, Szekanecz Z.

Clin Immunol. 2019 Feb;199:47-51. doi: 10.1016/j.clim.2018.12.011. Epub 2018 Dec 10. Review.

PMID:
30543922
19.

Enriched Cd141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis.

Canavan M, Walsh AM, Bhargava V, Wade SM, McGarry T, Marzaioli V, Moran B, Biniecka M, Convery H, Wade S, Orr C, Mullan R, Fletcher JM, Nagpal S, Veale DJ, Fearon U.

JCI Insight. 2018 Dec 6;3(23). pii: 95228. doi: 10.1172/jci.insight.95228.

20.

Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups.

Najm A, Le Goff B, Orr C, Thurlings R, Cañete JD, Humby F, Alivernini S, Manzo A, Just SA, Romão VC, Krenn V, Müller-Ladner U, Addimanda O, Tas SW, Stoenoiu M, Meric de Bellefon L, Durez P, Strand V, Wechalekar MD, Fonseca JE, Lauwerys B, Fearon U, Veale DJ; EULAR Synovitis Study Group and OMERACT Synovial Tissue Special Interest Group.

Arthritis Res Ther. 2018 Dec 3;20(1):265. doi: 10.1186/s13075-018-1762-1. Erratum in: Arthritis Res Ther. 2018 Dec 19;20(1):282.

21.

Altered metabolic pathways regulate synovial inflammation in rheumatoid arthritis.

Fearon U, Hanlon MM, Wade SM, Fletcher JM.

Clin Exp Immunol. 2019 Aug;197(2):170-180. doi: 10.1111/cei.13228. Epub 2018 Nov 11. Review.

PMID:
30357805
22.

Novel gene targets for miRNA146a and miRNA155 in anterior uveitis.

O'Rourke M, Trenkmann M, Connolly M, Fearon U, Murphy CC.

Br J Ophthalmol. 2019 Feb;103(2):279-285. doi: 10.1136/bjophthalmol-2018-312885. Epub 2018 Oct 8.

PMID:
30297336
23.

Altered expression of microRNA-23a in psoriatic arthritis modulates synovial fibroblast pro-inflammatory mechanisms via phosphodiesterase 4B.

Wade SM, Trenkmann M, McGarry T, Canavan M, Marzaioli V, Wade SC, Veale DJ, Fearon U.

J Autoimmun. 2019 Jan;96:86-93. doi: 10.1016/j.jaut.2018.08.008. Epub 2018 Sep 1.

24.

The Utility and Limitations of CRP, ESR and DAS28-CRP in Appraising Disease Activity in Rheumatoid Arthritis.

Orr CK, Najm A, Young F, McGarry T, Biniecka M, Fearon U, Veale DJ.

Front Med (Lausanne). 2018 Aug 3;5:185. doi: 10.3389/fmed.2018.00185. eCollection 2018.

25.

Interleukin 12 and interleukin 23 play key pathogenic roles in inflammatory and proliferative pathways in giant cell arteritis.

Conway R, O'Neill L, McCarthy GM, Murphy CC, Fabre A, Kennedy S, Veale DJ, Wade SM, Fearon U, Molloy ES.

Ann Rheum Dis. 2018 Dec;77(12):1815-1824. doi: 10.1136/annrheumdis-2018-213488. Epub 2018 Aug 10.

PMID:
30097452
26.

The pathogenesis of psoriatic arthritis.

Veale DJ, Fearon U.

Lancet. 2018 Jun 2;391(10136):2273-2284. doi: 10.1016/S0140-6736(18)30830-4. Epub 2018 Jun 1. Review.

PMID:
29893226
27.

Oxidative stress impairs energy metabolism in primary cells and synovial tissue of patients with rheumatoid arthritis.

Balogh E, Veale DJ, McGarry T, Orr C, Szekanecz Z, Ng CT, Fearon U, Biniecka M.

Arthritis Res Ther. 2018 May 29;20(1):95. doi: 10.1186/s13075-018-1592-1.

28.

JAK/STAT Blockade Alters Synovial Bioenergetics, Mitochondrial Function, and Proinflammatory Mediators in Rheumatoid Arthritis.

McGarry T, Orr C, Wade S, Biniecka M, Wade S, Gallagher L, Low C, Veale DJ, Fearon U.

Arthritis Rheumatol. 2018 Dec;70(12):1959-1970. doi: 10.1002/art.40569. Epub 2018 Oct 27.

29.

Ustekinumab for refractory giant cell arteritis: A prospective 52-week trial.

Conway R, O'Neill L, Gallagher P, McCarthy GM, Murphy CC, Veale DJ, Fearon U, Molloy ES.

Semin Arthritis Rheum. 2018 Dec;48(3):523-528. doi: 10.1016/j.semarthrit.2018.04.004. Epub 2018 Apr 22.

PMID:
29776658
30.

The pathogenic role of dendritic cells in non-infectious anterior uveitis.

O'Rourke M, Fearon U, Sweeney CM, Basdeo SA, Fletcher JM, Murphy CC, Canavan M.

Exp Eye Res. 2018 Aug;173:121-128. doi: 10.1016/j.exer.2018.05.008. Epub 2018 May 25.

PMID:
29763582
31.

Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus.

Cole S, Walsh A, Yin X, Wechalekar MD, Smith MD, Proudman SM, Veale DJ, Fearon U, Pitzalis C, Humby F, Bombardieri M, Axel A, Adams H 3rd, Chiu C, Sharp M, Alvarez J, Anderson I, Madakamutil L, Nagpal S, Guo Y.

Arthritis Res Ther. 2018 May 2;20(1):85. doi: 10.1186/s13075-018-1578-z.

32.

Hypoxia, oxidative stress and inflammation.

McGarry T, Biniecka M, Veale DJ, Fearon U.

Free Radic Biol Med. 2018 Sep;125:15-24. doi: 10.1016/j.freeradbiomed.2018.03.042. Epub 2018 Mar 27. Review.

PMID:
29601945
33.

Knee joint synovitis: study of correlations and diagnostic performances of ultrasonography compared with histopathology.

Najm A, Orr C, Gallagher L, Biniecka M, Gaigneux E, Le Goff B, Fearon U, Veale DJ.

RMD Open. 2018 Feb 8;4(1):e000616. doi: 10.1136/rmdopen-2017-000616. eCollection 2018.

34.

Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression.

Guo Y, Walsh AM, Canavan M, Wechalekar MD, Cole S, Yin X, Scott B, Loza M, Orr C, McGarry T, Bombardieri M, Humby F, Proudman SM, Pitzalis C, Smith MD, Friedman JR, Anderson I, Madakamutil L, Veale DJ, Fearon U, Nagpal S.

PLoS One. 2018 Feb 28;13(2):e0192704. doi: 10.1371/journal.pone.0192704. eCollection 2018.

35.

Corrigendum: Synovial tissue research: a state-of-the-art review.

Orr C, Vieira-Sousa E, Boyle DL, Buch MH, Buckley CD, Cañete JD, Catrina AI, Choy EHS, Emery P, Fearon U, Filer A, Gerlag D, Humby F, Isaacs JD, Just SA, Lauwerys BR, Goff BL, Manzo A, McGarry T, McInnes IB, Najm A, Pitzalis C, Pratt A, Smith M, Tak PP, Tas SW, Thurlings R, Fonseca JE, Veale DJ.

Nat Rev Rheumatol. 2017 Dec 19;14(1):60. doi: 10.1038/nrrheum.2017.206.

PMID:
29255214
36.

Synovial tissue research: a state-of-the-art review.

Orr C, Vieira-Sousa E, Boyle DL, Buch MH, Buckley CD, Cañete JD, Catrina AI, Choy EHS, Emery P, Fearon U, Filer A, Gerlag D, Humby F, Isaacs JD, Just SA, Lauwerys BR, Le Goff B, Manzo A, McGarry T, McInnes IB, Najm A, Pitzalis C, Pratt A, Smith M, Tak PP, Thurlings R, Fonseca JE, Veale DJ.

Nat Rev Rheumatol. 2017 Sep 22;13(10):630. doi: 10.1038/nrrheum.2017.161.

PMID:
28935945
37.

Reply.

McCarthy C, Reeves EP, Orr C, Fearon U, Veale DJ, McElvaney NG.

Arthritis Rheumatol. 2017 Dec;69(12):2404-2406. doi: 10.1002/art.40309. Epub 2017 Nov 8. No abstract available.

38.

Synovial Immunophenotype and Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis Patients: Relationship to Treatment Response and Radiologic Prognosis.

Orr C, Najm A, Biniecka M, McGarry T, Ng CT, Young F, Fearon U, Veale DJ.

Arthritis Rheumatol. 2017 Nov;69(11):2114-2123. doi: 10.1002/art.40218.

39.

Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells.

Rauber S, Luber M, Weber S, Maul L, Soare A, Wohlfahrt T, Lin NY, Dietel K, Bozec A, Herrmann M, Kaplan MH, Weigmann B, Zaiss MM, Fearon U, Veale DJ, Cañete JD, Distler O, Rivellese F, Pitzalis C, Neurath MF, McKenzie ANJ, Wirtz S, Schett G, Distler JHW, Ramming A.

Nat Med. 2017 Aug;23(8):938-944. doi: 10.1038/nm.4373. Epub 2017 Jul 17.

40.

Synovial tissue research: a state-of-the-art review.

Orr C, Vieira-Sousa E, Boyle DL, Buch MH, Buckley CD, Cañete JD, Catrina AI, Choy EHS, Emery P, Fearon U, Filer A, Gerlag D, Humby F, Isaacs JD, Just SA, Lauwerys BR, Le Goff B, Manzo A, McGarry T, McInnes IB, Najm A, Pitzalis C, Pratt A, Smith M, Tak PP, Thurlings R, Fonseca JE, Veale DJ, Tas SW.

Nat Rev Rheumatol. 2017 Aug;13(8):463-475. doi: 10.1038/nrrheum.2017.115. Epub 2017 Jul 13. Review. Erratum in: Nat Rev Rheumatol. 2017 Sep 22;13(10 ):630. Nat Rev Rheumatol. 2017 Dec 19;14 (1):60.

PMID:
28701760
41.

Response to: ustekinumab inhibits Th1 and Th17 polarisation in a giant-cell arteritis patient by Samson et al.

Conway R, Fearon U, Molloy ES.

Ann Rheum Dis. 2018 Feb;77(2):e7. doi: 10.1136/annrheumdis-2017-211669. Epub 2017 May 25. No abstract available.

PMID:
28546254
42.

Cellular and molecular perspectives in rheumatoid arthritis.

Veale DJ, Orr C, Fearon U.

Semin Immunopathol. 2017 Jun;39(4):343-354. doi: 10.1007/s00281-017-0633-1. Epub 2017 May 15. Review.

PMID:
28508153
43.

CD40L-Dependent Pathway Is Active at Various Stages of Rheumatoid Arthritis Disease Progression.

Guo Y, Walsh AM, Fearon U, Smith MD, Wechalekar MD, Yin X, Cole S, Orr C, McGarry T, Canavan M, Kelly S, Lin TA, Liu X, Proudman SM, Veale DJ, Pitzalis C, Nagpal S.

J Immunol. 2017 Jun 1;198(11):4490-4501. doi: 10.4049/jimmunol.1601988. Epub 2017 Apr 28.

44.

Brief Report: Genetic Variation of the α1 -Antitrypsin Gene Is Associated With Increased Autoantibody Production in Rheumatoid Arthritis.

McCarthy C, Orr C, Fee LT, Carroll TP, Dunlea DM, Hunt DJL, Dunne E, O'Connell P, McCarthy G, Kenny D, Fearon U, Veale DJ, Reeves EP, McElvaney NG.

Arthritis Rheumatol. 2017 Aug;69(8):1576-1579. doi: 10.1002/art.40127. Epub 2017 Jun 26.

45.

The role of metabolism in the pathogenesis of osteoarthritis.

Mobasheri A, Rayman MP, Gualillo O, Sellam J, van der Kraan P, Fearon U.

Nat Rev Rheumatol. 2017 May;13(5):302-311. doi: 10.1038/nrrheum.2017.50. Epub 2017 Apr 6. Review.

PMID:
28381830
46.

Resolution of TLR2-induced inflammation through manipulation of metabolic pathways in Rheumatoid Arthritis.

McGarry T, Biniecka M, Gao W, Cluxton D, Canavan M, Wade S, Wade S, Gallagher L, Orr C, Veale DJ, Fearon U.

Sci Rep. 2017 Feb 22;7:43165. doi: 10.1038/srep43165.

47.

Response to: 'Regulatory role of the JAK STAT kinase signalling system on the IL-23/IL-17 cytokine axis in psoriatic arthritis' by Raychaudhuri et al.

McGarry T, Gao W, Veale DJ, Fearon U.

Ann Rheum Dis. 2017 Oct;76(10):e37. doi: 10.1136/annrheumdis-2017-211081. Epub 2017 Feb 8. No abstract available.

PMID:
28179266
48.

Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by Regulatory T Cells.

Basdeo SA, Cluxton D, Sulaimani J, Moran B, Canavan M, Orr C, Veale DJ, Fearon U, Fletcher JM.

J Immunol. 2017 Mar 15;198(6):2249-2259. doi: 10.4049/jimmunol.1600737. Epub 2017 Feb 6.

49.

Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis.

Fearon U, Canavan M, Biniecka M, Veale DJ.

Nat Rev Rheumatol. 2016 Jul;12(7):385-97. doi: 10.1038/nrrheum.2016.69. Epub 2016 May 26. Review.

PMID:
27225300
50.

Ustekinumab for the treatment of refractory giant cell arteritis.

Conway R, O'Neill L, O'Flynn E, Gallagher P, McCarthy GM, Murphy CC, Veale DJ, Fearon U, Molloy ES.

Ann Rheum Dis. 2016 Aug;75(8):1578-9. doi: 10.1136/annrheumdis-2016-209351. Epub 2016 May 3. No abstract available.

PMID:
27143653

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