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Items: 1 to 50 of 180

1.

Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells.

Libiad M, Vitvitsky V, Bostelaar T, Bak DW, Lee HJ, Sakamoto N, Fearon ER, Lyssiotis CA, Weerapana E, Banerjee R.

J Biol Chem. 2019 Jun 18. pii: jbc.RA119.009442. doi: 10.1074/jbc.RA119.009442. [Epub ahead of print]

2.

Trp53 null and R270H mutant alleles have comparable effects in regulating invasion, metastasis, and gene expression in mouse colon tumorigenesis.

Tang J, Feng Y, Kuick R, Green M, Green M, Sakamoto N, Kurosu Y, Lin J, Cho KR, Fearon ER.

Lab Invest. 2019 May 31. doi: 10.1038/s41374-019-0269-y. [Epub ahead of print]

PMID:
31148594
3.

Lineage tracing suggests that ovarian endosalpingiosis does not result from escape of oviductal epithelium.

Wang Y, Sessine MS, Zhai Y, Tipton C, McCool K, Kuick R, Connolly DC, Fearon ER, Cho KR.

J Pathol. 2019 May 27. doi: 10.1002/path.5308. [Epub ahead of print]

PMID:
31131879
4.

Silencing the GUCA2A-GUCY2C tumor suppressor axis in CIN, serrated, and MSI colorectal neoplasia.

Bashir B, Merlino DJ, Rappaport JA, Gnass E, Palazzo JP, Feng Y, Fearon ER, Snook AE, Waldman SA.

Hum Pathol. 2019 May;87:103-114. doi: 10.1016/j.humpath.2018.11.032. Epub 2019 Feb 2.

PMID:
30716341
5.

An immunohistochemical approach to detect oncogenic CTNNB1 mutations in primary neoplastic tissues.

Akyol A, Güner G, Özşeker HS, Işık A, Atcı Ö, Uzun S, Atayar E, Ozaltin F, Gedikoğlu G, Sökmensüer C, Fearon ER.

Lab Invest. 2019 Jan;99(1):128-137. doi: 10.1038/s41374-018-0121-9. Epub 2018 Sep 3.

PMID:
30177831
6.

MOLECULAR FEATURES AND MOUSE MODELS OF COLORECTAL CANCER.

Fearon ER.

Trans Am Clin Climatol Assoc. 2018;129:56-62.

7.

Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma.

Schofield HK, Zeller J, Espinoza C, Halbrook CJ, Del Vecchio A, Magnuson B, Fabo T, Daylan AEC, Kovalenko I, Lee HJ, Yan W, Feng Y, Karim SA, Kremer DM, Kumar-Sinha C, Lyssiotis CA, Ljungman M, Morton JP, Galbán S, Fearon ER, Pasca di Magliano M.

JCI Insight. 2018 Jan 25;3(2). pii: 97422. doi: 10.1172/jci.insight.97422. eCollection 2018 Jan 25.

8.

Thiosulfate sulfurtransferase-like domain-containing 1 protein interacts with thioredoxin.

Libiad M, Motl N, Akey DL, Sakamoto N, Fearon ER, Smith JL, Banerjee R.

J Biol Chem. 2018 Feb 23;293(8):2675-2686. doi: 10.1074/jbc.RA117.000826. Epub 2018 Jan 18.

9.

ZBP-89 function in colonic stem cells and during butyrate-induced senescence.

Ocadiz-Ruiz R, Photenhauer AL, Hayes MM, Ding L, Fearon ER, Merchant JL.

Oncotarget. 2017 Oct 9;8(55):94330-94344. doi: 10.18632/oncotarget.21698. eCollection 2017 Nov 7.

10.

Lymph Node Metastases in Colon Cancer Are Polyclonal.

Ulintz PJ, Greenson JK, Wu R, Fearon ER, Hardiman KM.

Clin Cancer Res. 2018 May 1;24(9):2214-2224. doi: 10.1158/1078-0432.CCR-17-1425. Epub 2017 Dec 4.

11.

High-grade serous carcinomas arise in the mouse oviduct via defects linked to the human disease.

Zhai Y, Wu R, Kuick R, Sessine MS, Schulman S, Green M, Fearon ER, Cho KR.

J Pathol. 2017 Sep;243(1):16-25. doi: 10.1002/path.4927. Epub 2017 Jul 25. Erratum in: J Pathol. 2017 Oct;243(2):267.

12.

Autocrine lysophosphatidic acid signaling activates β-catenin and promotes lung allograft fibrosis.

Cao P, Aoki Y, Badri L, Walker NM, Manning CM, Lagstein A, Fearon ER, Lama VN.

J Clin Invest. 2017 Apr 3;127(4):1517-1530. doi: 10.1172/JCI88896. Epub 2017 Feb 27.

13.

YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis.

Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1643-1648. doi: 10.1073/pnas.1620290114. Epub 2017 Jan 27.

14.

BRAFV600E cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis.

Sakamoto N, Feng Y, Stolfi C, Kurosu Y, Green M, Lin J, Green ME, Sentani K, Yasui W, McMahon M, Hardiman KM, Spence JR, Horita N, Greenson JK, Kuick R, Cho KR, Fearon ER.

Elife. 2017 Jan 10;6. pii: e20331. doi: 10.7554/eLife.20331.

15.

Impact of oviductal versus ovarian epithelial cell of origin on ovarian endometrioid carcinoma phenotype in the mouse.

Wu R, Zhai Y, Kuick R, Karnezis AN, Garcia P, Naseem A, Hu TC, Fearon ER, Cho KR.

J Pathol. 2016 Nov;240(3):341-351. doi: 10.1002/path.4783.

16.

Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis.

Xue X, Ramakrishnan SK, Weisz K, Triner D, Xie L, Attili D, Pant A, Győrffy B, Zhan M, Carter-Su C, Hardiman KM, Wang TD, Dame MK, Varani J, Brenner D, Fearon ER, Shah YM.

Cell Metab. 2016 Sep 13;24(3):447-461. doi: 10.1016/j.cmet.2016.07.015. Epub 2016 Aug 18.

17.

Activation of Wnt/β-Catenin in Ewing Sarcoma Cells Antagonizes EWS/ETS Function and Promotes Phenotypic Transition to More Metastatic Cell States.

Pedersen EA, Menon R, Bailey KM, Thomas DG, Van Noord RA, Tran J, Wang H, Qu PP, Hoering A, Fearon ER, Chugh R, Lawlor ER.

Cancer Res. 2016 Sep 1;76(17):5040-53. doi: 10.1158/0008-5472.CAN-15-3422. Epub 2016 Jun 30.

18.

CDX2: Linking Cell and Patient Fates in Colon Cancer.

Fearon ER, Huang EH.

Cell Stem Cell. 2016 Feb 4;18(2):168-9. doi: 10.1016/j.stem.2016.01.011.

19.

Germline Sequence Variants and Ovarian Cancer: Known-Knowns and Known-Unknowns.

Stoffel EM, Fearon ER.

JAMA Oncol. 2016 Apr;2(4):491-2. doi: 10.1001/jamaoncol.2015.5622. No abstract available.

PMID:
26720286
20.

Intra-tumor genetic heterogeneity in rectal cancer.

Hardiman KM, Ulintz PJ, Kuick RD, Hovelson DH, Gates CM, Bhasi A, Rodrigues Grant A, Liu J, Cani AK, Greenson JK, Tomlins SA, Fearon ER.

Lab Invest. 2016 Jan;96(1):4-15. doi: 10.1038/labinvest.2015.131. Epub 2015 Nov 16.

21.

Tissue-Specific Effects of Reduced β-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium.

Feng Y, Sakamoto N, Wu R, Liu JY, Wiese A, Green ME, Green M, Akyol A, Roy BC, Zhai Y, Cho KR, Fearon ER.

PLoS Genet. 2015 Nov 3;11(11):e1005638. doi: 10.1371/journal.pgen.1005638. eCollection 2015 Nov.

22.

Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1.

Zhang H, Ramakrishnan SK, Triner D, Centofanti B, Maitra D, Győrffy B, Sebolt-Leopold JS, Dame MK, Varani J, Brenner DE, Fearon ER, Omary MB, Shah YM.

Sci Signal. 2015 Oct 6;8(397):ra98. doi: 10.1126/scisignal.aac5418.

23.

Arid1a inactivation in an Apc- and Pten-defective mouse ovarian cancer model enhances epithelial differentiation and prolongs survival.

Zhai Y, Kuick R, Tipton C, Wu R, Sessine M, Wang Z, Baker SJ, Fearon ER, Cho KR.

J Pathol. 2016 Jan;238(1):21-30. doi: 10.1002/path.4599. Epub 2015 Sep 15.

24.

An AXIN2 Mutant Allele Associated With Predisposition to Colorectal Neoplasia Has Context-Dependent Effects on AXIN2 Protein Function.

Mazzoni SM, Petty EM, Stoffel EM, Fearon ER.

Neoplasia. 2015 May;17(5):463-72. doi: 10.1016/j.neo.2015.04.006.

25.

Molecular subtyping of colorectal cancer: time to explore both intertumoral and intratumoral heterogeneity to evaluate patient outcome.

Fearon ER, Carethers JM.

Gastroenterology. 2015 Jan;148(1):10-3. doi: 10.1053/j.gastro.2014.11.024. Epub 2014 Nov 22. No abstract available.

26.

Regulation of Wnt signaling target gene expression by the histone methyltransferase DOT1L.

Gibbons GS, Owens SR, Fearon ER, Nikolovska-Coleska Z.

ACS Chem Biol. 2015 Jan 16;10(1):109-14. doi: 10.1021/cb500668u. Epub 2014 Nov 10.

PMID:
25361163
27.

AXIN1 and AXIN2 variants in gastrointestinal cancers.

Mazzoni SM, Fearon ER.

Cancer Lett. 2014 Dec 1;355(1):1-8. doi: 10.1016/j.canlet.2014.09.018. Epub 2014 Sep 16. Review.

28.

An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth.

Adler AS, McCleland ML, Yee S, Yaylaoglu M, Hussain S, Cosino E, Quinones G, Modrusan Z, Seshagiri S, Torres E, Chopra VS, Haley B, Zhang Z, Blackwood EM, Singh M, Junttila M, Stephan JP, Liu J, Pau G, Fearon ER, Jiang Z, Firestein R.

Genes Dev. 2014 May 15;28(10):1068-84. doi: 10.1101/gad.237206.113. Epub 2014 May 1.

29.

Rapamycin inhibition of polyposis and progression to dysplasia in a mouse model.

Hardiman KM, Liu J, Feng Y, Greenson JK, Fearon ER.

PLoS One. 2014 Apr 24;9(4):e96023. doi: 10.1371/journal.pone.0096023. eCollection 2014.

30.

KRAS and cancer stem cells in APC-mutant colorectal cancer.

Fearon ER, Wicha MS.

J Natl Cancer Inst. 2014 Feb;106(2):djt444. doi: 10.1093/jnci/djt444. No abstract available.

PMID:
24491303
31.

Biomarkers of coordinate metabolic reprogramming in colorectal tumors in mice and humans.

Manna SK, Tanaka N, Krausz KW, Haznadar M, Xue X, Matsubara T, Bowman ED, Fearon ER, Harris CC, Shah YM, Gonzalez FJ.

Gastroenterology. 2014 May;146(5):1313-24. doi: 10.1053/j.gastro.2014.01.017. Epub 2014 Jan 15.

32.

Investigation of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-diones as small molecule antagonists of β-catenin/TCF transcription.

Zeller J, Turbiak AJ, Powelson IA, Lee S, Sun D, Showalter HD, Fearon ER.

Bioorg Med Chem Lett. 2013 Nov 1;23(21):5814-20. doi: 10.1016/j.bmcl.2013.08.111. Epub 2013 Sep 7.

33.

Sox9 induction, ectopic Paneth cells, and mitotic spindle axis defects in mouse colon adenomatous epithelium arising from conditional biallelic Apc inactivation.

Feng Y, Sentani K, Wiese A, Sands E, Green M, Bommer GT, Cho KR, Fearon ER.

Am J Pathol. 2013 Aug;183(2):493-503. doi: 10.1016/j.ajpath.2013.04.013. Epub 2013 Jun 13.

34.

Type I to type II ovarian carcinoma progression: mutant Trp53 or Pik3ca confers a more aggressive tumor phenotype in a mouse model of ovarian cancer.

Wu R, Baker SJ, Hu TC, Norman KM, Fearon ER, Cho KR.

Am J Pathol. 2013 Apr;182(4):1391-9. doi: 10.1016/j.ajpath.2012.12.031.

35.

Multimodal imaging of growth and rapamycin-induced regression of colonic adenomas in apc mutation-dependent mouse.

Miller SJ, Heist KA, Feng Y, Galbán CJ, Rehemtulla A, Ross BD, Fearon ER, Wang TD.

Transl Oncol. 2012 Oct;5(5):313-20. Epub 2012 Oct 1.

36.

Cancer biology: a new RING to Wnt signaling.

Fearon ER, Spence JR.

Curr Biol. 2012 Oct 9;22(19):R849-51. doi: 10.1016/j.cub.2012.08.002.

37.

Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.

Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, Taniguchi K, Yu GY, Osterreicher CH, Hung KE, Datz C, Feng Y, Fearon ER, Oukka M, Tessarollo L, Coppola V, Yarovinsky F, Cheroutre H, Eckmann L, Trinchieri G, Karin M.

Nature. 2012 Nov 8;491(7423):254-8. doi: 10.1038/nature11465.

38.

Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis.

Dou W, Mukherjee S, Li H, Venkatesh M, Wang H, Kortagere S, Peleg A, Chilimuri SS, Wang ZT, Feng Y, Fearon ER, Mani S.

PLoS One. 2012;7(7):e36075. doi: 10.1371/journal.pone.0036075. Epub 2012 Jul 16.

39.

A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition.

Kim NH, Kim HS, Li XY, Lee I, Choi HS, Kang SE, Cha SY, Ryu JK, Yoon D, Fearon ER, Rowe RG, Lee S, Maher CA, Weiss SJ, Yook JI.

J Cell Biol. 2011 Oct 31;195(3):417-33. doi: 10.1083/jcb.201103097. Epub 2011 Oct 24.

40.

Preclinical testing of PI3K/AKT/mTOR signaling inhibitors in a mouse model of ovarian endometrioid adenocarcinoma.

Wu R, Hu TC, Rehemtulla A, Fearon ER, Cho KR.

Clin Cancer Res. 2011 Dec 1;17(23):7359-72. doi: 10.1158/1078-0432.CCR-11-1388. Epub 2011 Sep 8.

41.

Mutant KRAS promotes hyperplasia and alters differentiation in the colon epithelium but does not expand the presumptive stem cell pool.

Feng Y, Bommer GT, Zhao J, Green M, Sands E, Zhai Y, Brown K, Burberry A, Cho KR, Fearon ER.

Gastroenterology. 2011 Sep;141(3):1003-1013.e1-10. doi: 10.1053/j.gastro.2011.05.007. Epub 2011 May 18.

42.

MSX2 is an oncogenic downstream target of activated WNT signaling in ovarian endometrioid adenocarcinoma.

Zhai Y, Iura A, Yeasmin S, Wiese AB, Wu R, Feng Y, Fearon ER, Cho KR.

Oncogene. 2011 Oct 6;30(40):4152-62. doi: 10.1038/onc.2011.123. Epub 2011 Apr 18.

43.

In vivo fluorescence-based endoscopic detection of colon dysplasia in the mouse using a novel peptide probe.

Miller SJ, Joshi BP, Feng Y, Gaustad A, Fearon ER, Wang TD.

PLoS One. 2011 Mar 8;6(3):e17384. doi: 10.1371/journal.pone.0017384.

44.

Ancestries hidden in plain sight: methylation patterns for clonal analysis.

Fearon ER, Bommer GT.

Gastroenterology. 2011 Apr;140(4):1139-43. doi: 10.1053/j.gastro.2011.02.027. Epub 2011 Feb 23. No abstract available.

PMID:
21352867
45.

Molecular genetics of colorectal cancer.

Fearon ER.

Annu Rev Pathol. 2011;6:479-507. doi: 10.1146/annurev-pathol-011110-130235. Review.

PMID:
21090969
46.

CDX2 regulates multidrug resistance 1 gene expression in malignant intestinal epithelium.

Takakura Y, Hinoi T, Oue N, Sasada T, Kawaguchi Y, Okajima M, Akyol A, Fearon ER, Yasui W, Ohdan H.

Cancer Res. 2010 Sep 1;70(17):6767-78. doi: 10.1158/0008-5472.CAN-09-4701. Epub 2010 Aug 10.

47.

Loss of estrogen receptor 1 enhances cervical cancer invasion.

Zhai Y, Bommer GT, Feng Y, Wiese AB, Fearon ER, Cho KR.

Am J Pathol. 2010 Aug;177(2):884-95. doi: 10.2353/ajpath.2010.091166. Epub 2010 Jun 25.

48.

COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion.

van de Sluis B, Mao X, Zhai Y, Groot AJ, Vermeulen JF, van der Wall E, van Diest PJ, Hofker MH, Wijmenga C, Klomp LW, Cho KR, Fearon ER, Vooijs M, Burstein E.

J Clin Invest. 2010 Jun;120(6):2119-30. doi: 10.1172/JCI40583. Epub 2010 May 10.

49.

GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancer.

Watson RL, Spalding AC, Zielske SP, Morgan M, Kim AC, Bommer GT, Eldar-Finkelman H, Giordano T, Fearon ER, Hammer GD, Lawrence TS, Ben-Josef E.

Neoplasia. 2010 May;12(5):357-65.

50.

Rap1 stabilizes beta-catenin and enhances beta-catenin-dependent transcription and invasion in squamous cell carcinoma of the head and neck.

Goto M, Mitra RS, Liu M, Lee J, Henson BS, Carey T, Bradford C, Prince M, Wang CY, Fearon ER, D'Silva NJ.

Clin Cancer Res. 2010 Jan 1;16(1):65-76. doi: 10.1158/1078-0432.CCR-09-1122. Epub 2009 Dec 22.

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