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Items: 44

1.

Ebolavirus polymerase uses an unconventional genome replication mechanism.

Deflubé LR, Cressey TN, Hume AJ, Olejnik J, Haddock E, Feldmann F, Ebihara H, Fearns R, Mühlberger E.

Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8535-8543. doi: 10.1073/pnas.1815745116. Epub 2019 Apr 8.

2.

Killing two birds with one stone: How the respiratory syncytial virus polymerase initiates transcription and replication.

Noton SL, Tremaglio CZ, Fearns R.

PLoS Pathog. 2019 Feb 28;15(2):e1007548. doi: 10.1371/journal.ppat.1007548. eCollection 2019 Feb. No abstract available.

3.

Third Tofo Advanced Study Week on Emerging and Re-emerging Viruses, 2018.

Badolo A, Burt F, Daniel S, Fearns R, Gudo ES, Kielian M, Lescar J, Shi Y, von Brunn A, Weiss SR, Hilgenfeld R.

Antiviral Res. 2019 Feb;162:142-150. doi: 10.1016/j.antiviral.2018.12.015. Epub 2018 Dec 28. Review.

PMID:
30597184
4.

Development of an allosteric inhibitor class blocking RNA elongation by the respiratory syncytial virus polymerase complex.

Cox RM, Toots M, Yoon JJ, Sourimant J, Ludeke B, Fearns R, Bourque E, Patti J, Lee E, Vernachio J, Plemper RK.

J Biol Chem. 2018 Oct 26;293(43):16761-16777. doi: 10.1074/jbc.RA118.004862. Epub 2018 Sep 11.

PMID:
30206124
5.

Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses.

Yoon JJ, Toots M, Lee S, Lee ME, Ludeke B, Luczo JM, Ganti K, Cox RM, Sticher ZM, Edpuganti V, Mitchell DG, Lockwood MA, Kolykhalov AA, Greninger AL, Moore ML, Painter GR, Lowen AC, Tompkins SM, Fearns R, Natchus MG, Plemper RK.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00766-18. doi: 10.1128/AAC.00766-18. Print 2018 Aug.

6.

Mechanism for de novo initiation at two sites in the respiratory syncytial virus promoter.

Cressey TN, Noton SL, Nagendra K, Braun MR, Fearns R.

Nucleic Acids Res. 2018 Jul 27;46(13):6785-6796. doi: 10.1093/nar/gky480.

7.

Dual Catalytic Synthesis of Antiviral Compounds Based on Metallocarbene-Azide Cascade Chemistry.

Atienza BJP, Jensen LD, Noton SL, Ansalem AKV, Hobman T, Fearns R, Marchant DJ, West FG.

J Org Chem. 2018 Jul 6;83(13):6829-6842. doi: 10.1021/acs.joc.8b00222. Epub 2018 May 3.

PMID:
29663810
8.

RNA elongation by respiratory syncytial virus polymerase is calibrated by conserved region V.

Braun MR, Deflubé LR, Noton SL, Mawhorter ME, Tremaglio CZ, Fearns R.

PLoS Pathog. 2017 Dec 27;13(12):e1006803. doi: 10.1371/journal.ppat.1006803. eCollection 2017 Dec.

9.

Polymerases of paramyxoviruses and pneumoviruses.

Fearns R, Plemper RK.

Virus Res. 2017 Apr 15;234:87-102. doi: 10.1016/j.virusres.2017.01.008. Epub 2017 Jan 16. Review.

10.

New antiviral approaches for respiratory syncytial virus and other mononegaviruses: Inhibiting the RNA polymerase.

Fearns R, Deval J.

Antiviral Res. 2016 Oct;134:63-76. doi: 10.1016/j.antiviral.2016.08.006. Epub 2016 Aug 27. Review.

11.

Novel diversity-oriented synthesis-derived respiratory syncytial virus inhibitors identified via a high throughput replicon-based screen.

Duvall JR, VerPlank L, Ludeke B, McLeod SM, Lee MD 4th, Vishwanathan K, Mulrooney CA, Le Quement S, Yu Q, Palmer MA, Fleming P, Fearns R, Foley MA, Scherer CA.

Antiviral Res. 2016 Jul;131:19-25. doi: 10.1016/j.antiviral.2016.03.015. Epub 2016 Apr 6.

12.

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys.

Warren TK, Jordan R, Lo MK, Ray AS, Mackman RL, Soloveva V, Siegel D, Perron M, Bannister R, Hui HC, Larson N, Strickley R, Wells J, Stuthman KS, Van Tongeren SA, Garza NL, Donnelly G, Shurtleff AC, Retterer CJ, Gharaibeh D, Zamani R, Kenny T, Eaton BP, Grimes E, Welch LS, Gomba L, Wilhelmsen CL, Nichols DK, Nuss JE, Nagle ER, Kugelman JR, Palacios G, Doerffler E, Neville S, Carra E, Clarke MO, Zhang L, Lew W, Ross B, Wang Q, Chun K, Wolfe L, Babusis D, Park Y, Stray KM, Trancheva I, Feng JY, Barauskas O, Xu Y, Wong P, Braun MR, Flint M, McMullan LK, Chen SS, Fearns R, Swaminathan S, Mayers DL, Spiropoulou CF, Lee WA, Nichol ST, Cihlar T, Bavari S.

Nature. 2016 Mar 17;531(7594):381-5. doi: 10.1038/nature17180. Epub 2016 Mar 2. Erratum in: ACS Chem Biol. 2016 May 20;11(5):1463.

13.

Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach.

Aljabr W, Touzelet O, Pollakis G, Wu W, Munday DC, Hughes M, Hertz-Fowler C, Kenny J, Fearns R, Barr JN, Matthews DA, Hiscox JA.

J Virol. 2016 Apr 29;90(10):4876-4888. doi: 10.1128/JVI.02349-15. Print 2016 May 15.

14.

The Interferon Type I/III Response to Respiratory Syncytial Virus Infection in Airway Epithelial Cells Can Be Attenuated or Amplified by Antiviral Treatment.

McCutcheon KM, Jordan R, Mawhorter ME, Noton SL, Powers JG, Fearns R, Cihlar T, Perron M.

J Virol. 2015 Nov 25;90(4):1705-17. doi: 10.1128/JVI.02417-15. Print 2016 Feb 15.

15.

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate.

Deval J, Hong J, Wang G, Taylor J, Smith LK, Fung A, Stevens SK, Liu H, Jin Z, Dyatkina N, Prhavc M, Stoycheva AD, Serebryany V, Liu J, Smith DB, Tam Y, Zhang Q, Moore ML, Fearns R, Chanda SM, Blatt LM, Symons JA, Beigelman L.

PLoS Pathog. 2015 Jun 22;11(6):e1004995. doi: 10.1371/journal.ppat.1004995. eCollection 2015 Jun.

16.

Respiratory Syncytial Virus Inhibitor AZ-27 Differentially Inhibits Different Polymerase Activities at the Promoter.

Noton SL, Nagendra K, Dunn EF, Mawhorter ME, Yu Q, Fearns R.

J Virol. 2015 Aug;89(15):7786-98. doi: 10.1128/JVI.00530-15. Epub 2015 May 20.

17.

Decapping protein 1 phosphorylation modulates IL-8 expression during respiratory syncytial virus infection.

Dickey LL, Duncan JK, Hanley TM, Fearns R.

Virology. 2015 Jul;481:199-209. doi: 10.1016/j.virol.2015.02.043. Epub 2015 Mar 19.

18.

Initiation and regulation of paramyxovirus transcription and replication.

Noton SL, Fearns R.

Virology. 2015 May;479-480:545-54. doi: 10.1016/j.virol.2015.01.014. Epub 2015 Feb 13. Review.

19.

Interactome analysis of the human respiratory syncytial virus RNA polymerase complex identifies protein chaperones as important cofactors that promote L-protein stability and RNA synthesis.

Munday DC, Wu W, Smith N, Fix J, Noton SL, Galloux M, Touzelet O, Armstrong SD, Dawson JM, Aljabr W, Easton AJ, Rameix-Welti MA, de Oliveira AP, Simabuco FM, Ventura AM, Hughes DJ, Barr JN, Fearns R, Digard P, Eléouët JF, Hiscox JA.

J Virol. 2015 Jan 15;89(2):917-30. doi: 10.1128/JVI.01783-14. Epub 2014 Oct 29.

20.

Respiratory syncytial virus can infect basal cells and alter human airway epithelial differentiation.

Persson BD, Jaffe AB, Fearns R, Danahay H.

PLoS One. 2014 Jul 17;9(7):e102368. doi: 10.1371/journal.pone.0102368. eCollection 2014.

21.

Factors affecting de novo RNA synthesis and back-priming by the respiratory syncytial virus polymerase.

Noton SL, Aljabr W, Hiscox JA, Matthews DA, Fearns R.

Virology. 2014 Aug;462-463:318-27. doi: 10.1016/j.virol.2014.05.032. Epub 2014 Jul 8.

22.

Respiratory syncytial virus: virology, reverse genetics, and pathogenesis of disease.

Collins PL, Fearns R, Graham BS.

Curr Top Microbiol Immunol. 2013;372:3-38. doi: 10.1007/978-3-642-38919-1_1.

23.

Respiratory syncytial virus polymerase can initiate transcription from position 3 of the leader promoter.

Tremaglio CZ, Noton SL, Deflubé LR, Fearns R.

J Virol. 2013 Mar;87(6):3196-207. doi: 10.1128/JVI.02862-12. Epub 2013 Jan 2.

24.

The respiratory syncytial virus polymerase has multiple RNA synthesis activities at the promoter.

Noton SL, Deflubé LR, Tremaglio CZ, Fearns R.

PLoS Pathog. 2012;8(10):e1002980. doi: 10.1371/journal.ppat.1002980. Epub 2012 Oct 18.

25.
26.

Roles of the respiratory syncytial virus trailer region: effects of mutations on genome production and stress granule formation.

Hanley LL, McGivern DR, Teng MN, Djang R, Collins PL, Fearns R.

Virology. 2010 Oct 25;406(2):241-52. doi: 10.1016/j.virol.2010.07.006. Epub 2010 Aug 10.

27.

Evidence that the polymerase of respiratory syncytial virus initiates RNA replication in a nontemplated fashion.

Noton SL, Cowton VM, Zack CR, McGivern DR, Fearns R.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10226-31. doi: 10.1073/pnas.0913065107. Epub 2010 May 17.

28.

How RNA viruses maintain their genome integrity.

Barr JN, Fearns R.

J Gen Virol. 2010 Jun;91(Pt 6):1373-87. doi: 10.1099/vir.0.020818-0. Epub 2010 Mar 24. Review.

PMID:
20335491
29.

Akt inhibitor Akt-IV blocks virus replication through an Akt-independent mechanism.

Dunn EF, Fearns R, Connor JH.

J Virol. 2009 Nov;83(22):11665-72. doi: 10.1128/JVI.01092-09. Epub 2009 Sep 9.

30.

Cation currents in human airway epithelial cells induced by infection with influenza A virus.

Gallacher M, Brown SG, Hale BG, Fearns R, Olver RE, Randall RE, Wilson SM.

J Physiol. 2009 Jul 1;587(Pt 13):3159-73. doi: 10.1113/jphysiol.2009.171223. Epub 2009 Apr 29.

31.

Unravelling the complexities of respiratory syncytial virus RNA synthesis.

Cowton VM, McGivern DR, Fearns R.

J Gen Virol. 2006 Jul;87(Pt 7):1805-21. Review.

PMID:
16760383
35.

Mapping the transcription and replication promoters of respiratory syncytial virus.

Fearns R, Peeples ME, Collins PL.

J Virol. 2002 Feb;76(4):1663-72.

36.
37.

Rational design of live-attenuated recombinant vaccine virus for human respiratory syncytial virus by reverse genetics.

Collins PL, Whitehead SS, Bukreyev A, Fearns R, Teng MN, Juhasz K, Chanock RM, Murphy BR.

Adv Virus Res. 1999;54:423-51. Review.

PMID:
10547682
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