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Items: 15

1.

RAB7L1-Mediated Relocalization of LRRK2 to the Golgi Complex Causes Centrosomal Deficits via RAB8A.

Madero-Pérez J, Fernández B, Lara Ordóñez AJ, Fdez E, Lobbestael E, Baekelandt V, Hilfiker S.

Front Mol Neurosci. 2018 Nov 13;11:417. doi: 10.3389/fnmol.2018.00417. eCollection 2018.

2.

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.

Madero-Pérez J, Fdez E, Fernández B, Lara Ordóñez AJ, Blanca Ramírez M, Gómez-Suaga P, Waschbüsch D, Lobbestael E, Baekelandt V, Nairn AC, Ruiz-Martínez J, Aiastui A, López de Munain A, Lis P, Comptdaer T, Taymans JM, Chartier-Harlin MC, Beilina A, Gonnelli A, Cookson MR, Greggio E, Hilfiker S.

Mol Neurodegener. 2018 Jan 23;13(1):3. doi: 10.1186/s13024-018-0235-y.

3.

GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.

Blanca Ramírez M, Lara Ordóñez AJ, Fdez E, Madero-Pérez J, Gonnelli A, Drouyer M, Chartier-Harlin MC, Taymans JM, Bubacco L, Greggio E, Hilfiker S.

Hum Mol Genet. 2017 Jul 15;26(14):2747-2767. doi: 10.1093/hmg/ddx161.

4.

Cellular effects mediated by pathogenic LRRK2: homing in on Rab-mediated processes.

Madero-Pérez J, Fdez E, Fernández B, Lara Ordóñez AJ, Blanca Ramírez M, Romo Lozano M, Rivero-Ríos P, Hilfiker S.

Biochem Soc Trans. 2017 Feb 8;45(1):147-154. doi: 10.1042/BST20160392. Review.

PMID:
28202668
5.

LRRK2: from kinase to GTPase to microtubules and back.

Blanca Ramírez M, Lara Ordóñez AJ, Fdez E, Hilfiker S.

Biochem Soc Trans. 2017 Feb 8;45(1):141-146. doi: 10.1042/BST20160333. Review.

PMID:
28202667
6.

Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A.

Fernández B, Fdez E, Gómez-Suaga P, Gil F, Molina-Villalba I, Ferrer I, Patel S, Churchill GC, Hilfiker S.

Autophagy. 2016 Sep;12(9):1487-506. doi: 10.1080/15548627.2016.1190072. Epub 2016 Jul 6.

7.

LRRK2 and Parkinson's Disease: From Lack of Structure to Gain of Function.

Blanca Ramírez M, Madero-Perez J, Rivero-Rios P, Martinez-Salvador M, Lara Ordonez AJ, Fernandez B, Fdez E, Hilfiker S.

Curr Protein Pept Sci. 2017;18(7):677-686. doi: 10.2174/1389203717666160311121748. Review.

PMID:
26965688
8.

LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity.

Gómez-Suaga P, Rivero-Ríos P, Fdez E, Blanca Ramírez M, Ferrer I, Aiastui A, López De Munain A, Hilfiker S.

Hum Mol Genet. 2014 Dec 20;23(25):6779-96. doi: 10.1093/hmg/ddu395. Epub 2014 Jul 30.

PMID:
25080504
9.

Upstream deregulation of calcium signaling in Parkinson's disease.

Rivero-Ríos P, Gómez-Suaga P, Fdez E, Hilfiker S.

Front Mol Neurosci. 2014 Jun 17;7:53. doi: 10.3389/fnmol.2014.00053. eCollection 2014. Review.

10.

Novel insights into the neurobiology underlying LRRK2-linked Parkinson's disease.

Gómez-Suaga P, Fdez E, Fernández B, Martínez-Salvador M, Blanca Ramírez M, Madero-Pérez J, Rivero-Ríos P, Fuentes JM, Hilfiker S.

Neuropharmacology. 2014 Oct;85:45-56. doi: 10.1016/j.neuropharm.2014.05.020. Epub 2014 May 24. Review.

PMID:
24863040
11.

A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease.

Gómez-Suaga P, Fdez E, Blanca Ramírez M, Hilfiker S.

Parkinsons Dis. 2012;2012:324521. doi: 10.1155/2012/324521. Epub 2012 Dec 3.

12.

Transmembrane-domain determinants for SNARE-mediated membrane fusion.

Fdez E, Martínez-Salvador M, Beard M, Woodman P, Hilfiker S.

J Cell Sci. 2010 Jul 15;123(Pt 14):2473-80. doi: 10.1242/jcs.061325. Epub 2010 Jun 22.

13.

Sexy Regulation of SNARE-Mediated Membrane Fusion by Local Lipid Metabolism.

Fdez E, Hilfiker S.

Front Synaptic Neurosci. 2010 Jun 25;2:3. doi: 10.3389/fnsyn.2010.00003. eCollection 2010. No abstract available.

14.

A role for soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex dimerization during neurosecretion.

Fdez E, Jowitt TA, Wang MC, Rajebhosale M, Foster K, Bella J, Baldock C, Woodman PG, Hilfiker S.

Mol Biol Cell. 2008 Aug;19(8):3379-89. doi: 10.1091/mbc.E08-01-0010. Epub 2008 May 28.

15.

Vesicle pools and synapsins: new insights into old enigmas.

Fdez E, Hilfiker S.

Brain Cell Biol. 2006 Jun;35(2-3):107-15. Epub 2007 Oct 4. Review.

PMID:
17957477

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