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Items: 1 to 50 of 132

1.

Methylation Density Pattern of KEAP1 Gene in Lung Cancer Cell Lines Detected by Quantitative Methylation Specific PCR and Pyrosequencing.

Fabrizio FP, Sparaneo A, Centra F, Trombetta D, Storlazzi CT, Graziano P, Maiello E, Fazio VM, Muscarella LA.

Int J Mol Sci. 2019 May 31;20(11). pii: E2697. doi: 10.3390/ijms20112697.

2.

Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors.

Sparaneo A, Fabrizio FP, la Torre A, Graziano P, Di Maio M, Fontana A, Bisceglia M, Rossi A, Pizzolitto S, De Maglio G, Tancredi A, Grimaldi F, Balsamo T, Centra F, Manzorra MC, Trombetta D, Pantalone A, Bonfitto A, Maiello E, Fazio VM, Muscarella LA.

Int J Mol Sci. 2019 May 23;20(10). pii: E2531. doi: 10.3390/ijms20102531.

3.

EphB2 stem-related and EphA2 progression-related miRNA-based networks in progressive stages of CRC evolution: clinical significance and potential miRNA drivers.

De Robertis M, Mazza T, Fusilli C, Loiacono L, Poeta ML, Sanchez M, Massi E, Lamorte G, Diodoro MG, Pescarmona E, Signori E, Pesole G, Vescovi AL, Garcia-Foncillas J, Fazio VM.

Mol Cancer. 2018 Nov 30;17(1):169. doi: 10.1186/s12943-018-0912-z.

4.

In Vivo Evaluation of a New Recombinant Hyaluronidase to Improve Gene Electro-Transfer Protocols for DNA-Based Drug Delivery against Cancer.

De Robertis M, Pasquet L, Loiacono L, Bellard E, Messina L, Vaccaro S, Di Pasquale R, Fazio VM, Rols MP, Teissie J, Golzio M, Signori E.

Cancers (Basel). 2018 Oct 28;10(11). pii: E405. doi: 10.3390/cancers10110405.

5.

Current understanding and clinical utility of miRNAs regulation of colon cancer stem cells.

De Robertis M, Poeta ML, Signori E, Fazio VM.

Semin Cancer Biol. 2018 Dec;53:232-247. doi: 10.1016/j.semcancer.2018.08.008. Epub 2018 Aug 18. Review.

PMID:
30130662
6.

Integrated transcriptomic and epigenomic analysis of ovarian cancer reveals epigenetically silenced GULP1.

Maldonado L, Brait M, Izumchenko E, Begum S, Chatterjee A, Sen T, Loyo M, Barbosa A, Poeta ML, Makarev E, Zhavoronkov A, Fazio VM, Angioli R, Rabitti C, Ongenaert M, Van Criekinge W, Noordhuis MG, de Graeff P, Wisman GBA, van der Zee AGJ, Hoque MO.

Cancer Lett. 2018 Oct 1;433:242-251. doi: 10.1016/j.canlet.2018.06.030. Epub 2018 Jun 28.

PMID:
29964205
7.

Frequent NRG1 fusions in Caucasian pulmonary mucinous adenocarcinoma predicted by Phospho-ErbB3 expression.

Trombetta D, Graziano P, Scarpa A, Sparaneo A, Rossi G, Rossi A, Di Maio M, Antonello D, Mafficini A, Fabrizio FP, Manzorra MC, Balsamo T, Centra F, Simbolo M, Pantalone A, Notarangelo M, Parente P, Lucia Dimitri MC, Bonfitto A, Fiordelisi F, Storlazzi CT, L'Abbate A, Taurchini M, Maiello E, Fazio VM, Muscarella LA.

Oncotarget. 2018 Jan 3;9(11):9661-9671. doi: 10.18632/oncotarget.23800. eCollection 2018 Feb 9.

8.

ALK and NRG1 Fusions Coexist in a Patient with Signet Ring Cell Lung Adenocarcinoma.

Muscarella LA, Trombetta D, Fabrizio FP, Scarpa A, Fazio VM, Maiello E, Rossi A, Graziano P.

J Thorac Oncol. 2017 Oct;12(10):e161-e163. doi: 10.1016/j.jtho.2017.05.014. No abstract available.

9.

NRG1-ErbB Lost in Translation: A New Paradigm for Lung Cancer?

Trombetta D, Rossi A, Fabrizio FP, Sparaneo A, Graziano P, Fazio VM, Muscarella LA.

Curr Med Chem. 2017;24(38):4213-4228. doi: 10.2174/0929867324666170911170554. Review.

PMID:
28901268
10.

Gene Electrotransfer of Plasmid-Encoding IL-12 Recruits the M1 Macrophages and Antigen-Presenting Cells Inducing the Eradication of Aggressive B16F10 Murine Melanoma.

Lampreht Tratar U, Loiacono L, Cemazar M, Kamensek U, Fazio VM, Sersa G, Signori E.

Mediators Inflamm. 2017;2017:5285890. doi: 10.1155/2017/5285890. Epub 2017 May 16.

11.

A malignant inflammatory myofibroblastic tumor of the hypopharynx harboring the 3a/b variants of the EML4-ALK fusion gene.

Muscarella LA, Rossi G, Trombetta D, La Torre A, Di Candia L, Mengoli MC, Sparaneo A, Fazio VM, Graziano P.

Oncol Lett. 2017 Feb;13(2):593-598. doi: 10.3892/ol.2016.5504. Epub 2016 Dec 14.

12.

Stepwise analysis of MIR9 loci identifies miR-9-5p to be involved in Oestrogen regulated pathways in breast cancer patients.

Barbano R, Pasculli B, Rendina M, Fontana A, Fusilli C, Copetti M, Castellana S, Valori VM, Morritti M, Graziano P, Luigi C, Coco M, Picardo F, Mazza T, Evron E, Murgo R, Maiello E, Esteller M, Fazio VM, Parrella P.

Sci Rep. 2017 Mar 27;7:45283. doi: 10.1038/srep45283.

13.

Keap1/Nrf2 impairing revised: are we missing the single nucleotide polymorphisms?

Muscarella LA, Fazio VM.

J Thorac Dis. 2016 Dec;8(12):E1752-E1754. doi: 10.21037/jtd.2016.12.85. No abstract available.

14.

Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma.

Fabrizio FP, Costantini M, Copetti M, la Torre A, Sparaneo A, Fontana A, Poeta L, Gallucci M, Sentinelli S, Graziano P, Parente P, Pompeo V, De Salvo L, Simone G, Papalia R, Picardo F, Balsamo T, Flammia GP, Trombetta D, Pantalone A, Kok K, Paranita F, Muscarella LA, Fazio VM.

Oncotarget. 2017 Feb 14;8(7):11187-11198. doi: 10.18632/oncotarget.14492.

15.

Dysregulation of EGFR Pathway in EphA2 Cell Subpopulation Significantly Associates with Poor Prognosis in Colorectal Cancer.

De Robertis M, Loiacono L, Fusilli C, Poeta ML, Mazza T, Sanchez M, Marchionni L, Signori E, Lamorte G, Vescovi AL, Garcia-Foncillas J, Fazio VM.

Clin Cancer Res. 2017 Jan 1;23(1):159-170. doi: 10.1158/1078-0432.CCR-16-0709. Epub 2016 Jul 11.

16.

Collecting duct carcinoma of the kidney is associated with CDKN2A deletion and SLC family gene up-regulation.

Wang J, Papanicolau-Sengos A, Chintala S, Wei L, Liu B, Hu Q, Miles KM, Conroy JM, Glenn ST, Costantini M, Magi-Galluzzi C, Signoretti S, Choueiri T, Gallucci M, Sentinelli S, Fazio VM, Poeta ML, Liu S, Morrison C, Pili R.

Oncotarget. 2016 May 24;7(21):29901-15. doi: 10.18632/oncotarget.9093.

17.

The Post-Surgical Long-Term Behaviour of Lung Carcinoid Tumours.

Tancredi A, Muscarella LA, la Torre A, Scaramuzzi R, Valori VM, Fazio VM, Scaramuzzi G.

Indian J Surg. 2015 Dec;77(6):481-5. doi: 10.1007/s12262-015-1290-z. Epub 2015 May 31.

18.

Competitive allele-specific TaqMan PCR (Cast-PCR) is a sensitive, specific and fast method for BRAF V600 mutation detection in Melanoma patients.

Barbano R, Pasculli B, Coco M, Fontana A, Copetti M, Rendina M, Valori VM, Graziano P, Maiello E, Fazio VM, Parrella P.

Sci Rep. 2015 Dec 22;5:18592. doi: 10.1038/srep18592.

19.

TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival.

Micale L, Fusco C, Fontana A, Barbano R, Augello B, De Nittis P, Copetti M, Pellico MT, Mandriani B, Cocciadiferro D, Parrella P, Fazio VM, Dimitri LM, D'Angelo V, Novielli C, Larizza L, Daga A, Merla G.

BMC Cancer. 2015 Jun 16;15:470. doi: 10.1186/s12885-015-1449-9.

20.

A miRNA signature for defining aggressive phenotype and prognosis in gliomas.

Barbano R, Palumbo O, Pasculli B, Galasso M, Volinia S, D'Angelo V, Icolaro N, Coco M, Dimitri L, Graziano P, Copetti M, Valori VM, Maiello E, Carella M, Fazio VM, Parrella P.

PLoS One. 2014 Oct 3;9(10):e108950. doi: 10.1371/journal.pone.0108950. eCollection 2014.

21.

Evaluation of microRNA-10b prognostic significance in a prospective cohort of breast cancer patients.

Parrella P, Barbano R, Pasculli B, Fontana A, Copetti M, Valori VM, Poeta ML, Perrone G, Righi D, Castelvetere M, Coco M, Balsamo T, Morritti M, Pellegrini F, Onetti-Muda A, Maiello E, Murgo R, Fazio VM.

Mol Cancer. 2014 Jun 4;13:142. doi: 10.1186/1476-4598-13-142.

22.

CD74-NRG1 fusions in lung adenocarcinoma.

Fernandez-Cuesta L, Plenker D, Osada H, Sun R, Menon R, Leenders F, Ortiz-Cuaran S, Peifer M, Bos M, Daßler J, Malchers F, Schöttle J, Vogel W, Dahmen I, Koker M, Ullrich RT, Wright GM, Russell PA, Wainer Z, Solomon B, Brambilla E, Nagy-Mignotte H, Moro-Sibilot D, Brambilla CG, Lantuejoul S, Altmüller J, Becker C, Nürnberg P, Heuckmann JM, Stoelben E, Petersen I, Clement JH, Sänger J, Muscarella LA, la Torre A, Fazio VM, Lahortiga I, Perera T, Ogata S, Parade M, Brehmer D, Vingron M, Heukamp LC, Buettner R, Zander T, Wolf J, Perner S, Ansén S, Haas SA, Yatabe Y, Thomas RK.

Cancer Discov. 2014 Apr;4(4):415-22. doi: 10.1158/2159-8290.CD-13-0633. Epub 2014 Jan 27.

23.

The genetics of sports injuries and athletic performance.

Maffulli N, Margiotti K, Longo UG, Loppini M, Fazio VM, Denaro V.

Muscles Ligaments Tendons J. 2013 Aug 11;3(3):173-89. Review.

24.

Establishment and genetic characterization of ANGM-CSS, a novel, immortal cell line derived from a human glioblastoma multiforme.

Notarangelo A, Trombetta D, D'Angelo V, Parrella P, Palumbo O, Storlazzi CT, Impera L, Muscarella LA, La Torre A, Affuso A, Fazio VM, Carella M, Zelante L.

Int J Oncol. 2014 Mar;44(3):717-24. doi: 10.3892/ijo.2013.2224. Epub 2013 Dec 23.

PMID:
24366606
25.

Molecular dissection of the VHL gene in solitary capillary hemangioblastoma of the central nervous system.

Muscarella LA, la Torre A, Faienza A, Catapano D, Bisceglia M, D'Angelo V, Parrella P, Coco M, Fini G, Tancredi A, Zelante L, Fazio VM, D'Agruma L.

J Neuropathol Exp Neurol. 2014 Jan;73(1):50-8. doi: 10.1097/NEN.0000000000000024.

PMID:
24335534
26.

The fragile X protein binds mRNAs involved in cancer progression and modulates metastasis formation.

Lucá R, Averna M, Zalfa F, Vecchi M, Bianchi F, La Fata G, Del Nonno F, Nardacci R, Bianchi M, Nuciforo P, Munck S, Parrella P, Moura R, Signori E, Alston R, Kuchnio A, Farace MG, Fazio VM, Piacentini M, De Strooper B, Achsel T, Neri G, Neven P, Evans DG, Carmeliet P, Mazzone M, Bagni C.

EMBO Mol Med. 2013 Oct;5(10):1523-36. doi: 10.1002/emmm.201302847. Epub 2013 Sep 16. Erratum in: EMBO Mol Med. 2014 Apr;6(4):567.

27.

Association of promoter methylation of VGF and PGP9.5 with ovarian cancer progression.

Brait M, Maldonado L, Noordhuis MG, Begum S, Loyo M, Poeta ML, Barbosa A, Fazio VM, Angioli R, Rabitti C, Marchionni L, de Graeff P, van der Zee AG, Wisman GB, Sidransky D, Hoque MO.

PLoS One. 2013 Sep 27;8(9):e70878. doi: 10.1371/journal.pone.0070878. eCollection 2013. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/ccd51e37-fdf3-466e-b79f-2c390df9ab28. PLoS One. 2013;8(10). doi:10.1371/annotation/5d2e13d4-cb4e-44b1-a836-dff9b4144b5b. Noordhuis, Maartje [corrected to Noordhuis, Maartje G].

28.

VHL gene alterations in Italian patients with isolated renal cell carcinomas.

Muscarella LA, D'Agruma L, la Torre A, Gigante M, Coco M, Parrella P, Battaglia M, Carrieri G, Carella M, Zelante L, Fazio VM, Gesualdo L, Ranieri E.

Int J Biol Markers. 2013 Jun 28;28(2):208-15. doi: 10.5301/jbm.5000011.

PMID:
23558940
29.

Genome-wide methylation profiling and the PI3K-AKT pathway analysis associated with smoking in urothelial cell carcinoma.

Brait M, Munari E, LeBron C, Noordhuis MG, Begum S, Michailidi C, Gonzalez-Roibon N, Maldonado L, Sen T, Guerrero-Preston R, Cope L, Parrella P, Fazio VM, Ha PK, Netto GJ, Sidransky D, Hoque MO.

Cell Cycle. 2013 Apr 1;12(7):1058-70. doi: 10.4161/cc.24050. Epub 2013 Feb 22.

30.

Hyaluronidase contributes to early inflammatory events induced by electrotransfer in mouse skeletal muscle.

Chiarella P, De Santis S, Fazio VM, Signori E.

Hum Gene Ther. 2013 Apr;24(4):406-16. doi: 10.1089/hum.2012.215. Epub 2013 Mar 26.

PMID:
23360544
31.

Aberrant Keap1 methylation in breast cancer and association with clinicopathological features.

Barbano R, Muscarella LA, Pasculli B, Valori VM, Fontana A, Coco M, la Torre A, Balsamo T, Poeta ML, Marangi GF, Maiello E, Castelvetere M, Pellegrini F, Murgo R, Fazio VM, Parrella P.

Epigenetics. 2013 Jan;8(1):105-12. doi: 10.4161/epi.23319. Epub 2012 Dec 18.

32.

Aberrant genes promoter methylation in neural crest-derived tumors.

la Torre A, Muscarella LA, Parrella P, Balsamo T, Bisceglia M, Valori VM, la Torre A, Barbano R, Perrella E, Poeta ML, Melchionda G, Merla G, Maiello E, Pellicano R, Fazio VM.

Int J Biol Markers. 2012 Dec 27;27(4):e389-94. doi: 10.5301/JBM.2012.9766.

PMID:
23125005
33.

In vivo DNA electrotransfer for immunotherapy of cancer and neurodegenerative diseases.

Fioretti D, Iurescia S, Fazio VM, Rinaldi M.

Curr Drug Metab. 2013 Mar;14(3):279-90. Review.

PMID:
23116113
34.

Electroporation in DNA vaccination protocols against cancer.

Chiarella P, Fazio VM, Signori E.

Curr Drug Metab. 2013 Mar;14(3):291-9. Review.

PMID:
23116110
35.

Hormone and cytokine circadian alteration in non-small cell lung cancer patients.

Mazzoccoli G, Sothern RB, Francavilla M, Giuliani F, Carughi S, Muscarella LA, Fazio VM, Parrella P, Vinciguerra M, Tarquini R.

Int J Immunopathol Pharmacol. 2012 Jul-Sep;25(3):691-702.

PMID:
23058019
36.

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.

Peifer M, Fernández-Cuesta L, Sos ML, George J, Seidel D, Kasper LH, Plenker D, Leenders F, Sun R, Zander T, Menon R, Koker M, Dahmen I, Müller C, Di Cerbo V, Schildhaus HU, Altmüller J, Baessmann I, Becker C, de Wilde B, Vandesompele J, Böhm D, Ansén S, Gabler F, Wilkening I, Heynck S, Heuckmann JM, Lu X, Carter SL, Cibulskis K, Banerji S, Getz G, Park KS, Rauh D, Grütter C, Fischer M, Pasqualucci L, Wright G, Wainer Z, Russell P, Petersen I, Chen Y, Stoelben E, Ludwig C, Schnabel P, Hoffmann H, Muley T, Brockmann M, Engel-Riedel W, Muscarella LA, Fazio VM, Groen H, Timens W, Sietsma H, Thunnissen E, Smit E, Heideman DA, Snijders PJ, Cappuzzo F, Ligorio C, Damiani S, Field J, Solberg S, Brustugun OT, Lund-Iversen M, Sänger J, Clement JH, Soltermann A, Moch H, Weder W, Solomon B, Soria JC, Validire P, Besse B, Brambilla E, Brambilla C, Lantuejoul S, Lorimier P, Schneider PM, Hallek M, Pao W, Meyerson M, Sage J, Shendure J, Schneider R, Büttner R, Wolf J, Nürnberg P, Perner S, Heukamp LC, Brindle PK, Haas S, Thomas RK.

Nat Genet. 2012 Oct;44(10):1104-10. doi: 10.1038/ng.2396. Epub 2012 Sep 2.

37.

Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancer-specific biomarker of colorectal tumors.

Poeta ML, Massi E, Parrella P, Pellegrini P, De Robertis M, Copetti M, Rabitti C, Perrone G, Muda AO, Molinari F, Zanellato E, Crippa S, Caputo D, Caricato M, Frattini M, Coppola R, Fazio VM.

Genes Chromosomes Cancer. 2012 Dec;51(12):1133-43. doi: 10.1002/gcc.21998. Epub 2012 Aug 25.

PMID:
22927297
38.

BCR/ABL1 fusion transcripts generated from alternative splicing: implications for future targeted therapies in Ph+ leukaemias.

Chiarella P, Summa V, De Santis S, Signori E, Picardi E, Pesole G, Saglio G, Fazio VM.

Curr Mol Med. 2012 Jun;12(5):547-65. Review.

PMID:
22300134
39.

Comparison of circadian characteristics for cytotoxic lymphocyte subsets in non-small cell lung cancer patients versus controls.

Mazzoccoli G, Sothern RB, Parrella P, Muscarella LA, Fazio VM, Giuliani F, Polyakova V, Kvetnoy IM.

Clin Exp Med. 2012 Sep;12(3):181-94. doi: 10.1007/s10238-011-0153-6. Epub 2011 Sep 11.

PMID:
21910027
40.

Epitope-driven DNA vaccine design employing immunoinformatics against B-cell lymphoma: a biotech's challenge.

Iurescia S, Fioretti D, Fazio VM, Rinaldi M.

Biotechnol Adv. 2012 Jan-Feb;30(1):372-83. doi: 10.1016/j.biotechadv.2011.06.020. Epub 2011 Jul 2. Review.

PMID:
21745560
41.

Antiphase signalling in the neuroendocrine-immune system in healthy humans.

Mazzoccoli G, Muscarella LA, Fazio VM, Piepoli A, Pazienza V, Dagostino MP, Giuliani F, Polyakova VO, Kvetnoy I.

Biomed Pharmacother. 2011 Jul;65(4):275-9. doi: 10.1016/j.biopha.2011.02.002. Epub 2011 Apr 8.

PMID:
21737229
42.

Design and pre-clinical development of epitope-based DNA vaccines against B-cell lymphoma.

Iurescia S, Fioretti D, Fazio VM, Rinaldi M.

Curr Gene Ther. 2011 Oct;11(5):414-22. Review.

PMID:
21711228
43.

Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer.

Muscarella LA, Parrella P, D'Alessandro V, la Torre A, Barbano R, Fontana A, Tancredi A, Guarnieri V, Balsamo T, Coco M, Copetti M, Pellegrini F, De Bonis P, Bisceglia M, Scaramuzzi G, Maiello E, Valori VM, Merla G, Vendemiale G, Fazio VM.

Epigenetics. 2011 Jun;6(6):710-9. Epub 2011 Jun 1.

PMID:
21610322
44.

Gene expression of somatostatin receptor subtypes SSTR2a, SSTR3 and SSTR5 in peripheral blood of neuroendocrine lung cancer affected patients.

Muscarella LA, D'Alessandro V, la Torre A, Copetti M, De Cata A, Parrella P, Sperandeo M, Pellegrini F, Frusciante V, Maiello E, Merla G, Fazio VM, Vendemiale G.

Cell Oncol (Dordr). 2011 Oct;34(5):435-41. doi: 10.1007/s13402-011-0025-9. Epub 2011 Apr 19.

PMID:
21503779
45.

The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies.

De Robertis M, Massi E, Poeta ML, Carotti S, Morini S, Cecchetelli L, Signori E, Fazio VM.

J Carcinog. 2011 Mar 24;10:9. doi: 10.4103/1477-3163.78279.

46.

Comparison and critical analysis of robotized technology for monoclonal antibody high-throughput production.

Chiarella P, Leuener M, Fasci C, de Marco A, Santini MP, Fazio VM, Sawyer AM.

Biotechnol Prog. 2011 Mar-Apr;27(2):571-6. doi: 10.1002/btpr.564. Epub 2011 Mar 18.

PMID:
21425250
47.

Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome.

Muscarella LA, Barbano R, D'Angelo V, Copetti M, Coco M, Balsamo T, la Torre A, Notarangelo A, Troiano M, Parisi S, Icolaro N, Catapano D, Valori VM, Pellegrini F, Merla G, Carella M, Fazio VM, Parrella P.

Epigenetics. 2011 Mar;6(3):317-25. Epub 2011 Mar 1.

48.

High RAD51 mRNA expression characterize estrogen receptor-positive/progesteron receptor-negative breast cancer and is associated with patient's outcome.

Barbano R, Copetti M, Perrone G, Pazienza V, Muscarella LA, Balsamo T, Storlazzi CT, Ripoli M, Rinaldi M, Valori VM, Latiano TP, Maiello E, Stanziale P, Carella M, Mangia A, Pellegrini F, Bisceglia M, Muda AO, Altomare V, Murgo R, Fazio VM, Parrella P.

Int J Cancer. 2011 Aug 1;129(3):536-45. doi: 10.1002/ijc.25736. Epub 2010 Dec 9.

49.

Application of electroporation in DNA vaccination protocols.

Chiarella P, Fazio VM, Signori E.

Curr Gene Ther. 2010 Aug;10(4):281-6. Review.

PMID:
20504275
50.

Genetic immunization with CDR3-based fusion vaccine confers protection and long-term tumor-free survival in a mouse model of lymphoma.

Iurescia S, Fioretti D, Pierimarchi P, Signori E, Zonfrillo M, Tonon G, Fazio VM, Rinaldi M.

J Biomed Biotechnol. 2010;2010:316069. doi: 10.1155/2010/316069. Epub 2010 Apr 27.

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