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Items: 1 to 50 of 259

1.

The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?

Fawcett JW.

Neurochem Res. 2019 Aug 6. doi: 10.1007/s11064-019-02844-y. [Epub ahead of print] Review.

PMID:
31388931
2.

The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function.

Fawcett JW, Oohashi T, Pizzorusso T.

Nat Rev Neurosci. 2019 Aug;20(8):451-465. doi: 10.1038/s41583-019-0196-3. Epub 2019 Jul 1. Review.

PMID:
31263252
3.

Chondroitinase improves anatomical and functional outcomes after primate spinal cord injury.

Rosenzweig ES, Salegio EA, Liang JJ, Weber JL, Weinholtz CA, Brock JH, Moseanko R, Hawbecker S, Pender R, Cruzen CL, Iaci JF, Caggiano AO, Blight AR, Haenzi B, Huie JR, Havton LA, Nout-Lomas YS, Fawcett JW, Ferguson AR, Beattie MS, Bresnahan JC, Tuszynski MH.

Nat Neurosci. 2019 Aug;22(8):1269-1275. doi: 10.1038/s41593-019-0424-1. Epub 2019 Jun 24.

PMID:
31235933
4.

The challenge of recruitment for neurotherapeutic clinical trials in spinal cord injury.

Blight AR, Hsieh J, Curt A, Fawcett JW, Guest JD, Kleitman N, Kurpad SN, Kwon BK, Lammertse DP, Weidner N, Steeves JD.

Spinal Cord. 2019 May;57(5):348-359. doi: 10.1038/s41393-019-0276-2. Epub 2019 Apr 8. Review.

PMID:
30962518
5.

Inhibition of Semaphorin3A Promotes Ocular Dominance Plasticity in the Adult Rat Visual Cortex.

Boggio EM, Ehlert EM, Lupori L, Moloney EB, De Winter F, Vander Kooi CW, Baroncelli L, Mecollari V, Blits B, Fawcett JW, Verhaagen J, Pizzorusso T.

Mol Neurobiol. 2019 Sep;56(9):5987-5997. doi: 10.1007/s12035-019-1499-0. Epub 2019 Jan 31.

PMID:
30706367
6.

Intrinsic Determinants of Axon Regeneration.

Fawcett JW, Verhaagen J.

Dev Neurobiol. 2018 Oct;78(10):890-897. doi: 10.1002/dneu.22637. Epub 2018 Oct 21.

PMID:
30345655
7.

Aggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity.

Rowlands D, Lensjø KK, Dinh T, Yang S, Andrews MR, Hafting T, Fyhn M, Fawcett JW, Dick G.

J Neurosci. 2018 Nov 21;38(47):10102-10113. doi: 10.1523/JNEUROSCI.1122-18.2018. Epub 2018 Oct 3.

8.

The Paper that Restarted Modern Central Nervous System Axon Regeneration Research.

Fawcett JW.

Trends Neurosci. 2018 May;41(5):239-242. doi: 10.1016/j.tins.2018.02.012.

PMID:
29703373
9.

Integrins promote axonal regeneration after injury of the nervous system.

Nieuwenhuis B, Haenzi B, Andrews MR, Verhaagen J, Fawcett JW.

Biol Rev Camb Philos Soc. 2018 Aug;93(3):1339-1362. doi: 10.1111/brv.12398. Epub 2018 Feb 15. Review.

10.

Targeting Chondroitin Sulfate Glycosaminoglycans to Treat Cardiac Fibrosis in Pathological Remodeling.

Zhao RR, Ackers-Johnson M, Stenzig J, Chen C, Ding T, Zhou Y, Wang P, Ng SL, Li PY, Teo G, Rudd PM, Fawcett JW, Foo RSY.

Circulation. 2018 Jun 5;137(23):2497-2513. doi: 10.1161/CIRCULATIONAHA.117.030353. Epub 2018 Jan 25.

PMID:
29371215
11.

Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts.

Dulin JN, Adler AF, Kumamaru H, Poplawski GHD, Lee-Kubli C, Strobl H, Gibbs D, Kadoya K, Fawcett JW, Lu P, Tuszynski MH.

Nat Commun. 2018 Jan 8;9(1):84. doi: 10.1038/s41467-017-02613-x.

12.

Control of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG Interaction.

Kempf A, Boda E, Kwok JCF, Fritz R, Grande V, Kaelin AM, Ristic Z, Schmandke A, Schmandke A, Tews B, Fawcett JW, Pertz O, Buffo A, Schwab ME.

Dev Cell. 2017 Oct 9;43(1):24-34.e5. doi: 10.1016/j.devcel.2017.08.014. Epub 2017 Sep 21.

13.

EFA6 regulates selective polarised transport and axon regeneration from the axon initial segment.

Eva R, Koseki H, Kanamarlapudi V, Fawcett JW.

J Cell Sci. 2017 Nov 1;130(21):3663-3675. doi: 10.1242/jcs.207423. Epub 2017 Sep 21.

14.

Assessment of Thermal Pain Sensation in Rats and Mice Using the Hargreaves Test.

Cheah M, Fawcett JW, Andrews MR.

Bio Protoc. 2017 Aug 20;7(16). pii: e2506. doi: 10.21769/BioProtoc.2506.

15.

Antibody recognizing 4-sulfated chondroitin sulfate proteoglycans restores memory in tauopathy-induced neurodegeneration.

Yang S, Hilton S, Alves JN, Saksida LM, Bussey T, Matthews RT, Kitagawa H, Spillantini MG, Kwok JCF, Fawcett JW.

Neurobiol Aging. 2017 Nov;59:197-209. doi: 10.1016/j.neurobiolaging.2017.08.002. Epub 2017 Aug 9.

16.

Selective rab11 transport and the intrinsic regenerative ability of CNS axons.

Koseki H, Donegá M, Lam BY, Petrova V, van Erp S, Yeo GS, Kwok JC, Ffrench-Constant C, Eva R, Fawcett JW.

Elife. 2017 Aug 8;6. pii: e26956. doi: 10.7554/eLife.26956.

17.

Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory.

Foscarin S, Raha-Chowdhury R, Fawcett JW, Kwok JCF.

Aging (Albany NY). 2017 Jun 28;9(6):1607-1622. doi: 10.18632/aging.101256.

18.

Dorsal Root Ganglion Injection and Dorsal Root Crush Injury as a Model for Sensory Axon Regeneration.

Cheah M, Fawcett JW, Andrews MR.

J Vis Exp. 2017 May 3;(123). doi: 10.3791/55535.

19.

An integrin approach to axon regeneration.

Fawcett JW.

Eye (Lond). 2017 Feb;31(2):206-208. doi: 10.1038/eye.2016.293. Epub 2016 Dec 23. Review.

20.

Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity.

Sorg BA, Berretta S, Blacktop JM, Fawcett JW, Kitagawa H, Kwok JC, Miquel M.

J Neurosci. 2016 Nov 9;36(45):11459-11468. Review.

21.

Differential regenerative ability of sensory and motor neurons.

Cheah M, Fawcett JW, Haenzi B.

Neurosci Lett. 2017 Jun 23;652:35-40. doi: 10.1016/j.neulet.2016.11.004. Epub 2016 Nov 3. Review.

PMID:
27818349
22.

Axonal Localization of Integrins in the CNS Is Neuronal Type and Age Dependent.

Andrews MR, Soleman S, Cheah M, Tumbarello DA, Mason MR, Moloney E, Verhaagen J, Bensadoun JC, Schneider B, Aebischer P, Fawcett JW.

eNeuro. 2016 Jul 27;3(4). pii: ENEURO.0029-16.2016. doi: 10.1523/ENEURO.0029-16.2016. eCollection 2016 Jul-Aug.

23.

Axonal plasticity underpins the functional recovery following surgical decompression in a rat model of cervical spondylotic myelopathy.

Dhillon RS, Parker J, Syed YA, Edgley S, Young A, Fawcett JW, Jeffery ND, Franklin RJ, Kotter MR.

Acta Neuropathol Commun. 2016 Aug 23;4(1):89. doi: 10.1186/s40478-016-0359-7.

24.

Regional Regulation of Purkinje Cell Dendritic Spines by Integrins and Eph/Ephrins.

Heintz TG, Eva R, Fawcett JW.

PLoS One. 2016 Aug 12;11(8):e0158558. doi: 10.1371/journal.pone.0158558. eCollection 2016.

25.

Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Is Constitutively Expressed in Adult Central Nervous System (CNS) and Associated with Astrocyte-mediated Glial Scar Formation following Spinal Cord Injury.

Coulson-Thomas VJ, Lauer ME, Soleman S, Zhao C, Hascall VC, Day AJ, Fawcett JW.

J Biol Chem. 2016 Sep 16;291(38):19939-52. doi: 10.1074/jbc.M115.710673. Epub 2016 Jul 19.

26.

Canine olfactory ensheathing cells from the olfactory mucosa can be engineered to produce active chondroitinase ABC.

Carwardine D, Wong LF, Fawcett JW, Muir EM, Granger N.

J Neurol Sci. 2016 Aug 15;367:311-8. doi: 10.1016/j.jns.2016.06.011. Epub 2016 Jun 4.

PMID:
27423610
27.

Expression of an Activated Integrin Promotes Long-Distance Sensory Axon Regeneration in the Spinal Cord.

Cheah M, Andrews MR, Chew DJ, Moloney EB, Verhaagen J, Fässler R, Fawcett JW.

J Neurosci. 2016 Jul 6;36(27):7283-97. doi: 10.1523/JNEUROSCI.0901-16.2016.

28.

Bio-inspired nano tools for neuroscience.

Das S, Carnicer-Lombarte A, Fawcett JW, Bora U.

Prog Neurobiol. 2016 Jul;142:1-22. doi: 10.1016/j.pneurobio.2016.04.008. Epub 2016 Apr 20. Review.

PMID:
27107796
29.

The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity.

de Winter F, Kwok JC, Fawcett JW, Vo TT, Carulli D, Verhaagen J.

Neural Plast. 2016;2016:3679545. doi: 10.1155/2016/3679545. Epub 2016 Jan 14. Review.

30.

A Method for the Isolation and Culture of Adult Rat Retinal Pigment Epithelial (RPE) Cells to Study Retinal Diseases.

Heller JP, Kwok JC, Vecino E, Martin KR, Fawcett JW.

Front Cell Neurosci. 2015 Nov 20;9:449. doi: 10.3389/fncel.2015.00449. eCollection 2015.

31.

Chronic multichannel neural recordings from soft regenerative microchannel electrodes during gait.

Musick KM, Rigosa J, Narasimhan S, Wurth S, Capogrosso M, Chew DJ, Fawcett JW, Micera S, Lacour SP.

Sci Rep. 2015 Sep 24;5:14363. doi: 10.1038/srep14363.

32.

"GAG-ing with the neuron": The role of glycosaminoglycan patterning in the central nervous system.

Smith PD, Coulson-Thomas VJ, Foscarin S, Kwok JC, Fawcett JW.

Exp Neurol. 2015 Dec;274(Pt B):100-14. doi: 10.1016/j.expneurol.2015.08.004. Epub 2015 Aug 12. Review.

PMID:
26277685
33.

Exclusion of integrins from CNS axons is regulated by Arf6 activation and the AIS.

Franssen EH, Zhao RR, Koseki H, Kanamarlapudi V, Hoogenraad CC, Eva R, Fawcett JW.

J Neurosci. 2015 May 27;35(21):8359-75. doi: 10.1523/JNEUROSCI.2850-14.2015.

34.

Influence of extracellular matrix components on the expression of integrins and regeneration of adult retinal ganglion cells.

Vecino E, Heller JP, Veiga-Crespo P, Martin KR, Fawcett JW.

PLoS One. 2015 May 27;10(5):e0125250. doi: 10.1371/journal.pone.0125250. eCollection 2015.

35.

Large animal and primate models of spinal cord injury for the testing of novel therapies.

Kwon BK, Streijger F, Hill CE, Anderson AJ, Bacon M, Beattie MS, Blesch A, Bradbury EJ, Brown A, Bresnahan JC, Case CC, Colburn RW, David S, Fawcett JW, Ferguson AR, Fischer I, Floyd CL, Gensel JC, Houle JD, Jakeman LB, Jeffery ND, Jones LA, Kleitman N, Kocsis J, Lu P, Magnuson DS, Marsala M, Moore SW, Mothe AJ, Oudega M, Plant GW, Rabchevsky AS, Schwab JM, Silver J, Steward O, Xu XM, Guest JD, Tetzlaff W.

Exp Neurol. 2015 Jul;269:154-68. doi: 10.1016/j.expneurol.2015.04.008. Epub 2015 Apr 19.

PMID:
25902036
36.

The extracellular matrix in plasticity and regeneration after CNS injury and neurodegenerative disease.

Fawcett JW.

Prog Brain Res. 2015;218:213-26. doi: 10.1016/bs.pbr.2015.02.001. Epub 2015 Mar 29. Review.

PMID:
25890139
37.

Retinal glia promote dorsal root ganglion axon regeneration.

Lorber B, Chew DJ, Hauck SM, Chong RS, Fawcett JW, Martin KR.

PLoS One. 2015 Mar 27;10(3):e0115996. doi: 10.1371/journal.pone.0115996. eCollection 2015.

38.

Full length talin stimulates integrin activation and axon regeneration.

Tan CL, Kwok JC, Heller JP, Zhao R, Eva R, Fawcett JW.

Mol Cell Neurosci. 2015 Sep;68:1-8. doi: 10.1016/j.mcn.2015.03.011. Epub 2015 Mar 11.

39.

Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology.

Yang S, Cacquevel M, Saksida LM, Bussey TJ, Schneider BL, Aebischer P, Melani R, Pizzorusso T, Fawcett JW, Spillantini MG.

Exp Neurol. 2015 Mar;265:48-58. doi: 10.1016/j.expneurol.2014.11.013. Epub 2014 Dec 4.

40.

Neural ECM in regeneration and rehabilitation.

Yang S, Kwok JC, Fawcett JW.

Prog Brain Res. 2014;214:179-92. doi: 10.1016/B978-0-444-63486-3.00008-6. Review.

PMID:
25410358
41.

Kinesin KIF4A transports integrin β1 in developing axons of cortical neurons.

Heintz TG, Heller JP, Zhao R, Caceres A, Eva R, Fawcett JW.

Mol Cell Neurosci. 2014 Nov;63:60-71. doi: 10.1016/j.mcn.2014.09.003. Epub 2014 Sep 26.

PMID:
25260485
42.

Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression.

Tyzack GE, Sitnikov S, Barson D, Adams-Carr KL, Lau NK, Kwok JC, Zhao C, Franklin RJ, Karadottir RT, Fawcett JW, Lakatos A.

Nat Commun. 2014 Jul 11;5:4294. doi: 10.1038/ncomms5294.

43.

Targeting inhibitory chondroitin sulphate proteoglycans to promote plasticity after injury.

Kwok JC, Heller JP, Zhao RR, Fawcett JW.

Methods Mol Biol. 2014;1162:127-38. doi: 10.1007/978-1-4939-0777-9_10.

PMID:
24838963
44.

Mesenchymal stromal cells integrate and form longitudinally-aligned layers when delivered to injured spinal cord via a novel fibrin scaffold.

Hyatt AJ, Wang D, van Oterendorp C, Fawcett JW, Martin KR.

Neurosci Lett. 2014 May 21;569:12-7. doi: 10.1016/j.neulet.2014.03.023. Epub 2014 Mar 26.

45.

AAV vector-mediated secretion of chondroitinase provides a sensitive tracer for axonal arborisations.

Alves JN, Muir EM, Andrews MR, Ward A, Michelmore N, Dasgupta D, Verhaagen J, Moloney EB, Keynes RJ, Fawcett JW, Rogers JH.

J Neurosci Methods. 2014 Apr 30;227:107-20. doi: 10.1016/j.jneumeth.2014.02.010. Epub 2014 Feb 28.

PMID:
24583077
46.

The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system.

Moshayedi P, Ng G, Kwok JC, Yeo GS, Bryant CE, Fawcett JW, Franze K, Guck J.

Biomaterials. 2014 Apr;35(13):3919-25. doi: 10.1016/j.biomaterials.2014.01.038. Epub 2014 Feb 11.

47.

Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons.

Kappagantula S, Andrews MR, Cheah M, Abad-Rodriguez J, Dotti CG, Fawcett JW.

J Neurosci. 2014 Feb 12;34(7):2477-92. doi: 10.1523/JNEUROSCI.4432-13.2014.

48.

A microchannel neuroprosthesis for bladder control after spinal cord injury in rat.

Chew DJ, Zhu L, Delivopoulos E, Minev IR, Musick KM, Mosse CA, Craggs M, Donaldson N, Lacour SP, McMahon SB, Fawcett JW.

Sci Transl Med. 2013 Nov 6;5(210):210ra155. doi: 10.1126/scitranslmed.3007186.

49.

Targeting the neural extracellular matrix in neurological disorders.

Soleman S, Filippov MA, Dityatev A, Fawcett JW.

Neuroscience. 2013 Dec 3;253:194-213. doi: 10.1016/j.neuroscience.2013.08.050. Epub 2013 Sep 4. Review.

PMID:
24012743
50.

Semaphorin 3A binds to the perineuronal nets via chondroitin sulfate type E motifs in rodent brains.

Dick G, Tan CL, Alves JN, Ehlert EM, Miller GM, Hsieh-Wilson LC, Sugahara K, Oosterhof A, van Kuppevelt TH, Verhaagen J, Fawcett JW, Kwok JC.

J Biol Chem. 2013 Sep 20;288(38):27384-95. doi: 10.1074/jbc.M111.310029. Epub 2013 Aug 12.

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