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Items: 1 to 50 of 180

1.

Bioanalysis of free and liposomal Amphotericin B in rat plasma using solid phase extraction and protein precipitation followed by LC-MS/MS.

Su C, Yang H, Sun H, Fawcett JP, Sun D, Gu J.

J Pharm Biomed Anal. 2018 Jun 8;158:288-293. doi: 10.1016/j.jpba.2018.06.014. [Epub ahead of print]

PMID:
29902693
2.

Separation and simultaneous quantitation of PGF2α and its epimer 8-iso-PGF2α using modifier-assisted differential mobility spectrometry tandem mass spectrometry.

Liang C, Sun H, Meng X, Yin L, Fawcett JP, Yu H, Liu T, Gu J.

Acta Pharm Sin B. 2018 Mar;8(2):228-234. doi: 10.1016/j.apsb.2018.01.011. Epub 2018 Mar 10.

3.

Microbial eukaryotes have adapted to hypoxia by horizontal acquisitions of a gene involved in rhodoquinone biosynthesis.

Stairs CW, Eme L, Muñoz-Gómez SA, Cohen A, Dellaire G, Shepherd JN, Fawcett JP, Roger AJ.

Elife. 2018 Apr 26;7. pii: e34292. doi: 10.7554/eLife.34292.

4.
5.

Correction to: Beta2-Agonist Doping Control and Optical Isomer Challenges.

Jacobson GA, Fawcett JP.

Sports Med. 2018 Jun;48(6):1523. doi: 10.1007/s40279-018-0859-7.

PMID:
29363052
6.

Differential mobility spectrometry followed by tandem mass spectrometry with multiple ion monitoring for bioanalysis of eptifibatide in rat plasma.

Ren T, Li R, Meng X, Fawcett JP, Sun D, Gu J.

J Pharm Biomed Anal. 2018 Mar 20;151:260-265. doi: 10.1016/j.jpba.2018.01.019. Epub 2018 Jan 11.

PMID:
29358126
7.

The polarity protein Angiomotin p130 controls dendritic spine maturation.

Wigerius M, Quinn D, Diab A, Clattenburg L, Kolar A, Qi J, Krueger SR, Fawcett JP.

J Cell Biol. 2018 Feb 5;217(2):715-730. doi: 10.1083/jcb.201705184. Epub 2018 Jan 9.

PMID:
29317530
8.

A validated UPLC-MS/MS method coupled with protein precipitation and ion exchange solid phase extraction for the quantitation of porcine relaxin B29 in dog plasma and its application to a pharmacokinetic study.

Su C, Sun H, Yang H, Yin L, Zhang J, Fawcett JP, Gu J.

Anal Bioanal Chem. 2017 Nov;409(28):6559-6565. doi: 10.1007/s00216-017-0604-3. Epub 2017 Sep 9.

PMID:
28889219
9.

Differential mobility spectrometry tandem mass spectrometry with multiple ion monitoring for the bioanalysis of liraglutide.

Meng X, Xu H, Zhang Z, Fawcett JP, Li J, Yang Y, Gu J.

Anal Bioanal Chem. 2017 Aug;409(20):4885-4891. doi: 10.1007/s00216-017-0431-6. Epub 2017 Jun 28.

PMID:
28660337
10.

Development and Application of an MSALL-Based Approach for the Quantitative Analysis of Linear Polyethylene Glycols in Rat Plasma by Liquid Chromatography Triple-Quadrupole/Time-of-Flight Mass Spectrometry.

Zhou X, Meng X, Cheng L, Su C, Sun Y, Sun L, Tang Z, Fawcett JP, Yang Y, Gu J.

Anal Chem. 2017 May 16;89(10):5193-5200. doi: 10.1021/acs.analchem.6b04058. Epub 2017 Apr 26.

PMID:
28418637
11.
12.

The Hippo component YAP localizes in the nucleus of human papilloma virus positive oropharyngeal squamous cell carcinoma.

Alzahrani F, Clattenburg L, Muruganandan S, Bullock M, MacIsaac K, Wigerius M, Williams BA, Graham ME, Rigby MH, Trites JR, Taylor SM, Sinal CJ, Fawcett JP, Hart RD.

J Otolaryngol Head Neck Surg. 2017 Feb 22;46(1):15. doi: 10.1186/s40463-017-0187-1.

13.

Pan-neurexin perturbation results in compromised synapse stability and a reduction in readily releasable synaptic vesicle pool size.

Quinn DP, Kolar A, Wigerius M, Gomm-Kolisko RN, Atwi H, Fawcett JP, Krueger SR.

Sci Rep. 2017 Feb 21;7:42920. doi: 10.1038/srep42920.

14.

Determination of rabeprazole enantiomers in dog plasma by supercritical fluid chromatography tandem mass spectrometry and its application to a pharmacokinetic study.

Su C, Yang H, Meng X, Fawcett JP, Cao J, Yang Y, Gu J.

J Sep Sci. 2017 Feb;40(4):1010-1016. doi: 10.1002/jssc.201601232. Epub 2017 Jan 20.

PMID:
27991740
15.

Adipocyte-secreted chemerin is processed to a variety of isoforms and influences MMP3 and chemokine secretion through an NFkB-dependent mechanism.

Dranse HJ, Muruganandan S, Fawcett JP, Sinal CJ.

Mol Cell Endocrinol. 2016 Nov 15;436:114-29. doi: 10.1016/j.mce.2016.07.017. Epub 2016 Jul 25.

PMID:
27461525
16.

Determination of Flow Rates in Capillary Liquid Chromatography Coupled to a Nanoelectrospray Source using Droplet Image Analysis Software.

Cohen AM, Soto AJ, Fawcett JP.

Anal Chem. 2016 Aug 2;88(15):7476-80. doi: 10.1021/acs.analchem.6b01523. Epub 2016 Jul 13.

PMID:
27351615
17.

Data on the catalytic mechanism of thiol peroxidase mimics.

Zadehvakili B, Giles NM, Fawcett JP, Giles GI.

Data Brief. 2016 May 24;8:207-10. doi: 10.1016/j.dib.2016.05.037. eCollection 2016 Sep.

18.

Significant Improvement of Metabolic Characteristics and Bioactivities of Clopidogrel and Analogs by Selective Deuteration.

Xu X, Zhao X, Yang Z, Wang H, Meng X, Su C, Liu M, Fawcett JP, Yang Y, Gu J.

Molecules. 2016 May 30;21(6). pii: E704. doi: 10.3390/molecules21060704.

19.

Beta2-Agonist Doping Control and Optical Isomer Challenges.

Jacobson GA, Fawcett JP.

Sports Med. 2016 Dec;46(12):1787-1795. doi: 10.1007/s40279-016-0547-4. Erratum in: Sports Med. 2018 Jan 23;:.

PMID:
27164986
20.

Development and validation of an enantioselective SFC-MS/MS method for simultaneous separation and quantification of oxcarbazepine and its chiral metabolites in beagle dog plasma.

Yang Z, Xu X, Sun L, Zhao X, Wang H, Fawcett JP, Yang Y, Gu J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 May 1;1020:36-42. doi: 10.1016/j.jchromb.2016.03.013. Epub 2016 Mar 15. Review.

PMID:
27003707
21.

The design of redox active thiol peroxidase mimics: Dihydrolipoic acid recognition correlates with cytotoxicity and prooxidant action.

Zadehvakili B, McNeill SM, Fawcett JP, Giles GI.

Biochem Pharmacol. 2016 Mar 15;104:19-28. doi: 10.1016/j.bcp.2016.01.012. Epub 2016 Jan 19.

PMID:
26801688
22.

Application of a high-throughput, parallel HPLC system for quantitative chiral analysis of pantoprazole.

Wang H, Sun Y, Yang Y, Guo W, Zheng M, Zhang W, Fawcett JP, Gu J.

Bioanalysis. 2015 Dec;7(23):2981-90. doi: 10.4155/bio.15.215. Epub 2015 Nov 30.

PMID:
26616791
23.

Simultaneous determination of carboprost methylate and its active metabolite carboprost in dog plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application to a pharmacokinetic study.

Yin L, Meng X, Zhou X, Zhang T, Sun H, Yang Z, Yang B, Xiao N, Fawcett JP, Yang Y, Gu J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Aug 15;998-999:8-14. doi: 10.1016/j.jchromb.2015.05.039. Epub 2015 Jun 25.

PMID:
26149245
24.

NOS1AP Functionally Associates with YAP To Regulate Hippo Signaling.

Clattenburg L, Wigerius M, Qi J, Rainey JK, Rourke JL, Muruganandan S, Sinal CJ, Fawcett JP.

Mol Cell Biol. 2015 Jul;35(13):2265-77. doi: 10.1128/MCB.00062-15. Epub 2015 Apr 27.

25.

NCK is critical for the development of deleted in colorectal cancer (DCC) sensitive spinal circuits.

Lane C, Qi J, Fawcett JP.

J Neurochem. 2015 Sep;134(6):1008-14. doi: 10.1111/jnc.13137. Epub 2015 May 19.

27.

Sim1 is required for the migration and axonal projections of V3 interneurons in the developing mouse spinal cord.

Blacklaws J, Deska-Gauthier D, Jones CT, Petracca YL, Liu M, Zhang H, Fawcett JP, Glover JC, Lanuza GM, Zhang Y.

Dev Neurobiol. 2015 Sep;75(9):1003-17. doi: 10.1002/dneu.22266. Epub 2015 Feb 18.

28.

Determination of thymopentin in beagle dog blood by liquid chromatography with tandem mass spectrometry and its application to a preclinical pharmacokinetic study.

Shi M, Yang Y, Zhou X, Cai L, Fang C, Wang C, Sun H, Sun Y, Gao Y, Gu J, Fawcett JP.

J Sep Sci. 2015 May;38(8):1351-7. doi: 10.1002/jssc.201401198. Epub 2015 Mar 4.

PMID:
25631297
29.

Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons.

Toma JS, Shettar BC, Chipman PH, Pinto DM, Borowska JP, Ichida JK, Fawcett JP, Zhang Y, Eggan K, Rafuse VF.

J Neurosci. 2015 Jan 21;35(3):1291-306. doi: 10.1523/JNEUROSCI.2126-14.2015.

30.

Trantinterol, a novel β2-adrenoceptor agonist, noncompetitively inhibits P-glycoprotein function in vitro and in vivo.

Wang T, Sun Y, Ma W, Yang Z, Yang J, Liu J, Fan H, Yang Y, Gu J, Fawcett JP, Guo Y.

Mol Pharm. 2015 Jan 5;12(1):1-9. doi: 10.1021/mp500239v. Epub 2014 Nov 24.

PMID:
25389765
31.

Increases in mature brain-derived neurotrophic factor protein in the frontal cortex and basal forebrain during chronic sleep restriction in rats: possible role in initiating allostatic adaptation.

Wallingford JK, Deurveilher S, Currie RW, Fawcett JP, Semba K.

Neuroscience. 2014 Sep 26;277:174-83. doi: 10.1016/j.neuroscience.2014.06.067. Epub 2014 Jul 8.

PMID:
25010399
32.

Determination of a deuterohemin-peptide conjugate in rat plasma by liquid chromatography-tandem mass spectrometry and application to a preclinical pharmacokinetic study.

Wang H, Sun Y, Guo W, Fang C, Fawcett JP, Li W, Gao Y, Yang Y, Gu J.

J Pharm Biomed Anal. 2014 Sep;98:401-6. doi: 10.1016/j.jpba.2014.06.026. Epub 2014 Jun 23.

PMID:
25005890
33.

Kinetic and equilibrium studies of bile salt-liposome interactions.

Yang L, Feng F, Fawcett JP, Tucker IG.

J Liposome Res. 2015 Mar;25(1):58-66. doi: 10.3109/08982104.2014.928888. Epub 2014 Jun 24.

PMID:
24960448
34.

A rapid and sensitive UFLC-MS/MS method for the simultaneous determination of gentiopicroside and swertiamarin in rat plasma and its application in pharmacokinetics.

Feng B, Zhu H, Guan J, Zhao L, Gu J, Yin L, Fawcett JP, Liu W.

J Pharm Pharmacol. 2014 Oct;66(10):1369-76. doi: 10.1111/jphp.12266. Epub 2014 Apr 29.

PMID:
24780079
35.

Pharmacokinetic study of calenduloside E and its active metabolite oleanolic acid in beagle dog using liquid chromatography-tandem mass spectrometry.

Shi M, Yang Y, Sun Y, Cheng L, Zhao S, Xu H, Fawcett JP, Sun X, Gu J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Mar 1;951-952:129-34. doi: 10.1016/j.jchromb.2014.01.036. Epub 2014 Jan 30.

PMID:
24556278
36.

Phenolic esters of O-desmethylvenlafaxine with improved oral bioavailability and brain uptake.

Zhang Y, Yang Y, Zhao S, Yang Z, Yang H, Fawcett JP, Li Y, Gu J, Sun T.

Molecules. 2013 Dec 4;18(12):14920-34. doi: 10.3390/molecules181214920.

37.

A liquid chromatography-tandem mass spectrometric method for the simultaneous quantitation of five components of Ixeris sonchifoliain (Bge.) Hance in rat plasma and its application to a pharmacokinetic study.

Yin L, Shi M, Sun Y, Sun X, Meng H, Fawcett JP, Yang Y, Gu J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jul 15;931:12-6. doi: 10.1016/j.jchromb.2013.04.039. Epub 2013 May 20.

PMID:
23759690
38.

Effect of 12-oxochenodeoxycholate on the pharmacokinetics and pharmacodynamics of morphine 6-glucuronide in Wistar rats.

Yang L, Fawcett JP, Zhang H, Tucker IG.

J Pharm Pharmacol. 2013 Apr;65(4):561-6. doi: 10.1111/jphp.12020. Epub 2013 Jan 16.

PMID:
23488785
39.

Ultra-sensitive assay for paclitaxel in intracellular compartments of A549 cells using liquid chromatography-tandem mass spectrometry.

Wang T, Ma W, Sun Y, Yang Y, Zhang W, Fawcett JP, Du H, Gu J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jan 1;912:93-7. doi: 10.1016/j.jchromb.2012.10.033. Epub 2012 Nov 2.

PMID:
23262197
40.

Effect of ketocholate derivatives on methotrexate uptake in Caco-2 cell monolayers.

Chen G, Yang L, Zhang H, Tucker IG, Fawcett JP.

Int J Pharm. 2012 Aug 20;433(1-2):89-93. doi: 10.1016/j.ijpharm.2012.04.077. Epub 2012 May 7.

PMID:
22575673
41.

Acarbose bioequivalence: exploration of new pharmacodynamic parameters.

Zhang M, Yang J, Tao L, Li L, Ma P, Fawcett JP.

AAPS J. 2012 Jun;14(2):345-51. doi: 10.1208/s12248-012-9341-x. Epub 2012 Mar 15.

42.

Determination of landiolol, an ultra-short-acting β₁-receptor antagonist, in human plasma by liquid chromatography-tandem mass spectrometry.

He Q, Shi M, Liu X, Sun Y, Hu L, Yang Y, Fawcett JP, Gu J, Zhao L.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Apr 1;891-892:7-11. doi: 10.1016/j.jchromb.2011.12.024. Epub 2011 Dec 30.

PMID:
22418070
43.

The influence of probiotic treatment on sulfasalazine metabolism in rat.

Lee HJ, Zhang H, Orlovich DA, Fawcett JP.

Xenobiotica. 2012 Aug;42(8):791-7. doi: 10.3109/00498254.2012.660508. Epub 2012 Feb 21.

PMID:
22348441
44.

Comparative pharmacokinetics and bioavailability of escin Ia and isoescin Ia after administration of escin and of pure escin Ia and isoescin Ia in rat.

Wu XJ, Zhang ML, Cui XY, Gao F, He Q, Li XJ, Zhang JW, Fawcett JP, Gu JK.

J Ethnopharmacol. 2012 Jan 6;139(1):201-6. doi: 10.1016/j.jep.2011.11.003. Epub 2011 Nov 10.

PMID:
22094055
45.

Mechanistic studies of the effect of bile salts on rhodamine 123 uptake into RBE4 cells.

Yang L, Fawcett JP, Østergaard J, Zhang H, Tucker IG.

Mol Pharm. 2012 Jan 1;9(1):29-36. doi: 10.1021/mp200201y. Epub 2011 Nov 17.

PMID:
22050323
46.

Metabolism of L-selenomethionine and selenite by probiotic bacteria: in vitro and in vivo studies.

Krittaphol W, Wescombe PA, Thomson CD, McDowell A, Tagg JR, Fawcett JP.

Biol Trace Elem Res. 2011 Dec;144(1-3):1358-69. doi: 10.1007/s12011-011-9057-2. Epub 2011 Apr 15.

PMID:
21494803
47.

Effect of bile salts on the transport of morphine-6-glucuronide in rat brain endothelial cells.

Yang L, Zhang H, Fawcett JP, Mikov M, Tucker IG.

J Pharm Sci. 2011 Apr;100(4):1516-24. doi: 10.1002/jps.22390. Epub 2010 Nov 24.

PMID:
24081474
48.

Pharmacokinetics of felbinac after intravenous administration of felbinac trometamol in rats.

Zhang C, Cui X, Yang Y, Gao F, Sun Y, Gu J, Fawcett JP, Yang W, Wang W.

Xenobiotica. 2011 Apr;41(4):340-8. doi: 10.3109/00498254.2010.544422. Epub 2010 Dec 23.

PMID:
21182394
49.

Guidance of postural motoneurons requires MAPK/ERK signaling downstream of fibroblast growth factor receptor 1.

Soundararajan P, Fawcett JP, Rafuse VF.

J Neurosci. 2010 May 12;30(19):6595-606. doi: 10.1523/JNEUROSCI.4932-09.2010.

50.

The effects of an orally administered probiotic on sulfasalazine metabolism in individuals with rheumatoid arthritis: a preliminary study.

Lee HJ, Waller RD, Stebbings S, Highton J, Orlovich DA, Schmierer D, Fawcett JP.

Int J Rheum Dis. 2010 Feb 1;13(1):48-54. doi: 10.1111/j.1756-185X.2009.01449.x.

PMID:
20374384

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