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Items: 23

1.

Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding.

El Turk F, De Genst E, Guilliams T, Fauvet B, Hejjaoui M, Di Trani J, Chiki A, Mittermaier A, Vendruscolo M, Lashuel HA, Dobson CM.

Protein Sci. 2018 Jul;27(7):1262-1274. doi: 10.1002/pro.3412.

PMID:
29603451
2.

Chaperones convert the energy from ATP into the nonequilibrium stabilization of native proteins.

Goloubinoff P, Sassi AS, Fauvet B, Barducci A, De Los Rios P.

Nat Chem Biol. 2018 Apr;14(4):388-395. doi: 10.1038/s41589-018-0013-8. Epub 2018 Mar 5.

PMID:
29507388
3.

Membrane scission driven by the PROPPIN Atg18.

Gopaldass N, Fauvet B, Lashuel H, Roux A, Mayer A.

EMBO J. 2017 Nov 15;36(22):3274-3291. doi: 10.15252/embj.201796859. Epub 2017 Oct 13.

PMID:
29030482
4.

Misfolding and aggregation of nascent proteins: a novel mode of toxic cadmium action in vivo.

Tamás MJ, Fauvet B, Christen P, Goloubinoff P.

Curr Genet. 2018 Feb;64(1):177-181. doi: 10.1007/s00294-017-0748-x. Epub 2017 Sep 21. Review.

5.

Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.

de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF.

PLoS Biol. 2017 Apr 5;15(4):e1002601. doi: 10.1371/journal.pbio.1002601. eCollection 2017 Apr.

6.

The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.

de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF.

PLoS Biol. 2017 Mar 3;15(3):e2000374. doi: 10.1371/journal.pbio.2000374. eCollection 2017 Mar. Erratum in: PLoS Biol. 2017 Apr 5;15(4):e1002601.

7.

Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations.

Dikiy I, Fauvet B, Jovičić A, Mahul-Mellier AL, Desobry C, El-Turk F, Gitler AD, Lashuel HA, Eliezer D.

ACS Chem Biol. 2016 Sep 16;11(9):2428-37. doi: 10.1021/acschembio.6b00539. Epub 2016 Jul 11.

8.

Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein.

Fauvet B, Lashuel HA.

Methods Mol Biol. 2016;1345:3-20. doi: 10.1007/978-1-4939-2978-8_1.

PMID:
26453202
9.

The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity.

Khalaf O, Fauvet B, Oueslati A, Dikiy I, Mahul-Mellier AL, Ruggeri FS, Mbefo MK, Vercruysse F, Dietler G, Lee SJ, Eliezer D, Lashuel HA.

J Biol Chem. 2014 Aug 8;289(32):21856-76. doi: 10.1074/jbc.M114.553297. Epub 2014 Jun 16.

10.

c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.

Mahul-Mellier AL, Fauvet B, Gysbers A, Dikiy I, Oueslati A, Georgeon S, Lamontanara AJ, Bisquertt A, Eliezer D, Masliah E, Halliday G, Hantschel O, Lashuel HA.

Hum Mol Genet. 2014 Jun 1;23(11):2858-79. doi: 10.1093/hmg/ddt674. Epub 2014 Jan 9.

11.

Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology.

Haj-Yahya M, Fauvet B, Herman-Bachinsky Y, Hejjaoui M, Bavikar SN, Karthikeyan SV, Ciechanover A, Lashuel HA, Brik A.

Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17726-31. doi: 10.1073/pnas.1315654110. Epub 2013 Sep 16.

12.

One-pot total chemical synthesis of human α-synuclein.

Fauvet B, Butterfield SM, Fuks J, Brik A, Lashuel HA.

Chem Commun (Camb). 2013 Oct 18;49(81):9254-6. doi: 10.1039/c3cc45353g.

PMID:
23995579
13.

Alpha-synuclein post-translational modifications as potential biomarkers for Parkinson disease and other synucleinopathies.

Schmid AW, Fauvet B, Moniatte M, Lashuel HA.

Mol Cell Proteomics. 2013 Dec;12(12):3543-58. doi: 10.1074/mcp.R113.032730. Epub 2013 Aug 21. Review.

14.

Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket.

El-Turk F, Fauvet B, Ashrafi A, Ouertatani-Sakouhi H, Cho MK, Neri M, Cascella M, Rothlisberger U, Pojer F, Zweckstetter M, Lashuel H.

PLoS One. 2012;7(9):e45024. doi: 10.1371/journal.pone.0045024. Epub 2012 Sep 21.

15.
16.

Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein.

Fauvet B, Fares MB, Samuel F, Dikiy I, Tandon A, Eliezer D, Lashuel HA.

J Biol Chem. 2012 Aug 17;287(34):28243-62. doi: 10.1074/jbc.M112.383711. Epub 2012 Jun 20.

17.

Chemical strategies for controlling protein folding and elucidating the molecular mechanisms of amyloid formation and toxicity.

Butterfield S, Hejjaoui M, Fauvet B, Awad L, Lashuel HA.

J Mol Biol. 2012 Aug 10;421(2-3):204-36. doi: 10.1016/j.jmb.2012.01.051. Epub 2012 Feb 14. Review.

PMID:
22342932
18.

Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125.

Hejjaoui M, Butterfield S, Fauvet B, Vercruysse F, Cui J, Dikiy I, Prudent M, Olschewski D, Zhang Y, Eliezer D, Lashuel HA.

J Am Chem Soc. 2012 Mar 21;134(11):5196-210. doi: 10.1021/ja210866j. Epub 2012 Mar 13.

19.

α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.

Fauvet B, Mbefo MK, Fares MB, Desobry C, Michael S, Ardah MT, Tsika E, Coune P, Prudent M, Lion N, Eliezer D, Moore DJ, Schneider B, Aebischer P, El-Agnaf OM, Masliah E, Lashuel HA.

J Biol Chem. 2012 May 4;287(19):15345-64. doi: 10.1074/jbc.M111.318949. Epub 2012 Feb 7.

20.

An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity.

El Turk F, Fauvet B, Ouertatani-Sakouhi H, Lugari A, Betzi S, Roche P, Morelli X, Lashuel HA.

Bioorg Med Chem. 2010 Jul 15;18(14):5425-40. doi: 10.1016/j.bmc.2010.05.010. Epub 2010 May 13.

PMID:
20639113
21.

Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action.

Ouertatani-Sakouhi H, El-Turk F, Fauvet B, Cho MK, Pinar Karpinar D, Le Roy D, Dewor M, Roger T, Bernhagen J, Calandra T, Zweckstetter M, Lashuel HA.

J Biol Chem. 2010 Aug 20;285(34):26581-98. doi: 10.1074/jbc.M110.113951. Epub 2010 Jun 1.

22.

A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor.

Ouertatani-Sakouhi H, El-Turk F, Fauvet B, Roger T, Le Roy D, Karpinar DP, Leng L, Bucala R, Zweckstetter M, Calandra T, Lashuel HA.

Biochemistry. 2009 Oct 20;48(41):9858-70. doi: 10.1021/bi900957e.

23.

Combined voltage and calcium epifluorescence imaging in vitro and in vivo reveals subthreshold and suprathreshold dynamics of mouse barrel cortex.

Berger T, Borgdorff A, Crochet S, Neubauer FB, Lefort S, Fauvet B, Ferezou I, Carleton A, Lüscher HR, Petersen CC.

J Neurophysiol. 2007 May;97(5):3751-62. Epub 2007 Mar 14.

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