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Items: 1 to 50 of 77

1.

Antibiotics: Combatting Tolerance To Stop Resistance.

Windels EM, Michiels JE, Van den Bergh B, Fauvart M, Michiels J.

MBio. 2019 Sep 10;10(5). pii: e02095-19. doi: 10.1128/mBio.02095-19.

2.

Biochemical determinants of ObgE-mediated persistence.

Verstraeten N, Gkekas S, Kint CI, Deckers B, Van den Bergh B, Herpels P, Louwagie E, Knapen W, Wilmaerts D, Dewachter L, Fauvart M, Singh RK, Michiels J, Versées W.

Mol Microbiol. 2019 Sep 9. doi: 10.1111/mmi.14382. [Epub ahead of print]

PMID:
31498933
3.

High-throughput time-resolved morphology screening in bacteria reveals phenotypic responses to antibiotics.

Zahir T, Camacho R, Vitale R, Ruckebusch C, Hofkens J, Fauvart M, Michiels J.

Commun Biol. 2019 Jul 23;2:269. doi: 10.1038/s42003-019-0480-9. eCollection 2019.

4.

Silicon µPCR Chip for Forensic STR Profiling with Hybeacon Probe Melting Curves.

Cornelis S, Tytgat O, Fauvart M, Gansemans Y, Vander Plaetsen AS, Wiederkehr RS, Deforce D, Van Nieuwerburgh F, Stakenborg T.

Sci Rep. 2019 May 14;9(1):7341. doi: 10.1038/s41598-019-43946-5.

5.

Bacterial persistence promotes the evolution of antibiotic resistance by increasing survival and mutation rates.

Windels EM, Michiels JE, Fauvart M, Wenseleers T, Van den Bergh B, Michiels J.

ISME J. 2019 May;13(5):1239-1251. doi: 10.1038/s41396-019-0344-9. Epub 2019 Jan 15.

PMID:
30647458
6.

Development and validation of a glass-silicon microdroplet-based system to measure sulfite concentrations in beverages.

Vervoort Y, Wiederkehr RS, Smets M, Fauvart M, Stakenborg T, Woronoff G, Lagae L, Verstrepen KJ.

Anal Bioanal Chem. 2019 Feb;411(6):1127-1134. doi: 10.1007/s00216-018-1516-6. Epub 2019 Jan 14.

7.

Ultra-fast, sensitive and quantitative on-chip detection of group B streptococci in clinical samples.

Cai Q, Fauvart M, Wiederkehr RS, Jones B, Cools P, Goos P, Vaneechoutte M, Stakenborg T.

Talanta. 2019 Jan 15;192:220-225. doi: 10.1016/j.talanta.2018.09.041. Epub 2018 Sep 13.

PMID:
30348381
8.

Experimental Design, Population Dynamics, and Diversity in Microbial Experimental Evolution.

Van den Bergh B, Swings T, Fauvart M, Michiels J.

Microbiol Mol Biol Rev. 2018 Jul 25;82(3). pii: e00008-18. doi: 10.1128/MMBR.00008-18. Print 2018 Sep. Review.

9.

The Putative De-N-acetylase DnpA Contributes to Intracellular and Biofilm-Associated Persistence of Pseudomonas aeruginosa Exposed to Fluoroquinolones.

Khandekar S, Liebens V, Fauvart M, Tulkens PM, Michiels J, Van Bambeke F.

Front Microbiol. 2018 Jul 10;9:1455. doi: 10.3389/fmicb.2018.01455. eCollection 2018.

10.

Multiplex STR amplification sensitivity in a silicon microchip.

Cornelis S, Fauvart M, Gansemans Y, Vander Plaetsen AS, Colle F, Wiederkehr RS, Deforce D, Stakenborg T, Van Nieuwerburgh F.

Sci Rep. 2018 Jun 29;8(1):9853. doi: 10.1038/s41598-018-28229-9.

11.

Stabbed while Sleeping: Synthetic Retinoid Antibiotics Kill Bacterial Persister Cells.

Fauvart M, Van den Bergh B, Michiels J.

Mol Cell. 2018 Jun 7;70(5):763-764. doi: 10.1016/j.molcel.2018.05.029. Epub 2018 Jun 7.

12.

Fighting bacterial persistence: Current and emerging anti-persister strategies and therapeutics.

Defraine V, Fauvart M, Michiels J.

Drug Resist Updat. 2018 May;38:12-26. doi: 10.1016/j.drup.2018.03.002. Epub 2018 Apr 10. Review.

PMID:
29857815
13.

Repurposing AM404 for the treatment of oral infections by Porphyromonas gingivalis.

Gerits E, Spincemaille P, De Cremer K, De Brucker K, Beullens S, Thevissen K, Cammue BPA, Vandamme K, Fauvart M, Verstraeten N, Michiels J.

Clin Exp Dent Res. 2017 Apr 7;3(2):69-76. doi: 10.1002/cre2.65. eCollection 2017 Apr.

14.

Rapid and sensitive detection of viral nucleic acids using silicon microchips.

Powell L, Wiederkehr RS, Damascus P, Fauvart M, Buja F, Stakenborg T, Ray SC, Fiorini P, Osburn WO.

Analyst. 2018 May 29;143(11):2596-2603. doi: 10.1039/c8an00552d.

PMID:
29741175
15.

1-((2,4-Dichlorophenethyl)Amino)-3-Phenoxypropan-2-ol Kills Pseudomonas aeruginosa through Extensive Membrane Damage.

Defraine V, Liebens V, Loos E, Swings T, Weytjens B, Fierro C, Marchal K, Sharkey L, O'Neill AJ, Corbau R, Marchand A, Chaltin P, Fauvart M, Michiels J.

Front Microbiol. 2018 Feb 8;9:129. doi: 10.3389/fmicb.2018.00129. eCollection 2018.

16.

An integrative view of cell cycle control in Escherichia coli.

Dewachter L, Verstraeten N, Fauvart M, Michiels J.

FEMS Microbiol Rev. 2018 Mar 1;42(2):116-136. doi: 10.1093/femsre/fuy005. Review.

PMID:
29365084
17.

Antibacterial Activity of 1-[(2,4-Dichlorophenethyl)amino]-3-Phenoxypropan-2-ol against Antibiotic-Resistant Strains of Diverse Bacterial Pathogens, Biofilms and in Pre-clinical Infection Models.

Defraine V, Verstraete L, Van Bambeke F, Anantharajah A, Townsend EM, Ramage G, Corbau R, Marchand A, Chaltin P, Fauvart M, Michiels J.

Front Microbiol. 2017 Dec 22;8:2585. doi: 10.3389/fmicb.2017.02585. eCollection 2017.

18.

A Mutant Isoform of ObgE Causes Cell Death by Interfering with Cell Division.

Dewachter L, Verstraeten N, Jennes M, Verbeelen T, Biboy J, Monteyne D, Pérez-Morga D, Verstrepen KJ, Vollmer W, Fauvart M, Michiels J.

Front Microbiol. 2017 Jun 28;8:1193. doi: 10.3389/fmicb.2017.01193. eCollection 2017.

19.

Identification of 1-((2,4-Dichlorophenethyl)Amino)-3-Phenoxypropan-2-ol, a Novel Antibacterial Compound Active against Persisters of Pseudomonas aeruginosa.

Liebens V, Defraine V, Knapen W, Swings T, Beullens S, Corbau R, Marchand A, Chaltin P, Fauvart M, Michiels J.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00836-17. doi: 10.1128/AAC.00836-17. Print 2017 Sep.

20.

Adaptive tuning of mutation rates allows fast response to lethal stress in Escherichia coli.

Swings T, Van den Bergh B, Wuyts S, Oeyen E, Voordeckers K, Verstrepen KJ, Fauvart M, Verstraeten N, Michiels J.

Elife. 2017 May 2;6. pii: e22939. doi: 10.7554/eLife.22939.

21.

The bacterial cell cycle checkpoint protein Obg and its role in programmed cell death.

Dewachter L, Verstraeten N, Fauvart M, Michiels J.

Microb Cell. 2016 Mar 16;3(6):255-256. doi: 10.15698/mic2016.06.507.

22.

Formation, physiology, ecology, evolution and clinical importance of bacterial persisters.

Van den Bergh B, Fauvart M, Michiels J.

FEMS Microbiol Rev. 2017 May 1;41(3):219-251. doi: 10.1093/femsre/fux001. Review.

PMID:
28333307
23.

Structural and biochemical analysis of Escherichia coli ObgE, a central regulator of bacterial persistence.

Gkekas S, Singh RK, Shkumatov AV, Messens J, Fauvart M, Verstraeten N, Michiels J, Versées W.

J Biol Chem. 2017 Apr 7;292(14):5871-5883. doi: 10.1074/jbc.M116.761809. Epub 2017 Feb 21.

24.

In vitro activity of the antiasthmatic drug zafirlukast against the oral pathogens Porphyromonas gingivalis and Streptococcus mutans.

Gerits E, Van der Massen I, Vandamme K, De Cremer K, De Brucker K, Thevissen K, Cammue BPA, Beullens S, Fauvart M, Verstraeten N, Michiels J, Roberts M.

FEMS Microbiol Lett. 2017 Jan 1;364(2). doi: 10.1093/femsle/fnx005.

PMID:
28087617
25.

Repurposing Toremifene for Treatment of Oral Bacterial Infections.

Gerits E, Defraine V, Vandamme K, De Cremer K, De Brucker K, Thevissen K, Cammue BP, Beullens S, Fauvart M, Verstraeten N, Michiels J.

Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e01846-16. doi: 10.1128/AAC.01846-16. Print 2017 Mar.

26.

Multiplex SNP genotyping in whole blood using an integrated microfluidic lab-on-a-chip.

Zhang L, Cai Q, Wiederkehr RS, Fauvart M, Fiorini P, Majeed B, Tsukuda M, Matsuno T, Stakenborg T.

Lab Chip. 2016 Oct 5;16(20):4012-4019.

PMID:
27714026
27.

Reactive oxygen species do not contribute to ObgE*-mediated programmed cell death.

Dewachter L, Herpels P, Verstraeten N, Fauvart M, Michiels J.

Sci Rep. 2016 Sep 19;6:33723. doi: 10.1038/srep33723.

28.

Draft genome sequence of Enterococcus faecium strain LMG 8148.

Michiels JE, Van den Bergh B, Fauvart M, Michiels J.

Stand Genomic Sci. 2016 Sep 7;11(1):63. doi: 10.1186/s40793-016-0187-1. eCollection 2016.

29.

Draft genome sequence of Acinetobacter baumannii strain NCTC 13423, a multidrug-resistant clinical isolate.

Michiels JE, Van den Bergh B, Fauvart M, Michiels J.

Stand Genomic Sci. 2016 Sep 1;11(1):57. doi: 10.1186/s40793-016-0181-7. eCollection 2016.

30.

Frequency of antibiotic application drives rapid evolutionary adaptation of Escherichia coli persistence.

Van den Bergh B, Michiels JE, Wenseleers T, Windels EM, Boer PV, Kestemont D, De Meester L, Verstrepen KJ, Verstraeten N, Fauvart M, Michiels J.

Nat Microbiol. 2016 Mar 7;1:16020. doi: 10.1038/nmicrobiol.2016.20.

PMID:
27572640
31.

Membrane localization and topology of the DnpA protein control fluoroquinolone tolerance in Pseudomonas aeruginosa.

Liebens V, Frangipani E, Van der Leyden A, Fauvart M, Visca P, Michiels J.

FEMS Microbiol Lett. 2016 Sep;363(17). pii: fnw184. doi: 10.1093/femsle/fnw184. Epub 2016 Jul 31.

PMID:
27481702
32.

Should we develop screens for multi-drug antibiotic tolerance?

Van den Bergh B, Michiels JE, Fauvart M, Michiels J.

Expert Rev Anti Infect Ther. 2016 Jul;14(7):613-6. doi: 10.1080/14787210.2016.1194754. Epub 2016 Jun 8. No abstract available.

PMID:
27227426
33.

In Vitro Emergence of High Persistence upon Periodic Aminoglycoside Challenge in the ESKAPE Pathogens.

Michiels JE, Van den Bergh B, Verstraeten N, Fauvart M, Michiels J.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4630-7. doi: 10.1128/AAC.00757-16. Print 2016 Aug.

34.

Elucidation of the Mode of Action of a New Antibacterial Compound Active against Staphylococcus aureus and Pseudomonas aeruginosa.

Gerits E, Blommaert E, Lippell A, O'Neill AJ, Weytjens B, De Maeyer D, Fierro AC, Marchal K, Marchand A, Chaltin P, Spincemaille P, De Brucker K, Thevissen K, Cammue BP, Swings T, Liebens V, Fauvart M, Verstraeten N, Michiels J.

PLoS One. 2016 May 11;11(5):e0155139. doi: 10.1371/journal.pone.0155139. eCollection 2016.

35.

Efficacy of Artilysin Art-175 against Resistant and Persistent Acinetobacter baumannii.

Defraine V, Schuermans J, Grymonprez B, Govers SK, Aertsen A, Fauvart M, Michiels J, Lavigne R, Briers Y.

Antimicrob Agents Chemother. 2016 May 23;60(6):3480-8. doi: 10.1128/AAC.00285-16. Print 2016 Jun.

36.

Antibacterial activity of a new broad-spectrum antibiotic covalently bound to titanium surfaces.

Gerits E, Kucharíková S, Van Dijck P, Erdtmann M, Krona A, Lövenklev M, Fröhlich M, Dovgan B, Impellizzeri F, Braem A, Vleugels J, Robijns SC, Steenackers HP, Vanderleyden J, De Brucker K, Thevissen K, Cammue BP, Fauvart M, Verstraeten N, Michiels J.

J Orthop Res. 2016 Dec;34(12):2191-2198. doi: 10.1002/jor.23238. Epub 2016 Apr 6.

37.

Covalent immobilization of antimicrobial agents on titanium prevents Staphylococcus aureus and Candida albicans colonization and biofilm formation.

Kucharíková S, Gerits E, De Brucker K, Braem A, Ceh K, Majdič G, Španič T, Pogorevc E, Verstraeten N, Tournu H, Delattin N, Impellizzeri F, Erdtmann M, Krona A, Lövenklev M, Knezevic M, Fröhlich M, Vleugels J, Fauvart M, de Silva WJ, Vandamme K, Garcia-Forgas J, Cammue BP, Michiels J, Van Dijck P, Thevissen K.

J Antimicrob Chemother. 2016 Apr;71(4):936-45. doi: 10.1093/jac/dkv437. Epub 2015 Dec 24.

PMID:
26702917
38.

A Single-Amino-Acid Substitution in Obg Activates a New Programmed Cell Death Pathway in Escherichia coli.

Dewachter L, Verstraeten N, Monteyne D, Kint CI, Versées W, Pérez-Morga D, Michiels J, Fauvart M.

MBio. 2015 Dec 22;6(6):e01935-15. doi: 10.1128/mBio.01935-15.

39.

ANALYSIS OF THE MODE OF ACTION OF A PSEUDOMONAS AERUGINOSA ANTI-PERSISTER COMPOUND.

Defrayne V, Liebens V, Swings T, Corbau R, Marchand A, Chaltin P, Van Bambeke F, Anantharajah A, Fauvart M, Michiels J.

Commun Agric Appl Biol Sci. 2015;80(1):137-43. No abstract available.

PMID:
26630768
40.

A Whole-Cell-Based High-Throughput Screening Method to Identify Molecules Targeting Pseudomonas aeruginosa Persister Cells.

Liebens V, Defraine V, Fauvart M.

Methods Mol Biol. 2016;1333:113-20. doi: 10.1007/978-1-4939-2854-5_10.

PMID:
26468104
41.

A Historical Perspective on Bacterial Persistence.

Verstraeten N, Knapen W, Fauvart M, Michiels J.

Methods Mol Biol. 2016;1333:3-13. doi: 10.1007/978-1-4939-2854-5_1. Review.

PMID:
26468095
42.

Membrane depolarization-triggered responsive diversification leads to antibiotic tolerance.

Verstraeten N, Knapen WJ, Fauvart M, Michiels J.

Microb Cell. 2015 Jul 24;2(8):299-301. doi: 10.15698/mic2015.08.220.

43.

Obg and Membrane Depolarization Are Part of a Microbial Bet-Hedging Strategy that Leads to Antibiotic Tolerance.

Verstraeten N, Knapen WJ, Kint CI, Liebens V, Van den Bergh B, Dewachter L, Michiels JE, Fu Q, David CC, Fierro AC, Marchal K, Beirlant J, Versées W, Hofkens J, Jansen M, Fauvart M, Michiels J.

Mol Cell. 2015 Jul 2;59(1):9-21. doi: 10.1016/j.molcel.2015.05.011. Epub 2015 Jun 4.

44.

Fitness trade-offs explain low levels of persister cells in the opportunistic pathogen Pseudomonas aeruginosa.

Stepanyan K, Wenseleers T, Duéñez-Guzmán EA, Muratori F, Van den Bergh B, Verstraeten N, De Meester L, Verstrepen KJ, Fauvart M, Michiels J.

Mol Ecol. 2015 Apr;24(7):1572-83. doi: 10.1111/mec.13127. Epub 2015 Mar 17.

PMID:
25721227
45.

Identification and characterization of an anti-pseudomonal dichlorocarbazol derivative displaying anti-biofilm activity.

Liebens V, Gerits E, Knapen WJ, Swings T, Beullens S, Steenackers HP, Robijns S, Lippell A, O'Neill AJ, Veber M, Fröhlich M, Krona A, Lövenklev M, Corbau R, Marchand A, Chaltin P, De Brucker K, Thevissen K, Cammue BP, Fauvart M, Verstraeten N, Michiels J.

Bioorg Med Chem Lett. 2014 Dec 1;24(23):5404-8.

PMID:
25453797
46.

Adult human liver mesenchymal progenitor cells express phenylalanine hydroxylase.

Baruteau J, Nyabi O, Najimi M, Fauvart M, Sokal E.

J Pediatr Endocrinol Metab. 2014 Sep;27(9-10):863-8. doi: 10.1515/jpem-2013-0425.

PMID:
24825084
47.

Genomic analysis of cyclic-di-GMP-related genes in rhizobial type strains and functional analysis in Rhizobium etli.

Gao S, Romdhane SB, Beullens S, Kaever V, Lambrichts I, Fauvart M, Michiels J.

Appl Microbiol Biotechnol. 2014 May;98(10):4589-602. doi: 10.1007/s00253-014-5722-7. Epub 2014 Apr 12.

PMID:
24728599
48.

A putative de-N-acetylase of the PIG-L superfamily affects fluoroquinolone tolerance in Pseudomonas aeruginosa.

Liebens V, Defraine V, Van der Leyden A, De Groote VN, Fierro C, Beullens S, Verstraeten N, Kint C, Jans A, Frangipani E, Visca P, Marchal K, Versées W, Fauvart M, Michiels J.

Pathog Dis. 2014 Jun;71(1):39-54. doi: 10.1111/2049-632X.12174. Epub 2014 Apr 24.

PMID:
24692291
49.

Canonical and non-canonical EcfG sigma factors control the general stress response in Rhizobium etli.

Jans A, Vercruysse M, Gao S, Engelen K, Lambrichts I, Fauvart M, Michiels J.

Microbiologyopen. 2013 Dec;2(6):976-87. doi: 10.1002/mbo3.137. Epub 2013 Oct 28.

50.

Bacterial Obg proteins: GTPases at the nexus of protein and DNA synthesis.

Kint C, Verstraeten N, Hofkens J, Fauvart M, Michiels J.

Crit Rev Microbiol. 2014 Aug;40(3):207-24. doi: 10.3109/1040841X.2013.776510. Epub 2013 Mar 28. Review.

PMID:
23537324

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