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Items: 43

1.

Deficiency of Monoacylglycerol Lipase Enhances IgM Plasma Levels and Limits Atherogenesis in a CB2-Dependent Manner.

Guillamat Prats R, Rami M, Ring L, Rinne P, Lauer E, Lenglet S, Thomas A, Pagano S, Vuilleumier N, Cravatt BF, Weber C, Faussner A, Steffens S.

Thromb Haemost. 2019 Feb;119(2):348-351. doi: 10.1055/s-0038-1676769. Epub 2019 Jan 4.

PMID:
30609444
2.

Chronic Intake of the Selective Serotonin Reuptake Inhibitor Fluoxetine Enhances Atherosclerosis.

Rami M, Guillamat-Prats R, Rinne P, Salvermoser M, Ring L, Bianchini M, Blanchet X, Megens RTA, Döring Y, Walzog B, Soehnlein O, Weber C, Faussner A, Steffens S.

Arterioscler Thromb Vasc Biol. 2018 May;38(5):1007-1019. doi: 10.1161/ATVBAHA.117.310536. Epub 2018 Mar 22.

PMID:
29567680
3.

CD27 co-stimulation increases the abundance of regulatory T cells and reduces atherosclerosis in hyperlipidaemic mice.

Winkels H, Meiler S, Lievens D, Engel D, Spitz C, Bürger C, Beckers L, Dandl A, Reim S, Ahmadsei M, Hartwig H, Holdt LM, Hristov M, Megens RTA, Schmitt MM, Biessen EA, Borst J, Faussner A, Weber C, Lutgens E, Gerdes N.

Eur Heart J. 2017 Dec 21;38(48):3590-3599. doi: 10.1093/eurheartj/ehx517.

PMID:
29045618
4.

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.

von Hundelshausen P, Agten SM, Eckardt V, Blanchet X, Schmitt MM, Ippel H, Neideck C, Bidzhekov K, Leberzammer J, Wichapong K, Faussner A, Drechsler M, Grommes J, van Geffen JP, Li H, Ortega-Gomez A, Megens RT, Naumann R, Dijkgraaf I, Nicolaes GA, Döring Y, Soehnlein O, Lutgens E, Heemskerk JW, Koenen RR, Mayo KH, Hackeng TM, Weber C.

Sci Transl Med. 2017 Apr 5;9(384). pii: eaah6650. doi: 10.1126/scitranslmed.aah6650.

PMID:
28381538
5.

CD70 limits atherosclerosis and promotes macrophage function.

Winkels H, Meiler S, Smeets E, Lievens D, Engel D, Spitz C, Bürger C, Rinne P, Beckers L, Dandl A, Reim S, Ahmadsei M, Van den Bossche J, Holdt LM, Megens RT, Schmitt M, de Winther M, Biessen EA, Borst J, Faussner A, Weber C, Lutgens E, Gerdes N.

Thromb Haemost. 2017 Jan 5;117(1):164-175. doi: 10.1160/TH16-04-0318. Epub 2016 Oct 27.

PMID:
27786334
6.

Cross-Linking GPVI-Fc by Anti-Fc Antibodies Potentiates Its Inhibition of Atherosclerotic Plaque- and Collagen-Induced Platelet Activation.

Jamasbi J, Megens RT, Bianchini M, Uhland K, Münch G, Ungerer M, Sherman S, Faussner A, Brandl R, John C, Buchner J, Weber C, Lorenz R, Elia N, Siess W.

JACC Basic Transl Sci. 2016 Apr 25;1(3):131-142.. eCollection 2016 Apr. Review.

7.

Evaluation of the BDCA2-DTR Transgenic Mouse Model in Chronic and Acute Inflammation.

Mandl M, Drechsler M, Jansen Y, Neideck C, Noels H, Faussner A, Soehnlein O, Weber C, Döring Y.

PLoS One. 2015 Aug 7;10(8):e0134176. doi: 10.1371/journal.pone.0134176. eCollection 2015.

8.

Differential Inhibition of Human Atherosclerotic Plaque-Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies: Functional and Imaging Studies.

Jamasbi J, Megens RT, Bianchini M, Münch G, Ungerer M, Faussner A, Sherman S, Walker A, Goyal P, Jung S, Brandl R, Weber C, Lorenz R, Farndale R, Elia N, Siess W.

J Am Coll Cardiol. 2015 Jun 9;65(22):2404-15. doi: 10.1016/j.jacc.2015.03.573.

9.

Kinin release from human kininogen by 10 aspartic proteases produced by pathogenic yeast Candida albicans.

Kozik A, Gogol M, Bochenska O, Karkowska-Kuleta J, Wolak N, Kamysz W, Aoki W, Ueda M, Faussner A, Rapala-Kozik M.

BMC Microbiol. 2015 Mar 4;15:60. doi: 10.1186/s12866-015-0394-8.

10.

β-Catenin-dependent pathway activation by both promiscuous "canonical" WNT3a-, and specific "noncanonical" WNT4- and WNT5a-FZD receptor combinations with strong differences in LRP5 and LRP6 dependency.

Ring L, Neth P, Weber C, Steffens S, Faussner A.

Cell Signal. 2014 Feb;26(2):260-7. doi: 10.1016/j.cellsig.2013.11.021. Epub 2013 Nov 21.

PMID:
24269653
11.

Release of biologically active kinin peptides, Met-Lys-bradykinin and Leu-Met-Lys-bradykinin from human kininogens by two major secreted aspartic proteases of Candida parapsilosis.

Bras G, Bochenska O, Rapala-Kozik M, Guevara-Lora I, Faussner A, Kamysz W, Kozik A.

Peptides. 2013 Oct;48:114-23. doi: 10.1016/j.peptides.2013.08.003. Epub 2013 Aug 13.

PMID:
23954712
12.

Kinin-generating cellular model obtained from human glioblastoma cell line U-373.

Guevara-Lora I, Blonska B, Faussner A, Kozik A.

Acta Biochim Pol. 2013;60(3):299-305. Epub 2013 Jun 12.

13.

Interruption of the ionic lock in the bradykinin B2 receptor results in constitutive internalization and turns several antagonists into strong agonists.

Leschner J, Wennerberg G, Feierler J, Bermudez M, Welte B, Kalatskaya I, Wolber G, Faussner A.

J Pharmacol Exp Ther. 2013 Jan;344(1):85-95. doi: 10.1124/jpet.112.199190. Epub 2012 Oct 18.

PMID:
23086229
14.

Extracellular aspartic protease SAP2 of Candida albicans yeast cleaves human kininogens and releases proinflammatory peptides, Met-Lys-bradykinin and des-Arg(9)-Met-Lys-bradykinin.

Bras G, Bochenska O, Rapala-Kozik M, Guevara-Lora I, Faussner A, Kozik A.

Biol Chem. 2012 Aug;393(8):829-39. doi: 10.1515/hsz-2012-0157.

PMID:
22944684
15.

Binding characteristics of [3H]-JSM10292: a new cell membrane-permeant non-peptide bradykinin B2 receptor antagonist.

Faussner A, Schüssler S, Feierler J, Bermudez M, Pfeifer J, Schnatbaum K, Tradler T, Jochum M, Wolber G, Gibson C.

Br J Pharmacol. 2012 Oct;167(4):839-53. doi: 10.1111/j.1476-5381.2012.02054.x.

16.

Helix 8 plays a crucial role in bradykinin B(2) receptor trafficking and signaling.

Feierler J, Wirth M, Welte B, Schüssler S, Jochum M, Faussner A.

J Biol Chem. 2011 Dec 16;286(50):43282-93. doi: 10.1074/jbc.M111.256909. Epub 2011 Oct 20.

17.

Fever-like temperature modification differentially affects in vitro signaling of bradykinin B(1) and B(2) receptors.

Leschner J, Ring L, Feierler J, Dinkel K, Jochum M, Faussner A.

Biol Chem. 2011 Nov;392(11):1021-9. doi: 10.1515/BC.2011.095. Epub 2011 Aug 28.

PMID:
21871009
18.

Reporter gene HEK 293 cells and WNT/Frizzled fusion proteins as tools to study WNT signaling pathways.

Ring L, Peröbner I, Karow M, Jochum M, Neth P, Faussner A.

Biol Chem. 2011 Nov;392(11):1011-20. doi: 10.1515/BC.2011.164.

PMID:
21864196
19.

Kinin generation from exogenous kininogens at the surface of retinoic acid-differentiated human neuroblastoma IMR-32 cells after stimulation with interferon-γ.

Guevara-Lora I, Majkucinska M, Barbasz A, Faussner A, Kozik A.

Peptides. 2011 Jun;32(6):1193-200. doi: 10.1016/j.peptides.2011.04.019. Epub 2011 Apr 27.

PMID:
21549779
20.

Degradation of human kininogens with the release of kinin peptides by extracellular proteinases of Candida spp.

Rapala-Kozik M, Karkowska-Kuleta J, Ryzanowska A, Golda A, Barbasz A, Faussner A, Kozik A.

Biol Chem. 2010 Jul;391(7):823-30. doi: 10.1515/BC.2010.083.

PMID:
20624001
21.

A cysteine-type carboxypeptidase, cathepsin X, generates peptide receptor agonists.

Nägler DK, Kraus S, Feierler J, Mentele R, Lottspeich F, Jochum M, Faussner A.

Int Immunopharmacol. 2010 Jan;10(1):134-9. doi: 10.1016/j.intimp.2009.09.018. Epub 2009 Oct 1.

PMID:
19800993
22.

Novel small molecule bradykinin B2 receptor antagonists.

Gibson C, Schnatbaum K, Pfeifer JR, Locardi E, Paschke M, Reimer U, Richter U, Scharn D, Faussner A, Tradler T.

J Med Chem. 2009 Jul 23;52(14):4370-9. doi: 10.1021/jm9002445.

PMID:
19552431
23.

Alanine screening of the intracellular loops of the human bradykinin B receptor--effects on receptor maintenance, G protein activation and internalization.

Faussner A, Wennerberg G, Schüssler S, Feierler J, Seidl C, Jochum M, Proud D.

FEBS J. 2009 Jul;276(13):3491-503. doi: 10.1111/j.1742-4658.2009.07071.x. Epub 2009 May 18.

24.

Ca2+ signalling of kinins in cells expressing rat, mouse and human B1/B2-receptor.

Zubakova R, Gille A, Faussner A, Hilgenfeldt U.

Int Immunopharmacol. 2008 Feb;8(2):276-81. doi: 10.1016/j.intimp.2007.10.001. Epub 2007 Oct 25.

PMID:
18182240
25.

Kinin receptors in stimulated and characterized decidua tissue-derived cells.

Schremmer-Danninger E, Nägler DK, Miska K, Flaig MJ, Faussner A, Fink E, Raggi MC, Jochum M, Rehbock J.

Int Immunopharmacol. 2007 Jan;7(1):103-12. Epub 2006 Oct 3.

PMID:
17161823
26.

C-terminal fusion of eGFP to the bradykinin B2 receptor strongly affects down-regulation but not receptor internalization or signaling.

Kalatskaya I, Schüssler S, Seidl C, Jochum M, Faussner A.

Biol Chem. 2006 May;387(5):603-10.

PMID:
16740132
27.

The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B(1) and B(2) bradykinin receptors.

Faussner A, Bauer A, Kalatskaya I, Schüssler S, Seidl C, Proud D, Jochum M.

FEBS J. 2005 Jan;272(1):129-40.

29.

Mutation of tyrosine in the conserved NPXXY sequence leads to constitutive phosphorylation and internalization, but not signaling, of the human B2 bradykinin receptor.

Kalatskaya I, Schüssler S, Blaukat A, Müller-Esterl W, Jochum M, Proud D, Faussner A.

J Biol Chem. 2004 Jul 23;279(30):31268-76. Epub 2004 May 25.

30.

Downregulation of bradykinin B2 receptor in human fibroblasts during prolonged agonist exposure.

Blaukat A, Micke P, Kalatskaya I, Faussner A, Müller-Esterl W.

Am J Physiol Heart Circ Physiol. 2003 Jun;284(6):H1909-16.

31.

Expression levels strongly affect ligand-induced sequestration of B2 bradykinin receptors in transfected cells.

Faussner A, Bauer A, Kalatskaya I, Jochum M, Fritz H.

Am J Physiol Heart Circ Physiol. 2003 Jun;284(6):H1892-8.

33.

Comparison of the responses of B1 and B2 kinin receptors to agonist stimulation.

Faussner A, Bathon JM, Proud D.

Immunopharmacology. 1999 Dec;45(1-3):13-20.

PMID:
10614984
35.

Stable expression of the human kinin B1 receptor in Chinese hamster ovary cells. Characterization of ligand binding and effector pathways.

Austin CE, Faussner A, Robinson HE, Chakravarty S, Kyle DJ, Bathon JM, Proud D.

J Biol Chem. 1997 Apr 25;272(17):11420-5.

36.

B2 bradykinin receptors in cultured neonatal rat cardiomyocytes mediate a negative chronotropic and negative inotropic response.

Kasel AM, Faussner A, Pfeifer A, Müller U, Werdan K, Roscher AA.

Diabetes. 1996 Jan;45 Suppl 1:S44-50.

PMID:
8529800
37.

Bradykinin induces translocation of the protein kinase C isoforms alpha, epsilon, and zeta.

Tippmer S, Quitterer U, Kolm V, Faussner A, Roscher A, Mosthaf L, Müller-Esterl W, Häring H.

Eur J Biochem. 1994 Oct 1;225(1):297-304.

38.

Anti-idiotypic antibodies against the kinin receptor.

Haasemann M, Buschko J, Faussner A, Roscher AA, Hoebeke J, Burch R, Müller-Esterl W.

J Cardiovasc Pharmacol. 1992;20 Suppl 9:S47-54.

PMID:
1282630
39.

Anti-idiotypic antibodies against the kinin receptor.

Haasemann M, Buschko J, Faussner A, Roscher AA, Hoebeke J, Burch R, Muller-Esterl W.

Agents Actions Suppl. 1992;38 ( Pt 1):497-512.

PMID:
1281612
40.

Anti-idiotypic antibodies bearing the internal image of a bradykinin epitope. Production, characterization, and interaction with the kinin receptor.

Haasemann M, Buschko J, Faussner A, Roscher AA, Hoebeke J, Burch RM, Müller-Esterl W.

J Immunol. 1991 Dec 1;147(11):3882-92.

PMID:
1719093
41.

Solubilization and characterization of B2 bradykinin receptors from cultured human fibroblasts.

Faussner A, Heinz-Erian P, Klier C, Roscher AA.

J Biol Chem. 1991 May 25;266(15):9442-6.

42.
43.

Regulation of bradykinin action at the receptor level.

Roscher AA, Klier C, Dengler R, Faussner A, Müller-Esterl W.

J Cardiovasc Pharmacol. 1990;15 Suppl 6:S39-43.

PMID:
1697359

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