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Items: 25

1.

Characterising a healthy adult with a rare HAO1 knockout to support a therapeutic strategy for primary hyperoxaluria.

McGregor TL, Hunt KA, Yee E, Mason D, Nioi P, Ticau S, Pelosi M, Loken PR, Finer S, Lawlor DA, Fauman EB, Huang QQ, Griffiths CJ, MacArthur DG, Trembath RC, Oglesbee D, Lieske JC, Erbe DV, Wright J, van Heel DA.

Elife. 2020 Mar 24;9. pii: e54363. doi: 10.7554/eLife.54363.

2.

An Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors.

Harshfield EL, Koulman A, Ziemek D, Marney L, Fauman EB, Paul DS, Stacey D, Rasheed A, Lee JJ, Shah N, Jabeen S, Imran A, Abbas S, Hina Z, Qamar N, Mallick NH, Yaqoob Z, Saghir T, Rizvi SNH, Memon A, Rasheed SZ, Memon FU, Qureshi IH, Ishaq M, Frossard P, Danesh J, Saleheen D, Butterworth AS, Wood AM, Griffin JL.

J Proteome Res. 2019 Jun 7;18(6):2397-2410. doi: 10.1021/acs.jproteome.8b00786. Epub 2019 Apr 26.

3.

ProGeM: a framework for the prioritization of candidate causal genes at molecular quantitative trait loci.

Stacey D, Fauman EB, Ziemek D, Sun BB, Harshfield EL, Wood AM, Butterworth AS, Suhre K, Paul DS.

Nucleic Acids Res. 2019 Jan 10;47(1):e3. doi: 10.1093/nar/gky837.

4.

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms.

Howson JMM, Zhao W, Barnes DR, Ho WK, Young R, Paul DS, Waite LL, Freitag DF, Fauman EB, Salfati EL, Sun BB, Eicher JD, Johnson AD, Sheu WHH, Nielsen SF, Lin WY, Surendran P, Malarstig A, Wilk JB, Tybjærg-Hansen A, Rasmussen KL, Kamstrup PR, Deloukas P, Erdmann J, Kathiresan S, Samani NJ, Schunkert H, Watkins H; CARDIoGRAMplusC4D, Do R, Rader DJ, Johnson JA, Hazen SL, Quyyumi AA, Spertus JA, Pepine CJ, Franceschini N, Justice A, Reiner AP, Buyske S, Hindorff LA, Carty CL, North KE, Kooperberg C, Boerwinkle E, Young K, Graff M, Peters U, Absher D, Hsiung CA, Lee WJ, Taylor KD, Chen YH, Lee IT, Guo X, Chung RH, Hung YJ, Rotter JI, Juang JJ, Quertermous T, Wang TD, Rasheed A, Frossard P, Alam DS, Majumder AAS, Di Angelantonio E, Chowdhury R; EPIC-CVD, Chen YI, Nordestgaard BG, Assimes TL, Danesh J, Butterworth AS, Saleheen D.

Nat Genet. 2017 Jul;49(7):1113-1119. doi: 10.1038/ng.3874. Epub 2017 May 22.

5.

GWAS of self-reported mosquito bite size, itch intensity and attractiveness to mosquitoes implicates immune-related predisposition loci.

Jones AV, Tilley M, Gutteridge A, Hyde C, Nagle M, Ziemek D, Gorman D, Fauman EB, Chen X, Miller MR, Tian C, Hu Y, Hinds DA, Cox P, Scollen S.

Hum Mol Genet. 2017 Apr 1;26(7):1391-1406. doi: 10.1093/hmg/ddx036.

6.

An atlas of genetic influences on human blood metabolites.

Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, Walter K, Menni C, Chen L, Vasquez L, Valdes AM, Hyde CL, Wang V, Ziemek D, Roberts P, Xi L, Grundberg E; Multiple Tissue Human Expression Resource (MuTHER) Consortium, Waldenberger M, Richards JB, Mohney RP, Milburn MV, John SL, Trimmer J, Theis FJ, Overington JP, Suhre K, Brosnan MJ, Gieger C, Kastenmüller G, Spector TD, Soranzo N.

Nat Genet. 2014 Jun;46(6):543-550. doi: 10.1038/ng.2982. Epub 2014 May 11.

7.

Structure-based druggability assessment--identifying suitable targets for small molecule therapeutics.

Fauman EB, Rai BK, Huang ES.

Curr Opin Chem Biol. 2011 Aug;15(4):463-8. doi: 10.1016/j.cbpa.2011.05.020. Epub 2011 Jun 23. Review.

PMID:
21704549
8.

Structural bioinformatics in drug discovery.

Fauman EB, Hopkins AL, Groom CR.

Methods Biochem Anal. 2003;44:477-97. Review. No abstract available.

PMID:
12647400
9.

Identification of a novel mitogen-activated protein kinase kinase activation domain recognized by the inhibitor PD 184352.

Delaney AM, Printen JA, Chen H, Fauman EB, Dudley DT.

Mol Cell Biol. 2002 Nov;22(21):7593-602.

10.

RNA methylation under heat shock control.

Bügl H, Fauman EB, Staker BL, Zheng F, Kushner SR, Saper MA, Bardwell JC, Jakob U.

Mol Cell. 2000 Aug;6(2):349-60.

11.

Analysis of a mutation in phosphodiesterase type 4 that alters both inhibitor activity and nucleotide selectivity.

Herman SB, Juilfs DM, Fauman EB, Juneau P, Menetski JP.

Mol Pharmacol. 2000 May;57(5):991-9.

PMID:
10779384
12.

Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A.

Fauman EB, Cogswell JP, Lovejoy B, Rocque WJ, Holmes W, Montana VG, Piwnica-Worms H, Rink MJ, Saper MA.

Cell. 1998 May 15;93(4):617-25.

13.

Structure and function of the protein tyrosine phosphatases.

Fauman EB, Saper MA.

Trends Biochem Sci. 1996 Nov;21(11):413-7. Review.

PMID:
8987394
14.

The X-ray crystal structures of Yersinia tyrosine phosphatase with bound tungstate and nitrate. Mechanistic implications.

Fauman EB, Yuvaniyama C, Schubert HL, Stuckey JA, Saper MA.

J Biol Chem. 1996 Aug 2;271(31):18780-8.

15.
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A ligand-induced conformational change in the Yersinia protein tyrosine phosphatase.

Schubert HL, Fauman EB, Stuckey JA, Dixon JE, Saper MA.

Protein Sci. 1995 Sep;4(9):1904-13.

18.

The Cys(X)5Arg catalytic motif in phosphoester hydrolysis.

Zhang ZY, Wang Y, Wu L, Fauman EB, Stuckey JA, Schubert HL, Saper MA, Dixon JE.

Biochemistry. 1994 Dec 27;33(51):15266-70.

PMID:
7803389
19.

Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 A and the complex with tungstate.

Stuckey JA, Schubert HL, Fauman EB, Zhang ZY, Dixon JE, Saper MA.

Nature. 1994 Aug 18;370(6490):571-5.

20.

Water-mediated substrate/product discrimination: the product complex of thymidylate synthase at 1.83 A.

Fauman EB, Rutenber EE, Maley GF, Maley F, Stroud RM.

Biochemistry. 1994 Feb 15;33(6):1502-11.

PMID:
8312270
21.

Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.

Finer-Moore J, Fauman EB, Foster PG, Perry KM, Santi DV, Stroud RM.

J Mol Biol. 1993 Aug 20;232(4):1101-16.

PMID:
8371269
22.

Structure of a non-peptide inhibitor complexed with HIV-1 protease. Developing a cycle of structure-based drug design.

Rutenber E, Fauman EB, Keenan RJ, Fong S, Furth PS, Ortiz de Montellano PR, Meng E, Kuntz ID, DeCamp DL, Salto R, et al.

J Biol Chem. 1993 Jul 25;268(21):15343-6.

23.

Tracking conformational states in allosteric transitions of phosphorylase.

Browner MF, Fauman EB, Fletterick RJ.

Biochemistry. 1992 Nov 24;31(46):11297-304.

PMID:
1445867
24.

Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate.

Montfort WR, Perry KM, Fauman EB, Finer-Moore JS, Maley GF, Hardy L, Maley F, Stroud RM.

Biochemistry. 1990 Jul 31;29(30):6964-77. Erratum in: Biochemistry 1990 Dec 4;29(48):10864.

PMID:
2223754
25.

Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases.

Perry KM, Fauman EB, Finer-Moore JS, Montfort WR, Maley GF, Maley F, Stroud RM.

Proteins. 1990;8(4):315-33.

PMID:
2128651

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