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Items: 1 to 50 of 301

1.

Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.

Dominy SS, Lynch C, Ermini F, Benedyk M, Marczyk A, Konradi A, Nguyen M, Haditsch U, Raha D, Griffin C, Holsinger LJ, Arastu-Kapur S, Kaba S, Lee A, Ryder MI, Potempa B, Mydel P, Hellvard A, Adamowicz K, Hasturk H, Walker GD, Reynolds EC, Faull RLM, Curtis MA, Dragunow M, Potempa J.

Sci Adv. 2019 Jan 23;5(1):eaau3333. doi: 10.1126/sciadv.aau3333. eCollection 2019 Jan.

2.

Regional protein expression in human Alzheimer's brain correlates with disease severity.

Xu J, Patassini S, Rustogi N, Riba-Garcia I, Hale BD, Phillips AM, Waldvogel H, Haines R, Bradbury P, Stevens A, Faull RLM, Dowsey AW, Cooper GJS, Unwin RD.

Commun Biol. 2019 Feb 4;2:43. doi: 10.1038/s42003-018-0254-9. eCollection 2019.

3.

Chemical neuroanatomy of the substantia nigra in the ovine brain.

Murray SJ, Black BL, Reid SJ, Rudiger SR, Simon Bawden C, Snell RG, Waldvogel HJ, Faull RLM.

J Chem Neuroanat. 2019 Jan 18;97:43-56. doi: 10.1016/j.jchemneu.2019.01.007. [Epub ahead of print]

PMID:
30664938
4.

Sex- and age-related changes in GABA signaling components in the human cortex.

Pandya M, Palpagama TH, Turner C, Waldvogel HJ, Faull RL, Kwakowsky A.

Biol Sex Differ. 2019 Jan 14;10(1):5. doi: 10.1186/s13293-018-0214-6.

5.

Cerebellar degeneration correlates with motor symptoms in Huntington disease.

Singh-Bains MK, Mehrabi NF, Sehji T, Austria MDR, Tan AYS, Tippett LJ, Dragunow M, Waldvogel HJ, Faull RLM.

Ann Neurol. 2019 Jan 11. doi: 10.1002/ana.25413. [Epub ahead of print]

PMID:
30635944
6.

Publisher Correction: Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease.

Dong X, Liao Z, Gritsch D, Hadzhiev Y, Bai Y, Locascio JJ, Guennewig B, Liu G, Blauwendraat C, Wang T, Adler CH, Hedreen JC, Faull RLM, Frosch MP, Nelson PT, Rizzu P, Cooper AA, Heutink P, Beach TG, Mattick JS, Müller F, Scherzer CR.

Nat Neurosci. 2019 Jan;22(1):144-147. doi: 10.1038/s41593-018-0277-z.

PMID:
30482917
7.

Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease.

Dong X, Liao Z, Gritsch D, Hadzhiev Y, Bai Y, Locascio JJ, Guennewig B, Liu G, Blauwendraat C, Wang T, Adler CH, Hedreen JC, Faull RLM, Frosch MP, Nelson PT, Rizzu P, Cooper AA, Heutink P, Beach TG, Mattick JS, Müller F, Scherzer CR.

Nat Neurosci. 2018 Oct;21(10):1482-1492. doi: 10.1038/s41593-018-0223-0. Epub 2018 Sep 17. Erratum in: Nat Neurosci. 2019 Jan;22(1):144-147.

PMID:
30224808
8.

PU.1 regulates Alzheimer's disease-associated genes in primary human microglia.

Rustenhoven J, Smith AM, Smyth LC, Jansson D, Scotter EL, Swanson MEV, Aalderink M, Coppieters N, Narayan P, Handley R, Overall C, Park TIH, Schweder P, Heppner P, Curtis MA, Faull RLM, Dragunow M.

Mol Neurodegener. 2018 Aug 20;13(1):44. doi: 10.1186/s13024-018-0277-1.

9.

Gamma-aminobutyric acid A receptors in Alzheimer's disease: highly localized remodeling of a complex and diverse signaling pathway.

Kwakowsky A, Calvo-Flores Guzmán B, Govindpani K, Waldvogel HJ, Faull RL.

Neural Regen Res. 2018 Aug;13(8):1362-1363. doi: 10.4103/1673-5374.235240. No abstract available.

10.

Markers for human brain pericytes and smooth muscle cells.

Smyth LCD, Rustenhoven J, Scotter EL, Schweder P, Faull RLM, Park TIH, Dragunow M.

J Chem Neuroanat. 2018 Oct;92:48-60. doi: 10.1016/j.jchemneu.2018.06.001. Epub 2018 Jun 7.

PMID:
29885791
11.

Stereological Methods to Quantify Cell Loss in the Huntington's Disease Human Brain.

Mehrabi NF, Singh-Bains MK, Waldvogel HJ, Faull RLM.

Methods Mol Biol. 2018;1780:1-16. doi: 10.1007/978-1-4939-7825-0_1.

PMID:
29856011
12.

Subventricular zone lipidomic architecture loss in Huntington's disease.

Hunter M, Demarais NJ, Faull RLM, Grey AC, Curtis MA.

J Neurochem. 2018 Sep;146(5):613-630. doi: 10.1111/jnc.14468. Epub 2018 Aug 8.

PMID:
29804301
13.

Unique and shared inflammatory profiles of human brain endothelia and pericytes.

Smyth LCD, Rustenhoven J, Park TI, Schweder P, Jansson D, Heppner PA, O'Carroll SJ, Mee EW, Faull RLM, Curtis M, Dragunow M.

J Neuroinflammation. 2018 May 11;15(1):138. doi: 10.1186/s12974-018-1167-8.

14.

Differential Fatty Acid-Binding Protein Expression in Persistent Radial Glia in the Human and Sheep Subventricular Zone.

Dieriks BV, Dean JM, Aronica E, Waldvogel HJ, Faull RLM, Curtis MA.

Dev Neurosci. 2018;40(2):145-161. doi: 10.1159/000487633. Epub 2018 Apr 20.

PMID:
29680832
15.

The GABAergic system as a therapeutic target for Alzheimer's disease.

Calvo-Flores Guzmán B, Vinnakota C, Govindpani K, Waldvogel HJ, Faull RLM, Kwakowsky A.

J Neurochem. 2018 Sep;146(6):649-669. doi: 10.1111/jnc.14345. Epub 2018 Aug 1. Review.

PMID:
29645219
16.

GABAA receptor subunit expression changes in the human Alzheimer's disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus.

Kwakowsky A, Calvo-Flores Guzmán B, Pandya M, Turner C, Waldvogel HJ, Faull RL.

J Neurochem. 2018 Jun;145(5):374-392. doi: 10.1111/jnc.14325.

PMID:
29485232
17.

Modelling physiological and pathological conditions to study pericyte biology in brain function and dysfunction.

Rustenhoven J, Smyth LC, Jansson D, Schweder P, Aalderink M, Scotter EL, Mee EW, Faull RLM, Park TI, Dragunow M.

BMC Neurosci. 2018 Feb 22;19(1):6. doi: 10.1186/s12868-018-0405-4.

18.

Neurochemical Characterization of PSA-NCAM+ Cells in the Human Brain and Phenotypic Quantification in Alzheimer's Disease Entorhinal Cortex.

Murray HC, Swanson MEV, Dieriks BV, Turner C, Faull RLM, Curtis MA.

Neuroscience. 2018 Feb 21;372:289-303. doi: 10.1016/j.neuroscience.2017.12.019.

PMID:
29429526
19.

Layer-specific lipid signatures in the human subventricular zone demonstrated by imaging mass spectrometry.

Hunter M, Demarais NJ, Faull RLM, Grey AC, Curtis MA.

Sci Rep. 2018 Feb 7;8(1):2551. doi: 10.1038/s41598-018-20793-4.

20.

Brain urea increase is an early Huntington's disease pathogenic event observed in a prodromal transgenic sheep model and HD cases.

Handley RR, Reid SJ, Brauning R, Maclean P, Mears ER, Fourie I, Patassini S, Cooper GJS, Rudiger SR, McLaughlan CJ, Verma PJ, Gusella JF, MacDonald ME, Waldvogel HJ, Bawden CS, Faull RLM, Snell RG.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11293-E11302. doi: 10.1073/pnas.1711243115. Epub 2017 Dec 11.

21.

GABAA and GABAB receptor subunit localization on neurochemically identified neurons of the human subthalamic nucleus.

Wu XH, Song JJ, Faull RLM, Waldvogel HJ.

J Comp Neurol. 2018 Apr 1;526(5):803-823. doi: 10.1002/cne.24368. Epub 2017 Dec 22.

PMID:
29218727
22.

A ventral glomerular deficit in Parkinson's disease revealed by whole olfactory bulb reconstruction.

Zapiec B, Dieriks BV, Tan S, Faull RLM, Mombaerts P, Curtis MA.

Brain. 2017 Oct 1;140(10):2722-2736. doi: 10.1093/brain/awx208.

23.

Metal concentrations and distributions in the human olfactory bulb in Parkinson's disease.

Gardner B, Dieriks BV, Cameron S, Mendis LHS, Turner C, Faull RLM, Curtis MA.

Sci Rep. 2017 Sep 5;7(1):10454. doi: 10.1038/s41598-017-10659-6.

24.

Towards a Better Understanding of GABAergic Remodeling in Alzheimer's Disease.

Govindpani K, Calvo-Flores Guzmán B, Vinnakota C, Waldvogel HJ, Faull RL, Kwakowsky A.

Int J Mol Sci. 2017 Aug 21;18(8). pii: E1813. doi: 10.3390/ijms18081813. Review.

25.

Alzheimer's disease markers in the aged sheep (Ovis aries).

Reid SJ, Mckean NE, Henty K, Portelius E, Blennow K, Rudiger SR, Bawden CS, Handley RR, Verma PJ, Faull RLM, Waldvogel HJ, Zetterberg H, Snell RG.

Neurobiol Aging. 2017 Oct;58:112-119. doi: 10.1016/j.neurobiolaging.2017.06.020. Epub 2017 Jun 24.

PMID:
28728117
26.

The Complexity of Clinical Huntington's Disease: Developments in Molecular Genetics, Neuropathology and Neuroimaging Biomarkers.

Tippett LJ, Waldvogel HJ, Snell RG, Vonsattel JP, Young AB, Faull RLM.

Adv Neurobiol. 2017;15:129-161. doi: 10.1007/978-3-319-57193-5_5. Review.

PMID:
28674980
27.

Evidence for widespread, severe brain copper deficiency in Alzheimer's dementia.

Xu J, Church SJ, Patassini S, Begley P, Waldvogel HJ, Curtis MA, Faull RLM, Unwin RD, Cooper GJS.

Metallomics. 2017 Aug 16;9(8):1106-1119. doi: 10.1039/c7mt00074j.

PMID:
28654115
28.

Effect of post-mortem delay on N-terminal huntingtin protein fragments in human control and Huntington disease brain lysates.

Schut MH, Patassini S, Kim EH, Bullock J, Waldvogel HJ, Faull RLM, Pepers BA, den Dunnen JT, van Ommen GB, van Roon-Mom WMC.

PLoS One. 2017 Jun 1;12(6):e0178556. doi: 10.1371/journal.pone.0178556. eCollection 2017.

29.

The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington's disease patients.

Neueder A, Landles C, Ghosh R, Howland D, Myers RH, Faull RLM, Tabrizi SJ, Bates GP.

Sci Rep. 2017 May 2;7(1):1307. doi: 10.1038/s41598-017-01510-z.

30.

The immunohistochemical distribution of the GABAA receptor α1, α2, α3, β2/3 and γ2 subunits in the human thalamus.

Waldvogel HJ, Munkle M, van Roon-Mom W, Mohler H, Faull RLM.

J Chem Neuroanat. 2017 Jul;82:39-55. doi: 10.1016/j.jchemneu.2017.04.006. Epub 2017 Apr 23.

PMID:
28445782
31.

Impaired expression of GABA transporters in the human Alzheimer's disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus.

Fuhrer TE, Palpagama TH, Waldvogel HJ, Synek BJL, Turner C, Faull RL, Kwakowsky A.

Neuroscience. 2017 May 20;351:108-118. doi: 10.1016/j.neuroscience.2017.03.041. Epub 2017 Apr 4.

PMID:
28385633
32.

Insulin promotes cell migration by regulating PSA-NCAM.

Monzo HJ, Coppieters N, Park TIH, Dieriks BV, Faull RLM, Dragunow M, Curtis MA.

Exp Cell Res. 2017 Jun 1;355(1):26-39. doi: 10.1016/j.yexcr.2017.03.029. Epub 2017 Mar 21.

PMID:
28341445
33.

α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson's disease patients.

Dieriks BV, Park TI, Fourie C, Faull RL, Dragunow M, Curtis MA.

Sci Rep. 2017 Feb 23;7:42984. doi: 10.1038/srep42984.

34.

Effect of Estradiol on Neurotrophin Receptors in Basal Forebrain Cholinergic Neurons: Relevance for Alzheimer's Disease.

Kwakowsky A, Milne MR, Waldvogel HJ, Faull RL.

Int J Mol Sci. 2016 Dec 17;17(12). pii: E2122. doi: 10.3390/ijms17122122. Review.

35.
36.

Symptom heterogeneity in Huntington's disease correlates with neuronal degeneration in the cerebral cortex.

Mehrabi NF, Waldvogel HJ, Tippett LJ, Hogg VM, Synek BJ, Faull RL.

Neurobiol Dis. 2016 Dec;96:67-74. doi: 10.1016/j.nbd.2016.08.015. Epub 2016 Aug 25.

PMID:
27569581
37.

Comparison of Huntington's disease CAG Repeat Length Stability in Human Motor Cortex and Cingulate Gyrus.

Geraerts FC, Snell RG, Faull RL, Williams L, Jacobsen JC, Reid SJ.

J Huntingtons Dis. 2016 Oct 1;5(3):297-301.

PMID:
27716680
38.

Interferon-γ blocks signalling through PDGFRβ in human brain pericytes.

Jansson D, Scotter EL, Rustenhoven J, Coppieters N, Smyth LC, Oldfield RL, Bergin PS, Mee EW, Graham ES, Faull RL, Dragunow M.

J Neuroinflammation. 2016 Sep 21;13(1):249.

39.

The role of the human globus pallidus in Huntington's disease.

Singh-Bains MK, Waldvogel HJ, Faull RL.

Brain Pathol. 2016 Nov;26(6):741-751. doi: 10.1111/bpa.12429. Review.

PMID:
27529459
40.

C9ORF72 and UBQLN2 mutations are causes of amyotrophic lateral sclerosis in New Zealand: a genetic and pathologic study using banked human brain tissue.

Scotter EL, Smyth L, Bailey JAWT, Wong CH, de Majo M, Vance CA, Synek BJ, Turner C, Pereira J, Charleston A, Waldvogel HJ, Curtis MA, Dragunow M, Shaw CE, Smith BN, Faull RLM.

Neurobiol Aging. 2017 Jan;49:214.e1-214.e5. doi: 10.1016/j.neurobiolaging.2016.06.019. Epub 2016 Jul 5.

PMID:
27480424
41.

Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels.

Horvath S, Langfelder P, Kwak S, Aaronson J, Rosinski J, Vogt TF, Eszes M, Faull RL, Curtis MA, Waldvogel HJ, Choi OW, Tung S, Vinters HV, Coppola G, Yang XW.

Aging (Albany NY). 2016 Jul;8(7):1485-512. doi: 10.18632/aging.101005.

42.

Transcriptome sequencing reveals aberrant alternative splicing in Huntington's disease.

Lin L, Park JW, Ramachandran S, Zhang Y, Tseng YT, Shen S, Waldvogel HJ, Curtis MA, Faull RL, Troncoso JC, Pletnikova O, Ross CA, Davidson BL, Xing Y.

Hum Mol Genet. 2016 Aug 15;25(16):3454-3466. doi: 10.1093/hmg/ddw187. Epub 2016 Jul 4.

43.

Distribution of PSA-NCAM in normal, Alzheimer's and Parkinson's disease human brain.

Murray HC, Low VF, Swanson ME, Dieriks BV, Turner C, Faull RL, Curtis MA.

Neuroscience. 2016 Aug 25;330:359-75. doi: 10.1016/j.neuroscience.2016.06.003. Epub 2016 Jun 7.

PMID:
27282086
44.

Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia.

Xu J, Begley P, Church SJ, Patassini S, McHarg S, Kureishy N, Hollywood KA, Waldvogel HJ, Liu H, Zhang S, Lin W, Herholz K, Turner C, Synek BJ, Curtis MA, Rivers-Auty J, Lawrence CB, Kellett KA, Hooper NM, Vardy ER, Wu D, Unwin RD, Faull RL, Dowsey AW, Cooper GJ.

Sci Rep. 2016 Jun 9;6:27524. doi: 10.1038/srep27524.

45.

Metabolite mapping reveals severe widespread perturbation of multiple metabolic processes in Huntington's disease human brain.

Patassini S, Begley P, Xu J, Church SJ, Reid SJ, Kim EH, Curtis MA, Dragunow M, Waldvogel HJ, Snell RG, Unwin RD, Faull RL, Cooper GJ.

Biochim Biophys Acta. 2016 Sep;1862(9):1650-62. doi: 10.1016/j.bbadis.2016.06.002. Epub 2016 Jun 4.

46.

Globus pallidus degeneration and clinicopathological features of Huntington disease.

Singh-Bains MK, Tippett LJ, Hogg VM, Synek BJ, Roxburgh RH, Waldvogel HJ, Faull RL.

Ann Neurol. 2016 Aug;80(2):185-201. doi: 10.1002/ana.24694. Epub 2016 Jun 24.

PMID:
27255697
47.

Cultured pericytes from human brain show phenotypic and functional differences associated with differential CD90 expression.

Park TI, Feisst V, Brooks AE, Rustenhoven J, Monzo HJ, Feng SX, Mee EW, Bergin PS, Oldfield R, Graham ES, Curtis MA, Faull RL, Dunbar PR, Dragunow M.

Sci Rep. 2016 May 24;6:26587. doi: 10.1038/srep26587.

48.

Graded perturbations of metabolism in multiple regions of human brain in Alzheimer's disease: Snapshot of a pervasive metabolic disorder.

Xu J, Begley P, Church SJ, Patassini S, Hollywood KA, Jüllig M, Curtis MA, Waldvogel HJ, Faull RL, Unwin RD, Cooper GJ.

Biochim Biophys Acta. 2016 Jun;1862(6):1084-92. doi: 10.1016/j.bbadis.2016.03.001. Epub 2016 Mar 5.

49.

Mapping the calcitonin receptor in human brain stem.

Bower RL, Eftekhari S, Waldvogel HJ, Faull RL, Tajti J, Edvinsson L, Hay DL, Walker CS.

Am J Physiol Regul Integr Comp Physiol. 2016 May 1;310(9):R788-93. doi: 10.1152/ajpregu.00539.2015. Epub 2016 Feb 24.

50.

TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function.

Rustenhoven J, Aalderink M, Scotter EL, Oldfield RL, Bergin PS, Mee EW, Graham ES, Faull RL, Curtis MA, Park TI, Dragunow M.

J Neuroinflammation. 2016 Feb 11;13:37. doi: 10.1186/s12974-016-0503-0.

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