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Improvement of antibody functionality by structure-guided paratope engraftment.

Liu Q, Lai YT, Zhang P, Louder MK, Pegu A, Rawi R, Asokan M, Chen X, Shen CH, Chuang GY, Yang ES, Miao H, Wang Y, Fauci AS, Kwong PD, Mascola JR, Lusso P.

Nat Commun. 2019 Feb 13;10(1):721. doi: 10.1038/s41467-019-08658-4.


Ending the HIV Epidemic: A Plan for the United States.

Fauci AS, Redfield RR, Sigounas G, Weahkee MD, Giroir BP.

JAMA. 2019 Feb 7. doi: 10.1001/jama.2019.1343. [Epub ahead of print] No abstract available.


Influenza Vaccines: Good, But We Can Do Better.

Paules CI, Fauci AS.

J Infect Dis. 2019 Jan 31. doi: 10.1093/infdis/jiy633. [Epub ahead of print] No abstract available.


HIV Viral Load and Transmissibility of HIV Infection: Undetectable Equals Untransmittable.

Eisinger RW, Dieffenbach CW, Fauci AS.

JAMA. 2019 Feb 5;321(5):451-452. doi: 10.1001/jama.2018.21167. No abstract available.


Immunity to Influenza: Catching a Moving Target To Improve Vaccine Design.

Paules CI, McDermott AB, Fauci AS.

J Immunol. 2019 Jan 15;202(2):327-331. doi: 10.4049/jimmunol.1890025. No abstract available.


Role of T-cell trafficking in the pathogenesis of HIV disease.

Cicala C, Arthos J, Fauci AS.

Curr Opin HIV AIDS. 2019 Mar;14(2):115-120. doi: 10.1097/COH.0000000000000529.


Addressing the Tuberculosis Epidemic: 21st Century Research for an Ancient Disease.

Fauci AS.

JAMA. 2018 Oct 2;320(13):1315-1316. doi: 10.1001/jama.2018.12852. No abstract available.


The Extended Impact of Human Immunodeficiency Virus/AIDS Research.

Schwetz TA, Fauci AS.

J Infect Dis. 2019 Jan 1;219(1):6-9. doi: 10.1093/infdis/jiy441.


Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7.

Lertjuthaporn S, Cicala C, Van Ryk D, Liu M, Yolitz J, Wei D, Nawaz F, Doyle A, Horowitch B, Park C, Lu S, Lou Y, Wang S, Pan R, Jiang X, Villinger F, Byrareddy SN, Santangelo PJ, Morris L, Wibmer CK, Biris K, Mason RD, Gorman J, Hiatt J, Martinelli E, Roederer M, Fujikawa D, Gorini G, Franchini G, Arakelyan A, Ansari AA, Pattanapanyasat K, Kong XP, Fauci AS, Arthos J.

PLoS Pathog. 2018 Aug 28;14(8):e1007278. doi: 10.1371/journal.ppat.1007278. eCollection 2018 Aug.


Ending the HIV Epidemic in the United States: Closing the Implementation Gaps.

Marston HD, Dieffenbach CW, Fauci AS.

Ann Intern Med. 2018 Sep 18;169(6):411-412. doi: 10.7326/M18-1944. Epub 2018 Aug 21. No abstract available.


Tickborne Diseases - Confronting a Growing Threat.

Paules CI, Marston HD, Bloom ME, Fauci AS.

N Engl J Med. 2018 Aug 23;379(8):701-703. doi: 10.1056/NEJMp1807870. Epub 2018 Jul 25. No abstract available.


MAdCAM costimulation through Integrin-α4β7 promotes HIV replication.

Nawaz F, Goes LR, Ray JC, Olowojesiku R, Sajani A, Ansari AA, Perrone I, Hiatt J, Van Ryk D, Wei D, Waliszewski M, Soares MA, Jelicic K, Connors M, Migueles SA, Martinelli E, Villinger F, Cicala C, Fauci AS, Arthos J.

Mucosal Immunol. 2018 Sep;11(5):1342-1351. doi: 10.1038/s41385-018-0044-1. Epub 2018 Jun 6.


US and Cuban Scientists Forge Collaboration on Arbovirus Research.

Pérez-Ávila J, Guzmán-Tirado MG, Fraga-Nodarse J, Handley G, Meegan J, Pelegrino-Martínez de la Cotera JL, Fauci AS.

MEDICC Rev. 2018 Apr;20(2):32-34.


Novel Vaccine Technologies: Essential Components of an Adequate Response to Emerging Viral Diseases.

Graham BS, Mascola JR, Fauci AS.

JAMA. 2018 Apr 10;319(14):1431-1432. doi: 10.1001/jama.2018.0345. No abstract available.


Monoclonal Antibodies for Emerging Infectious Diseases - Borrowing from History.

Marston HD, Paules CI, Fauci AS.

N Engl J Med. 2018 Apr 19;378(16):1469-1472. doi: 10.1056/NEJMp1802256. Epub 2018 Mar 7. No abstract available.


A Universal Influenza Vaccine: The Strategic Plan for the National Institute of Allergy and Infectious Diseases.

Erbelding EJ, Post DJ, Stemmy EJ, Roberts PC, Augustine AD, Ferguson S, Paules CI, Graham BS, Fauci AS.

J Infect Dis. 2018 Jul 2;218(3):347-354. doi: 10.1093/infdis/jiy103.


The Role of Integrin α4β7 in HIV Pathogenesis and Treatment.

Arthos J, Cicala C, Nawaz F, Byrareddy SN, Villinger F, Santangelo PJ, Ansari AA, Fauci AS.

Curr HIV/AIDS Rep. 2018 Apr;15(2):127-135. doi: 10.1007/s11904-018-0382-3. Review.


Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120.

Yolitz J, Schwing C, Chang J, Van Ryk D, Nawaz F, Wei D, Cicala C, Arthos J, Fauci AS.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2443-2448. doi: 10.1073/pnas.1722627115. Epub 2018 Feb 20.


Ending the HIV/AIDS Pandemic1.

Eisinger RW, Fauci AS.

Emerg Infect Dis. 2018 Mar;24(3):413-416. doi: 10.3201/eid2403.171797. Review.


Integrin α4β7 expression on peripheral blood CD4+ T cells predicts HIV acquisition and disease progression outcomes.

Sivro A, Schuetz A, Sheward D, Joag V, Yegorov S, Liebenberg LJ, Yende-Zuma N, Stalker A, Mwatelah RS, Selhorst P, Garrett N, Samsunder N, Balgobin A, Nawaz F, Cicala C, Arthos J, Fauci AS, Anzala AO, Kimani J, Bagaya BS, Kiwanuka N, Williamson C, Kaul R, Passmore JS, Phanuphak N, Ananworanich J, Ansari A, Abdool Karim Q, Abdool Karim SS, McKinnon LR; CAPRISA004 and RV254 study groups.

Sci Transl Med. 2018 Jan 24;10(425). pii: eaam6354. doi: 10.1126/scitranslmed.aam6354.


PEPFAR - 15 Years and Counting the Lives Saved.

Fauci AS, Eisinger RW.

N Engl J Med. 2018 Jan 25;378(4):314-316. doi: 10.1056/NEJMp1714773. No abstract available.


Reimagining the Research Approach to Tuberculosis.

Fauci AS, Eisinger RW.

Am J Trop Med Hyg. 2018 Mar;98(3):650-652. doi: 10.4269/ajtmh.17-0999. Epub 2018 Jan 11.


Early treatment of SIV+ macaques with an α4β7 mAb alters virus distribution and preserves CD4+ T cells in later stages of infection.

Santangelo PJ, Cicala C, Byrareddy SN, Ortiz KT, Little D, Lindsay KE, Gumber S, Hong JJ, Jelicic K, Rogers KA, Zurla C, Villinger F, Ansari AA, Fauci AS, Arthos J.

Mucosal Immunol. 2018 May;11(3):932-946. doi: 10.1038/mi.2017.112. Epub 2017 Dec 20.


A Universal Flu Vaccine Is Vital.

Paules CI, Fauci AS.

Sci Am. 2018 Jan 16;318(2):8. doi: 10.1038/scientificamerican0218-8. No abstract available.


Pandemic Zika: A Formidable Challenge to Medicine and Public Health.

Morens DM, Fauci AS.

J Infect Dis. 2017 Dec 16;216(suppl_10):S857-S859. doi: 10.1093/infdis/jix383. No abstract available.


A randomized controlled safety/efficacy trial of therapeutic vaccination in HIV-infected individuals who initiated antiretroviral therapy early in infection.

Sneller MC, Justement JS, Gittens KR, Petrone ME, Clarridge KE, Proschan MA, Kwan R, Shi V, Blazkova J, Refsland EW, Morris DE, Cohen KW, McElrath MJ, Xu R, Egan MA, Eldridge JH, Benko E, Kovacs C, Moir S, Chun TW, Fauci AS.

Sci Transl Med. 2017 Dec 6;9(419). pii: eaan8848. doi: 10.1126/scitranslmed.aan8848.


Chasing Seasonal Influenza - The Need for a Universal Influenza Vaccine.

Paules CI, Sullivan SG, Subbarao K, Fauci AS.

N Engl J Med. 2018 Jan 4;378(1):7-9. doi: 10.1056/NEJMp1714916. Epub 2017 Nov 29. No abstract available.


What Recent History Has Taught Us About Responding to Emerging Infectious Disease Threats.

Paules CI, Eisinger RW, Marston HD, Fauci AS.

Ann Intern Med. 2017 Dec 5;167(11):805-811. doi: 10.7326/M17-2496. Epub 2017 Nov 14.


An HIV Vaccine Is Essential for Ending the HIV/AIDS Pandemic.

Fauci AS.

JAMA. 2017 Oct 24;318(16):1535-1536. doi: 10.1001/jama.2017.13505. No abstract available.


The Pathway to a Universal Influenza Vaccine.

Paules CI, Marston HD, Eisinger RW, Baltimore D, Fauci AS.

Immunity. 2017 Oct 17;47(4):599-603. doi: 10.1016/j.immuni.2017.09.007.


The Critical Role of Biomedical Research in Pandemic Preparedness.

Marston HD, Paules CI, Fauci AS.

JAMA. 2017 Nov 14;318(18):1757-1758. doi: 10.1001/jama.2017.15033. No abstract available.


Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing.

Guzzo C, Ichikawa D, Park C, Phillips D, Liu Q, Zhang P, Kwon A, Miao H, Lu J, Rehm C, Arthos J, Cicala C, Cohen MS, Fauci AS, Kehrl JH, Lusso P.

Sci Immunol. 2017 May 12;2(11). pii: eaam7341. doi: 10.1126/sciimmunol.aam7341.


Early antibody therapy can induce long-lasting immunity to SHIV.

Nishimura Y, Gautam R, Chun TW, Sadjadpour R, Foulds KE, Shingai M, Klein F, Gazumyan A, Golijanin J, Donaldson M, Donau OK, Plishka RJ, Buckler-White A, Seaman MS, Lifson JD, Koup RA, Fauci AS, Nussenzweig MC, Martin MA.

Nature. 2017 Mar 23;543(7646):559-563. doi: 10.1038/nature21435. Epub 2017 Mar 13.


Yellow Fever - Once Again on the Radar Screen in the Americas.

Paules CI, Fauci AS.

N Engl J Med. 2017 Apr 13;376(15):1397-1399. doi: 10.1056/NEJMp1702172. Epub 2017 Mar 8. No abstract available.


B-cell responses to HIV infection.

Moir S, Fauci AS.

Immunol Rev. 2017 Jan;275(1):33-48. doi: 10.1111/imr.12502. Review.


Emerging and Reemerging Infectious Diseases: The Dichotomy Between Acute Outbreaks and Chronic Endemicity.

Paules CI, Fauci AS.

JAMA. 2017 Feb 21;317(7):691-692. doi: 10.1001/jama.2016.21079. No abstract available.


Association Between Human Immunodeficiency Virus Infection and Cardiovascular Diseases: Finding a Solution to Double Jeopardy.

Hadigan C, Paules CI, Fauci AS.

JAMA Cardiol. 2017 Feb 1;2(2):123-124. doi: 10.1001/jamacardio.2016.5177. No abstract available.


Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption.

Bar KJ, Sneller MC, Harrison LJ, Justement JS, Overton ET, Petrone ME, Salantes DB, Seamon CA, Scheinfeld B, Kwan RW, Learn GH, Proschan MA, Kreider EF, Blazkova J, Bardsley M, Refsland EW, Messer M, Clarridge KE, Tustin NB, Madden PJ, Oden K, O'Dell SJ, Jarocki B, Shiakolas AR, Tressler RL, Doria-Rose NA, Bailer RT, Ledgerwood JE, Capparelli EV, Lynch RM, Graham BS, Moir S, Koup RA, Mascola JR, Hoxie JA, Fauci AS, Tebas P, Chun TW.

N Engl J Med. 2016 Nov 24;375(21):2037-2050. Epub 2016 Nov 9.


Meeting the Challenge of Epidemic Chikungunya.

Morens DM, Fauci AS.

J Infect Dis. 2016 Dec 15;214(suppl 5):S434-S435. No abstract available.


Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy.

Byrareddy SN, Arthos J, Cicala C, Villinger F, Ortiz KT, Little D, Sidell N, Kane MA, Yu J, Jones JW, Santangelo PJ, Zurla C, McKinnon LR, Arnold KB, Woody CE, Walter L, Roos C, Noll A, Van Ryk D, Jelicic K, Cimbro R, Gumber S, Reid MD, Adsay V, Amancha PK, Mayne AE, Parslow TG, Fauci AS, Ansari AA.

Science. 2016 Oct 14;354(6309):197-202.


A Randomized, Controlled Trial of ZMapp for Ebola Virus Infection.

PREVAIL II Writing Group; Multi-National PREVAIL II Study Team, Davey RT Jr, Dodd L, Proschan MA, Neaton J, Neuhaus Nordwall J, Koopmeiners JS, Beigel J, Tierney J, Lane HC, Fauci AS, Massaquoi MBF, Sahr F, Malvy D.

N Engl J Med. 2016 Oct 13;375(15):1448-1456.


Considerations for Developing a Zika Virus Vaccine.

Marston HD, Lurie N, Borio LL, Fauci AS.

N Engl J Med. 2016 Sep 29;375(13):1209-12. doi: 10.1056/NEJMp1607762. No abstract available.


Antimicrobial Resistance.

Marston HD, Dixon DM, Knisely JM, Palmore TN, Fauci AS.

JAMA. 2016 Sep 20;316(11):1193-1204. doi: 10.1001/jama.2016.11764.


The Role of the Virtuous Investigator in Protecting Human Research Subjects.

Grady C, Fauci AS.

Perspect Biol Med. 2016;59(1):122-31. doi: 10.1353/pbm.2016.0021.


Defective HIV-1 proviruses produce novel protein-coding RNA species in HIV-infected patients on combination antiretroviral therapy.

Imamichi H, Dewar RL, Adelsberger JW, Rehm CA, O'Doherty U, Paxinos EE, Fauci AS, Lane HC.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8783-8. doi: 10.1073/pnas.1609057113. Epub 2016 Jul 18.


The Acquired Immune Deficiency Syndrome: The Ever-Broadening Clinical Spectrum.

Fauci AS.

JAMA. 2016 Jul 12;316(2):230. doi: 10.1001/jama.2015.17093. No abstract available.


An HIV Vaccine: Mapping Uncharted Territory.

Fauci AS.

JAMA. 2016 Jul 12;316(2):143-4. doi: 10.1001/jama.2016.7538. No abstract available.


Maturational characteristics of HIV-specific antibodies in viremic individuals.

Meffre E, Louie A, Bannock J, Kim LJ, Ho J, Frear CC, Kardava L, Wang W, Buckner CM, Wang Y, Fankuchen OR, Gittens KR, Chun TW, Li Y, Fauci AS, Moir S.

JCI Insight. 2016;1(3). pii: e84610. Epub 2016 Mar 17.


Maintenance of HIV-Specific Memory B-Cell Responses in Elite Controllers Despite Low Viral Burdens.

Buckner CM, Kardava L, Zhang X, Gittens K, Justement JS, Kovacs C, McDermott AB, Li Y, Sajadi MM, Chun TW, Fauci AS, Moir S.

J Infect Dis. 2016 Aug 1;214(3):390-8. doi: 10.1093/infdis/jiw163. Epub 2016 Apr 27.


Severe Meningoencephalitis in a Case of Ebola Virus Disease: A Case Report.

Chertow DS, Nath A, Suffredini AF, Danner RL, Reich DS, Bishop RJ, Childs RW, Arai AE, Palmore TN, Lane HC, Fauci AS, Davey RT.

Ann Intern Med. 2016 Aug 16;165(4):301-4. doi: 10.7326/M15-3066. Epub 2016 Apr 5. No abstract available.

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