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Thiazinoquinones as New Promising Multistage Schistosomicidal Compounds Impacting Schistosoma mansoni and Egg Viability.

Gimmelli R, Persico M, Imperatore C, Saccoccia F, Guidi A, Casertano M, Luciano P, Pietrantoni A, Bertuccini L, Paladino A, Papoff G, Menna M, Fattorusso C, Ruberti G.

ACS Infect Dis. 2020 Jan 10;6(1):124-137. doi: 10.1021/acsinfecdis.9b00252. Epub 2019 Nov 27.


Tetra-substituted pyrrole derivatives act as potent activators of p53 in melanoma cells.

Proto MC, Fiore D, Forte G, Cuozzo P, Ramunno A, Fattorusso C, Gazzerro P, Pascale M, Franceschelli S.

Invest New Drugs. 2019 Jun 26. doi: 10.1007/s10637-019-00813-4. [Epub ahead of print]


Covalent Inhibitors of Plasmodium falciparum Glyceraldehyde 3-Phosphate Dehydrogenase with Antimalarial Activity in Vitro.

Cullia G, Bruno S, Parapini S, Margiotta M, Tamborini L, Pinto A, Galbiati A, Mozzarelli A, Persico M, Paladino A, Fattorusso C, Taramelli D, Conti P.

ACS Med Chem Lett. 2019 Feb 20;10(4):590-595. doi: 10.1021/acsmedchemlett.8b00592. eCollection 2019 Apr 11.


Exploring the antimalarial potential of the methoxy-thiazinoquinone scaffold: Identification of a new lead candidate.

Imperatore C, Persico M, Senese M, Aiello A, Casertano M, Luciano P, Basilico N, Parapini S, Paladino A, Fattorusso C, Menna M.

Bioorg Chem. 2019 Apr;85:240-252. doi: 10.1016/j.bioorg.2018.12.031. Epub 2019 Jan 3.


Electrostatic Map Of Proteasome α-Rings Encodes The Design of Allosteric Porphyrin-Based Inhibitors Able To Affect 20S Conformation By Cooperative Binding.

Dato AD, Cunsolo A, Persico M, Santoro AM, D'Urso A, Milardi D, Purrello R, Stefanelli M, Paolesse R, Tundo GR, Sbardella D, Fattorusso C, Coletta M.

Sci Rep. 2017 Dec 6;7(1):17098. doi: 10.1038/s41598-017-17008-7.


Insight into the Mechanism of Action of Marine Cytotoxic Thiazinoquinones.

Imperatore C, Cimino P, Cebrián-Torrejón G, Persico M, Aiello A, Senese M, Fattorusso C, Menna M, Doménech-Carbó A.

Mar Drugs. 2017 Nov 2;15(11). pii: E335. doi: 10.3390/md15110335.


The interaction of heme with plakortin and a synthetic endoperoxide analogue: new insights into the heme-activated antimalarial mechanism.

Persico M, Fattorusso R, Taglialatela-Scafati O, Chianese G, de Paola I, Zaccaro L, Rondinelli F, Lombardo M, Quintavalla A, Trombini C, Fattorusso E, Fattorusso C, Farina B.

Sci Rep. 2017 Apr 6;7:45485. doi: 10.1038/srep45485.


Computer-Aided Drug Discovery from Marine Compounds: Identification of the Three-Dimensional Structural Features Responsible for Antimalarial Activity.

Fattorusso C, Persico M, Rondinelli F, Orteca N, Di Dato A.

Prog Mol Subcell Biol. 2017;55:105-158. doi: 10.1007/978-3-319-51284-6_4.


Investigating the Neuroprotective Effects of Turmeric Extract: Structural Interactions of β-Amyloid Peptide with Single Curcuminoids.

Randino R, Grimaldi M, Persico M, De Santis A, Cini E, Cabri W, Riva A, D'Errico G, Fattorusso C, D'Ursi AM, Rodriquez M.

Sci Rep. 2016 Dec 22;6:38846. doi: 10.1038/srep38846.


Benzodiazepine Scaffold as Drug-like Molecular Simplification of FR235222: A Chemical Tool for Exploring HDAC Inhibition.

Randino R, Moronese I, Cini E, Bizzarro V, Persico M, Grimaldi M, Scrima M, D'Ursi AM, Novellino E, Sobarzo-Sanchez E, Rastrelli L, Fattorusso C, Petrella A, Rodriquez M, Taddei M.

Curr Top Med Chem. 2017;17(4):441-459.


Use of Integrated Computational Approaches in the Search for New Therapeutic Agents.

Persico M, Di Dato A, Orteca N, Cimino P, Novellino E, Fattorusso C.

Mol Inform. 2016 Sep;35(8-9):309-25. doi: 10.1002/minf.201501028. Epub 2016 Jul 25. Review.


Cationic porphyrins are tunable gatekeepers of the 20S proteasome.

Santoro AM, Cunsolo A, D'Urso A, Sbardella D, Tundo GR, Ciaccio C, Coletta M, Diana D, Fattorusso R, Persico M, Di Dato A, Fattorusso C, Milardi D, Purrello R.

Chem Sci. 2016 Feb 1;7(2):1286-1297. doi: 10.1039/c5sc03312h. Epub 2015 Nov 9.


Protein Interfaces as Targets in Drug Discovery.

Fattorusso C, Persico M.

Curr Top Med Chem. 2015;15(20):2003-4. No abstract available.


From Protein Communication to Drug Discovery.

Persico M, Di Dato A, Orteca N, Fattorusso C, Novellino E, Andreoli M, Ferlini C.

Curr Top Med Chem. 2015;15(20):2019-31. Review.


Correction to new anticancer agents mimicking protein recognition motifs.

Persico M, Ramunno A, Maglio V, Franceschelli S, Esposito C, Carotenuto A, Brancaccio D, De Pasquale V, Pavone LM, Varra M, Orteca N, Novellino E, Fattorusso C.

J Med Chem. 2015 May 14;58(9):4088. doi: 10.1021/acs.jmedchem.5b00607. Epub 2015 Apr 30. No abstract available.


Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells.

Andreoli M, Persico M, Kumar A, Orteca N, Kumar V, Pepe A, Mahalingam S, Alegria AE, Petrella L, Sevciunaite L, Camperchioli A, Mariani M, Di Dato A, Novellino E, Scambia G, Malhotra SV, Ferlini C, Fattorusso C.

J Med Chem. 2014 Oct 9;57(19):7916-32. doi: 10.1021/jm5009902. Epub 2014 Sep 26.


Endoperoxide polyketides from a Chinese Plakortis simplex: further evidence of the impact of stereochemistry on antimalarial activity of simple 1,2-dioxanes.

Chianese G, Persico M, Yang F, Lin HW, Guo YW, Basilico N, Parapini S, Taramelli D, Taglialatela-Scafati O, Fattorusso C.

Bioorg Med Chem. 2014 Sep 1;22(17):4572-80. doi: 10.1016/j.bmc.2014.07.034. Epub 2014 Jul 27.


GTP is an allosteric modulator of the interaction between the guanylate-binding protein 1 and the prosurvival kinase PIM1.

Persico M, Petrella L, Orteca N, Di Dato A, Mariani M, Andreoli M, De Donato M, Scambia G, Novellino E, Ferlini C, Fattorusso C.

Eur J Med Chem. 2015 Feb 16;91:132-44. doi: 10.1016/j.ejmech.2014.07.093. Epub 2014 Jul 27.


Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue.

Scuotto M, Persico M, Bucci M, Vellecco V, Borbone N, Morelli E, Oliviero G, Novellino E, Piccialli G, Cirino G, Varra M, Fattorusso C, Mayol L.

Org Biomol Chem. 2014 Jul 28;12(28):5235-42. doi: 10.1039/c4ob00149d.


Further optimization of plakortin pharmacophore: structurally simple 4-oxymethyl-1,2-dioxanes with promising antimalarial activity.

Persico M, Parapini S, Chianese G, Fattorusso C, Lombardo M, Petrizza L, Quintavalla A, Rondinelli F, Basilico N, Taramelli D, Trombini C, Fattorusso E, Taglialatela-Scafati O.

Eur J Med Chem. 2013;70:875-86. doi: 10.1016/j.ejmech.2013.10.050. Epub 2013 Oct 27.


New anticancer agents mimicking protein recognition motifs.

Persico M, Ramunno A, Maglio V, Franceschelli S, Esposito C, Carotenuto A, Brancaccio D, De Pasquale V, Pavone LM, Varra M, Orteca N, Novellino E, Fattorusso C.

J Med Chem. 2013 Sep 12;56(17):6666-80. doi: 10.1021/jm400947b. Epub 2013 Aug 19. Erratum in: J Med Chem. 2015 May 14;58(9):4088.


Investigating the role of T7 and T12 residues on the biological properties of thrombin-binding aptamer: enhancement of anticoagulant activity by a single nucleobase modification.

Borbone N, Bucci M, Oliviero G, Morelli E, Amato J, D'Atri V, D'Errico S, Vellecco V, Cirino G, Piccialli G, Fattorusso C, Varra M, Mayol L, Persico M, Scuotto M.

J Med Chem. 2012 Dec 13;55(23):10716-28. doi: 10.1021/jm301414f. Epub 2012 Nov 19.


Histone deacetylase inhibitors in the treatment of cancer: overview and perspectives.

Giannini G, Cabri W, Fattorusso C, Rodriquez M.

Future Med Chem. 2012 Jul;4(11):1439-60. doi: 10.4155/fmc.12.80. Review.


A new class of antimalarial dioxanes obtained through a simple two-step synthetic approach: rational design and structure-activity relationship studies.

Persico M, Quintavalla A, Rondinelli F, Trombini C, Lombardo M, Fattorusso C, Azzarito V, Taramelli D, Parapini S, Corbett Y, Chianese G, Fattorusso E, Taglialatela-Scafati O.

J Med Chem. 2011 Dec 22;54(24):8526-40. doi: 10.1021/jm201056j. Epub 2011 Nov 23.


Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation.

Botta CB, Cabri W, Cini E, De Cesare L, Fattorusso C, Giannini G, Persico M, Petrella A, Rondinelli F, Rodriquez M, Russo A, Taddei M.

J Med Chem. 2011 Apr 14;54(7):2165-82. doi: 10.1021/jm101373a. Epub 2011 Mar 18.


Investigation of the Bcl-2 multimerisation process: structural and functional implications.

Camperchioli A, Mariani M, Bartollino S, Petrella L, Persico M, Orteca N, Scambia G, Shahabi S, Ferlini C, Fattorusso C.

Biochim Biophys Acta. 2011 May;1813(5):850-7. doi: 10.1016/j.bbamcr.2011.02.006. Epub 2011 Feb 12.


Antimalarials based on the dioxane scaffold of plakortin. A concise synthesis and SAR studies.

Fattorusso C, Persico M, Basilico N, Taramelli D, Fattorusso E, Scala F, Taglialatela-Scafati O.

Bioorg Med Chem. 2011 Jan 1;19(1):312-20. doi: 10.1016/j.bmc.2010.11.014. Epub 2010 Nov 11.


Manadoperoxides A-D from the Indonesian sponge Plakortis cfr. simplex. Further insights on the structure-activity relationships of simple 1,2-dioxane antimalarials.

Fattorusso C, Persico M, Calcinai B, Cerrano C, Parapini S, Taramelli D, Novellino E, Romano A, Scala F, Fattorusso E, Taglialatela-Scafati O.

J Nat Prod. 2010 Jun 25;73(6):1138-45. doi: 10.1021/np100196b.


Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors.

Butini S, Campiani G, Franceschini S, Trotta F, Kumar V, Guarino E, Borrelli G, Fiorini I, Novellino E, Fattorusso C, Persico M, Orteca N, Sandager-Nielsen K, Jacobsen TA, Madsen K, Scheel-Kruger J, Gemma S.

J Med Chem. 2010 Jun 24;53(12):4803-7. doi: 10.1021/jm100294b.


Insight into the mechanism of action of plakortins, simple 1,2-dioxane antimalarials.

Taglialatela-Scafati O, Fattorusso E, Romano A, Scala F, Barone V, Cimino P, Stendardo E, Catalanotti B, Persico M, Fattorusso C.

Org Biomol Chem. 2010 Feb 21;8(4):846-56. doi: 10.1039/b918600j. Epub 2009 Dec 16.


Full relative stereochemistry assignment and conformational analysis of 13,19-didesmethyl spirolide C via NMR- and molecular modeling-based techniques. A step towards understanding spirolide's mechanism of action.

Ciminiello P, Catalanotti B, Dell'aversano C, Fattorusso C, Fattorusso E, Forino M, Grauso L, Leo A, Tartaglione L.

Org Biomol Chem. 2009 Sep 21;7(18):3674-81. doi: 10.1039/b907649b. Epub 2009 Jul 16.


Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77.

Ferlini C, Cicchillitti L, Raspaglio G, Bartollino S, Cimitan S, Bertucci C, Mozzetti S, Gallo D, Persico M, Fattorusso C, Campiani G, Scambia G.

Cancer Res. 2009 Sep 1;69(17):6906-14. doi: 10.1158/0008-5472.CAN-09-0540. Epub 2009 Aug 11.


Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.

Morelli E, Gemma S, Budriesi R, Campiani G, Novellino E, Fattorusso C, Catalanotti B, Coccone SS, Ros S, Borrelli G, Persico M, Fiorini I, Nacci V, Ioan P, Chiarini A, Hamon M, Cagnotto A, Mennini T, Fracasso C, Colovic M, Caccia S, Butini S.

J Med Chem. 2009 Jun 11;52(11):3548-62. doi: 10.1021/jm900018b.


Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials.

Gemma S, Campiani G, Butini S, Joshi BP, Kukreja G, Coccone SS, Bernetti M, Persico M, Nacci V, Fiorini I, Novellino E, Taramelli D, Basilico N, Parapini S, Yardley V, Croft S, Keller-Maerki S, Rottmann M, Brun R, Coletta M, Marini S, Guiso G, Caccia S, Fattorusso C.

J Med Chem. 2009 Jan 22;52(2):502-13. doi: 10.1021/jm801352s.


Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.

Butini S, Gemma S, Campiani G, Franceschini S, Trotta F, Borriello M, Ceres N, Ros S, Coccone SS, Bernetti M, De Angelis M, Brindisi M, Nacci V, Fiorini I, Novellino E, Cagnotto A, Mennini T, Sandager-Nielsen K, Andreasen JT, Scheel-Kruger J, Mikkelsen JD, Fattorusso C.

J Med Chem. 2009 Jan 8;52(1):151-69. doi: 10.1021/jm800689g.


Stereostructure assignment of medium-sized rings through an NMR-computational combined approach. Application to the new germacranes ketopelenolides C and D.

Fattorusso E, Luciano P, Romano A, Taglialatela-Scafati O, Appendino G, Borriello M, Fattorusso C.

J Nat Prod. 2008 Dec;71(12):1988-92. doi: 10.1021/np8003547.


Old and new targets for innovative antimalarial compounds: the different strategies of the Italian Malaria Network.

Basilico N, Bosisio E, Buelli F, Campiani G, Casagrande M, Castelli F, Coghi P, Corbett Y, Cortelezzi L, D'Alessandro S, Dell'Agli M, Esposito F, Fattorusso C, Fattorusso E, Finaurini S, Galli GV, Gemma S, Habluetzel A, Lucantoni L, Melato S, Monti D, Olliaro P, Omodeo-Salè F, Parapini S, Persico M, Rizzi M, Romeo S, Rossi F, Rusconi C, Sparatore A, Scafati OT, van den Bogaart E, Taramelli D, Vaiana N, Yerbanga S.

Parassitologia. 2008 Jun;50(1-2):133-6.


Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the "primer grip" region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants.

Zanoli S, Gemma S, Butini S, Brindisi M, Joshi BP, Campiani G, Fattorusso C, Persico M, Crespan E, Cancio R, Spadari S, Hübscher U, Maga G.

Biochem Pharmacol. 2008 Jul 15;76(2):156-68. doi: 10.1016/j.bcp.2008.04.009. Epub 2008 Apr 29.


Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.

Butini S, Campiani G, Borriello M, Gemma S, Panico A, Persico M, Catalanotti B, Ros S, Brindisi M, Agnusdei M, Fiorini I, Nacci V, Novellino E, Belinskaya T, Saxena A, Fattorusso C.

J Med Chem. 2008 Jun 12;51(11):3154-70. doi: 10.1021/jm701253t. Epub 2008 May 15.


Discovery of a new series of jatrophane and lathyrane diterpenes as potent and specific P-glycoprotein modulators.

Barile E, Borriello M, Di Pietro A, Doreau A, Fattorusso C, Fattorusso E, Lanzotti V.

Org Biomol Chem. 2008 May 21;6(10):1756-62. doi: 10.1039/b800485d. Epub 2008 Mar 28.


Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies.

Gemma S, Campiani G, Butini S, Kukreja G, Coccone SS, Joshi BP, Persico M, Nacci V, Fiorini I, Novellino E, Fattorusso E, Taglialatela-Scafati O, Savini L, Taramelli D, Basilico N, Parapini S, Morace G, Yardley V, Croft S, Coletta M, Marini S, Fattorusso C.

J Med Chem. 2008 Mar 13;51(5):1278-94. doi: 10.1021/jm701247k. Epub 2008 Feb 16.


Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents.

Fattorusso C, Campiani G, Kukreja G, Persico M, Butini S, Romano MP, Altarelli M, Ros S, Brindisi M, Savini L, Novellino E, Nacci V, Fattorusso E, Parapini S, Basilico N, Taramelli D, Yardley V, Croft S, Borriello M, Gemma S.

J Med Chem. 2008 Mar 13;51(5):1333-43. doi: 10.1021/jm7012375. Epub 2008 Feb 16.


Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling.

Gemma S, Kukreja G, Campiani G, Butini S, Bernetti M, Joshi BP, Savini L, Basilico N, Taramelli D, Yardley V, Bertamino A, Novellino E, Persico M, Catalanotti B, Fattorusso C.

Bioorg Med Chem Lett. 2007 Jul 1;17(13):3535-9. Epub 2007 Apr 29.


Artarborol, a nor-caryophyllane sesquiterpene alcohol from Artemisia arborescens. stereostructure assignment through concurrence of NMR data and computational analysis.

Fattorusso C, Stendardo E, Appendino G, Fattorusso E, Luciano P, Romano A, Taglialatela-Scafati O.

Org Lett. 2007 Jun 7;9(12):2377-80. Epub 2007 May 10.


Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore.

Gemma S, Campiani G, Butini S, Kukreja G, Joshi BP, Persico M, Catalanotti B, Novellino E, Fattorusso E, Nacci V, Savini L, Taramelli D, Basilico N, Morace G, Yardley V, Fattorusso C.

J Med Chem. 2007 Feb 22;50(4):595-8. Epub 2007 Jan 31.


Endoperoxide derivatives from marine organisms: 1,2-dioxanes of the plakortin family as novel antimalarial agents.

Fattorusso C, Campiani G, Catalanotti B, Persico M, Basilico N, Parapini S, Taramelli D, Campagnuolo C, Fattorusso E, Romano A, Taglialatela-Scafati O.

J Med Chem. 2006 Nov 30;49(24):7088-94.


Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains.

Gemma S, Kukreja G, Fattorusso C, Persico M, Romano MP, Altarelli M, Savini L, Campiani G, Fattorusso E, Basilico N, Taramelli D, Yardley V, Butini S.

Bioorg Med Chem Lett. 2006 Oct 15;16(20):5384-8. Epub 2006 Aug 4.


Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.

Gemma S, Gabellieri E, Huleatt P, Fattorusso C, Borriello M, Catalanotti B, Butini S, De Angelis M, Novellino E, Nacci V, Belinskaya T, Saxena A, Campiani G.

J Med Chem. 2006 Jun 1;49(11):3421-5.


Conformational flexibility in the peripheral site of Torpedo californica acetylcholinesterase revealed by the complex structure with a bifunctional inhibitor.

Colletier JP, Sanson B, Nachon F, Gabellieri E, Fattorusso C, Campiani G, Weik M.

J Am Chem Soc. 2006 Apr 12;128(14):4526-7.


Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines.

Mulligan JM, Greene LM, Cloonan S, Mc Gee MM, Onnis V, Campiani G, Fattorusso C, Lawler M, Williams DC, Zisterer DM.

Mol Pharmacol. 2006 Jul;70(1):60-70. Epub 2006 Mar 29.


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