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Items: 7

1.

The Effect of Small Oligomeric Protein Aggregates on the Immunogenicity of Intravenous and Subcutaneous Administered Antibodies.

Fathallah AM, Chiang M, Mishra A, Kumar S, Xue L, Middaugh R, Balu-Iyer SV.

J Pharm Sci. 2015 Nov;104(11):3691-702. doi: 10.1002/jps.24592. Epub 2015 Jul 30.

PMID:
26228094
2.

Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade.

Kelleher RJ Jr, Balu-Iyer S, Loyall J, Sacca AJ, Shenoy GN, Peng P, Iyer V, Fathallah AM, Berenson CS, Wallace PK, Tario J, Odunsi K, Bankert RB.

Cancer Immunol Res. 2015 Nov;3(11):1269-78. doi: 10.1158/2326-6066.CIR-15-0086. Epub 2015 Jun 25.

3.

Anatomical, physiological, and experimental factors affecting the bioavailability of sc-administered large biotherapeutics.

Fathallah AM, Balu-Iyer SV.

J Pharm Sci. 2015 Feb;104(2):301-6. doi: 10.1002/jps.24277. Epub 2014 Nov 19.

4.

Effects of hypertonic buffer composition on lymph node uptake and bioavailability of rituximab, after subcutaneous administration.

Fathallah AM, Turner MR, Mager DE, Balu-Iyer SV.

Biopharm Drug Dispos. 2015 Mar;36(2):115-25. doi: 10.1002/bdd.1925. Epub 2014 Dec 20.

5.

O-phospho-l-serine mediates hyporesponsiveness toward FVIII in hemophilia A-murine model by inducing tolerogenic properties in dendritic cells.

Fathallah AM, Ramakrishnan R, Balu-Iyer SV.

J Pharm Sci. 2014 Nov;103(11):3457-3463. doi: 10.1002/jps.24173. Epub 2014 Sep 29.

PMID:
25266204
6.

Immunogenicity of subcutaneously administered therapeutic proteins--a mechanistic perspective.

Fathallah AM, Bankert RB, Balu-Iyer SV.

AAPS J. 2013 Oct;15(4):897-900. doi: 10.1208/s12248-013-9510-6. Epub 2013 Jul 16. Review.

7.

Immunogenicity and pharmacokinetic studies of recombinant factor VIII containing lipid cochleates.

Kosloski MP, Peng A, Varma PR, Fathallah AM, Miclea RD, Mager DE, Balu-iyer SV.

Drug Deliv. 2011 May;18(4):246-54. doi: 10.3109/10717544.2010.536269. Epub 2010 Nov 30.

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