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Items: 48


Sphingosine 1-phosphate but not Fingolimod protects neurons against excitotoxic cell death by inducing neurotrophic gene expression in astrocytes.

Tran C, Heng B, Teo JD, Humphrey SJ, Qi Y, Couttas TA, Stefen H, Brettle M, Fath T, Guillemin GJ, Don AS.

J Neurochem. 2019 Nov 19:e14917. doi: 10.1111/jnc.14917. [Epub ahead of print]


Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease.

Lei M, Teo JD, Song H, McEwen HP, Yup Lee J, Couttas TA, Duncan T, Chesworth R, Bertz J, Przybyla M, Van Eersel J, Heng B, Guillemin GJ, Ittner LM, Fath T, Garner B, Ittner A, Karl T, Don AS.

J Neurosci. 2019 Nov 27;39(48):9645-9659. doi: 10.1523/JNEUROSCI.0524-19.2019. Epub 2019 Oct 22.


Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice.

Brettle M, Stefen H, Djordjevic A, Fok SYY, Chan JW, van Hummel A, van der Hoven J, Przybyla M, Volkerling A, Ke YD, Delerue F, Ittner LM, Fath T.

Front Mol Neurosci. 2019 Sep 27;12:231. doi: 10.3389/fnmol.2019.00231. eCollection 2019.


Tropomodulin's Actin-Binding Abilities Are Required to Modulate Dendrite Development.

Gray KT, Stefen H, Ly TNA, Keller CJ, Colpan M, Wayman GA, Pate E, Fath T, Kostyukova AS.

Front Mol Neurosci. 2018 Oct 9;11:357. doi: 10.3389/fnmol.2018.00357. eCollection 2018.


A Novel Microfluidic Device-Based Neurite Outgrowth Inhibition Assay Reveals the Neurite Outgrowth-Promoting Activity of Tropomyosin Tpm3.1 in Hippocampal Neurons.

Stefen H, Hassanzadeh-Barforoushi A, Brettle M, Fok S, Suchowerska AK, Tedla N, Barber T, Warkiani ME, Fath T.

Cell Mol Neurobiol. 2018 Nov;38(8):1557-1563. doi: 10.1007/s10571-018-0620-7. Epub 2018 Sep 14.


A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism.

Turner N, Lim XY, Toop HD, Osborne B, Brandon AE, Taylor EN, Fiveash CE, Govindaraju H, Teo JD, McEwen HP, Couttas TA, Butler SM, Das A, Kowalski GM, Bruce CR, Hoehn KL, Fath T, Schmitz-Peiffer C, Cooney GJ, Montgomery MK, Morris JC, Don AS.

Nat Commun. 2018 Aug 21;9(1):3165. doi: 10.1038/s41467-018-05613-7.


Peptide Nanofiber Substrates for Long-Term Culturing of Primary Neurons.

Martin AD, Chua SW, Au CG, Stefen H, Przybyla M, Lin Y, Bertz J, Thordarson P, Fath T, Ke YD, Ittner LM.

ACS Appl Mater Interfaces. 2018 Aug 1;10(30):25127-25134. doi: 10.1021/acsami.8b07560. Epub 2018 Jul 20.


Hypoxic postconditioning enhances functional recovery following endothelin-1 induced middle cerebral artery occlusion in conscious rats.

Nguyen HL, Ruhoff AM, Fath T, Jones NM.

Exp Neurol. 2018 Aug;306:177-189. doi: 10.1016/j.expneurol.2018.05.018. Epub 2018 May 17.


Tropomyosin isoforms have specific effects on the transcriptome of undifferentiated and differentiated B35 neuroblastoma cells.

Stefen H, Suchowerska AK, Chen BJ, Brettle M, Kuschelewski J, Gunning PW, Janitz M, Fath T.

FEBS Open Bio. 2018 Feb 19;8(4):570-583. doi: 10.1002/2211-5463.12386. eCollection 2018 Apr.


Expression Pattern of the Aspartyl-tRNA Synthetase DARS in the Human Brain.

Fröhlich D, Suchowerska AK, Voss C, He R, Wolvetang E, von Jonquieres G, Simons C, Fath T, Housley GD, Klugmann M.

Front Mol Neurosci. 2018 Mar 20;11:81. doi: 10.3389/fnmol.2018.00081. eCollection 2018.


Developmental Profiling of Tropomyosin Expression in Mouse Brain Reveals Tpm4.2 as the Major Post-synaptic Tropomyosin in the Mature Brain.

Suchowerska AK, Fok S, Stefen H, Gunning PW, Hardeman EC, Power J, Fath T.

Front Cell Neurosci. 2017 Dec 22;11:421. doi: 10.3389/fncel.2017.00421. eCollection 2017.


Functional characterisation of filamentous actin probe expression in neuronal cells.

Patel S, Fok SYY, Stefen H, Tomanić T, Parić E, Herold R, Brettle M, Djordjevic A, Fath T.

PLoS One. 2017 Nov 16;12(11):e0187979. doi: 10.1371/journal.pone.0187979. eCollection 2017.


Special issue on 'Cytoskeleton-dependent regulation of neuronal network formation'.

Fath T, Kostyukova AS, Foa L.

Mol Cell Neurosci. 2017 Oct;84:1-3. doi: 10.1016/j.mcn.2017.09.008. No abstract available.


Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice.

Tonkin RS, Bowles C, Perera CJ, Keating BA, Makker PGS, Duffy SS, Lees JG, Tran C, Don AS, Fath T, Liu L, O'Carroll SJ, Nicholson LFB, Green CR, Gorrie C, Moalem-Taylor G.

Exp Neurol. 2018 Feb;300:1-12. doi: 10.1016/j.expneurol.2017.10.016. Epub 2017 Oct 18.


Tau exacerbates excitotoxic brain damage in an animal model of stroke.

Bi M, Gladbach A, van Eersel J, Ittner A, Przybyla M, van Hummel A, Chua SW, van der Hoven J, Lee WS, Müller J, Parmar J, Jonquieres GV, Stefen H, Guccione E, Fath T, Housley GD, Klugmann M, Ke YD, Ittner LM.

Nat Commun. 2017 Sep 7;8(1):473. doi: 10.1038/s41467-017-00618-0.


A role for tropomyosins in activity-dependent bulk endocytosis?

Gormal R, Valmas N, Fath T, Meunier F.

Mol Cell Neurosci. 2017 Oct;84:112-118. doi: 10.1016/j.mcn.2017.04.003. Epub 2017 May 22. Review.


Actin regulation by tropomodulin and tropomyosin in neuronal morphogenesis and function.

Gray KT, Kostyukova AS, Fath T.

Mol Cell Neurosci. 2017 Oct;84:48-57. doi: 10.1016/j.mcn.2017.04.002. Epub 2017 Apr 19. Review.


In vivocharacterization of the aspartyl-tRNA synthetase DARS: Homing in on the leukodystrophy HBSL.

Fröhlich D, Suchowerska AK, Spencer ZH, von Jonquieres G, Klugmann CB, Bongers A, Delerue F, Stefen H, Ittner LM, Fath T, Housley GD, Klugmann M.

Neurobiol Dis. 2017 Jan;97(Pt A):24-35. doi: 10.1016/j.nbd.2016.10.008. Epub 2016 Nov 2.


Tropomyosins in the healthy and diseased nervous system.

Brettle M, Patel S, Fath T.

Brain Res Bull. 2016 Sep;126(Pt 3):311-323. doi: 10.1016/j.brainresbull.2016.06.004. Epub 2016 Jun 11. Review.


The Only Constant Is Change: Next Generation Materials and Medical Device Design for Physical and Mental Health.

Knothe Tate ML, Fath T.

Adv Healthc Mater. 2016 Aug;5(15):1840-3. doi: 10.1002/adhm.201600437. Epub 2016 Jun 9. Review.


Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease.

Couttas TA, Kain N, Suchowerska AK, Quek LE, Turner N, Fath T, Garner B, Don AS.

Neurobiol Aging. 2016 Jul;43:89-100. doi: 10.1016/j.neurobiolaging.2016.03.027. Epub 2016 Apr 4.


Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease.

Stefen H, Chaichim C, Power J, Fath T.

Neural Plast. 2016;2016:2371970. doi: 10.1155/2016/2371970. Epub 2016 Apr 5. Review.


Tropomodulin isoforms utilize specific binding functions to modulate dendrite development.

Gray KT, Suchowerska AK, Bland T, Colpan M, Wayman G, Fath T, Kostyukova AS.

Cytoskeleton (Hoboken). 2016 Jun;73(6):316-28. doi: 10.1002/cm.21304. Epub 2016 Jun 8.


Soluble LILRA3 promotes neurite outgrowth and synapses formation through a high-affinity interaction with Nogo 66.

An H, Brettle M, Lee T, Heng B, Lim CK, Guillemin GJ, Lord MS, Klotzsch E, Geczy CL, Bryant K, Fath T, Tedla N.

J Cell Sci. 2016 Mar 15;129(6):1198-209. doi: 10.1242/jcs.182006. Epub 2016 Jan 29.


Amyotrophic lateral sclerosis-associated mutant profilin 1 increases dendritic arborisation and spine formation in primary hippocampal neurons.

Brettle M, Suchowerska AK, Chua SW, Ittner LM, Fath T.

Neurosci Lett. 2015 Nov 16;609:223-8. doi: 10.1016/j.neulet.2015.09.034. Epub 2015 Oct 21.


Cell elasticity is regulated by the tropomyosin isoform composition of the actin cytoskeleton.

Jalilian I, Heu C, Cheng H, Freittag H, Desouza M, Stehn JR, Bryce NS, Whan RM, Hardeman EC, Fath T, Schevzov G, Gunning PW.

PLoS One. 2015 May 15;10(5):e0126214. doi: 10.1371/journal.pone.0126214. eCollection 2015.


Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments.

Schevzov G, Kee AJ, Wang B, Sequeira VB, Hook J, Coombes JD, Lucas CA, Stehn JR, Musgrove EA, Cretu A, Assoian R, Fath T, Hanoch T, Seger R, Pleines I, Kile BT, Hardeman EC, Gunning PW.

Mol Biol Cell. 2015 Jul 1;26(13):2475-90. doi: 10.1091/mbc.E14-10-1453. Epub 2015 May 13.


Tropomyosins induce neuritogenesis and determine neurite branching patterns in B35 neuroblastoma cells.

Curthoys NM, Freittag H, Connor A, Desouza M, Brettle M, Poljak A, Hall A, Hardeman E, Schevzov G, Gunning PW, Fath T.

Mol Cell Neurosci. 2014 Jan;58:11-21. doi: 10.1016/j.mcn.2013.10.011. Epub 2013 Nov 6.


A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells.

Stehn JR, Haass NK, Bonello T, Desouza M, Kottyan G, Treutlein H, Zeng J, Nascimento PR, Sequeira VB, Butler TL, Allanson M, Fath T, Hill TA, McCluskey A, Schevzov G, Palmer SJ, Hardeman EC, Winlaw D, Reeve VE, Dixon I, Weninger W, Cripe TP, Gunning PW.

Cancer Res. 2013 Aug 15;73(16):5169-82. doi: 10.1158/0008-5472.CAN-12-4501. Erratum in: Cancer Res. 2013 Oct 1;73(19):6094.


Tropomodulins and tropomyosins - organizers of cellular microcompartments.

Fath T.

Biomol Concepts. 2013 Feb;4(1):89-101. doi: 10.1515/bmc-2012-0037. Review.


Antibodies to surface dopamine-2 receptor in autoimmune movement and psychiatric disorders.

Dale RC, Merheb V, Pillai S, Wang D, Cantrill L, Murphy TK, Ben-Pazi H, Varadkar S, Aumann TD, Horne MK, Church AJ, Fath T, Brilot F.

Brain. 2012 Nov;135(Pt 11):3453-68. doi: 10.1093/brain/aws256. Epub 2012 Oct 11.


Functional diversity of actin cytoskeleton in neurons and its regulation by tropomyosin.

Schevzov G, Curthoys NM, Gunning PW, Fath T.

Int Rev Cell Mol Biol. 2012;298:33-94. doi: 10.1016/B978-0-12-394309-5.00002-X. Review.


Tropomyosin isoforms and reagents.

Schevzov G, Whittaker SP, Fath T, Lin JJ, Gunning PW.

Bioarchitecture. 2011 Jul;1(4):135-164. Epub 2011 Jul 1.


Tropomodulins are negative regulators of neurite outgrowth.

Fath T, Fischer RS, Dehmelt L, Halpain S, Fowler VM.

Eur J Cell Biol. 2011 Apr;90(4):291-300. doi: 10.1016/j.ejcb.2010.10.014. Epub 2010 Dec 10.


New aspects of tropomyosin-regulated neuritogenesis revealed by the deletion of Tm5NM1 and 2.

Fath T, Agnes Chan YK, Vrhovski B, Clarke H, Curthoys N, Hook J, Lemckert F, Schevzov G, Tam P, Watson CM, Khoo PL, Gunning P.

Eur J Cell Biol. 2010 Jul;89(7):489-98. doi: 10.1016/j.ejcb.2009.11.028. Epub 2010 Mar 12.


Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation.

Hundelt M, Fath T, Selle K, Oesterwind K, Jordan J, Schultz C, Götz J, von Engelhardt J, Monyer H, Lewejohann L, Sachser N, Bakota L, Brandt R.

Neurobiol Aging. 2011 Jun;32(6):991-1006. doi: 10.1016/j.neurobiolaging.2009.06.007. Epub 2009 Aug 5.


Primary support cultures of hippocampal and substantia nigra neurons.

Fath T, Ke YD, Gunning P, Götz J, Ittner LM.

Nat Protoc. 2009;4(1):78-85. doi: 10.1038/nprot.2008.199.


Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia.

Ittner LM, Fath T, Ke YD, Bi M, van Eersel J, Li KM, Gunning P, Götz J.

Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15997-6002. doi: 10.1073/pnas.0808084105. Epub 2008 Oct 2.


Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response.

Götz J, David D, Hoerndli F, Ke YD, Schonrock N, Wiesner A, Fath T, Bokhari L, Lim YA, Deters N, Ittner LM.

Neurodegener Dis. 2008;5(3-4):179-81. doi: 10.1159/000113696. Epub 2008 Mar 6. Review.


Divergent regulation of the sarcomere and the cytoskeleton.

Schevzov G, Fath T, Vrhovski B, Vlahovich N, Rajan S, Hook J, Joya JE, Lemckert F, Puttur F, Lin JJ, Hardeman EC, Wieczorek DF, O'Neill GM, Gunning PW.

J Biol Chem. 2008 Jan 4;283(1):275-83. Epub 2007 Oct 18.


Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease.

Fath T, Eidenmüller J, Brandt R.

J Neurosci. 2002 Nov 15;22(22):9733-41.


Structural and functional implications of tau hyperphosphorylation: information from phosphorylation-mimicking mutated tau proteins.

Eidenmüller J, Fath T, Hellwig A, Reed J, Sontag E, Brandt R.

Biochemistry. 2000 Oct 31;39(43):13166-75.


Herpes simplex virus-mediated expression of the axonal protein tau in human model neurons (NT2-N cells).

Fath T, Eidenmüller J, Maas T, Brandt R.

Microsc Res Tech. 2000 Jan 15;48(2):85-96.


[Dentacolor veneer for crowns and bridges with the Silicoater process--a clinical trial].

Brauner H, Fath T.

Dtsch Zahnarztl Z. 1989 Jan;44(1):34-6. German.


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