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Items: 9

1.

Nuclear receptor CAR-ERα signaling regulates the estrogen sulfotransferase gene in the liver.

Yi M, Fashe M, Arakawa S, Moore R, Sueyoshi T, Negishi M.

Sci Rep. 2020 Mar 19;10(1):5001. doi: 10.1038/s41598-020-61767-9.

2.

Ser100-Phosphorylated RORα Orchestrates CAR and HNF4α to Form Active Chromatin Complex in Response to Phenobarbital to Regulate Induction of CYP2B6.

Fashe M, Hashiguchi T, Negishi M, Sueyoshi T.

Mol Pharmacol. 2020 Mar;97(3):191-201. doi: 10.1124/mol.119.118273. Epub 2020 Jan 10.

3.

In vitro sulfonation of 7-hydroxycoumarin derivatives in liver cytosol of human and six animal species.

Juvonen RO, Pentikäinen O, Huuskonen J, Timonen J, Kärkkäinen O, Heikkinen A, Fashe M, Raunio H.

Xenobiotica. 2020 Jan 8:1-9. doi: 10.1080/00498254.2020.1711544. [Epub ahead of print]

PMID:
31903849
4.

A phosphorylation-deficient mutant of retinoid X receptor α at Thr 167 alters fasting response and energy metabolism in mice.

Sueyoshi T, Sakuma T, Shindo S, Fashe M, Kanayama T, Ray M, Moore R, Negishi M.

Lab Invest. 2019 Oct;99(10):1470-1483. doi: 10.1038/s41374-019-0266-1. Epub 2019 May 31.

5.

Phenobarbital-induced phosphorylation converts nuclear receptor RORα from a repressor to an activator of the estrogen sulfotransferase gene Sult1e1 in mouse livers.

Fashe M, Hashiguchi T, Yi M, Moore R, Negishi M.

FEBS Lett. 2018 Aug;592(16):2760-2768. doi: 10.1002/1873-3468.13199. Epub 2018 Aug 10.

6.

Species-Specific Differences in the in Vitro Metabolism of Lasiocarpine.

Fashe MM, Juvonen RO, Petsalo A, Räsänen J, Pasanen M.

Chem Res Toxicol. 2015 Oct 19;28(10):2034-44. doi: 10.1021/acs.chemrestox.5b00253. Epub 2015 Oct 2.

PMID:
26395423
7.

In silico prediction of the site of oxidation by cytochrome P450 3A4 that leads to the formation of the toxic metabolites of pyrrolizidine alkaloids.

Fashe MM, Juvonen RO, Petsalo A, Vepsäläinen J, Pasanen M, Rahnasto-Rilla M.

Chem Res Toxicol. 2015 Apr 20;28(4):702-10. doi: 10.1021/tx500478q. Epub 2015 Feb 17.

PMID:
25651456
8.

Rational design of novel CYP2A6 inhibitors.

Tani N, Juvonen RO, Raunio H, Fashe M, Leppänen J, Zhao B, Tyndale RF, Rahnasto-Rilla M.

Bioorg Med Chem. 2014 Dec 1;22(23):6655-6664. doi: 10.1016/j.bmc.2014.10.001. Epub 2014 Oct 13.

PMID:
25458499
9.

Identification of a new reactive metabolite of pyrrolizidine alkaloid retrorsine: (3H-pyrrolizin-7-yl)methanol.

Fashe MM, Juvonen RO, Petsalo A, Rahnasto-Rilla M, Auriola S, Soininen P, Vepsäläinen J, Pasanen M.

Chem Res Toxicol. 2014 Nov 17;27(11):1950-7. doi: 10.1021/tx5002964. Epub 2014 Oct 21.

PMID:
25295702

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