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Items: 1 to 50 of 193

1.

Highly structured slow solar wind emerging from an equatorial coronal hole.

Bale SD, Badman ST, Bonnell JW, Bowen TA, Burgess D, Case AW, Cattell CA, Chandran BDG, Chaston CC, Chen CHK, Drake JF, de Wit TD, Eastwood JP, Ergun RE, Farrell WM, Fong C, Goetz K, Goldstein M, Goodrich KA, Harvey PR, Horbury TS, Howes GG, Kasper JC, Kellogg PJ, Klimchuk JA, Korreck KE, Krasnoselskikh VV, Krucker S, Laker R, Larson DE, MacDowall RJ, Maksimovic M, Malaspina DM, Martinez-Oliveros J, McComas DJ, Meyer-Vernet N, Moncuquet M, Mozer FS, Phan TD, Pulupa M, Raouafi NE, Salem C, Stansby D, Stevens M, Szabo A, Velli M, Woolley T, Wygant JR.

Nature. 2019 Dec;576(7786):237-242. doi: 10.1038/s41586-019-1818-7. Epub 2019 Dec 4.

PMID:
31802007
2.

High-Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates.

Clement HA, Boghi M, McDonald RM, Bernier L, Coe JW, Farrell W, Helal CJ, Reese MR, Sach NW, Lee JC, Hall DG.

Angew Chem Int Ed Engl. 2019 Dec 16;58(51):18405-18409. doi: 10.1002/anie.201909308. Epub 2019 Oct 31.

PMID:
31591755
3.

First inter-laboratory study of a Supercritical Fluid Chromatography method for the determination of pharmaceutical impurities.

Dispas A, Marini R, Desfontaine V, Veuthey JL, Kotoni D, Losacco LG, Clarke A, Muscat Galea C, Mangelings D, Jocher BM, Regalado EL, Plachká K, Nováková L, Wuyts B, François I, Gray M, Aubin AJ, Tarafder A, Cazes M, Desvignes C, Villemet L, Sarrut M, Raimbault A, Lemasson E, Lesellier E, West C, Leek T, Wong M, Dai L, Zhang K, Grand-Guillaume Perrenoud A, Brunelli C, Hennig P, Bertin S, Mauge F, Da Costa N, Farrell WP, Hill M, Desphande N, Grangrade M, Sadaphule S, Yadav R, Rane S, Shringare S, Iguiniz M, Heinisch S, Lefevre J, Corbel E, Roques N, Heyden YV, Guillarme D, Hubert P.

J Pharm Biomed Anal. 2018 Nov 30;161:414-424. doi: 10.1016/j.jpba.2018.08.042. Epub 2018 Aug 23.

PMID:
30216790
4.

Kinetically guided radical-based synthesis of C(sp3)-C(sp3) linkages on DNA.

Wang J, Lundberg H, Asai S, Martín-Acosta P, Chen JS, Brown S, Farrell W, Dushin RG, O'Donnell CJ, Ratnayake AS, Richardson P, Liu Z, Qin T, Blackmond DG, Baran PS.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6404-E6410. doi: 10.1073/pnas.1806900115. Epub 2018 Jun 26.

5.

Applicability of supercritical fluid chromatography - mass spectrometry to metabolomics. I - Optimization of separation conditions for the simultaneous analysis of hydrophilic and lipophilic substances.

Desfontaine V, Losacco GL, Gagnebin Y, Pezzatti J, Farrell WP, González-Ruiz V, Rudaz S, Veuthey JL, Guillarme D.

J Chromatogr A. 2018 Aug 10;1562:96-107. doi: 10.1016/j.chroma.2018.05.055. Epub 2018 May 28.

PMID:
29861304
6.

A deep ocean acoustic noise floor, 1-800 Hz.

Berger J, Bidlot JR, Dzieciuch MA, Farrell WE, Worcester PF, Stephen RA.

J Acoust Soc Am. 2018 Feb;143(2):1223. doi: 10.1121/1.5025042.

PMID:
29495750
7.

A platform for automated nanomole-scale reaction screening and micromole-scale synthesis in flow.

Perera D, Tucker JW, Brahmbhatt S, Helal CJ, Chong A, Farrell W, Richardson P, Sach NW.

Science. 2018 Jan 26;359(6374):429-434. doi: 10.1126/science.aap9112.

PMID:
29371464
8.

In situ measurements of Saturn's ionosphere show that it is dynamic and interacts with the rings.

Wahlund JE, Morooka MW, Hadid LZ, Persoon AM, Farrell WM, Gurnett DA, Hospodarsky G, Kurth WS, Ye SY, Andrews DJ, Edberg NJT, Eriksson AI, Vigren E.

Science. 2018 Jan 5;359(6371):66-68. doi: 10.1126/science.aao4134. Epub 2017 Dec 11.

PMID:
29229651
9.

Epigenome-wide association study of rheumatoid arthritis identifies differentially methylated loci in B cells.

Julià A, Absher D, López-Lasanta M, Palau N, Pluma A, Waite Jones L, Glossop JR, Farrell WE, Myers RM, Marsal S.

Hum Mol Genet. 2017 Jul 15;26(14):2803-2811. doi: 10.1093/hmg/ddx177.

PMID:
28475762
11.

Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity.

Lopchuk JM, Fjelbye K, Kawamata Y, Malins LR, Pan CM, Gianatassio R, Wang J, Prieto L, Bradow J, Brandt TA, Collins MR, Elleraas J, Ewanicki J, Farrell W, Fadeyi OO, Gallego GM, Mousseau JJ, Oliver R, Sach NW, Smith JK, Spangler JE, Zhu H, Zhu J, Baran PS.

J Am Chem Soc. 2017 Mar 1;139(8):3209-3226. doi: 10.1021/jacs.6b13229. Epub 2017 Feb 20.

12.

The FIELDS Instrument Suite for Solar Probe Plus: Measuring the Coronal Plasma and Magnetic Field, Plasma Waves and Turbulence, and Radio Signatures of Solar Transients.

Bale SD, Goetz K, Harvey PR, Turin P, Bonnell JW, de Wit TD, Ergun RE, MacDowall RJ, Pulupa M, Andre M, Bolton M, Bougeret JL, Bowen TA, Burgess D, Cattell CA, Chandran BDG, Chaston CC, Chen CHK, Choi MK, Connerney JE, Cranmer S, Diaz-Aguado M, Donakowski W, Drake JF, Farrell WM, Fergeau P, Fermin J, Fischer J, Fox N, Glaser D, Goldstein M, Gordon D, Hanson E, Harris SE, Hayes LM, Hinze JJ, Hollweg JV, Horbury TS, Howard RA, Hoxie V, Jannet G, Karlsson M, Kasper JC, Kellogg PJ, Kien M, Klimchuk JA, Krasnoselskikh VV, Krucker S, Lynch JJ, Maksimovic M, Malaspina DM, Marker S, Martin P, Martinez-Oliveros J, McCauley J, McComas DJ, McDonald T, Meyer-Vernet N, Moncuquet M, Monson SJ, Mozer FS, Murphy SD, Odom J, Oliverson R, Olson J, Parker EN, Pankow D, Phan T, Quataert E, Quinn T, Ruplin SW, Salem C, Seitz D, Sheppard DA, Siy A, Stevens K, Summers D, Szabo A, Timofeeva M, Vaivads A, Velli M, Yehle A, Werthimer D, Wygant JR.

Space Sci Rev. 2016 Dec;204(1-4):49-82. doi: 10.1007/s11214-016-0244-5. Epub 2016 Mar 31.

13.

DNA methylation at diagnosis is associated with response to disease-modifying drugs in early rheumatoid arthritis.

Glossop JR, Nixon NB, Emes RD, Sim J, Packham JC, Mattey DL, Farrell WE, Fryer AA.

Epigenomics. 2017 Apr;9(4):419-428. doi: 10.2217/epi-2016-0042. Epub 2016 Nov 25.

PMID:
27885849
14.

Steric Switching from Photochemical to Thermal Reaction Pathways for Enhanced Efficiency in Metal-Mediated Nitrogen Fixation.

Duman LM, Farrell WS, Zavalij PY, Sita LR.

J Am Chem Soc. 2016 Nov 16;138(45):14856-14859. Epub 2016 Nov 4.

PMID:
27779843
15.

Epidrug-induced upregulation of functional somatostatin type 2 receptors in human pancreatic neuroendocrine tumor cells.

Veenstra MJ, van Koetsveld PM, Dogan F, Farrell WE, Feelders RA, Lamberts SWJ, de Herder WW, Vitale G, Hofland LJ.

Oncotarget. 2016 May 19;9(19):14791-14802. doi: 10.18632/oncotarget.9462. eCollection 2018 Mar 13.

16.

Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies.

Wu P, Farrell WE, Haworth KE, Emes RD, Kitchen MO, Glossop JR, Hanna FW, Fryer AA.

Epigenetics. 2018;13(2):122-128. doi: 10.1080/15592294.2016.1166321. Epub 2018 Jan 25.

17.

Near roadway air pollution across a spatially extensive road and cycling network.

Farrell W, Weichenthal S, Goldberg M, Valois MF, Shekarrizfard M, Hatzopoulou M.

Environ Pollut. 2016 May;212:498-507. doi: 10.1016/j.envpol.2016.02.041. Epub 2016 Mar 8.

PMID:
26967536
18.

The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization.

Stamelos VA, Fisher N, Bamrah H, Voisey C, Price JC, Farrell WE, Redman CW, Richardson A.

PLoS One. 2016 Mar 7;11(3):e0150696. doi: 10.1371/journal.pone.0150696. eCollection 2016.

19.

Quantitative genome-wide methylation analysis of high-grade non-muscle invasive bladder cancer.

Kitchen MO, Bryan RT, Emes RD, Glossop JR, Luscombe C, Cheng KK, Zeegers MP, James ND, Devall AJ, Mein CA, Gommersall L, Fryer AA, Farrell WE.

Epigenetics. 2016 Mar 3;11(3):237-46. doi: 10.1080/15592294.2016.1154246. Epub 2016 Mar 1.

20.

Genome-wide profiling in treatment-naive early rheumatoid arthritis reveals DNA methylome changes in T and B lymphocytes.

Glossop JR, Emes RD, Nixon NB, Packham JC, Fryer AA, Mattey DL, Farrell WE.

Epigenomics. 2016 Feb;8(2):209-24. doi: 10.2217/epi.15.103. Epub 2015 Nov 10.

PMID:
26556652
21.

Methylation of HOXA9 and ISL1 Predicts Patient Outcome in High-Grade Non-Invasive Bladder Cancer.

Kitchen MO, Bryan RT, Haworth KE, Emes RD, Luscombe C, Gommersall L, Cheng KK, Zeegers MP, James ND, Devall AJ, Fryer AA, Farrell WE.

PLoS One. 2015 Sep 2;10(9):e0137003. doi: 10.1371/journal.pone.0137003. eCollection 2015.

22.

Metal-Mediated Production of Isocyanates, R3 EN=C=O from Dinitrogen, Carbon Dioxide, and R3 ECl.

Keane AJ, Farrell WS, Yonke BL, Zavalij PY, Sita LR.

Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10220-4. doi: 10.1002/anie.201502293. Epub 2015 Jun 26.

PMID:
26118362
23.

DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue-derived FLS.

Glossop JR, Haworth KE, Emes RD, Nixon NB, Packham JC, Dawes PT, Fryer AA, Mattey DL, Farrell WE.

Epigenomics. 2015;7(4):539-51. doi: 10.2217/epi.15.15.

PMID:
26111028
24.

Metal-catalyzed "on-demand" production of carbonyl sulfide from carbon monoxide and elemental sulfur.

Farrell WS, Zavalij PY, Sita LR.

Angew Chem Int Ed Engl. 2015 Mar 27;54(14):4269-73. doi: 10.1002/anie.201410353. Epub 2015 Mar 3.

PMID:
25737195
25.

Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells.

Kitchen MO, Yacqub-Usman K, Emes RD, Richardson A, Clayton RN, Farrell WE.

Pituitary. 2015 Oct;18(5):674-84. doi: 10.1007/s11102-014-0630-5.

PMID:
25557289
26.

Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation.

Trivellin G, Daly AF, Faucz FR, Yuan B, Rostomyan L, Larco DO, Schernthaner-Reiter MH, Szarek E, Leal LF, Caberg JH, Castermans E, Villa C, Dimopoulos A, Chittiboina P, Xekouki P, Shah N, Metzger D, Lysy PA, Ferrante E, Strebkova N, Mazerkina N, Zatelli MC, Lodish M, Horvath A, de Alexandre RB, Manning AD, Levy I, Keil MF, Sierra Mde L, Palmeira L, Coppieters W, Georges M, Naves LA, Jamar M, Bours V, Wu TJ, Choong CS, Bertherat J, Chanson P, Kamenický P, Farrell WE, Barlier A, Quezado M, Bjelobaba I, Stojilkovic SS, Wess J, Costanzi S, Liu P, Lupski JR, Beckers A, Stratakis CA.

N Engl J Med. 2014 Dec 18;371(25):2363-74. doi: 10.1056/NEJMoa1408028. Epub 2014 Dec 3.

27.

Methylation of the FGFR2 gene is associated with high birth weight centile in humans.

Haworth KE, Farrell WE, Emes RD, Ismail KM, Carroll WD, Hubball E, Rooney A, Yates AM, Mein C, Fryer AA.

Epigenomics. 2014;6(5):477-91. doi: 10.2217/epi.14.40. Review.

PMID:
25431941
28.

Genome-wide DNA methylation profiling in rheumatoid arthritis identifies disease-associated methylation changes that are distinct to individual T- and B-lymphocyte populations.

Glossop JR, Emes RD, Nixon NB, Haworth KE, Packham JC, Dawes PT, Fryer AA, Mattey DL, Farrell WE.

Epigenetics. 2014 Sep;9(9):1228-37. doi: 10.4161/epi.29718. Epub 2014 Jul 7.

29.

Evaluation of stationary phases packed with superficially porous particles for the analysis of pharmaceutical compounds using supercritical fluid chromatography.

Perrenoud AG, Farrell WP, Aurigemma CM, Aurigemma NC, Fekete S, Guillarme D.

J Chromatogr A. 2014 Sep 19;1360:275-87. doi: 10.1016/j.chroma.2014.07.078. Epub 2014 Aug 1.

PMID:
25129391
30.

Epigenetics of pituitary tumours: an update.

Farrell WE.

Curr Opin Endocrinol Diabetes Obes. 2014 Aug;21(4):299-305. doi: 10.1097/MED.0000000000000078. Review.

PMID:
24983395
31.

Characterizing the impact of traffic and the built environment on near-road ultrafine particle and black carbon concentrations.

Weichenthal S, Farrell W, Goldberg M, Joseph L, Hatzopoulou M.

Environ Res. 2014 Jul;132:305-10. doi: 10.1016/j.envres.2014.04.007. Epub 2014 May 14.

32.

High throughput method for the indirect detection of intramolecular hydrogen bonding.

Goetz GH, Farrell W, Shalaeva M, Sciabola S, Anderson D, Yan J, Philippe L, Shapiro MJ.

J Med Chem. 2014 Apr 10;57(7):2920-9. doi: 10.1021/jm401859b. Epub 2014 Mar 31.

PMID:
24641175
33.

Wave-wave interactions and deep ocean acoustics.

Guralnik Z, Bourdelais J, Zabalgogeazcoa X, Farrell WE.

J Acoust Soc Am. 2013 Oct;134(4):3161-73. doi: 10.1121/1.4818782.

PMID:
24116513
34.

Surface gravity waves and their acoustic signatures, 1-30 Hz, on the mid-Pacific sea floor.

Farrell WE, Munk W.

J Acoust Soc Am. 2013 Oct;134(4):3134-43. doi: 10.1121/1.4818780.

PMID:
24116511
35.

The EFEMP1 gene: a frequent target for epigenetic silencing in multiple human pituitary adenoma subtypes.

Duong CV, Yacqub-Usman K, Emes RD, Clayton RN, Farrell WE.

Neuroendocrinology. 2013;98(3):200-11. doi: 10.1159/000355624. Epub 2013 Nov 6.

PMID:
24080855
36.

Epigenome-wide profiling identifies significant differences in DNA methylation between matched-pairs of T- and B-lymphocytes from healthy individuals.

Glossop JR, Nixon NB, Emes RD, Haworth KE, Packham JC, Dawes PT, Fryer AA, Mattey DL, Farrell WE.

Epigenetics. 2013 Nov;8(11):1188-97. doi: 10.4161/epi.26265. Epub 2013 Sep 4.

PMID:
24005183
37.

Improving recording accuracy, transparency, and performance for obstetric quality measures in a community hospital-based obstetrics department.

Gilbert WM, Bliss MC, Johnson A, Farrell W, Gregg L, Swanson C.

Jt Comm J Qual Patient Saf. 2013 Jun;39(6):258-66.

PMID:
23789163
38.

Periodic bursts of Jovian non-Io decametric radio emission.

Panchenko M, Rucker HO, Farrell WM.

Planet Space Sci. 2013 Mar;77(100):3-11.

39.

A web-based route planning tool to reduce cyclists' exposures to traffic pollution: a case study in Montreal, Canada.

Hatzopoulou M, Weichenthal S, Barreau G, Goldberg M, Farrell W, Crouse D, Ross N.

Environ Res. 2013 May;123:58-61. doi: 10.1016/j.envres.2013.03.004. Epub 2013 Apr 4.

PMID:
23562391
40.

Preincubation of pituitary tumor cells with the epidrugs zebularine and trichostatin A are permissive for retinoic acid-augmented expression of the BMP-4 and D2R genes.

Yacqub-Usman K, Duong CV, Clayton RN, Farrell WE.

Endocrinology. 2013 May;154(5):1711-21. doi: 10.1210/en.2013-1061. Epub 2013 Mar 28.

PMID:
23539512
41.

Structure-based design, SAR analysis and antitumor activity of PI3K/mTOR dual inhibitors from 4-methylpyridopyrimidinone series.

Cheng H, Hoffman JE, Le PT, Pairish M, Kania R, Farrell W, Bagrodia S, Yuan J, Sun S, Zhang E, Xiang C, Dalvie D, Rahavendran SV.

Bioorg Med Chem Lett. 2013 May 1;23(9):2787-92. doi: 10.1016/j.bmcl.2013.02.020. Epub 2013 Feb 13.

PMID:
23506825
42.

Combined influence of gene-specific cord blood methylation and maternal smoking habit on birth weight.

Haworth KE, Farrell WE, Emes RD, Ismail KM, Carroll WD, Borthwick HA, Yates AM, Hubball E, Rooney A, Khanam M, Aggarwal N, Jones PW, Fryer AA.

Epigenomics. 2013 Feb;5(1):37-49. doi: 10.2217/epi.12.72.

PMID:
23414319
43.

Investigation of polar organic solvents compatible with Corona Charged Aerosol Detection and their use for the determination of sugars by hydrophilic interaction liquid chromatography.

Hutchinson JP, Remenyi T, Nesterenko P, Farrell W, Groeber E, Szucs R, Dicinoski G, Haddad PR.

Anal Chim Acta. 2012 Oct 31;750:199-206. doi: 10.1016/j.aca.2012.04.002. Epub 2012 Apr 11.

PMID:
23062441
44.

Quantitative, genome-wide analysis of the DNA methylome in sporadic pituitary adenomas.

Duong CV, Emes RD, Wessely F, Yacqub-Usman K, Clayton RN, Farrell WE.

Endocr Relat Cancer. 2012 Nov 19;19(6):805-16. doi: 10.1530/ERC-12-0251. Print 2012 Dec.

PMID:
23045325
45.

Antiepileptic drugs and the fetal epigenome.

Emes RD, Clifford H, Haworth KE, Farrell WE, Fryer AA, Carroll WD, Ismail KM.

Epilepsia. 2013 Jan;54(1):e16-9. doi: 10.1111/j.1528-1167.2012.03673.x. Epub 2012 Sep 27.

46.

Epigenomic silencing of the BMP-4 gene in pituitary adenomas: a potential target for epidrug-induced re-expression.

Yacqub-Usman K, Duong CV, Clayton RN, Farrell WE.

Endocrinology. 2012 Aug;153(8):3603-12. doi: 10.1210/en.2012-1231. Epub 2012 Jun 14.

PMID:
22700770
47.

The pituitary tumour epigenome: aberrations and prospects for targeted therapy.

Yacqub-Usman K, Richardson A, Duong CV, Clayton RN, Farrell WE.

Nat Rev Endocrinol. 2012 Apr 24;8(8):486-94. doi: 10.1038/nrendo.2012.54. Review.

PMID:
22525730
48.

Make way for the 'next generation': application and prospects for genome-wide, epigenome-specific technologies in endocrine research.

Emes RD, Farrell WE.

J Mol Endocrinol. 2012 May 29;49(1):R19-27. doi: 10.1530/JME-12-0045. Print 2012 Aug. Review.

PMID:
22525352
49.

Automated approach for the rapid identification of purification conditions using a unified, walk-up high performance liquid chromatography/supercritical fluid chromatography/mass spectrometry screening system.

Aurigemma CM, Farrell WP, Simpkins J, Bayliss M, Alimuddin M, Wang W.

J Chromatogr A. 2012 Mar 16;1229:260-7. doi: 10.1016/j.chroma.2012.01.048. Epub 2012 Jan 25.

PMID:
22321950
50.

Unique gene expression profile associated with an early-onset multiple endocrine neoplasia (MEN1)-associated pituitary adenoma.

Farrell WE, Azevedo MF, Batista DL, Smith A, Bourdeau I, Horvath A, Boguszewski M, Quezado M, Stratakis CA.

J Clin Endocrinol Metab. 2011 Nov;96(11):E1905-14. doi: 10.1210/jc.2011-1127. Epub 2011 Sep 14.

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