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Synthesis and evaluation of novel chromanone and quinolinone analogues of uniflorol as anti-leishmanial agents.

Castro H, Cruz T, de Aguiar Amaral P, da Silva Cardoso P, Alsaffar A, Farrell P, Tomás AM, Barlow JW.

Heliyon. 2020 Mar 20;6(3):e03614. doi: 10.1016/j.heliyon.2020.e03614. eCollection 2020 Mar.


Use of Lactated Ringers Solution Compared With Normal Saline Is Associated With Shorter Length of Stay in Pediatric Acute Pancreatitis.

Farrell PR, Farrell LM, Hornung L, Abu-El-Haija M.

Pancreas. 2020 Mar;49(3):375-380. doi: 10.1097/MPA.0000000000001498.


B cells infected with Type 2 Epstein-Barr virus (EBV) have increased NFATc1/NFATc2 activity and enhanced lytic gene expression in comparison to Type 1 EBV infection.

Romero-Masters JC, Huebner SM, Ohashi M, Bristol JA, Benner BE, Barlow EA, Turk GL, Nelson SE, Baiu DC, Van Sciver N, Ranheim EA, Gumperz J, Sherer NM, Farrell PJ, Johannsen EC, Kenney SC.

PLoS Pathog. 2020 Feb 14;16(2):e1008365. doi: 10.1371/journal.ppat.1008365. eCollection 2020 Feb.


Applying whole-genome sequencing in relation to phenotype and outcomes in siblings with cystic fibrosis.

Wilk MA, Braun AT, Farrell PM, Laxova A, Brown DM, Holt JM, Birch CL, Sosonkina N, Wilk BM, Worthey EA.

Cold Spring Harb Mol Case Stud. 2020 Feb 3;6(1). pii: a004531. doi: 10.1101/mcs.a004531. Print 2020 Feb.


Phenotype of children with inconclusive cystic fibrosis diagnosis after newborn screening.

Munck A, Bourmaud A, Bellon G, Picq P, Farrell PM; DPAM Study Group.

Pediatr Pulmonol. 2020 Apr;55(4):918-928. doi: 10.1002/ppul.24634. Epub 2020 Jan 9.


A flow cytometric granularity assay for the quantification of infectious virus.

Logan M, Manalil J, Notte C, Kearse C, George S, Zeiser A, Farrell P, Aucoin MG.

Vaccine. 2019 Nov 8;37(47):7090-7099. doi: 10.1016/j.vaccine.2019.02.059. Epub 2019 Apr 16.


The future of cystic fibrosis care: a global perspective.

Bell SC, Mall MA, Gutierrez H, Macek M, Madge S, Davies JC, Burgel PR, Tullis E, Castaños C, Castellani C, Byrnes CA, Cathcart F, Chotirmall SH, Cosgriff R, Eichler I, Fajac I, Goss CH, Drevinek P, Farrell PM, Gravelle AM, Havermans T, Mayer-Hamblett N, Kashirskaya N, Kerem E, Mathew JL, McKone EF, Naehrlich L, Nasr SZ, Oates GR, O'Neill C, Pypops U, Raraigh KS, Rowe SM, Southern KW, Sivam S, Stephenson AL, Zampoli M, Ratjen F.

Lancet Respir Med. 2020 Jan;8(1):65-124. doi: 10.1016/S2213-2600(19)30337-6. Epub 2019 Sep 27. Review. Erratum in: Lancet Respir Med. 2019 Dec;7(12):e40.


Spin Lock Adiabatic Correction (SLAC) for B1-insensitive pulse design at 7T.

Green EM, Blunck Y, Tahayori B, Farrell PM, Korte JC, Johnston LA.

J Magn Reson. 2019 Nov;308:106595. doi: 10.1016/j.jmr.2019.106595. Epub 2019 Sep 11.


Using Target Engagement Biomarkers to Predict Clinical Efficacy of MetAP2 Inhibitors.

Farrell PJ, Zopf CJ, Huang HJ, Balakrishna D, Holub C, Bilakovics J, Fanjul A, Matuszkiewicz J, Plonowski A, Rolzin P, Banerjee U, Ermolieff J, Cheruvallath ZS, McBride C, Bartkowski D, Mazur C, Pachori A, Larson CJ.

J Pharmacol Exp Ther. 2019 Nov;371(2):299-308. doi: 10.1124/jpet.119.259028. Epub 2019 Sep 19.


Increased association between Epstein-Barr virus EBNA2 from type 2 strains and the transcriptional repressor BS69 restricts EBNA2 activity.

Ponnusamy R, Khatri R, Correia PB, Wood CD, Mancini EJ, Farrell PJ, West MJ.

PLoS Pathog. 2019 Jul 8;15(7):e1007458. doi: 10.1371/journal.ppat.1007458. eCollection 2019 Jul.


50 Years Ago in TheJournal ofPediatrics: Esophageal Injury by Liquid Chlorine Bleach: Experimental Study.

Farrell PR, Farrell MK.

J Pediatr. 2019 Jun;209:159. doi: 10.1016/j.jpeds.2018.12.036. No abstract available.


MetAP2 inhibition increases energy expenditure through direct action on brown adipocytes.

Huang HJ, Holub C, Rolzin P, Bilakovics J, Fanjul A, Satomi Y, Plonowski A, Larson CJ, Farrell PJ.

J Biol Chem. 2019 Jun 14;294(24):9567-9575. doi: 10.1074/jbc.RA118.007302. Epub 2019 May 2.


Inconclusive diagnosis after a positive newborn bloodspot screening result for cystic fibrosis; clarification of the harmonised international definition.

Southern KW, Barben J, Gartner S, Munck A, Castellani C, Mayell SJ, Davies JC, Winters V, Murphy J, Salinas D, McColley SA, Ren CL, Farrell PM.

J Cyst Fibros. 2019 Nov;18(6):778-780. doi: 10.1016/j.jcf.2019.04.010. Epub 2019 Apr 24. No abstract available.


Access to a Nutritious Diet in Samoa: Local Insights.

Farrell P, Thow AM, Schuster S, Vizintin P, Negin J.

Ecol Food Nutr. 2019 May-Jun;58(3):189-206. doi: 10.1080/03670244.2019.1582528. Epub 2019 Apr 8.


Towards a multi-level and a multi-disciplinary approach to DNA oncovirus virulence.

Alizon S, Bravo IG, Farrell PJ, Roberts S.

Philos Trans R Soc Lond B Biol Sci. 2019 May 27;374(1773):20190041. doi: 10.1098/rstb.2019.0041.


Essential role of inverted repeat in Epstein-Barr virus IR-1 in B cell transformation; geographical variation of the viral genome.

Bridges R, Correia S, Wegner F, Venturini C, Palser A, White RE, Kellam P, Breuer J, Farrell PJ.

Philos Trans R Soc Lond B Biol Sci. 2019 May 27;374(1773):20180299. doi: 10.1098/rstb.2018.0299.


Active management is required to turn the tide for depleted Ostrea edulis stocks from the effects of overfishing, disease and invasive species.

Helmer L, Farrell P, Hendy I, Harding S, Robertson M, Preston J.

PeerJ. 2019 Feb 28;7:e6431. doi: 10.7717/peerj.6431. eCollection 2019.


Conditional validation sampling for consistent risk estimation with binary outcome data subject to misclassification.

Gravel CA, Farrell PJ, Krewski D.

Pharmacoepidemiol Drug Saf. 2019 Feb;28(2):227-233. doi: 10.1002/pds.4701.


Requirement for PRC1 subunit BMI1 in host gene activation by Epstein-Barr virus protein EBNA3C.

Paschos K, Bazot Q, Lees J, Farrell PJ, Allday MJ.

Nucleic Acids Res. 2019 Apr 8;47(6):2807-2821. doi: 10.1093/nar/gky1323.


Whooping crane use of riverine stopover sites.

Baasch DM, Farrell PD, Howlin S, Pearse AT, Farnsworth JM, Smith CB.

PLoS One. 2019 Jan 9;14(1):e0209612. doi: 10.1371/journal.pone.0209612. eCollection 2019.


Associations between sociodemographic and behaviour factors, and dietary risk factors for overweight and obesity, in Samoan women.

Farrell P, Negin J, Awoke M, Thow AM, Taua M, Faumuina T, Mihrshahi S, Vizintin P, Richards J.

Appetite. 2019 Mar 1;134:155-161. doi: 10.1016/j.appet.2018.12.037. Epub 2018 Dec 26.


Analysis of Penalties Imposed on Organisations for Breaching Safety and Health Regulations in the United Kingdom.

Arewa AO, Theophilus S, Ifelebuegu A, Farrell P.

Saf Health Work. 2018 Dec;9(4):388-397. doi: 10.1016/ Epub 2018 Feb 2.


Identification of molecular signatures of cystic fibrosis disease status with plasma-based functional genomics.

Levy H, Jia S, Pan A, Zhang X, Kaldunski M, Nugent ML, Reske M, Feliciano RA, Quintero D, Renda MM, Woods KJ, Murkowski K, Johnson K, Verbsky J, Dasu T, Ideozu JE, McColley S, Quasney MW, Dahmer MK, Avner E, Farrell PM, Cannon CL, Jacob H, Simpson PM, Hessner MJ.

Physiol Genomics. 2019 Jan 1;51(1):27-41. doi: 10.1152/physiolgenomics.00109.2018. Epub 2018 Dec 12.


Investigating whooping crane habitat in relation to hydrology, channel morphology and a water-centric management strategy on the central Platte River, Nebraska.

Farnsworth JM, Baasch DM, Farrell PD, Smith CB, Werbylo KL.

Heliyon. 2018 Oct 13;4(10):e00851. doi: 10.1016/j.heliyon.2018.e00851. eCollection 2018 Oct.


Quantitative chest computerized tomography and FEV1 equally identify pulmonary exacerbation risk in children with cystic fibrosis.

Sanders DB, Li Z, Parker-McGill K, Farrell P, Brody AS.

Pediatr Pulmonol. 2018 Oct;53(10):1369-1377. doi: 10.1002/ppul.24144. Epub 2018 Aug 29.


Psychedelics and psychotherapy in Canada: Humphry Osmond and Aldous Huxley.

Dyck E, Farrell P.

Hist Psychol. 2018 Aug;21(3):240-253. doi: 10.1037/hop0000088.


Epstein-Barr Virus and Cancer.

Farrell PJ.

Annu Rev Pathol. 2019 Jan 24;14:29-53. doi: 10.1146/annurev-pathmechdis-012418-013023. Epub 2018 Aug 20. Review.


Sequence Variation of Epstein-Barr Virus: Viral Types, Geography, Codon Usage, and Diseases.

Correia S, Bridges R, Wegner F, Venturini C, Palser A, Middeldorp JM, Cohen JI, Lorenzetti MA, Bassano I, White RE, Kellam P, Breuer J, Farrell PJ.

J Virol. 2018 Oct 29;92(22). pii: e01132-18. doi: 10.1128/JVI.01132-18. Print 2018 Nov 15.


Estimating the age of p.(Phe508del) with family studies of geographically distinct European populations and the early spread of cystic fibrosis.

Farrell P, Férec C, Macek M, Frischer T, Renner S, Riss K, Barton D, Repetto T, Tzetis M, Giteau K, Duno M, Rogers M, Levy H, Sahbatou M, Fichou Y, Le Maréchal C, Génin E.

Eur J Hum Genet. 2018 Dec;26(12):1832-1839. doi: 10.1038/s41431-018-0234-z. Epub 2018 Aug 8.


A validation sampling approach for consistent estimation of adverse drug reaction risk with misclassified right-censored survival data.

Gravel CA, Dewanji A, Farrell PJ, Krewski D.

Stat Med. 2018 Nov 30;37(27):3887-3903. doi: 10.1002/sim.7854. Epub 2018 Aug 6.


A cancer-associated Epstein-Barr virus BZLF1 promoter variant enhances lytic infection.

Bristol JA, Djavadian R, Albright ER, Coleman CB, Ohashi M, Hayes M, Romero-Masters JC, Barlow EA, Farrell PJ, Rochford R, Kalejta RF, Johannsen EC, Kenney SC.

PLoS Pathog. 2018 Jul 27;14(7):e1007179. doi: 10.1371/journal.ppat.1007179. eCollection 2018 Jul.


Integrating species-centric and geomorphic-centric views of interior least tern and piping plover habitat selection.

Farnsworth JM, Baasch DM, Farrell PD.

Heliyon. 2018 Jun 5;4(6):e00648. doi: 10.1016/j.heliyon.2018.e00648. eCollection 2018 Jun.


The Cooperative Functions of the EBNA3 Proteins Are Central to EBV Persistence and Latency.

Styles CT, Paschos K, White RE, Farrell PJ.

Pathogens. 2018 Mar 17;7(1). pii: E31. doi: 10.3390/pathogens7010031. Review.


Early life growth patterns persist for 12 years and impact pulmonary outcomes in cystic fibrosis.

Sanders DB, Zhang Z, Farrell PM, Lai HJ; Wisconsin CF Neonatal Screening Group.

J Cyst Fibros. 2018 Jul;17(4):528-535. doi: 10.1016/j.jcf.2018.01.006. Epub 2018 Feb 1.


Poor recovery from cystic fibrosis pulmonary exacerbations is associated with poor long-term outcomes.

Sanders DB, Zhao Q, Li Z, Farrell PM.

Pediatr Pulmonol. 2017 Oct;52(10):1268-1275. doi: 10.1002/ppul.23765. Epub 2017 Sep 7.


Poor recovery from a pulmonary exacerbation does not lead to accelerated FEV1 decline.

Sanders DB, Li Z, Zhao Q, Farrell PM.

J Cyst Fibros. 2017 Jul 29. pii: S1569-1993(17)30818-4. doi: 10.1016/j.jcf.2017.07.003. [Epub ahead of print]


Recognition and treatment of sleep-disordered breathing: an important component of chronic disease management.

Farrell PC, Richards G.

J Transl Med. 2017 May 25;15(1):114. doi: 10.1186/s12967-017-1211-y. Review.


How food insecurity could lead to obesity in LMICs: When not enough is too much: a realist review of how food insecurity could lead to obesity in low- and middle-income countries.

Farrell P, Thow AM, Abimbola S, Faruqui N, Negin J.

Health Promot Int. 2018 Oct 1;33(5):812-826. doi: 10.1093/heapro/dax026.


Natural Variation of Epstein-Barr Virus Genes, Proteins, and Primary MicroRNA.

Correia S, Palser A, Elgueta Karstegl C, Middeldorp JM, Ramayanti O, Cohen JI, Hildesheim A, Fellner MD, Wiels J, White RE, Kellam P, Farrell PJ.

J Virol. 2017 Jul 12;91(15). pii: e00375-17. doi: 10.1128/JVI.00375-17. Print 2017 Aug 1.


Molluscum Contagiosum Virus Protein MC005 Inhibits NF-κB Activation by Targeting NEMO-Regulated IκB Kinase Activation.

Brady G, Haas DA, Farrell PJ, Pichlmair A, Bowie AG.

J Virol. 2017 Jul 12;91(15). pii: e00545-17. doi: 10.1128/JVI.00545-17. Print 2017 Aug 1.


Evaluation of a novel mentor program to improve surgical care for US hospitals.

Berian JR, Thomas JM, Minami CA, Farrell PR, O'Leary KJ, Williams MV, Prachand VN, Halverson AL, Bilimoria KY, Johnson JK.

Int J Qual Health Care. 2017 Apr 1;29(2):234-242. doi: 10.1093/intqhc/mzx005.


MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody.

Farrell PJ, Matuszkiewicz J, Balakrishna D, Pandya S, Hixon MS, Kamran R, Chu S, Lawson JD, Okada K, Hori A, Mizutani A, Iwata H, de Jong R, Hibner B, Vincent P.

Mol Cancer Ther. 2017 Jul;16(7):1269-1278. doi: 10.1158/1535-7163.MCT-16-0771. Epub 2017 Mar 24.


Roles of RUNX in B Cell Immortalisation.

West MJ, Farrell PJ.

Adv Exp Med Biol. 2017;962:283-298. doi: 10.1007/978-981-10-3233-2_18. Review.


The Evolution of the Medical School Deanship: From Patriarch to CEO to System Dean.

Schieffler DA, Farrell PM, Kahn MJ, Culbertson RA.

Perm J. 2017;21:16-069. doi: 10.7812/TPP/16-069.


Diagnosis of Cystic Fibrosis in Nonscreened Populations.

Sosnay PR, White TB, Farrell PM, Ren CL, Derichs N, Howenstine MS, Nick JA, De Boeck K.

J Pediatr. 2017 Feb;181S:S52-S57.e2. doi: 10.1016/j.jpeds.2016.09.068.


Diagnosis of Cystic Fibrosis: Consensus Guidelines from the Cystic Fibrosis Foundation.

Farrell PM, White TB, Ren CL, Hempstead SE, Accurso F, Derichs N, Howenstine M, McColley SA, Rock M, Rosenfeld M, Sermet-Gaudelus I, Southern KW, Marshall BC, Sosnay PR.

J Pediatr. 2017 Feb;181S:S4-S15.e1. doi: 10.1016/j.jpeds.2016.09.064. Erratum in: J Pediatr. 2017 May;184:243.


Diagnosis of Cystic Fibrosis in Screened Populations.

Farrell PM, White TB, Howenstine MS, Munck A, Parad RB, Rosenfeld M, Sommerburg O, Accurso FJ, Davies JC, Rock MJ, Sanders DB, Wilschanski M, Sermet-Gaudelus I, Blau H, Gartner S, McColley SA.

J Pediatr. 2017 Feb;181S:S33-S44.e2. doi: 10.1016/j.jpeds.2016.09.065.


Applying Cystic Fibrosis Transmembrane Conductance Regulator Genetics and CFTR2 Data to Facilitate Diagnoses.

Sosnay PR, Salinas DB, White TB, Ren CL, Farrell PM, Raraigh KS, Girodon E, Castellani C.

J Pediatr. 2017 Feb;181S:S27-S32.e1. doi: 10.1016/j.jpeds.2016.09.063.


Cystic Fibrosis Diagnostic Challenges over 4 Decades: Historical Perspectives and Lessons Learned.

Farrell PM, White TB, Derichs N, Castellani C, Rosenstein BJ.

J Pediatr. 2017 Feb;181S:S16-S26. doi: 10.1016/j.jpeds.2016.09.067.


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