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Items: 47


CRISPR/Cas9 mutations in the rice Waxy/GBSSI gene induce allele-specific and zygosity-dependent feedback effects on endosperm starch biosynthesis.

Pérez L, Soto E, Farré G, Juanos J, Villorbina G, Bassie L, Medina V, Serrato AJ, Sahrawy M, Rojas JA, Romagosa I, Muñoz P, Zhu C, Christou P.

Plant Cell Rep. 2019 Mar;38(3):417-433. doi: 10.1007/s00299-019-02388-z. Epub 2019 Feb 4.


CRISPR/Cas9-induced monoallelic mutations in the cytosolic AGPase large subunit gene APL2 induce the ectopic expression of APL2 and the corresponding small subunit gene APS2b in rice leaves.

Pérez L, Soto E, Villorbina G, Bassie L, Medina V, Muñoz P, Capell T, Zhu C, Christou P, Farré G.

Transgenic Res. 2018 Oct;27(5):423-439. doi: 10.1007/s11248-018-0089-7. Epub 2018 Aug 11.


Unexpected synergistic HIV neutralization by a triple microbicide produced in rice endosperm.

Vamvaka E, Farré G, Molinos-Albert LM, Evans A, Canela-Xandri A, Twyman RM, Carrillo J, Ordóñez RA, Shattock RJ, O'Keefe BR, Clotet B, Blanco J, Khush GS, Christou P, Capell T.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7854-E7862. doi: 10.1073/pnas.1806022115. Epub 2018 Jul 30.


The Arabidopsis ORANGE (AtOR) gene promotes carotenoid accumulation in transgenic corn hybrids derived from parental lines with limited carotenoid pools.

Berman J, Zorrilla-López U, Medina V, Farré G, Sandmann G, Capell T, Christou P, Zhu C.

Plant Cell Rep. 2017 Jun;36(6):933-945. doi: 10.1007/s00299-017-2126-z. Epub 2017 Mar 17.


Biofortification of crops with nutrients: factors affecting utilization and storage.

Díaz-Gómez J, Twyman RM, Zhu C, Farré G, Serrano JC, Portero-Otin M, Muñoz P, Sandmann G, Capell T, Christou P.

Curr Opin Biotechnol. 2017 Apr;44:115-123. doi: 10.1016/j.copbio.2016.12.002. Epub 2017 Jan 6. Review.


Patterns of CRISPR/Cas9 activity in plants, animals and microbes.

Bortesi L, Zhu C, Zischewski J, Perez L, Bassié L, Nadi R, Forni G, Lade SB, Soto E, Jin X, Medina V, Villorbina G, Muñoz P, Farré G, Fischer R, Twyman RM, Capell T, Christou P, Schillberg S.

Plant Biotechnol J. 2016 Dec;14(12):2203-2216. doi: 10.1111/pbi.12634. Epub 2016 Oct 11. Review.


Red Anthocyanins and Yellow Carotenoids Form the Color of Orange-Flower Gentian (Gentiana lutea L. var. aurantiaca).

Berman J, Sheng Y, Gómez Gómez L, Veiga T, Ni X, Farré G, Capell T, Guitián J, Guitián P, Sandmann G, Christou P, Zhu C.

PLoS One. 2016 Sep 2;11(9):e0162410. doi: 10.1371/journal.pone.0162410. eCollection 2016.


Reconstruction of the astaxanthin biosynthesis pathway in rice endosperm reveals a metabolic bottleneck at the level of endogenous β-carotene hydroxylase activity.

Bai C, Berman J, Farre G, Capell T, Sandmann G, Christou P, Zhu C.

Transgenic Res. 2017 Feb;26(1):13-23. doi: 10.1007/s11248-016-9977-x. Epub 2016 Aug 27.


Engineered maize as a source of astaxanthin: processing and application as fish feed.

Breitenbach J, Nogueira M, Farré G, Zhu C, Capell T, Christou P, Fleck G, Focken U, Fraser PD, Sandmann G.

Transgenic Res. 2016 Dec;25(6):785-793. Epub 2016 Aug 12.


Identification of line-specific strategies for improving carotenoid production in synthetic maize through data-driven mathematical modeling.

Comas J, Benfeitas R, Vilaprinyo E, Sorribas A, Solsona F, Farré G, Berman J, Zorrilla U, Capell T, Sandmann G, Zhu C, Christou P, Alves R.

Plant J. 2016 Sep;87(5):455-71. doi: 10.1111/tpj.13210. Epub 2016 Jul 18.


Metabolic engineering of astaxanthin biosynthesis in maize endosperm and characterization of a prototype high oil hybrid.

Farré G, Perez-Fons L, Decourcelle M, Breitenbach J, Hem S, Zhu C, Capell T, Christou P, Fraser PD, Sandmann G.

Transgenic Res. 2016 Aug;25(4):477-89. doi: 10.1007/s11248-016-9943-7. Epub 2016 Mar 1.


Corrigendum. Standards for plant synthetic biology: a common syntax for exchanges of DNA parts.

Patron NJ, Orzaez O, Marillonnet S, Warzecha H, Matthewman C, Youles M, Raitskin O, Leveau A, Farré G, Rogers C.

New Phytol. 2016 Jan;209(2):885. doi: 10.1111/nph.13773. Epub 2015 Nov 12. No abstract available.


Standards for plant synthetic biology: a common syntax for exchange of DNA parts.

Patron NJ, Orzaez D, Marillonnet S, Warzecha H, Matthewman C, Youles M, Raitskin O, Leveau A, Farré G, Rogers C, Smith A, Hibberd J, Webb AA, Locke J, Schornack S, Ajioka J, Baulcombe DC, Zipfel C, Kamoun S, Jones JD, Kuhn H, Robatzek S, Van Esse HP, Sanders D, Oldroyd G, Martin C, Field R, O'Connor S, Fox S, Wulff B, Miller B, Breakspear A, Radhakrishnan G, Delaux PM, Loqué D, Granell A, Tissier A, Shih P, Brutnell TP, Quick WP, Rischer H, Fraser PD, Aharoni A, Raines C, South PF, Ané JM, Hamberger BR, Langdale J, Stougaard J, Bouwmeester H, Udvardi M, Murray JA, Ntoukakis V, Schäfer P, Denby K, Edwards KJ, Osbourn A, Haseloff J.

New Phytol. 2015 Oct;208(1):13-9. doi: 10.1111/nph.13532. Epub 2015 Jul 14. Erratum in: New Phytol. 2016 Jan;209(2):885.


Knowledge-driven approaches for engineering complex metabolic pathways in plants.

Farré G, Twyman RM, Christou P, Capell T, Zhu C.

Curr Opin Biotechnol. 2015 Apr;32:54-60. doi: 10.1016/j.copbio.2014.11.004. Epub 2014 Nov 25. Review.


Engineering complex metabolic pathways in plants.

Farré G, Blancquaert D, Capell T, Van Der Straeten D, Christou P, Zhu C.

Annu Rev Plant Biol. 2014;65:187-223. doi: 10.1146/annurev-arplant-050213-035825. Epub 2014 Feb 26. Review.


Engineering metabolic pathways in plants by multigene transformation.

Zorrilla-López U, Masip G, Arjó G, Bai C, Banakar R, Bassie L, Berman J, Farré G, Miralpeix B, Pérez-Massot E, Sabalza M, Sanahuja G, Vamvaka E, Twyman RM, Christou P, Zhu C, Capell T.

Int J Dev Biol. 2013;57(6-8):565-76. doi: 10.1387/ijdb.130162pc. Review.


A question of balance: achieving appropriate nutrient levels in biofortified staple crops.

Sanahuja G, Farré G, Berman J, Zorrilla-López U, Twyman RM, Capell T, Christou P, Zhu C.

Nutr Res Rev. 2013 Dec;26(2):235-45. doi: 10.1017/S0954422413000176. Epub 2013 Oct 18. Review.


Ascorbic acid synthesis and metabolism in maize are subject to complex and genotype-dependent feedback regulation during endosperm development.

Sanahuja G, Farré G, Bassie L, Zhu C, Christou P, Capell T.

Biotechnol J. 2013 Oct;8(10):1221-30. doi: 10.1002/biot.201300064. Epub 2013 Jul 11.


Fast quantitative method for the analysis of carotenoids in transgenic maize.

Rivera SM, Vilaró F, Zhu C, Bai C, Farré G, Christou P, Canela-Garayoa R.

J Agric Food Chem. 2013 Jun 5;61(22):5279-85. doi: 10.1021/jf400694z. Epub 2013 May 24.


Targeted transcriptomic and metabolic profiling reveals temporal bottlenecks in the maize carotenoid pathway that may be addressed by multigene engineering.

Farré G, Maiam Rivera S, Alves R, Vilaprinyo E, Sorribas A, Canela R, Naqvi S, Sandmann G, Capell T, Zhu C, Christou P.

Plant J. 2013 Aug;75(3):441-55. doi: 10.1111/tpj.12214. Epub 2013 May 30.


Can the world afford to ignore biotechnology solutions that address food insecurity?

Berman J, Zhu C, Pérez-Massot E, Arjó G, Zorrilla-López U, Masip G, Banakar R, Sanahuja G, Farré G, Miralpeix B, Bai C, Vamvaka E, Sabalza M, Twyman RM, Bassié L, Capell T, Christou P.

Plant Mol Biol. 2013 Sep;83(1-2):5-19. doi: 10.1007/s11103-013-0027-2. Epub 2013 Feb 21.


Biofortification of plants with altered antioxidant content and composition: genetic engineering strategies.

Zhu C, Sanahuja G, Yuan D, Farré G, Arjó G, Berman J, Zorrilla-López U, Banakar R, Bai C, Pérez-Massot E, Bassie L, Capell T, Christou P.

Plant Biotechnol J. 2013 Feb;11(2):129-41. doi: 10.1111/j.1467-7652.2012.00740.x. Epub 2012 Sep 13. Review.


The contribution of transgenic plants to better health through improved nutrition: opportunities and constraints.

Pérez-Massot E, Banakar R, Gómez-Galera S, Zorrilla-López U, Sanahuja G, Arjó G, Miralpeix B, Vamvaka E, Farré G, Rivera SM, Dashevskaya S, Berman J, Sabalza M, Yuan D, Bai C, Bassie L, Twyman RM, Capell T, Christou P, Zhu C.

Genes Nutr. 2013 Jan;8(1):29-41. doi: 10.1007/s12263-012-0315-5. Epub 2012 Aug 29.


Transgenic rice grains expressing a heterologous ρ-hydroxyphenylpyruvate dioxygenase shift tocopherol synthesis from the γ to the α isoform without increasing absolute tocopherol levels.

Farré G, Sudhakar D, Naqvi S, Sandmann G, Christou P, Capell T, Zhu C.

Transgenic Res. 2012 Oct;21(5):1093-7. doi: 10.1007/s11248-012-9601-7. Epub 2012 Feb 24.


Combinatorial genetic transformation of cereals and the creation of metabolic libraries for the carotenoid pathway.

Farre G, Naqvi S, Sanahuja G, Bai C, Zorrilla-López U, Rivera SM, Canela R, Sandman G, Twyman RM, Capell T, Zhu C, Christou P.

Methods Mol Biol. 2012;847:419-35. doi: 10.1007/978-1-61779-558-9_33.


Nutritious crops producing multiple carotenoids--a metabolic balancing act.

Farré G, Bai C, Twyman RM, Capell T, Christou P, Zhu C.

Trends Plant Sci. 2011 Oct;16(10):532-40. doi: 10.1016/j.tplants.2011.08.001. Epub 2011 Sep 6. Review.


The potential impact of plant biotechnology on the Millennium Development Goals.

Yuan D, Bassie L, Sabalza M, Miralpeix B, Dashevskaya S, Farre G, Rivera SM, Banakar R, Bai C, Sanahuja G, Arjó G, Avilla E, Zorrilla-López U, Ugidos-Damboriena N, López A, Almacellas D, Zhu C, Capell T, Hahne G, Twyman RM, Christou P.

Plant Cell Rep. 2011 Mar;30(3):249-65. doi: 10.1007/s00299-010-0987-5. Epub 2011 Jan 20.


Nutritionally enhanced crops and food security: scientific achievements versus political expediency.

Farre G, Twyman RM, Zhu C, Capell T, Christou P.

Curr Opin Biotechnol. 2011 Apr;22(2):245-51. doi: 10.1016/j.copbio.2010.11.002. Epub 2010 Nov 29. Review.


High-value products from transgenic maize.

Naqvi S, Ramessar K, Farré G, Sabalza M, Miralpeix B, Twyman RM, Capell T, Zhu C, Christou P.

Biotechnol Adv. 2011 Jan-Feb;29(1):40-53. doi: 10.1016/j.biotechadv.2010.08.009. Epub 2010 Sep 15.


Synergistic metabolism in hybrid corn indicates bottlenecks in the carotenoid pathway and leads to the accumulation of extraordinary levels of the nutritionally important carotenoid zeaxanthin.

Naqvi S, Zhu C, Farre G, Sandmann G, Capell T, Christou P.

Plant Biotechnol J. 2011 Apr;9(3):384-93. doi: 10.1111/j.1467-7652.2010.00554.x. Epub 2010 Aug 29.


The regulation of carotenoid pigmentation in flowers.

Zhu C, Bai C, Sanahuja G, Yuan D, Farré G, Naqvi S, Shi L, Capell T, Christou P.

Arch Biochem Biophys. 2010 Dec 1;504(1):132-41. doi: 10.1016/ Epub 2010 Aug 3. Review.


Simultaneous expression of Arabidopsis ρ-hydroxyphenylpyruvate dioxygenase and MPBQ methyltransferase in transgenic corn kernels triples the tocopherol content.

Naqvi S, Farré G, Zhu C, Sandmann G, Capell T, Christou P.

Transgenic Res. 2011 Feb;20(1):177-81. doi: 10.1007/s11248-010-9393-6. Epub 2010 Apr 18.


Promoter diversity in multigene transformation.

Peremarti A, Twyman RM, Gómez-Galera S, Naqvi S, Farré G, Sabalza M, Miralpeix B, Dashevskaya S, Yuan D, Ramessar K, Christou P, Zhu C, Bassie L, Capell T.

Plant Mol Biol. 2010 Jul;73(4-5):363-78. doi: 10.1007/s11103-010-9628-1. Epub 2010 Mar 31. Review.


Cloning and functional characterization of the maize carotenoid isomerase and β-carotene hydroxylase genes and their regulation during endosperm maturation.

Li Q, Farre G, Naqvi S, Breitenbach J, Sanahuja G, Bai C, Sandmann G, Capell T, Christou P, Zhu C.

Transgenic Res. 2010 Dec;19(6):1053-68. doi: 10.1007/s11248-010-9381-x. Epub 2010 Mar 11.


Study of inborn errors of metabolism in urine from patients with unexplained mental retardation.

Sempere A, Arias A, Farré G, García-Villoria J, Rodríguez-Pombo P, Desviat LR, Merinero B, García-Cazorla A, Vilaseca MA, Ribes A, Artuch R, Campistol J.

J Inherit Metab Dis. 2010 Feb;33(1):1-7. doi: 10.1007/s10545-009-9004-y. Epub 2010 Jan 5.


The humanitarian impact of plant biotechnology: recent breakthroughs vs bottlenecks for adoption.

Farre G, Ramessar K, Twyman RM, Capell T, Christou P.

Curr Opin Plant Biol. 2010 Apr;13(2):219-25. doi: 10.1016/j.pbi.2009.11.002. Epub 2010 Jan 25.


When more is better: multigene engineering in plants.

Naqvi S, Farré G, Sanahuja G, Capell T, Zhu C, Christou P.

Trends Plant Sci. 2010 Jan;15(1):48-56. doi: 10.1016/j.tplants.2009.09.010. Epub 2009 Oct 21. Review.


Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways.

Naqvi S, Zhu C, Farre G, Ramessar K, Bassie L, Breitenbach J, Perez Conesa D, Ros G, Sandmann G, Capell T, Christou P.

Proc Natl Acad Sci U S A. 2009 May 12;106(19):7762-7. doi: 10.1073/pnas.0901412106. Epub 2009 Apr 27.


Cloning and sequencing of cDNA encoding for the testis-specific fox (Vulpes vulpes) sperm polypeptide Vb of the cytochrome C oxidase.

Verdier Y, Farré G, Rouet N, Kele Z, Janáky T, Boué F.

J Androl. 2005 May-Jun;26(3):319-27.


Identification of a new, testis-specific sperm antigen localized on the principal piece of the spermatozoa tail in the fox (Vulpes vulpes).

Verdier Y, Farré G, Rouet N, Kele Z, Janáky T, Boué F.

Biol Reprod. 2005 Feb;72(2):502-8. Epub 2004 Oct 27.


Mapping and ablation of ventricular fibrillation associated with long-QT and Brugada syndromes.

Haïssaguerre M, Extramiana F, Hocini M, Cauchemez B, Jaïs P, Cabrera JA, Farré J, Leenhardt A, Sanders P, Scavée C, Hsu LF, Weerasooriya R, Shah DC, Frank R, Maury P, Delay M, Garrigue S, Clémenty J.

Circulation. 2003 Aug 26;108(8):925-8. Epub 2003 Aug 18. Erratum in: Circulation. 2005 Jan 25:111(3):378. Farre, Gerónimo [corrected to Farré, Jerónimo].


Retinoic acid receptor and retinoid X receptor alterations in lung cancer precursor lesions.

Martinet N, Alla F, Farré G, Labib T, Drouot H, Vidili R, Picard E, Gaube MP, Le Faou D, Siat J, Borelly J, Vermylen P, Bazarbachi T, Vignaud JM, Martinet Y.

Cancer Res. 2000 Jun 1;60(11):2869-75.


Fundamental and modal processes in the evolution of natural systems.

Farre GL.

Ann N Y Acad Sci. 2000;901:237-43.


Predictive survival markers in patients with surgically resected non-small cell lung carcinoma.

Moldvay J, Scheid P, Wild P, Nabil K, Siat J, Borrelly J, Marie B, Farré G, Labib T, Pottier G, Sesboüé R, Bronner C, Vignaud JM, Martinet Y, Martinet N.

Clin Cancer Res. 2000 Mar;6(3):1125-34.


Reduced synthesis and rapid esterification of cholesterol in the liver of hamsters with spontaneous hypercholesterolemia.

Sablé-Amplis R, Sicart R, Farré G.

Comp Biochem Physiol B. 1987;86(4):725-9.


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