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Items: 1 to 50 of 104

1.

Myotonic dystrophy type 1: clinical manifestations in children and adolescents.

Ho G, Carey KA, Cardamone M, Farrar MA.

Arch Dis Child. 2018 Jun 5. pii: archdischild-2018-314837. doi: 10.1136/archdischild-2018-314837. [Epub ahead of print]

PMID:
29871899
2.

Chemotherapy-Induced Peripheral Neuropathy in Long-term Survivors of Childhood Cancer: Clinical, Neurophysiological, Functional, and Patient-Reported Outcomes.

Kandula T, Farrar MA, Cohn RJ, Mizrahi D, Carey K, Johnston K, Kiernan MC, Krishnan AV, Park SB.

JAMA Neurol. 2018 May 14. doi: 10.1001/jamaneurol.2018.0963. [Epub ahead of print]

PMID:
29799906
3.

Financial, opportunity and psychosocial costs of spinal muscular atrophy: an exploratory qualitative analysis of Australian carer perspectives.

Farrar MA, Carey KA, Paguinto SG, Chambers G, Kasparian NA.

BMJ Open. 2018 May 24;8(5):e020907. doi: 10.1136/bmjopen-2017-020907.

4.

Identification of Cellular Sources of IL-2 Needed for Regulatory T Cell Development and Homeostasis.

Owen DL, Mahmud SA, Vang KB, Kelly RM, Blazar BR, Smith KA, Farrar MA.

J Immunol. 2018 Jun 15;200(12):3926-3933. doi: 10.4049/jimmunol.1800097. Epub 2018 May 4.

PMID:
29728511
5.

New and developing therapies in spinal muscular atrophy.

Kariyawasam D, Carey KA, Jones KJ, Farrar MA.

Paediatr Respir Rev. 2018 Apr 5. pii: S1526-0542(18)30048-4. doi: 10.1016/j.prrv.2018.03.003. [Epub ahead of print] Review.

PMID:
29703692
6.

Congenital titinopathy: Comprehensive characterisation and pathogenic insights.

Oates EC, Jones KJ, Donkervoort S, Charlton A, Brammah S, Smith JE 3rd, Ware JS, Yau KS, Swanson LC, Whiffin N, Peduto AJ, Bournazos A, Waddell LB, Farrar MA, Sampaio HA, Teoh HL, Lamont PJ, Mowat D, Fitzsimons RB, Corbett AJ, Ryan MM, O'Grady GL, Sandaradura SA, Ghaoui R, Joshi HB, Marshall JL, Nolan MA, Kaur S, Punetha J, Töpf A, Harris E, Bakshi M, Genetti CA, Marttila M, Werlauff U, Streichenberger N, Pestronk A, Mazanti I, Pinner JR, Vuillerot C, Grosmann C, Camacho A, Mohassel P, Leach ME, Foley AR, Bharucha-Goebel D, Collins J, Connolly AM, Gilbreath HR, Iannaccone ST, Castro D, Cummings BB, Webster RI, Lazaro L, Vissing J, Coppens S, Deconinck N, Luk HM, Thomas NH, Foulds NC, Illingworth MA, Ellard S, McLean CA, Phadke R, Ravenscroft G, Witting N, Hackman P, Richard I, Cooper ST, Kamsteeg EJ, Hoffman EP, Bushby K, Straub V, Udd B, Ferreiro A, North KN, Clarke NF, Lek M, Beggs AH, Bönnemann CG, MacArthur DG, Granzier H, Davis MR, Laing NG.

Ann Neurol. 2018 Apr 25. doi: 10.1002/ana.25241. [Epub ahead of print]

PMID:
29691892
7.

Nusinersen for SMA: expanded access programme.

Farrar MA, Teoh HL, Carey KA, Cairns A, Forbes R, Herbert K, Holland S, Jones KJ, Menezes MP, Morrison M, Munro K, Villano D, Webster R, Woodcock IR, Yiu EM, Sampaio H, Ryan MM.

J Neurol Neurosurg Psychiatry. 2018 Mar 16. pii: jnnp-2017-317412. doi: 10.1136/jnnp-2017-317412. [Epub ahead of print]

PMID:
29549190
8.

Cannabis for paediatric epilepsy: challenges and conundrums.

Chen KA, Farrar MA, Cardamone M, Lawson JA.

Med J Aust. 2018 Feb 19;208(3):132-136.

PMID:
29438649
9.

Integrating exome sequencing into a diagnostic pathway for epileptic encephalopathy: Evidence of clinical utility and cost effectiveness.

Palmer EE, Schofield D, Shrestha R, Kandula T, Macintosh R, Lawson JA, Andrews I, Sampaio H, Johnson AM, Farrar MA, Cardamone M, Mowat D, Elakis G, Lo W, Zhu Y, Ying K, Morris P, Tao J, Dias KR, Buckley M, Dinger ME, Cowley MJ, Roscioli T, Kirk EP, Bye A, Sachdev RK.

Mol Genet Genomic Med. 2018 Mar;6(2):186-199. doi: 10.1002/mgg3.355. Epub 2018 Jan 4.

10.

Multimodal quantitative examination of nerve function in colorectal cancer patients prior to chemotherapy.

Kandula T, Farrar MA, Krishnan AV, Murray J, Timmins HC, Goldstein D, Lin CS, Kiernan MC, Park SB.

Muscle Nerve. 2018 Apr;57(4):615-621. doi: 10.1002/mus.25968. Epub 2017 Sep 30.

PMID:
28881477
11.

Combination therapeutics of Nilotinib and radiation in acute lymphoblastic leukemia as an effective method against drug-resistance.

Kaveh K, Takahashi Y, Farrar MA, Storme G, Guido M, Piepenburg J, Penning J, Foo J, Leder KZ, Hui SK.

PLoS Comput Biol. 2017 Jul 6;13(7):e1005482. doi: 10.1371/journal.pcbi.1005482. eCollection 2017 Jul.

12.

STAT5 deletion in macrophages alters ductal elongation and branching during mammary gland development.

Brady NJ, Farrar MA, Schwertfeger KL.

Dev Biol. 2017 Aug 1;428(1):232-244. doi: 10.1016/j.ydbio.2017.06.007. Epub 2017 Jun 9.

13.

Neurophysiological and clinical outcomes in chemotherapy-induced neuropathy in cancer.

Kandula T, Farrar MA, Kiernan MC, Krishnan AV, Goldstein D, Horvath L, Grimison P, Boyle F, Baron-Hay S, Park SB.

Clin Neurophysiol. 2017 Jul;128(7):1166-1175. doi: 10.1016/j.clinph.2017.04.009. Epub 2017 Apr 25. Review.

PMID:
28511129
14.

Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival.

Katerndahl CDS, Heltemes-Harris LM, Willette MJL, Henzler CM, Frietze S, Yang R, Schjerven H, Silverstein KAT, Ramsey LB, Hubbard G, Wells AD, Kuiper RP, Scheijen B, van Leeuwen FN, Müschen M, Kornblau SM, Farrar MA.

Nat Immunol. 2017 Jun;18(6):694-704. doi: 10.1038/ni.3716. Epub 2017 Apr 3.

15.

Quality of life and excessive daytime sleepiness in children and adolescents with myotonic dystrophy type 1.

Ho G, Widger J, Cardamone M, Farrar MA.

Sleep Med. 2017 Apr;32:92-96. doi: 10.1016/j.sleep.2016.12.005. Epub 2016 Dec 21.

PMID:
28366348
16.

STAT5 and CD4 + T Cell Immunity.

Owen DL, Farrar MA.

F1000Res. 2017 Jan 11;6:32. doi: 10.12688/f1000research.9838.1. eCollection 2017. Review.

17.

Burning pain: axonal dysfunction in erythromelalgia.

Farrar MA, Lee MJ, Howells J, Andrews PI, Lin CS.

Pain. 2017 May;158(5):900-911. doi: 10.1097/j.pain.0000000000000856.

18.

Emerging therapies and challenges in spinal muscular atrophy.

Farrar MA, Park SB, Vucic S, Carey KA, Turner BJ, Gillingwater TH, Swoboda KJ, Kiernan MC.

Ann Neurol. 2017 Mar;81(3):355-368. doi: 10.1002/ana.24864. Epub 2017 Feb 17. Review.

19.

Motor cortical dysfunction develops in spinocerebellar ataxia type 3.

Farrar MA, Vucic S, Nicholson G, Kiernan MC.

Clin Neurophysiol. 2016 Nov;127(11):3418-3424. doi: 10.1016/j.clinph.2016.09.005. Epub 2016 Sep 15.

PMID:
27689815
20.

Pediatric chemotherapy induced peripheral neuropathy: A systematic review of current knowledge.

Kandula T, Park SB, Cohn RJ, Krishnan AV, Farrar MA.

Cancer Treat Rev. 2016 Nov;50:118-128. doi: 10.1016/j.ctrv.2016.09.005. Epub 2016 Sep 10. Review.

PMID:
27664395
21.

Glial mitochondropathy in infantile neuroaxonal dystrophy: pathophysiological and therapeutic implications.

Farrar MA, Teoh HL, Brammah S, Roscioli T, Cardamone M.

Brain. 2016 Dec;139(Pt 12):e67. Epub 2016 Aug 6. No abstract available.

PMID:
27497490
22.

Whole Genome Sequencing Identifies a 78 kb Insertion from Chromosome 8 as the Cause of Charcot-Marie-Tooth Neuropathy CMTX3.

Brewer MH, Chaudhry R, Qi J, Kidambi A, Drew AP, Menezes MP, Ryan MM, Farrar MA, Mowat D, Subramanian GM, Young HK, Zuchner S, Reddel SW, Nicholson GA, Kennerson ML.

PLoS Genet. 2016 Jul 20;12(7):e1006177. doi: 10.1371/journal.pgen.1006177. eCollection 2016 Jul.

23.

Heterologous Vaccination and Checkpoint Blockade Synergize To Induce Antileukemia Immunity.

Manlove LS, Schenkel JM, Manlove KR, Pauken KE, Williams RT, Vezys V, Farrar MA.

J Immunol. 2016 Jun 1;196(11):4793-804. doi: 10.4049/jimmunol.1600130. Epub 2016 Apr 25.

24.

Clinical Characteristics and Functional Motor Outcomes of Enterovirus 71 Neurological Disease in Children.

Teoh HL, Mohammad SS, Britton PN, Kandula T, Lorentzos MS, Booy R, Jones CA, Rawlinson W, Ramachandran V, Rodriguez ML, Andrews PI, Dale RC, Farrar MA, Sampaio H.

JAMA Neurol. 2016 Mar;73(3):300-7. doi: 10.1001/jamaneurol.2015.4388.

PMID:
26785318
25.

Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia.

Heltemes-Harris LM, Larson JD, Starr TK, Hubbard GK, Sarver AL, Largaespada DA, Farrar MA.

Oncogene. 2016 Jun 30;35(26):3454-64. doi: 10.1038/onc.2015.405. Epub 2015 Oct 26.

26.

Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells.

Manlove LS, Berquam-Vrieze KE, Pauken KE, Williams RT, Jenkins MK, Farrar MA.

J Immunol. 2015 Oct 15;195(8):4028-37. doi: 10.4049/jimmunol.1501291. Epub 2015 Sep 16.

27.

Interleukin-7 is required for CD4(+) T cell activation and autoimmune neuroinflammation.

Lawson BR, Gonzalez-Quintial R, Eleftheriadis T, Farrar MA, Miller SD, Sauer K, McGavern DB, Kono DH, Baccala R, Theofilopoulos AN.

Clin Immunol. 2015 Dec;161(2):260-9. doi: 10.1016/j.clim.2015.08.007. Epub 2015 Aug 25.

28.

Pathophysiology of motor dysfunction in a childhood motor neuron disease caused by mutations in the riboflavin transporter.

Menezes MP, Farrar MA, Webster R, Antony J, O'Brien K, Ouvrier R, Kiernan MC, Burns J, Vucic S.

Clin Neurophysiol. 2016 Jan;127(1):911-918. doi: 10.1016/j.clinph.2015.05.012. Epub 2015 Jun 3.

PMID:
26092362
29.

Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells.

Hepworth MR, Fung TC, Masur SH, Kelsen JR, McConnell FM, Dubrot J, Withers DR, Hugues S, Farrar MA, Reith W, Eberl G, Baldassano RN, Laufer TM, Elson CO, Sonnenberg GF.

Science. 2015 May 29;348(6238):1031-5. doi: 10.1126/science.aaa4812. Epub 2015 Apr 23.

30.

The Genetics of Spinal Muscular Atrophy: Progress and Challenges.

Farrar MA, Kiernan MC.

Neurotherapeutics. 2015 Apr;12(2):290-302. doi: 10.1007/s13311-014-0314-x. Review.

31.

Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia.

Liu GJ, Cimmino L, Jude JG, Hu Y, Witkowski MT, McKenzie MD, Kartal-Kaess M, Best SA, Tuohey L, Liao Y, Shi W, Mullighan CG, Farrar MA, Nutt SL, Smyth GK, Zuber J, Dickins RA.

Genes Dev. 2014 Jun 15;28(12):1337-50. doi: 10.1101/gad.240416.114.

32.

Axonal dysfunction, dysmyelination, and conduction failure in hereditary neuropathy with liability to pressure palsies.

Farrar MA, Park SB, Krishnan AV, Kiernan MC, Lin CS.

Muscle Nerve. 2014 Jun;49(6):858-65. doi: 10.1002/mus.24085.

PMID:
24752454
33.

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.

Mahmud SA, Manlove LS, Schmitz HM, Xing Y, Wang Y, Owen DL, Schenkel JM, Boomer JS, Green JM, Yagita H, Chi H, Hogquist KA, Farrar MA.

Nat Immunol. 2014 May;15(5):473-81. doi: 10.1038/ni.2849. Epub 2014 Mar 16.

34.

Identification of KLHL41 Mutations Implicates BTB-Kelch-Mediated Ubiquitination as an Alternate Pathway to Myofibrillar Disruption in Nemaline Myopathy.

Gupta VA, Ravenscroft G, Shaheen R, Todd EJ, Swanson LC, Shiina M, Ogata K, Hsu C, Clarke NF, Darras BT, Farrar MA, Hashem A, Manton ND, Muntoni F, North KN, Sandaradura SA, Nishino I, Hayashi YK, Sewry CA, Thompson EM, Yau KS, Brownstein CA, Yu TW, Allcock RJ, Davis MR, Wallgren-Pettersson C, Matsumoto N, Alkuraya FS, Laing NG, Beggs AH.

Am J Hum Genet. 2013 Dec 5;93(6):1108-17. doi: 10.1016/j.ajhg.2013.10.020. Epub 2013 Nov 21.

35.

Interleukin-2 and STAT5 in regulatory T cell development and function.

Mahmud SA, Manlove LS, Farrar MA.

JAKSTAT. 2013 Jan 1;2(1):e23154. doi: 10.4161/jkst.23154. Review.

36.

Constitutively active STAT5 constructs.

Heltemes-Harris LM, Farrar MA.

Methods Mol Biol. 2013;967:225-32. doi: 10.1007/978-1-62703-242-1_16.

PMID:
23296733
37.

No gain - no pain?

Lin CS, Farrar MA.

J Neurol Neurosurg Psychiatry. 2013 Apr;84(4):364. doi: 10.1136/jnnp-2012-304098. Epub 2012 Nov 21. No abstract available.

PMID:
23172870
38.

Evolution of peripheral nerve function in humans: novel insights from motor nerve excitability.

Farrar MA, Park SB, Lin CS, Kiernan MC.

J Physiol. 2013 Jan 1;591(1):273-86. doi: 10.1113/jphysiol.2012.240820. Epub 2012 Sep 24.

39.

Pathophysiological insights derived by natural history and motor function of spinal muscular atrophy.

Farrar MA, Vucic S, Johnston HM, du Sart D, Kiernan MC.

J Pediatr. 2013 Jan;162(1):155-9. doi: 10.1016/j.jpeds.2012.05.067. Epub 2012 Jul 17.

40.

Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo.

Zou T, Satake A, Corbo-Rodgers E, Schmidt AM, Farrar MA, Maltzman JS, Kambayashi T.

J Immunol. 2012 Jul 1;189(1):28-32. doi: 10.4049/jimmunol.1200507. Epub 2012 May 23.

41.

IL-7 functionally segregates the pro-B cell stage by regulating transcription of recombination mediators across cell cycle.

Johnson K, Chaumeil J, Micsinai M, Wang JM, Ramsey LB, Baracho GV, Rickert RC, Strino F, Kluger Y, Farrar MA, Skok JA.

J Immunol. 2012 Jun 15;188(12):6084-92. doi: 10.4049/jimmunol.1200368. Epub 2012 May 11.

42.

Corticomotoneuronal integrity and adaptation in spinal muscular atrophy.

Farrar MA, Vucic S, Johnston HM, Kiernan MC.

Arch Neurol. 2012 Apr;69(4):467-73. doi: 10.1001/archneurol.2011.1697.

PMID:
22491191
43.

The role of STAT5 in lymphocyte development and transformation.

Heltemes-Harris LM, Farrar MA.

Curr Opin Immunol. 2012 Apr;24(2):146-52. doi: 10.1016/j.coi.2012.01.015. Epub 2012 Feb 16. Review.

44.

A developmentally controlled competitive STAT5-PU.1 DNA binding mechanism regulates activity of the Ig κ E3' enhancer.

Hodawadekar S, Park K, Farrar MA, Atchison ML.

J Immunol. 2012 Mar 1;188(5):2276-84. doi: 10.4049/jimmunol.1102239. Epub 2012 Jan 25.

45.

Turning transcription on or off with STAT5: when more is less.

Farrar MA, Harris LM.

Nat Immunol. 2011 Nov 16;12(12):1139-40. doi: 10.1038/ni.2163. No abstract available.

PMID:
22089213
46.

Dysfunction of axonal membrane conductances in adolescents and young adults with spinal muscular atrophy.

Farrar MA, Vucic S, Lin CS, Park SB, Johnston HM, du Sart D, Bostock H, Kiernan MC.

Brain. 2011 Nov;134(Pt 11):3185-97. doi: 10.1093/brain/awr229. Epub 2011 Sep 16.

47.

Foxp3(+) regulatory T cell expansion required for sustaining pregnancy compromises host defense against prenatal bacterial pathogens.

Rowe JH, Ertelt JM, Aguilera MN, Farrar MA, Way SS.

Cell Host Microbe. 2011 Jul 21;10(1):54-64. doi: 10.1016/j.chom.2011.06.005.

48.

Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia.

Heltemes-Harris LM, Willette MJ, Ramsey LB, Qiu YH, Neeley ES, Zhang N, Thomas DA, Koeuth T, Baechler EC, Kornblau SM, Farrar MA.

J Exp Med. 2011 Jun 6;208(6):1135-49. doi: 10.1084/jem.20101947. Epub 2011 May 23.

49.

The role of STAT5 in the development, function, and transformation of B and T lymphocytes.

Heltemes-Harris LM, Willette MJ, Vang KB, Farrar MA.

Ann N Y Acad Sci. 2011 Jan;1217:18-31. doi: 10.1111/j.1749-6632.2010.05907.x. Review.

PMID:
21276004
50.

Enhancement of T-cell-mediated antitumor response: angiostatic adjuvant to immunotherapy against cancer.

Dings RP, Vang KB, Castermans K, Popescu F, Zhang Y, Oude Egbrink MG, Mescher MF, Farrar MA, Griffioen AW, Mayo KH.

Clin Cancer Res. 2011 May 15;17(10):3134-45. doi: 10.1158/1078-0432.CCR-10-2443. Epub 2011 Jan 20.

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